Cerebrospinal fluid and serum antimicroglial antibodies: prospects for early diagnosis of Alzheimer′s disease

References

• Neuroinflammation Working Group: Inflammation and Alzheimer's disease. Neurobiol Aging21, 383–421 (2000).
   PubMed Web of Science ®Google Scholar
• •Extremely important review of current concepts about inflammatory mechanisms in AD.
   Google Scholar
• McGeer E, McGeer P Chronic inflammation in Alzheimer's disease offers therapeutic opportunities. Expert Rev Neurotherapeutics 1, 53–60 (2001).
   PubMedGoogle Scholar
• McGeer PL, McGeer EG. Inflammation, autotoxicity and Alzheimer's disease Neurobial Aging22, 799–809 (2001).
   Google Scholar
• Werkle HC, Linington H, I assmann H, Meyermann R Cellular immune reactivity within the CNS. Tend Aiwusci. 9,271–277 (1986).
   Google Scholar
• •One of the first reports to challenge the dogma of an immunological priviledged CNS.
   Google Scholar
• Rogers J, Luber-Narod J, Styren S, Civin H. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neumbial Aging9, 339–349 (1988).
   PubMed Web of Science ®Google Scholar
• Caley DW, Maxwell DS. An electron microscopic study of the neuroglia duringpostnatal development of the rat cerebrum. Comp. Neural. 133,45–70 (1968).
   Google Scholar
• McGeer P, Itagaki S, Tago H, McGeer EG. Reactive microglia in patients with senile dementia of the Alzheimer's type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci. Lett. 79, 195–200 (1987).
   PubMed Web of Science ®Google Scholar
• •First demonstration of imniunocompetent microglia in the CNS.
   Google Scholar
• Guilian D. Ameoboid microglia as effectors of inflammation in the central nervous system. Neumsd Res: 18, 155–171 (1987).
   Google Scholar
• •One of the primary studies demonstrating that microglia have the potential to express immunocompetent antigens.
   Google Scholar
• Ishii T, Haga S. Immunoelectron microscopic localization of complement in amyloid fibrils of senile plaques. Acta Neuropathol 63, 296–300 (1984).
   PubMed Web of Science ®Google Scholar
• McGeer P, Akiyama H, Itagak S, McGeer EG. Activation of the classical complement pathway in brain tissue of Alzheimer's patients. Neurosci. Lett. 197,341–346 (1989).
   Google Scholar
• Webster S, Luc LF, Brachova L eta]. Molecular and cellular characterization of the membrane attack complex C5b-9 in Alzheimer's disease Neumbial Aging18, 415–421 (1997).
   Google Scholar
• Giulian D. Neurogenetics '99. Microglia and the immune pathology of Alzheimer's disease. Am. j Hum. Genet. 65,13-18 (1999).
   Google Scholar
• Peress N, Fleit H, Perillo E. Identification of Pc gamma RI, II, III on normal human ramified microglia and microglia in senile plaques. I Neumimmunology 48,71–80 (1993).
   Google Scholar
• Rogers L, Kirby LC, Hempelman SR. Clinical trial of indomethacin in Alzheimer's disease. Neurology43, 1609–1611 (1993).
   Google Scholar
• •First clinical trial involving anti-inflammatory agents in AD.
   Google Scholar
• Anonymous. Consensus report of the Working Group on: 'Molecular and Biochemical Markers of Alzheimer's disease.' The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group. Neurobial Aging 19,109–116 (1998).
   Google Scholar
• Kalter K, Kelly S. Alzheimer's disease. Evaluation of immunological indices. NY State Med 75,1222–1225 (1975).
   PubMedGoogle Scholar
• Tavolato B, Argentiero V. Immunological indices in presenile Alzheimer's disease. Neural Sci. 46,325–331 (1980).
   PubMedGoogle Scholar
• Fudenberg IIf I, Whitten HD, Aranaud P, Khansari N, Tsang KY, Hmaes CG. Immune diagnosis of a subset of Alzheimer's disease with preliminary implications for immunotherapy Biomed Pharmacother. 38,290–297 (1984).
   Google Scholar
• Hampel H, Kotter HU, Padberg F, Korschenhausen DA, Moller HJ. Oligoclonal bands and blood—cerebrospinal- fluid barrier dysfunction in a subset of patients with Alzheimer's disease: comparison with vascular dementia, major depression and multiple sclerosis. Alzheimer Dis. Assoc. Disord 1,9–19 (1999).
   Google Scholar
• Teunissen CE, de Vente J, Steinbusch HWM, De Bruijn C. Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid Neurobial Aging-23, 485–508 (2002).
   Google Scholar
• •Excellent overview of the status of biomarkers for AD.
   Google Scholar
• Nandy K. Alzheimer's disease: Senile dementia and related disorders. In: Aging (Vol. 4. Katzman RD, Terry RD, Bick KL (Eds). Raven Press Publisher, New York, NY, USA, 503–512 (1978).
   Google Scholar
• Terryberry JW, Thor G, Peter JB. Autoantibodies in neurodegenerative diseases antigen-specific frequencies and intrathecal analysis. Neurobial Aging19, 205–216 (1998).
   Google Scholar
• •Excellent overview of the current relationship between antibrain antibodies and neurodegenerative disorders.
   Google Scholar
• Rogers J, Rovigatti U. Immunologic and tissue culture approaches to the neurobiology of aging. Neurobial Aging9, 759–762 (1988).
   Google Scholar
• Whittingham S, Lennon V, Mackay IE etal Absence of brain antibodies in senile dementia Br. Psychiatry 116,447–448 (1970).
   Google Scholar
• Husby G, Li L, Davis L et al Antibodies to human caudate nucleus neurons in Huntington's Chorea. j Clin. Invest. 59, 922–932 (1977).
   PubMed Web of Science ®Google Scholar
• •Possibly one of the first demonstrations that antibodies from a patient recognize neuronal structures in the human brain.
   Google Scholar
• Foley P, Bradford H, Docherty M eta]. Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease. j Neural 235 466–471 (1988).
   Google Scholar
• Chapman J, Korczyn AD, Hareuveni M, Michaelson DM. Antibodies to cholinergic cell bodies in Alzheimer's disease. In: Alzheimer's, and Parkinson's diseases: Strategies for Research and Development. Fisher A, Hanin I, Lachman C (Eds). Plenum Press, New York, NY, USA, 329–333 (1986).
   Google Scholar
• McRae-Degueurce A, Booj S, Haglid K etal Antibodies in the cerebrospinal fluid of some Alzheimer's diseases patients recognize cholinergic neurons in the rat central nervous system. Proc. Natl Acad. Li. USA 84,9214–9218 (1987).
   PubMedGoogle Scholar
• Finit HM, Kemeny E, Luine V, Weksler ME, Zabriskie JB. Antivascular antibodies in the sera of patients with senile dementia of the Alzheimer's type. I Geronotal 42, 180–184 (1987).
   Google Scholar
• Chapman J, Bachar O, Korczyn et al Alzheimer's disease antibodies bind specifically to neurofilament protein in Torpedo cholinergic neurons j Neuroscience 9,2710-2717(1989).
   Google Scholar
• Gaskin F, Kingsley BS, Fu SM. Autoantibodies to neurofibrillary tangles and brain tissue in Alzheimer's disease. Establishment of Epstein-Barr virus transformed antibody-producing cell lines. EAp. Med. 165,245–250 (1987).
   Google Scholar
• McRae A, Blennon K, Gottfries CG, Walin A, Dahlström A. Brain specific antibodies in the CSF of patients with Alzheimer's disease and other types of dementias. In: Biological Markers in Dementia of Alzheimer Type. Fowler CJ, Carlson LA, Gottfries CG, Winblad B (Eds). Smith-Gordon Publishers, London, UK, 135–148 (1990).
   Google Scholar
• McRae A, Ling EA, Polinsky R, Gotffries CG, Dahlström A. Antibodies in the cerebrospinal fluid of some Alzheimer's disease patients recognize amoeboid microglial cells in the developing rat central nervous system. Neuroscience 41,739–752 (1991).
   Google Scholar
• •First report of microglia antibodies in the CSF of AD patients.
   Google Scholar
• McRae A, Dahlstrom A, Polinsky R, Ling EA. Cerebrospinal fluid antibodies: potential diagnostic markers for immune mechanisms in Alzheimer's disease. Behavioural Brain Res. 57,225–234 (1993).
   Google Scholar
• •First demonstration of the presence of activated microglia in a patient's biopsy as recognized by the patient's own CSE
   Google Scholar
• Raff MC, Fields KL, Hakomori S, Mirsky R, Pruss RM, Winter J. Cell-type specific markers for distinguishing and studying neurons and the major class of glial cells in culture Brain Res. 174,283–308 (1979).
   Google Scholar
• Ling EA, Penney D, Leblond CR Use of carbon labeling to demonstrate the role of blood monocytes as the precursors of the `ameboid cells' in the corpus callosum of postnatal rats./ Comp. Neurology193,631–657 (1980).
   PubMed Web of Science ®Google Scholar
• •One of the hallmark papers concerning the origin of microglia.
   Google Scholar
• Ling EA, Kaur C, Wong WC. Expression of major histocompatibility complex antigens and CR3 complement receptors in activated microglia following an injection of ricin into the sciatic nerve in rats. Ifistal Ifistopath. 7,93-100 (1992).
   Google Scholar
• Ling EA, Dahlström A, Polinsky R, Nee L, McRae A. Studies of activated microglia cells and macrophages using Alzheimer's disease cerebrospinal fluid in adult rats with experimentally induced lesions. Neuroscience 51,815–825 (1992).
   Google Scholar
• Morioka T, Kalehua A, Streit W The microglial reaction in the rat dorsal hippocampus following transient forebrain ischaemia I Cereb. Blood Flow Metab. 11, 966–997 (1991).
   PubMed Web of Science ®Google Scholar
• McRae A, Rudolphi K, Schubert P Propentofylline depresses amyloid and Alzheimer's CSF microglial antigens after ischaemia. NeumReponc5,1193–1196 (1993).
   Google Scholar
• Dahlstrom A, Wigander A, Lundmark K, Gottfries CG, McRae A. Investigations on autoantibodies in Alzheimer's and Parkinson's diseases, using defined neuronal cultures. J. Neural Bans. 29, (Suppl.) 195–206 (1990).
   Google Scholar
• Lemke MR, Glatzel M, Henneberg AE. Antimicroglia antibodies in sera of Alzheimer's disease patients. Biol. Psychiatry 45,508–511 (1999).
   Google Scholar
• Giulian D. Microglia and diseases of the nervous system In: Current Issues in Neurology 1992 Vol .12 Mosby Year Book Inc., MO, USA, 23–54 (1992).
   Google Scholar
• •Excellent overview of the participation of microglia in neurodegenerative disorders.
   Google Scholar
• Thomas WE. Brain macrophages: evaluation of microglia and their function. Brain Res. Rev. 17,61–74 (1992).
   Google Scholar
• •Excellent overview of the participation of microglia in neurodegenerative disorders.
   Google Scholar
• McRae A, Dahlstrom A, Ling EA. Microglial in neurodegenerative disorders: emphasis on Alzheimer's disease. Gerontology43, 95–108 (1997).
   Google Scholar
• Banati RB, Gehrmann J, Kellner M, Holsboer E Antibodies against microglia/ brain macrophages in the cerebrospinal fluid of a patient with acute amyotrophic lateral sclerosis and presenile dementia. Clin. Neuropathol 14,197–200 (1995).
   Google Scholar
• Miklossy J, Lepori D, Genton C, Kraftsik R, Pillevuit O, Bosman FT Curly fiber and tangle-like structures in the ependyma and the choroid plexus — A pathogenetic relationship with the cortical Alzheimer-type changes? I Neuropathol Exp. Neural 57,104–114 (1998).
   Google Scholar
• Cagnin A, Brooks DJ, Gunn RN et al 117 vivo measurement of activated microglia in dementia. Lancet 358,461–467 (2001).
   PubMed Web of Science ®Google Scholar
• •One of the first demonstrations of activated microglia in a patient using PET.
   Google Scholar
• Schubert P, Banati R, Dux E, Gehrmann J, Rudolphi K, Kreutzberg GW. Reactive oxygen intermediates in microglial cells differentiating into brain macrophages: depression by propentofylline and relation to adenosine. Krieglstein J, Oberpichler H (Eds). Wiss Verl Ges, Stuttgart, Germany, 461–467 (1992).
   Google Scholar
• Schubert P, Ogata T, Rudolphi K etal Support of Homestatic glial cells signaling: A novel therapeutic approach by propentofylline Ann. NY Acad. Sci. 826, 337–347 (1997)
   PubMedGoogle Scholar
• McRae A, Schubert P, Ogata T et al. Post ischemic glial responses and amyloid accumulation are modified by propentofylline Neuroprotective pharmacon for Alzheimer’s disease? In: Alzheimer’s Disease: Biology, Diagnosis and Therapeutics. Iqbal I, Winblad B, Nishimura T, Takeda M,Wisniewski HM (Eds). John Wiley & Sons Publishers, New York, NY, USA, 757–765 (1997).
   Google Scholar
• Guilian D, Baker TJ, Shih LCN eta]. Interleukin I of the central nervous system is produced by amoeboid microglia I. Exp. Med. 164,594–604 (1986).
   Google Scholar
• •One of the first publications demonstrating that activated microglia produce cytoldnes.
   Google Scholar
• Koriyama Y, Yamazaki M, Chiba K, Mohri T Evaluation of neurotoxicity of Alzheimer's amyloid beta protein (beta42) in cultured hippocampal cells and its prevention by propentofylline. Jpn Pharmacol 82,301–306 (2000).
   Google Scholar
• Rother M, Erkinjuntti T, Roessner M et al. Propentofylline in the treatment of Alzheimer’s disease and vascular dementia: a review of Phase III trials. Geriatr. Cogn. Disord. Suppl. 1, 36–43 (1998).
   Google Scholar
• • First report of a clinical trial in which a drug demonstrated the ability to treat the progression of AD.
   Google Scholar
• McRae-Degueurce A, Haglid K Rosengren et al. Antibodies recognizing cholinergic neurons and thyroglobuline are found in the cerebrospinal fluid of a subgroup of patients with Alzheimer’s disease. Drug Devel. Res. 15, 153–163 (1988).
   Google Scholar
• Ewins D, Rossor M, Butler J. Association between autoimmune thyroid disease and familial Alzheimer's disease Cl/n. Endocrinology35, 93–96 (1991).
   Google Scholar
• Genovesi G, Paolini P, Marcellini L etal Relationship between autoimmune thyroid disease and Alzheimer's disease. Panminerva Med. 38,61–63 (1996).
   PubMedGoogle Scholar
• McRae A, Ling EA. Microglia; an antigen for Alzheimer's cerebrospinal fluid antibodies In: Topical Issues in Microglia Research. Ling EA, Tan CK, Tan CBS (Eds). Goh Bros Enterprise Humanities Press Publisher, Singapore, 109–117 (1996).
   Google Scholar
• Benveniste EN, Nguyen VT, O'Keefe GM. Immunological aspects of microglia: relevance to Alzheimer's disease. Neurochem. Int. 39,381-391 (2001)
   Google Scholar
• McGeer PL, Schulzer M, McGeer EG. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology47,425-432 (1996). Extensive report of epidemiological studies which emphasized the significance of inflammation in AD.
   Google Scholar
• Veld BA, Launer LJ, Hoes AW etal NSAIDs and incidence Alzheimer's disease. The Rotterdam study. Neurobial Aging19, 607–611 (1998).
   Google Scholar
• Stewart WF, Kawas C, Corrada M, Meter EJ. Risk of Alzheimer's disease and duration of NSAID use. Neurology48, 626–632 (1997).
   PubMed Web of Science ®Google Scholar
• Lim GP, Yang F, Chu T et al Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. I Neurosci. 20,5709-5714. (2000). One of the first reports to demonstrate that NSAIDs have the potential to interfere with plaques formation.
   Google Scholar
• Mackenzie I. Post mortem studies of the effect of anti-inflammatory drugs on Alzheimer's type pathology and associated inflammation. Neurobial Aging22, 819–822 (2001).
   Google Scholar
• Tan J, Town T Paris D etal Microglial activation resulting from CD4O—CD4OL interaction after beta amyloid stimulation. Science 286,2352–2355 (1999).
   PubMed Web of Science ®Google Scholar
• Tan J, Town T, Mori T CD45 opposes beta amyloid peptide induced microglial activation via inhibition of pp44/42 mitogen activated protein kinase Neumsci. 20,7587–7594 (2000).
   Google Scholar
• Eikelenboom P, Stam FC. Immunoglobulines and complement factors in senile plaques. An immunoperoxidase study. Acta Neuropathol 57,239–242 (1982).
   PubMed Web of Science ®Google Scholar
• Ishii T, Haga S. Immunoelectron microscopic localization of immunoglobulines in amyloid fibrils of senile plaques. Acta Neuropathol 36,243–249 (1976).
   PubMedGoogle Scholar
• •Probably the earliest account of the existence of IgG in AD plaques.
   Google Scholar
• Rogers J, Cooper NR, Webster S etal Complement activation by beta amyloid in Alzheimer's disease. Proc. Natl Acad. Sci USA 89,10016–10020 (1992).
   PubMed Web of Science ®Google Scholar
• •Initial report indicating that a major component of AD pathology could activate complement.
   Google Scholar
• Haga S, Ikeda K, Sato M, Ishii T Synthetic Alzheimer amyloid 13/A4 peptides enhance production of complement C3 component by cultured microglial cells. Brain Res. 601, 88–94 (1993).
   PubMed Web of Science ®Google Scholar
• Yong Shen Lih-Fen Lue Li-Bang Yang eta]. Complement activation by neurofibrillary tangles in Alzheimer's disease Neurosci _Lett. 305,165–168 (2001).
   Google Scholar
• Singh VK. Neuroimmune axis as a basis of therapy in Alzheimer's disease Frog. Drug Res. 34,383–393 (1990).
   Google Scholar
• Corder EH, Saunders AM, Strittmatter WJ etal Gene dose of apolipoprotein E Type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261 921–923 (1993).
   PubMed Web of Science ®Google Scholar
• Papassotiropoulos A, Bagli M, Jessen F et al A genetic variant of the inflammatory cytokine interleukin-6 delays the onset the initial onset and reduces the risk for sporadic Alzheimer's disease Ann. Neural 45,666–668 (1999).
   Google Scholar
• Nissl E Ueber einige Beziehungen zwischen Nervenzellener-krankungen und glisen Erscheinungen bei verschiedenen Psychosen. Arch. Psych. 32,1–21 (1899).
   Google Scholar
• Griffin WST, Sheng JG, Roberts G. Interleukin-1 expression in different plaques types in Alzheimer's disease. Significance in plaque formation. J: Neuropathol Exp. Neural 54,276–281 (1995)
   Google Scholar
• Sheng JG, Mrak RE, Griffin WST. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94,1–5 (1997)
   Google Scholar
• Hao SA-J, Dheen T, Ling E-A. Expression of macrophage colony-stimulating factor and its in microglia activation is linked to teratogen-induced neuronal damage. Neuroscience 112,889–900 (2002).
   Google Scholar
• Giulian D, Haverkamp LJ, Yu JH etal Specific domains of beta-amyloid from Alzheimer plaque elicit neurone killing in human microglia. j Neurosci 16,6021–6037 (1996).
   PubMed Web of Science ®Google Scholar
• Rio-Hortega P Microglial. In: Cytology and Cellular Pathology of the Nervous System (Vol. 2). Penfield W (Ed.), Paul B Hoeber Publisher, New York, NY, USA, 481–584 (1932).
   Google Scholar
• •The beginning of the marvelous microglia.
   Google Scholar