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Editorial

Preventing and treating Alzheimer’s disease: strategies and prospects

Pages 565-569 | Published online: 10 Jan 2014

References

  • Katzman R. The prevalence and malignancy of Alzheimer's disease. Arch. Neurol. 33,217(1976).
  • Katzman R, Bick K. Alzheimer's Disease: the Changing View. New Yolk Academic Press, NY, USA (2000).
  • Pollen DA. Hannah's Heirs: the Que s tFo r the Genetic Origins of Alzheimer's Disease. Oxford University Press, NY, USA (1993).
  • Bernheimer H, Hornykiewicz, 0. Decreased homovanillic acid concentration in the brain in parkinsonian subjects as an expression of a disorder of central dopamine metabolism. Klin. Wochenschr . 43,711-715(1965).
  • Drachman D, Leavitt J. Human memory and the cholinergic system: a relationship to aging? Arch NeuroL 30,113–121 (1974).
  • Bowen DM, Smith CB, White P, Davison AN. Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain 99(3),459–496 (1976).
  • White P, Hiley CR, Goodhardt MJ et al. Neocortical cholinergic neurons in elderly people. Lancet 1(8013), 668–671 (1977).
  • Davies P, Maloney AJ. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2(8000), 1403 (1976).
  • Davies P, Verth AH. Regional distribution of muscarinic acetylcholine receptor in normal and Alzheimer's-type dementia brains. Brain Res. 138(2), 385–392 (1977).
  • Whitehouse PJ, Price DL, Clark AW, Coyle JT, DeLong MR. Alzheimer's disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann. Neurol. 10(2), 122–126 (1981).
  • Summers WK, Viesselman JO, Marsh GM, Candelora K. Use of THA in treatment of Alzheimer-like dementia: pilot study in twelve patients. BioL Psych. 16(2), 145–153 (1981).
  • Davis KL, Thal U, Gamzu ER et al. A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group. N. Engl. J. Med. 327(18), 1253–1259 (1992).
  • Francis PT, Palmer AM, Sims NR et aL Neurochemical studies of early-onset Alzheimer's disease. Possible influence on treatment. N. EngL J. Med. 313(1), 7–11 (1985).
  • Glenner GG, Wong C W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Corn. 120(3), 885–890 (1984).
  • Selkoe DJ. Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann. NY Acad. Sci. 924, 17–25 (2000).
  • Selkoe DJ. Alzheimer's disease is a synaptic failure. Science 298(5594), 789–791 (2002).
  • Selkoe DJ, Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Ann. Rev. PharmacoL Toxicol. 43,545–584(2003).
  • Schenk D, Seubert P, Ciccarelli RB. Immunotherapy with I3-amyloid for Alzheimer's disease: a new frontier. DNA Cell. Biol. 20(11),679-681 (2001).
  • Plant LD, Boyle J P, Smith IF, Peers C, Pearson HA. The production of amyloid 13 peptide is a critical requirement for the viability of central neurons. J. Neurosci. 23(13), 5531–5535 (2003).
  • Price DL, Whitehouse PJ, Struble RG et aL Alzheimer's disease and Down's syndrome. Ann. NY Acad. Sci. 396, 145–164 (1982).
  • Wisniewski HM, Rabe A. Discrepancy between Alzheimer-type neuropathology and dementia in persons with Down's syndrome. Ann. NY Acad. Sci. 477, 247–260 (1986).
  • Goate A. Molecular genetics of Alzheimer's disease. Geriatrics 52\(Suppl. 2), S9—S12 (1997).
  • St George-Hyslop P, Haines J et aL Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nature Ge n. 2(4), 330–334 (1992).
  • Saunders A, Strittmatter W, Schmechel D et aL Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology 4 3, 1467–1472 (1993).
  • Mayeux R, Saunders A, Shea S etal. Utility of apolipoprotein E genotype in the diagnosis of Alzheimer's disease. N. EngL J. Med. 338, (1998).
  • Duff K, Eckman C, Zehr C et aL Increased amyloid-13 42(43) in brains of mice expressing mutant presenilin 1. Na t u re383(6602), 710–713 (1996).
  • Savonenko AV, Xu GM, Price DL, Borchelt DR, Markowska AL. Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE. NeurobioL Dis. 12(3), 194–211 (2003).
  • Refolo LM, Pappolla MA, LaFrancois J et al. A cholesterol-lowering drug reduces I3-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 8(5), 890–899 (2001).
  • Seshadri S, Drachman D, Lippa C. Apolipoprotein E e4 allele and the lifetime risk of Alzheimer's disease: what physicians know and what they should know. Arch. Ne u ro 1. 52, 107 4–1080 (1995).
  • Drachman D. Aging and the brain: a new frontier. Ann. NeuroL 42, 819–828 (1997).
  • Beal M. Aging, energy and oxidative stress in neurodegenerative diseases. Ann. NeuroL 38, 357–366 (1995).
  • Wei Y-H, Kao S-H, Lee H-C. Simultaneous increase of mitochondrial DNA detections and lipid peroxidation in human aging. In: Pharmacological Intervention in Aging and Age-Associated Disorders. Kitani K, Aoba A, Goto S (Eds). New York Academy of Sciences, NY, USA, 24–43 (1996).
  • Buee L, Hof PR, Bouras C et aL Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders. Acta Neuropathologica 87(5), 469–480 (1994).
  • Sparks DL, Hunsaker JC 3rd, Scheff SW, Kryscio RJ, Henson JL, Markesbery WR. Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease. Neurobiol. Aging 11(6), 601–607 (1990).
  • Strittmatter W, Saunders A, Schmechel D et al. Apolipoprotein E: high-avidity binding to I3-amyloid and increased frequency of Type 4 allele in late-onset familial Alzheimer's disease. Pr o c . Nail Acad. Sci. USA 90, 1977-1981 (1993).
  • Jick H, Zornberg G, Jick S, Seshadri S, Drachman D. Statins and the risk of dementia. Lancet 356, 1627–1631 (2000).
  • Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer's disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. NeuroL 57(10), 1439–1443 (2000).
  • Rockwood K, Kirkland S, Hogan DB et aL Use of lipid-lowering agents, indication bias and the risk of dementia in community-dwelling elderly people. Arch. NeuroL 59(2), 223–227 (2002).
  • Fassbender K, Simons M, Bergmann C et al. Simvastatin strongly reduces levels of Alzheimer's disease I3-amyloid peptides AP 42 and AI3 40 in vitro and in vivo. Proc. Nat! Acad. Sci. USA 98(10), 5856–5861 (2001).

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