Acid-sensing ion channels and pain: therapeutic potential?

References

• Papers of special note have been highlighted as:
   Google Scholar
• of interest
   Google Scholar
• of considerable interest
   Google Scholar
• Jacobus WE, Taylor GJ 4th, Hollis DP, Nunnally RL. Phosphorus nuclear magnetic resonance of perfused working rat hearts. Nature 265, 756758 (1977).
   Google Scholar
• Carpenter KJ, Nandi M, Dickenson AH. Peripheral administration of low pH solutions causes activation and sensitisation of convergent dorsal horn neurones in the anaesthetised rat. Neurosci. Lett. 298, 179 182 (2001).
   Google Scholar
• Kress M, Reeh PW. Chemical excitation and sensitization in nociceptors. In: Neurobiology of Nociceptors. Cervero F, Belmonte C (Eds). Oxford University Press, NY, USA, 258297 (1996).
   Google Scholar
• Keele CA, Armstrong D. Substances Producing Pain and Itch. Edward Arnold, London, UK (1964).
   Google Scholar
• Steen KH, Reeh PW. Sustained graded pain and hyperalgesia from harmless experimental tissue acidosis in human skin. Neurosci. Lett. 154, 113116 (1993).
   Web of Science ®Google Scholar
• Issberner U, Reeh PW, Steen KH. Pain due to tissue acidosis: a mechanism for inflammatory and ischemic myalgia? Neurosci. Lett. 208, 191194 (1996).
   Google Scholar
• Kobal G, Hummel T. Brain responses to chemical stimulation of the trigeminal nerve in man. In: Chemical Senses. Green BG, Mason JR, Kare MR (Eds). Marcel Dekker, NY, USA, 123139 (1989).
   Google Scholar
• Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature 413, 203210 (2001).
   Web of Science ®Google Scholar
• Concise overview about molecular mechanisms underlying nociception.
   Google Scholar
• Bevan S, Geppetti P. Protons: small stimulants of capsaicin-sensitive sensory nerves. Trends. Neurosci. 17, 509512 (1994).
   Web of Science ®Google Scholar
• Steen KH, Reeh PW, Anton F, Handwerker HO. Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J. Neurosci. 12, 8695 (1992).
   Web of Science ®Google Scholar
• Sutherland SP, Benson CJ, Adelman JP, McCleskey EW. Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. Proc. Natl. Acad. Sci. USA 98, 711716 (2001).
   Google Scholar
• Krishtal OA, Pidoplichko VI. A receptor for protons in the nerve cell membrane. Neuroscience 5, 23252327 (1980).
   Web of Science ®Google Scholar
• Bevan S, Yeats J. Protons activate a cation conductance in a subpopulation of rat dorsal root ganglion neurones. J. Physiol. 433, 145161 (1991).
   Web of Science ®Google Scholar
• Petersen M, LaMotte RH. Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 54, 3742 (1993).
   Web of Science ®Google Scholar
• Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816824 (1997).
   Web of Science ®Google Scholar
• Gunthorpe MJ, Benham CD, Randall A, Davis JB. The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol. Sci. 23, 183191 (2002).
   Web of Science ®Google Scholar
• Tominaga M, Caterina MJ, Malmberg AB et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21, 531543 (1998).
   Web of Science ®Google Scholar
• Caterina MJ, Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Ann. Rev. Neurosci. 24, 487517 (2001).
   Web of Science ®Google Scholar
• Cortright DN, Crandall M, Sanchez JF, Zou T, Krause JE, White G. The tissue distribution and functional characterization of human VR1. Biochem. Biophys. Res. Commun. 281, 11831189 (2001).
   Google Scholar
• Cobbe SM, Poole-Wilson PA. The time of onset and severity of acidosis in myocardial ischaemia. J. Mol. Cell Cardiol. 12, 745 760 (1980).
   Web of Science ®Google Scholar
• Cobbe SM, Poole-Wilson PA. Continuous coronary sinus and arterial pH monitoring during pacing-induced ischemia in coronary artery disease. Br. Heart J. 47, 369374 (1982).
   Google Scholar
• Waldmann R, Lazdunski M. H+-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels. Curr. Opin. Neurobiol. 8, 418424 (1998).
   Web of Science ®Google Scholar
• Benos DJ, Stanton BA. Functional domains within the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. J. Physiol. 520, 631644 (1999).
   Web of Science ®Google Scholar
• Reeh PW, Kress M. Molecular physiology of proton transduction in nociceptors. Curr. Opin. Pharmacol. 1, 4551 (2001).
   Google Scholar
• Provides a good overview of ion channels and mechanisms involved in proton transduction in nociceptors.
   Google Scholar
• Yiangou Y, Facer P, Smith JA et al. Increased acid-sensing ion channel ASIC-3 in inflamed human intestine. Eur. J. Gastroenterol. Hepatol. 13, 891896 (2001).
   Google Scholar
• Price MP, McIlwrath SL, Xie J et al. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 32, 10711083 (2001).
   Web of Science ®Google Scholar
• Lingueglia E, de Weille JR, Bassilana F et al. A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J. Biol. Chem. 272, 2977829783 (1997).
   Web of Science ®Google Scholar
• Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, Shimada S. Amilorideblockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J. Clin. Invest. 110, 1185 1190 (2002).
   Web of Science ®Google Scholar
• First paper demonstrating that amiloride and capsazepine are effective in reducing acid-evoked pain in humans.
   Google Scholar
• Hille B. Ionic Channels of Excitable Membranes. Sinauer, VT, USA (2001).
   Google Scholar
• Askwith CC, Cheng C, Ikuma M, Benson C, Price MP, Welsh MJ. Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and protongated DEG/ENaC channels. Neuron 26, 133141 (2000).
   Web of Science ®Google Scholar
• de Weille JR, Bassilana F, Lazdunski M, Waldmann R. Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel. FEBS Lett. 433, 257260 (1998).
   Web of Science ®Google Scholar
• Babini E, Paukert M, Geisler HS, Grnder S. Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1). J. Biol. Chem. 277, 41597 41603 (2002).
   Google Scholar
• Waldmann R, Bassilana F, de Weille J, Champigny G, Heurteaux C, Lazdunski M. Molecular cloning of a noninactivating proton-gated Na+ channel specific for sensory neurons. J. Biol. Chem. 272, 2097520978 (1997).
   Web of Science ®Google Scholar
• Price MP, Lewin GR, McIlwrath SL et al. The mammalian sodium channel BNC1 is required for normal touch sensation. Nature 407, 10071011 (2000).
   Web of Science ®Google Scholar
• Dessirier JM, OMahony M, Iodi-Carstens M, Carstens E. Sensory properties of citric acid: psychophysical evidence for sensitization, self-desensitization, crossdesensitization and cross-stimulus-induced recovery following capsaicin. Chem. Senses 25, 769780 (2000).
   Web of Science ®Google Scholar
• Sudo S, Sudo M, Simons CT, Dessirier JM, Iodi Carstens M, Carstens E. Activation of neurons in trigeminal caudalis by noxious oral acidic or salt stimuli is not reduced by amiloride. Brain Res. 18, 237243 (2003).
   Google Scholar
• Ugawa S, Yamamoto T, Ueda T et al. Amiloride-insensitive currents of the acidsensing ion channel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel. J. Neurosci. 23, 36163622 (2003).
   Google Scholar
• Steen KH, Wegner H, Reeh PW. The pH response of rat cutaneous nociceptors correlates with extracellular [Na+] and is increased under amiloride. Eur. J. Neurosci. 11, 27832792 (1999).
   Google Scholar
• Lang F, Busch GL, Ritter M et al. Functional significance of cell volume regulatory mechanisms. Physiol. Rev. 78, 247306 (1998).
   Web of Science ®Google Scholar
• Voilley N, de Weille J, Mamet J, Lazdunski M. Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acidsensing ion channels in nociceptors. J. Neurosci. 15, 80268033 (2001).
   Google Scholar
• Provides evidence that some kinds of nonsteroidal anti-inflammatory drugs at very high concentrations directly inhibit the activity of acid-sensing ion channels.
   Google Scholar
• Mamet J, Baron A, Lazdunski M, Voilley N. Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels. J. Neurosci. 22, 1066210670 (2002).
   Web of Science ®Google Scholar
• Chuang HH, Prescott ED, Kong H et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2- mediated inhibition. Nature 411, 957962 (2001).
   Web of Science ®Google Scholar
• Suzuki M, Mizuno A, Kodaira K, Imai M. Impaired pressure sensation in mice lacking TRPV4. J. Biol. Chem. 278, 2266422668 (2003).
   Google Scholar
• Akopian AN, Chen CC, Ding Y, Cesare P, Wood JN. A new member of the acidsensing ion channel family. Neuroreport 11, 22172222 (2000).
   Google Scholar
• Grnder S, Geissler HS, Bssler EL, Ruppersberg JP. A new member of acidsensing ion channels from pituitary gland. Neuroreport 11, 16071611 (2000).
   Web of Science ®Google Scholar
• Babinski K, Le KT, Seguela P. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. J. Neurochem. 72, 5157 (1999).
   Google Scholar
• Wemmie JA, Chen J, Askwith CC et al. The acid-activated ion channel ASIC contributes to synaptic plasticity, learning and memory. Neuron 34, 463477 (2002).
   Web of Science ®Google Scholar
• Birder LA, Nakamura Y, Kiss S et al. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat. Neurosci. 5, 856860 (2002).
   Google Scholar
• Mezey E, Toth ZE, Cortright DN et al. Distribution of mRNA for vanilloid receptor subtype 1 (VR1) and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc. Natl. Acad. Sci. USA 97, 36553660 (2000).
   Google Scholar
• Rigoni M, Trevisani M, Gazzieri D et al. Neurogenic responses mediated by vanilloid receptor-1 (TRPV1) are blocked by the high affinity antagonist, iodoresiniferatoxin. Br. J. Pharmacol. 138, 977 985 (2003).
   Google Scholar