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Review

Current therapeutic approaches to primary CNS lymphoma

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Pages 673-683 | Published online: 10 Jan 2014

References

  • Papers of special note have been highlighted as:
  • of interest
  • of considerable interest
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  • Largest published retrospective series reporting clinicopathological and therapeutic characteristics of 378 immunocompetent primary CNS lymphoma patients.
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  • Largest Phase II trial using combination chemotherapy and radiotherapy analyzing some relevent aspects on neurotoxicity.
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  • Currently the first, unique, randomized trial in primary CNS lymphoma immunocompetent patients, suggesting CHOP regimen plays no role in the treatment of these malignancies.
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  • Largest series of refractory or relapsed primary CNS lymphoma patients treated with intensive chemotherapy followed by peripheral blood stem cell transplantation.
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  • Phase II trial enhancing the possibility of treating primary CNS lymphoma patients with exclusive chemotherapy deferring radiotherapy.
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  • Interesting study evaluating the role of high-dose chemotherapy followed by autologous stem cell transplantation in patients with newly diagnosed primary CNS lymphoma.
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  • Assesses the activity and toxicity of blood brain barrier disruption, an experimental therapy in primary CNS lymphoma.
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  • First phase II trial assessing activity and tolerance of temozolomide as salvage therapy in primary CNS lymphoma patients.
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