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Drug Evaluation

Ziprasidone: a novel psychotropic with unique properties

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Pages 179-186 | Published online: 10 Jan 2014

References

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  • •An elaboration of ziprasidone's metabolism and the relevant clinical sequelae.
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  • ••The major clinical trial detailing ziprasidone's efficacy and side effects.
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  • •Represents the major study of ziprasidone in the treatment of schizoaffective disorder.
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  • ••Investigates the efficacy of ziprasidone in the treatment of acute mania. It indicates that doses of more than 120 mg/day may be needed for a robust clinical effect.
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  • ••Important paper in the future ofpsychopharmacology. It suggests that the relevant factors in antipsychotic efficacy extrapyramidol symptoms are dissociation rates from the D2 receptor. Furthermore, it suggests that all other notions (i.e. serotonergic system) do not reflect the reality of lower extrapyramidal symptom rates.
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