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Review

Disease-modifying drugs for the early treatment of multiple sclerosis

Pages 455-463 | Published online: 10 Jan 2014

References

  • Compston A, Coles A. Multiple sclerosis. Lancet359, 1221–1231 (2002).
  • Keegan BM, Noseworthy JH. Multiple sclerosis. Ann. Rev Med. 53, 285–302 (2002).
  • Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neumlogy46, 907–911 (1996).
  • Weinshenker BG, Bass B, Rice GP et al The natural history of multiple sclerosis: a geographically based study 1. Clinical course and disability. Brain 112, 133–146 (1989).
  • Galboiz J, Miller A. Immunological indicators of disease activity and prognosis in multiple sclerosis. CUI7: Opin. Neural 15, 233–237 (2002).
  • Wekerle H, Linington C, Lassmann H, Meyermann R. Cellular immune reactivity within the CNS. Trends. Neumsci. 9, 271–277 (1986).
  • Brack W, Bitsch A, Kolenda H, Bruck Y, Stiefel M, Lassmann H. Inflammatorycentral nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann. Neural. 42,783–793 (1997).
  • Dalton CM, Brex PA, Jenkins R et al. Progressive ventricular enlargement in patients with clinically isolated syndromes is associated with the early development of multiple sclerosis. j Neural Neurosurg. Byddatry73, 141–7 (2002).
  • Trapp BD, Peterson J, Ransohoff RM, Rudick RA, Mirk S, B6 L. Axonal transection in the lesions of multiple sclerosis. N Engl. I Med. 338, 278–285 (1998).
  • Trapp BD, Ransohoff R, Rudick R. Axonal pathology in multiple sclerosis: relationship to neurologic disability. Cun: Opin. Neural. 12,295-302 (1999).
  • Trapp BD, Ransohoff RM, Fisher E, Rudick RA. Neurodegeneration in multiple sclerosis: relationship to neurological disability. Neuroscientist 5,48–57 (1999).
  • Goodin DS, Frohman EM, Garmany GP Jr et al Disease modifying therapies in multiple sclerosis. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Ailitylogy58, 169–178 (2002).
  • •A review and consensus statement on the efficacy of disease-modifying therapies in multiple sclerosis (MS).
  • Kurtzke JE Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology33, 1444–1452 (1983).
  • Filippi M, Horsfield MA, Ader HJ et al. Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis. Ann. Neural. 43, 499–506 (1998).
  • Rieckmann P, Toyka KV, Austrian—German—Swiss Multiple Sclerosis Therapy Consensus Group. Escalating immunotherapy of multiple sclerosis. Eur Neural. 42,121–127 (1999).
  • •Consensus statement of the German-speaking Austrian—German—Swiss Multiple Sclerosis Therapy Consensus Group on the escalating imrnunotherapy of MS.
  • The IFN-B Multiple Sclerosis Study Group. Interferon-0- lb is effective in relapsing-remitting multiple sclerosis I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology43,655–661 (1993).
  • Jacobs LD, Cookfair DL, Rudick RA et al Intramuscular interferon-p-la for disease progression in relapsing multiple sclerosis. Ann. New& 39,285–294 (1996).
  • PRISMS Study Group. Randomized double-blind placebo-controlled study of interferon-p-la in relapsing/remitting multiple sclerosis. Lancet 352,1498–1504 (1998).
  • Bornstein MB, Miller A, Slagle S et al. A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis. N Engl. Med. 317,408-414 (1987).
  • Johnson IQ, Brooks BR, Cohen JA et al. Copolymer 1 Multiple Sclerosis Study Group. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a Phase III multicenter, double-blind placebo-controlled trial. Neurology 45, 1268–1276 (1995).
  • Johnson IQ, Brooks BR, Cohen JA et al Extended use of glatiramer acetate (Copaxone) is well-tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Copolymer 1 Multiple Sclerosis Study Group. Neurology50,701–708 (1998).
  • Cord. G, Filippi M, Wolinsky JS, European/Canadian Glatiramer Acetate Study Group. European/Canadian, multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging-measured disease activity and burden in patients with relapsing multiple sclerosis. Ann. Neural. 49,290–297 (2001).
  • Johnson IQ, Brooks BR, Ford CC et al. Glatiramer acetate (Copaxone): comparison of continuous versus delayed therapy in a 6-year organized multiple sclerosis trial. Mult. Scler. 9,585-591 (2003).
  • MS-Therapie Konsensus Gruppe. Immunmodulatorische Stufentherapie der multiplen Sklerose. 1. Erganzung. Dezember 2000. Nervenatzt72, 150–157 (2001).
  • •An update of reference [15] including the early use of disease-modifying treatments.
  • Oger J, Freedman M. Consensus statement of the Canadian MS clinics network on the use of disease modifying agents in multiple sclerosis. Can. New& Li 26,294 (1999).
  • •Consensus statement from Canada on the use of disease-modifying treatments in MS.
  • Filippini G, Munari L, Incorvaia B et al. Interferons in relapsing remitting multiple sclerosis: a systematic review. Lancet 361, 545–552 (2003).
  • Goodin S. Interferons in relapsing remitting multiple sclerosis. Lancet 361, 1821 (2003).
  • Kappos L, Kesselring J. Interferons in relapsing remitting multiple sclerosis. Lancet361, 1821–1822 (2003).
  • Paty D, Arnason B, Li D, Traboulsee A. Interferons in relapsing remitting multiple sclerosis. Lancet 361,1822 (2003).
  • Freedman M, King J, Oger J, Sharief M, Hartung HP, PRISMS Study Group. Interferons in relapsing remitting multiple sclerosis. Lancet 361,1822–1823 (2003).
  • European Study Group on Interferon-3-lb in Secondary-Progressive MS. Placebo-controlled multicentre randomized trial of interferon-p-lb in treatment of secondary-progressive multiple sclerosis. Lancet 352, 1491–1497 (1998).
  • Goodkin DE, North American Study Group on Interferon p-lb in Secondary-Progressive MS. Interferon-0 - lb in secondary-progressive MS: clinical and MRI results of a 3-year randomized controlled trial. Neurology54,2352 (2000)
  • SPECTRIMS Study Group. Randomized controlled trial of interferon-3-la in secondary-progressive MS: clinical results. Neumlogy56, 1496–1504 (2001).
  • Li DK, Zhao GJ, Paty DW, UBC MS/MRI Analysis Research Group, SPECTRIMS Study Group. Randomized controlled trial of interferon-p-la in secondary-progressive MS: MRI results. Neurology56, 1505–1513 (2001).
  • Kappos L, Polman C, Pozzilli C, Thompson A, Beckmann K, Dahlke F, European Study Group on Interferon-3-lb in Secondary-Progressive MS. Final analysis of the European multicenter trial on IFN-0-lb in secondary-progressive MS. Neumlogy57, 1969-1975 (2001).
  • Cohen JA, Cutter GR, Fischer JS et al. IMPACT Investigators. Benefit of interferon-3-la on MSFC progression in secondary-progressive MS. Neurology 59, 679–687 (2002).
  • Hartung HP, Gonsette R, König N et al. Mitoxantrone in Multiple Sclerosis Study Group. Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomized, multicentre trial. Lancet 360, 2018–2025 (2002).
  • Goodin DS, Arnason BG, Coyle PK, Frohman EM, Paty DW. The use of mitoxantrone (Novantrone) for the treatment of multiple sclerosis. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology61, 1332–1338 (2003).
  • PRISMS Study Group, University of British Columbia MS/MRI Analysis Group. PRISMS 4. Long-term efficacy of interferon-3-la in relapsing MS. Neurology 56,1628–1636 (2001).
  • Paty D, Kappos L, Stam Moraga M, Alsop J, Abdalla J, PRIMS Group. Long-term observational efficacy and safety follow-up of the PRISMS cohort. 19th Congress of the European Committee for Research and Treatment in MS, Milan, 17–20 September (2003).
  • Jacobs LD, Beck R, Simon JH et al. Intramuscular interferon-p- la therapy initiated during a first demyelinating event in multiple sclerosis. N Engl. I Med. 343, 898–904 (2000).
  • ••Phase III clinical trial in patients with clinically isolated syndroms suggestive of MS (Controlled High-Risk Subjects Avonex Multiple Sclerosis Prevetion Study).
  • Comi G, Filippi M, Barkhof F et al Early Treatment of Multiple Sclerosis Study Group. Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomized study. Lancet 357, 1576–1582 (2001).
  • ••Phase III clinical trial in patients withclinically isolated syndroms suggestive of MS (Early Treatment of Multiple Sclerosis Study).
  • Jeffery DR. Early intervention with immunomodulatory agents in the treatment of multiple sclerosis. j Neural. Sc]. 197, 1–8 (2002).
  • Coyle PK, Hartung HP Use of interferon-0 in multiple sclerosis: rationale for early treatment and evidence for dose- and frequency-dependent effects on clinical response. Mult. Scler. 8, 2–9 (2002).
  • Bay-as A, Rieckmann P Managing the adverse effects of interferon-0 therapy in multiple sclerosis. Drug. Sal 22,149–159 (2000).
  • Ziemssen T, Neuhaus O, Hohlfeld R. Risk—benefit assessment of glatiramer acetate in multiple sclerosis. Drug. Sal 24, 979–990 (2001).
  • Durelli L, Verdun E, Barbero P et al. Every- other-day interferon-0-1b versus once-weekly interferon-0-1a for multiple sclerosis: results of a 2-year prospective randomized multicentre study (INCOMIN). Lancet 359,1453–1460 (2002).
  • Panitch H, Goodin DS, Francis G et al EVIDENCE Study Group, University of British Columbia MS/MRI Research Group. Randomized, comparative study of interferon-0-1a treatment regimens in MS: the EVIDENCE Trial. Neurology59, 1496–1506 (2002).
  • Clanet M, Radue EW, Kappos L et al European IFN-0-1a (Avonex) Dose-Comparison Study Investigators. A randomized, double-blind, dose-comparison study of weekly interferon-0-1a in relapsing MS. Neurology59, 1507–1517 (2002).
  • Maurer M, Rieckmann P Relapsing- remitting multiple sclerosis. What is the potential for combination therapy? Biodrugs 13,149–158 (2000).
  • •Review on the rationale and potential of combination therapies in MS.
  • Noseworthy JH. Management of multiple sclerosis: current trials and future options. Gun: Opin. Neural. 16, 289–297 (2003).
  • •Overview of currently performed and/or planned clinical trials.
  • National Multiple Sclerosis Society USA (NMSS). Disease management consensus statement wwwnnmorg (Accessed April 2004)

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