Deep brain stimulation in the treatment of neurological and psychiatric disease

References

• Benabid AL, Pollak P, Gao D, Hoffman D, Limousin P, Gay E. Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J. Neumsurg. 84203–214 (1996).
   Google Scholar
• ••Seminal paper describing deep brain stimulation (DBS) results in patients with tremor.
   Google Scholar
• Schuurman PR, Bosch DA, Bossuyt PM et al A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl. Merl 342(7), 461–468 (2000).
   Google Scholar
• ••Randomized, prospective comparison ofDBS to radiofrequency ablation in ventralis interrnedius (VEVI). Out of 33 DBS patients, 30 and 27 of 34 lesion patients had abolition of their tremor.
   Google Scholar
• Lang AE, Lozano AM, Montgomery E et al Posteroventral medial pallidotomy in advanced Parkinson's disease. N Engl. Merl 337(15), 1036–1042 (1997).
   Google Scholar
• Kumar R, Lang AE, Rodriguez-Oroz MC et al Deep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease. Neurology55(12 Suppl. 6), S34—S39 (2000).
   Google Scholar
• Iacono RP, Lonser RR, Maeda G et al Chronic anterior pallidal stimulation for Parkinson's disease. Acta Neumchir 137(1-2), 106–112 (1995).
   PubMed Web of Science ®Google Scholar
• Alexander GE, Crutcher MD, DeLong MR. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, 'prefrontal' and 'limbic' functions. Frog: Brain Res. 85,119-146 (1990). Seminal paper describing segregated, parallel frontal-subcortical circuits underlying the pathophysiology of Parkinson's disease (PD).
   Google Scholar
• Pollak P, Benabid AL, Gross C et al effects of the stimulation of the subthalamic nucleus in parkinson's disease. Rev Nemo'. 149(3), 175–176 (1993).
   Google Scholar
• ••First report of subthalamic nucleus (STN)DBS for PD.
   Google Scholar
• Lozano AM, Dostrovsky J, Chen R, Ashby P Deep brain stimulation for Parkinson's disease: disrupting the disruption. Lancet Neural. 1(4), 225–331 (2002).
   Google Scholar
• Benazzouz A, Hallett M. Mechanism of action of deep brain stimulation. Neurology 55(12 Suppl. 6), S13—S16 (2000).
   Google Scholar
• Do MT, Bean BR Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation. Neuron 39(1), 109–120 (2003).
   PubMed Web of Science ®Google Scholar
• •Characterizes the unique cadre of ion-channels on STN neurons that underlie their ability to fire at high and sustained rates, thereby making 'depolarization blockade' an unlikely mechanism underlying STN DBS.
   Google Scholar
• Surmeier DJ, Bevan MD. 'The little engine that could': voltage-dependent Na(+) channels and the subthalamic nucleus. Neuron 39(1), 5–6 (2003).
   PubMed Web of Science ®Google Scholar
• Benazzouz A, Gao DM, Ni ZG et al. Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat. Neumscience 99(2), 289–295 (2000).
   PubMed Web of Science ®Google Scholar
• Wu YR, Levy R, Ashby P, Tasker RR and Dostrovsky JO. Does stimulation of the GPi control dyskinesia by activating inhibitory axons? May Disoni 16(2), 208–216 (2001).
   Google Scholar
• Dostrovsky JO, Lozano AM. Mechanisms of deep brain stimulation. May Disoni 17 (Suppl. 3), S63—S68 (2002).
   Google Scholar
• Hashimoto T, Elder CM, Okun MS, Patrick SK and Vitek JL. Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons. J. Neurosci 23(5), 1916-1923 (2003).
   Google Scholar
• •Contrary to the model of depolarization blockade, stimulating STN increased the firing rate of target globus pallidus intema (GPi) neurons but regularized their firing pattern. Consistent with activation of efferent fibers.
   Google Scholar
• Dostrovsky JO, Levy R, Wu JP et al. Microstimulation-induced inhibition of neuronal firing in human globus pallidus. Neurophysiol 84(1), 570–574 (2000).
   PubMed Web of Science ®Google Scholar
• •Stimulating within GPi decreased local firing rate, likely as a result of local release of y-aminobutyric acid type A from afferent fibers.
   Google Scholar
• Windels F, Bruet N, Poupard A et al. Effects of high frequency stimulation of subthalamic nucleus on extracellular glutamate and GABA in substantia nigra and globus pallidus in the normal rat. Eur. Neurosci. 12(11), 4141–4146 (2000).
   PubMed Web of Science ®Google Scholar
• •STN DBS increased glutamate release in target nuclei, consistent with activation of efferent fibers.
   Google Scholar
• Carbon M, Eidelberg D. Modulation of regional brain function by deep brain stimulation: studies with positron emission tomography. Curr Opin. Neural 15(4), 451–455 (2002).
   Google Scholar
• Perlmutter JS, Mink JW, Bastian AJ et al Blood flow responses to deep brain stimulation of thalamus. Neurology58 (9), 1388–1394 (2002).
   PubMed Web of Science ®Google Scholar
• Gross RE, Lozano AM. Advances in neurostimulation for movement disorders. Neural Res. 22(3), 247–258 (2000).
   Google Scholar
• Koller W, Pahwa R, Busenbark K et al High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann. Neural 42(3), 292–299 (1997).
   PubMed Web of Science ®Google Scholar
• Tasker RR. Deep brain stimulation is preferable to thalamotomy for tremor suppression. Surg. Neural 49(2), 145–153 (1998).
   PubMedGoogle Scholar
• Bryant JA, De Salles A, Cabatan C et al The impact of thalamic stimulation on activities of daily living for essential tremor. Surg. Neural 59(6), 479–485 (2003).
   PubMedGoogle Scholar
• •Long-term benefits were less than expected from thalamic DBS for essential tremor.
   Google Scholar
• Koller WC, Lyons KE, Wilkinson SB, Troster AI, Pahwa R. Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor. Mov. Disarl. 16(3), 464–468 (2001).
   Google Scholar
• Kitagawa M, Murata J, Kikuchi S et al Deep brain stimulation of subthalamic area for severe proximal tremor. Neurology 55(1), 114–116 (2000).
   PubMed Web of Science ®Google Scholar
• Hooper J, Taylor R, Pentland B and Whittle IR. A prospective study of thalamic deep brain stimulation for the treatment of movement disorders in multiple sclerosis. Br. Neurosurg. 16(2), 102–109 (2002).
   Google Scholar
• Berk C, Carr J, Sinden M, Martzke J, Honey CR. Thalamic deep brain stimulation for the treatment of tremor due to multiple sclerosis: a prospective study of tremor and quality of life. J. Neurosurg. 97(4), 815–820 (2002).
   Google Scholar
• Schulder M, Semas T, Mahalick D, Adler R, Cook S. Thalamic stimulation in patients with multiple sclerosis. Stereotact. Funct. Neurosurg. 72(2–4), 196–201 (1999).
   Google Scholar
• Deep brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl. Merl 345(13), 956–963 (2001).
   Google Scholar
• ••An important multicenter trial that gainedFood and Drug Administration approval for STN and GPi DBS for PD but patients were not randomized to the respective target nuclei.
   Google Scholar
• Simuni T, Jaggi JL, Mulholland H et al Bilateral stimulation of the subthalamic nucleus in patients with Parkinson's disease: a study of efficacy and safety. I Neurosurg. 96(4), 666–672 (2002).
   Google Scholar
• Ostergaard K, Sunde N, DuPont E. Effects of bilateral stimulation of the subthalamic nucleus in patients with severe Parkinson's disease and motor fluctuations. Mov. Disarl. 17(4), 693–700 (2002).
   Google Scholar
• Rodriguez-Oroz MC, Gorospe A, Guridi J et al Bilateral deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Neurology55 (12 Suppl. 6), S45—S51 (2000).
   Google Scholar
• Thobois S, Mertens P, Guenot M et al Subthalamic nucleus stimulation in Parkinson's disease: clinical evaluation of 18 patients. Neural 249(5), 529–534 (2002).
   Google Scholar
• Loher TJ, Burgunder JM, Pohle T et al. Long-term pallidal deep brain stimulation in patients with advanced Parkinson's disease: 1-year follow-up study. I Neurosurg. 96 (5), 844–853 (2002).
   Google Scholar
• Burchiel KJ, Anderson VC, Favre J and Hammerstad JR Comparison of pallidal and subthalamic nucleus deep brain stimulation for advanced Parkinson's disease: results of a randomized, blinded pilot study. Neurosurgery45(6), 1375–1384 (1999).
   PubMed Web of Science ®Google Scholar
• •Randomized, prospective trial that was unfortunately grossly underpowered statistically to make reasonable conclusions but was a precursor to ongoing trials of STN versus GPi DBS.
   Google Scholar
• Volkmann J, Allert N, Voges J et al Safety and efficacy of pallidal or subthalamic nucleus stimulation in advanced PD. Neurology56 (4), 548–551 (2001).
   PubMed Web of Science ®Google Scholar
• Krack P, Batir A, van Blercom N et al Five year follow-up of bilateral stimulation of the subthalamic nucleus for advanced Parkinson's disease. N Engl. I Merl 349(20), 1925–1934 (2003).
   Google Scholar
• •Demonstrates maintenance of significant benefits from bilateral STN DBS over 5 years, although progression of levodopa nonresponsive symptoms progress.
   Google Scholar
• Pahwa R, Wilkinson SB, Overman J, Lyons KE. Bilateral subthalamic stimulation in patients with Parkinson's disease: long-term follow-up.j Neurosurg. 99 (1), 71–77 (2003).
   Google Scholar
• •More limited results of STN DBS for PD probably resulted from suboptimal levodopa response preoperatively, a strong predictor of postoperative results.
   Google Scholar
• Kleiner-Fisman G, Fisman DN, Sime E et al Long-term follow-up of bilateral deep brain stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease. I Neurosurg. 99(3), 489–495 (2003).
   Google Scholar
• Dujardin K, Defebvre L, Krystkowiak P, Blond S, Destee A. Influence of chronic bilateral stimulation of the subthalamic nucleus on cognitive function in Parkinson's disease. I Neural. 248(7), 603–611 (2001).
   PubMed Web of Science ®Google Scholar
• Alegret M, Junque C, Valldeoriola F et al Effects of bilateral subthalamic stimulation on cognitive function in Parkinson's disease. Arch. Neural. 58(8), 1223–1227 (2001).
   PubMed Web of Science ®Google Scholar
• Woods SP, Fields JA, Troster AT. Neuropsychological sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease: a critical review. Neuropsychol Rev 12(2), 111–126 (2002).
   PubMed Web of Science ®Google Scholar
• Gironell A, Kulisevsky J, Rami L et al Effects of pallidotomy and bilateral subthalamic stimulation on cognitive function in Parkinson's disease. A controlled comparative study. I New& 250(8), 917–923 (2003).
   Google Scholar
• Saint-Cyr JA, Trepanier LL, Kumar R, Lozano AM and Lang AE. Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease. Brain 123 (Pt 10), 2091–2108 (2000).
   PubMed Web of Science ®Google Scholar
• •One of the few studies showing cognitive sequelae to STN DBS, perhaps related to an older patient cohort.
   Google Scholar
• Perozzo P, Rizzone M, Bergamasco B et al. Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: comparison of pre and postoperative neuropsychological evaluation. J. Neural. Sc]. 192(1–2), 9–15 (2001).
   Google Scholar
• Bejjani BP, Damier P, Arnulf I et al Transient acute depression induced by high-frequency deep-brain stimulation. N Engl. Merl 340(19), 1476–1480 (1999).
   Google Scholar
• ••Striking and immediate effects withstimulator being switched on and off, probably related to limbic activation (as shown on positron emission tomography imaging) of the limbic region of STN or underlying substantia nigra reticulata.
   Google Scholar
• Krack P, Kumar R, Ardouin C et al Mirthful laughter induced by subthalamic nucleus stimulation. May Disoni 16(5), 867–875 (2001).
   PubMed Web of Science ®Google Scholar
• •Similarly striking DBS — related uncontrollable laughter elicited by principal investigator's prominent facial feature.
   Google Scholar
• Kulisevsky J, Berthier ML, Gironell A et al Mania following deep brain stimulation for Parkinson's disease. Neurology 59 (9), 1421–1424 (2002).
   PubMed Web of Science ®Google Scholar
• Berney A, Vingerhoets F, Perrin A et al Effect on mood of subthalamic DBS for Parkinson's disease: a consecutive series of 24 patients. Neurology59(9), 1427–1429 (2002).
   Google Scholar
• •Mood effects of DBS were not predicted by premorbid affective dysfunction or other predictors.
   Google Scholar
• Mayberg HS, Lozano AM. Penfield revisited? Understanding and modifying behavior by deep brain stimulation for PD. Neurology 59(9), 1298–1299 (2002) .
   PubMed Web of Science ®Google Scholar
• Kumar R, Dagher A, Hutchison WD, Lang AE, Lozano AM. Globus pallidus deep brain stimulation for generalized dystonia: clinical and PET investigation. Neurology 53(4), 871–874 (1999).
   PubMed Web of Science ®Google Scholar
• Coubes P, Echenne B, Roubertie A et al Treatment of early-onset generalized dystonia by chronic bilateral stimulation of the internal globus pallidus. apropos of a case. Neumchirurgie 45 (2), 139–144 (1999).
   PubMed Web of Science ®Google Scholar
• Tronnier VM, Fogel W Pallidal stimulation for generalized dystonia. Report of three cases.j Neurosurg 92(3), 453–456 (2000).
   PubMed Web of Science ®Google Scholar
• Loher TJ, Hasdemir MG, Burgunder JM, Krauss JK. Long-term follow-up study of chronic globus pallidus intemus stimulation for posttraumatic hemidystonia. I Neurosurg 92 (3), 457–460 (2000).
   PubMed Web of Science ®Google Scholar
• Andaluz N, Taha JM, Dalvi A. Bilateral pallidal deep brain stimulation for cervical and truncal dystonia. Neumlogy57 (3), 557–558 (2001).
   PubMed Web of Science ®Google Scholar
• Vercueil L, Pollak P, Fraix V et al. Deep brain stimulation in the treatment of severe dystonia. j Neural 248(8), 695–700 (2001).
   PubMed Web of Science ®Google Scholar
• Bereznai B, Steude U, Seelos K, Botzel K. Chronic high-frequency globus pallidus intemus stimulation in different types of dystonia: a clinical, video and MRI report of six patients presenting with segmental, cervical and generalized dystonia. May. Disoni 17(1), 138–144 (2002).
   PubMed Web of Science ®Google Scholar
• Krauss JK. Deep brain stimulation for dystonia in adults. Overview and developments. Stemotact. Funct. Neurosurg. 78(3–4), 168–182 (2002).
   Google Scholar
• Vercueil L, Krack P, Pollak P. Results of deep brain stimulation for dystonia: a critical reappraisal. May. Disairl. 17\(Suppl. 3), S89—S93 (2002).
   Google Scholar
• Vesper J, Klostermann F, Funk T, Stockhammer F, Brock M. Deep brain stimulation of the globus pallidus intemus (GPI) for torsion dystonia — a report of two cases. Acta Neurochir. Suppl 7,983–1088 (2002).
   Google Scholar
• Volkmann J, Benecke R. Deep brain stimulation for dystonia: patient selection and evaluation. May. Disord. 17\(Suppl. 3), S112—S115 (2002).
   Google Scholar
• Krauss JK, Loher TJ, Weigel R et al Chronic stimulation of the globus pallidus intemus for treatment of nonYT1 generalized dystonia and choreoathetosis: 2-year follow-up. I Neurosurg. 98(4), 785–792 (2003).
   Google Scholar
• Kupsch A, Kuehn A, Klaffke S et al Deep brain stimulation in dystonia. I Neural. 250, S147—S152 (2003).
   Web of Science ®Google Scholar
• Yianni J, Bain PG, Gregory RP et al Postoperative progress of dystonia patients following globus pallidus intemus deep brain stimulation. Eur. I Neural. 10(3), 239–247 (2003).
   PubMed Web of Science ®Google Scholar
• Cif L, El Fertit H, Vayssiere N et al Treatment of dystonic syndromes by chronic electrical stimulation of the internal globus pallidus. I Neurosurg. Sc]. 47(1), 52–55 (2003).
   Google Scholar
• Krauss JK, Loher TJ, Pohle T et al Pallidal deep brain stimulation in patients with cervical dystonia and severe cervical dyskinesias with cervical myelopathy. Nemo'. Neurosurg. Psychiatry 72 (2), 249–256 (2002).
   Google Scholar
• Islekel S, Zileli M, Zileli B. Unilateral pallidal stimulation in cervical dystonia. Stemotact. Funct. Neurosurg. 72 (2–4), 248–252 (1999).
   Google Scholar
• Yianni J, Bain P, Giladi N et al Globus pallidus intemus deep brain stimulation for dystonic conditions: a prospective audit. May. Disord 18(4), 436–442 (2003).
   PubMed Web of Science ®Google Scholar
• Ghilca J, Villemure JG, Miklossy J et al. Postanoxic generalized dystonia improved by bilateral Voa thalamic deep brain stimulation. Aiurology58(2), 311–313 (2002).
   Google Scholar
• Benabid AL, Koudsie A, Pollak P et al Future prospects of brain stimulation. Nemo'. Res. 22(3), 237–246 (2000).
   Google Scholar
• Sun B, Li D, Sun C et al Target selection for primary dystonia deep brain stimulation: GPi or STN. In: 2003 Quadrennial Meeting of theAmerican Society for Stemotactic and Functional Neurosurgery NY, USA (2003).
   Google Scholar
• Vandewalle V, van der Linden C, Groenewegen HJ, Caemaert J. Stereotactic treatment of Gilles de la Tourette syndrome by high frequency stimulation of thalamus. Lancet 353(9154), 724 (1999).
   PubMed Web of Science ®Google Scholar
• Flaherty AW, Eskandar EN, Williams ZM, Cebula C, Cosgrove GR. Novel mood, creativity and tic control after anterior internal capsule and nucleus accumbens DBS for Tourette syndrome. In: 2003 Deep Brain Stimulation Consortium Meeting. Washington DC, USA (2003).
   Google Scholar
• Cooper IS, Amin I, Riklan M, Waltz JM, Poon TR Chronic cerebellar stimulation in epilepsy. Clinical and anatomical studies. Arch. Neural 33(8), 559–570 (1976).
   Google Scholar
• Van Buren JM, Wood JH, Oakley J, Hambrecht E Preliminary evaluation of cerebellar stimulation by double-blind stimulation and biological criteria in the treatment of epilepsy. I Neurosurg: 48(3), 407–416 (1978).
   PubMed Web of Science ®Google Scholar
• Wright GD, McLellan DL, Brice JG. A double-blind trial of chronic cerebellar stimulation in twelve patients with severe epilepsy. .1. Nemo'. Neurosurg. Psychiatry 47(8), 769–774 (1984).
   Google Scholar
• Upton AR, Cooper IS, Springman M, Amin I. Suppression of seizures and psychosis of limbic system origin by chronic stimulation of anterior nucleus of the thalamus. Int. j Neural. 19,202–230 (1985).
   Google Scholar
• Chkhenkeli SA, Chkhenkeli IS. Effects of therapeutic stimulation of nucleus caudatus on epileptic electrical activity of brain in patients with intractable epilepsy. Stereotact. Funct. Neumsurg 69(1–4 Pt 2), 221–2214 (1997).
   Google Scholar
• Velasco F, Velasco M, Jimenez F et al. Predictors in the treatment of difficult-to-control seizures by electrical stimulation of the centromedian thalamic nucleus. Neurosurgery 47(2), 295–305 (2000).
   PubMed Web of Science ®Google Scholar
• •Long-standing benefits of centromedian (CM)/parafascicular (Pf) DBS in 49 patients in an open-label study.
   Google Scholar
• Fisher RS, Uematsu S, Krauss GL et al Placebo-controlled pilot study of centromedian thalamic stimulation in treatment of intractable seizures. Epilepsia 33(5), 841–851 (1992).
   PubMed Web of Science ®Google Scholar
• ••Prospective, placebo-controlled trial ofCM/Pf DBS but design issues limited impact. Several patients had marked benefits.
   Google Scholar
• Mirski MA, Rossell LA, Terry JB, Fisher RS. Anticonvulsant effect of anterior thalamic high frequency electrical stimulation in the rat. Epilepsy Res. 28(2), 89–100 (1997).
   Google Scholar
• Hodaie M, Wennberg RA, Dostrovsky JO and Lozano AM. Chronic anterior thalamus stimulation for intractable epilepsy. Epilepsia 43 (6), 603–608 (2002).
   PubMed Web of Science ®Google Scholar
• ••Open-label trial of anterior nucleus DBS.Of the five patients, the three who experienced a greater than 50% seizure reduction had cortical recruiting rhythms elicited by low-frequency DBS.
   Google Scholar
• Iadarola MJ, Gale K. Substantia nigra: site of anticonvulsant activity mediated by y-aminobutyric acid. Science 218(4578), 1237–1240 (1982).
   PubMed Web of Science ®Google Scholar
• Gale K. Subcortical structures and pathways involved in convulsive seizure generation. j Clin. Neurophysiol 9(2), 264–277 (1992).
   Web of Science ®Google Scholar
• Dybdal D, Gale K. Postural and anticonvulsant effects of inhibition of the rat subthalamic nucleus. j Neumsci. 20(17), 6728–6733 (2000).
   Google Scholar
• •Bilateral pharmacological inhibition of STN abolished limbic seizures in rats.
   Google Scholar
• Bressand K, Dematteis M, Ming Gao D et al Superior colliculus firing changes after lesion or electrical stimulation of the subthalamic nucleus in the rat. Brain Res. 943(1), 93–100 (2002).
   Google Scholar
• Deransart C and Depaulis A. The control of seizures by the basal ganglia? A review of experimental data. Epileptic Disorcl. 4\(Suppl. 3), S61—S72 (2002).
   Google Scholar
• Vercueil L, Benazzouz A, Deransart C et al High-frequency stimulation of the subthalamic nucleus suppresses absence seizures in the rat: comparison with neurotoxic lesions. Epilepsy Res. 31(1), 39–46 (1998).
   Google Scholar
• Lado FA, Velisek L, Moshe SL. The effect of electrical stimulation of the subthalamic nucleus on seizures is frequency dependent. Epilepsia 44 (2), 157–164 (2003) .
   PubMed Web of Science ®Google Scholar
• •High frequency STN DBS increased and low-frequency decreased seizure threshold.
   Google Scholar
• Velisek L, Veliskova J, Moshe SL. Electrical stimulation of substantia nigra pars reticulata is anticonvulsant in adult and young male rats. Exp. Neural 173(1), 145–152 (2002).
   Google Scholar
• Chabardes S, Kahane P, Minotti L et al. Deep brain stimulation in epilepsy with particular reference to the subthalamic nucleus. Epileptic Disarl. 4\(Suppl. 3), S83—S93 (2002).
   Google Scholar
• ••Important pilot study of STN DBS tocontrol epilepsy with promising results in several patients.
   Google Scholar
• Loddenkemper T, Pan A, Neme S et al Deep brain stimulation in epilepsy. j Clin. Neurophysiol 18(6), 514–532 (2001).
   Web of Science ®Google Scholar
• Dinner DS, Neme S, Nair D et al. EEG and evoked potential recording from the subthalamic nucleus for deep brain stimulation of intractable epilepsy. Clin. Neurophysiol 113(9), 1391–1402 (2002).
   PubMed Web of Science ®Google Scholar
• •Seizures could be recorded from STN, establishing its participation in seizure pathways.
   Google Scholar
• Velasco M, Velasco F, Velasco AL et al Subacute electrical stimulation of the hippocampus blocks intractable temporal lobe seizures and paroxysmal EEG activities. Epilepsia 41(2), 158–169 (2000).
   PubMed Web of Science ®Google Scholar
• ••Clinical seizures abolished in seven out of ten patients acutely stimulated over 16 days prior to hippocarnpectomy.
   Google Scholar
• Velasco M, Velasco F and Velasco AL. Centromedian-thalamic and hippocampal electrical stimulation for the control of intractable epileptic seizures. J. Clin. Neurophysiol 18(6), 495–513 (2001).
   Google Scholar
• Vonck K, Boon P, Achten E, De Reuck J, Caemaert J. Long-term amygdalohippocampal stimulation for refractory temporal lobe epilepsy. Ann. Neural. 52(5), 556–565 (2002).
   Google Scholar
• ••Three patients experienced over a 50%seizure reduction over 13 months with few adverse effects.
   Google Scholar
• Osorio I, Frei MG, Manly BF et al An introduction to contingent (closed-loop) brain electrical stimulation for seizure blockage, to ultra-short-term clinical trials and to multidimensional statistical analysis of therapeutic efficacy.' Clin. Neurophysiol 18(6), 533–544 (2001).
   Web of Science ®Google Scholar
• Le Van Quyen M, Martinerie J, Navarro V et al Anticipation of epileptic seizures from standard EEG recordings. Lancet 357(9251), 183–188 (2001).
   PubMed Web of Science ®Google Scholar
• Navarro V, Martinerie J, Le Van Quyen M et al Seizure anticipation in human neocortical partial epilepsy. Brain. 125(Pt 3), 640–655 (2002).
   Google Scholar
• Osorio I, Frei MG and Wilkinson SB. Real-time automated detection and quantitative analysis of seizures and short-term prediction of clinical onset. Epilepsia 39(6), 615–627 (1998).
   PubMed Web of Science ®Google Scholar
• Iasemidis LD. Epileptic seizure prediction and control. IEEE Trans. Blamed Eng. 50(5), 549–558 (2003).
   Google Scholar
• Iasemidis LD, Shiau DS, Chaovalitwongse W et al Adaptive epileptic seizure prediction system. IEEE Trans. Blamed Eng. 50(5), 616–627 (2003).
   Google Scholar
• Fins JJ. From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research. Ai,urasiffg. Clin. N. Am. 14(2), 303–319 (2003).
   Google Scholar
• Kopell BH, Rezai AR. Psychiatric neurosurgery: a historical perspective. Neurosurg. Clin. N. ATM 14(2), 181–197 (2003).
   Google Scholar
• Greenberg BD, Price LH, Rauch SL et al Neurosurgery for intractable obsessive—compulsive disorder and depression: critical issues. Neurosurg: Clin. N. Am. 14(2), 199–212 (2003).
   Google Scholar
• Canterbury RJ. Deep brain stimulation for obsessive—compulsive disorder. Neurosurg. 98(5), 941–942 (2003).
   Google Scholar
• Skoog G, Skoog I. A 40-year follow-up of patients with obsessive—compulsive disorder. Arch. Gen. Psychiatry 56 (2), 121–127 (1999).
   Google Scholar
• Cosgrove GR, Rauch SL. Stereotactic cingulotomy. Neumsurg Gun, N Am. 14(2), 225–235 (2003).
   Google Scholar
• Nuttin B, Cosyns P, Demeulemeester H, Gybels J, Meyerson B. Electrical stimulation in anterior limbs of internal capsules in patients with obsessive—compulsive disorder. Lancet 354(9189), 1526 (1999).
   PubMed Web of Science ®Google Scholar
• •Seminal report of beneficial effects in three out of four stimulated patients.
   Google Scholar
• Nuttin BJ, Gabriels LA, Cosyns PR et al. Long-term electrical capsular stimulation in patients with obsessive—compulsive disorder. Neumsurgety 52 (6), 1263–1274 (2003).
   PubMed Web of Science ®Google Scholar
• ••Blinded, crossover assessmentdemonstrating decrease in Yale—Brown Obsessive—Compulsive Scale from 32.3 to 19.8 after 21 months in four patients. tii Gabriels L, Cosyns P, Nuttin B, Demeulemeester H, Gybels J. Deep brain stimulation for treatment-refractory obsessive—compulsive disorder: psychopathological and neuropsychological outcome in three cases. Acta Psychiatr. Scantl 107(4), 275–282 (2003).
   Google Scholar
• Tass PA, Klosterkotter J, Schneider F et al Obsessive—compulsive disorder: development of demand-controlled deep brain stimulation with methods from stochastic phase resetting. Neuropsychopharmacology28\(Suppl. 1), S27—S34 (2003).
   Google Scholar
• Mayberg HS. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. BE Merl Bull 65193–65207 (2003).
   Google Scholar
• Mayberg H. Depression, II: localization of pathophysiology. Am. J. Psych. 159 (12), 1979 (2002).
   Google Scholar
• Tasker RR, Vilela Filho 0. Deep brain stimulation for neuropathic pain. Stetrotact. Funct. Neurosurg 65(1–4), 122–124 (1995).
   Google Scholar
• Kumar K, Toth C, Nath RK. Deep brain stimulation for intractable pain: a 15-year experience. Neumsurget y40(4), 736–737 (1997).
   Google Scholar
• •Despite limitations in the USA, DBS for pain has continued over the years in Canada.
   Google Scholar
• Green AL, Nandi D, Armstrong G, Carter H, Aziz T Postherpetic trigeminal neuralgia treated with deep brain stimulation. J. an. Neurosci. 10(4), 512–514 (2003).
   Google Scholar
• Nandi D, Smith H, Owen S et al. Pen—ventricular grey stimulation versus motor cortex stimulation for post stroke neuropathic pain. I Gun. Neurosci. 9 (5), 557–561 (2002).
   Web of Science ®Google Scholar
• May A, Leone M. Update on cluster headache. Cum Opin. Neural. 16(3), 333–340 (2003).
   Google Scholar
• Leone M, Franzini A, Bussone G. Stereotactic stimulation of posterior hypothalamic gray matter in a patient with intractable cluster headache. N Engl. Merl 345(19), 1428–1429 (2001).
   Google Scholar
• Leone M, Franzini A, Broggi G, Bussone G. Hypothalamic deep brain stimulation for intractable chronic cluster headache: a 3-year follow-up. Neural. Sci.24\(Suppl. 2), S143—S145 (2003).
   Google Scholar
• Yamamoto T, Katayama Y, Oshima H et al Deep brain stimulation therapy for a persistent vegetative state. Acta Neurochir. Suppl 7979–7982 (2002).
   Google Scholar
• Vitek JL, Bakay RA, Freeman A et al Randomized trial of pallidotomy versus medical therapy for Parkinson's disease. Ann. Neural. 53(5), 558–569 (2003).
   PubMed Web of Science ®Google Scholar
• Visser-Vandewalle V, van der Linden C, Temel Y. Long-term motor effect of unilateral pallidal stimulation in 26 patients with advanced Parkinson's disease. J. Neumsurg. 99,701-707 (2003).
   Google Scholar