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Review

C-reactive protein, cardiovascular disease and stroke: new roles for an old biomarker

, , , , &
Pages 507-518 | Published online: 10 Jan 2014

References

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  • •A new and exciting area of potential therapy for acute stroke.
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  • •The first and one of the few papers on CRP and myocardial infarction (MI) in a minority population (Asian—Americans). Demonstrates roughly equivalent risk of high CRP for Mt compared with Caucasians.
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  • •Classic early paper on CRP and CVD. Also shows CRP is lower in regular users of aspirin.
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  • •High impact paper showing that CRP was more predictive than cholesterol screening for CVD in women.
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  • •One of the few studies of CRP and CVD in the elderly.
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  • •One of the few studies of CRP and CVD in the elderly. Suggests that interleuldn-6 may be a better marker than CRP for stroke risk in the elderly.
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  • ••Excellent comparison of the relativepredictive abilities of different novel risk factors for atherosclerosis suggesting that CRP is more predictive than other novel risk factors and a better screening tool.
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  • ••Comprehensive evidence-based summarystatement and guidelines for health professionals regarding CRP testing.
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  • •Good paper showing statins can be effective in lowering CRP and thus may play a role in reducing inflammation.
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  • •Interesting paper showing that the glitazones may also play a role in reducing inflammation and that CRP may be linked to glycemic control.
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  • •Good paper making the case that CRP may be more predictive than cholesterol for CVD.
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  • •Excellent paper showing the powerful effects of specific dietary compounds in lowering lipids and CRP equivalent in efficacy to first generation statins.
  • Tomaszewski M, Charchar FJ, Przybycin M et al. Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity: how low can you go? Arterioscler. Thromb. Vasc. Biol. 23,1640–1644 (2003).
  • •Provocative paper showing that exercise may lower CRP levels independent of body fat loss.
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  • •Good current and concise review of this topic.
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  • Brull DJ, Serrano N, Zito F et al. Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease. Arterioscler. Thromb. Vasc. Biol. 11, 2063–2069 (2003).
  • •Important new information on how subtle variations in human genes might affect CVD risk through variation in CRP levels.
  • Toyoda K, Chu Y, Heistad DD. Gene therapy for cerebral vascular disease: update 2003. Br. Pharmacol 139,1–9 (2003).

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