Therapeutic hypothermia for stroke: do new outfits change an old friend?

References

• Sarti C, Rastenyte D, Cepaitis Z, Tuomilehto J. International trends in mortality after stroke, 1968 to 1994. Stroke 31(7), 1588–1601 (2000).
   PubMed Web of Science ®Google Scholar
• American Heart Association. Stroke. In: Heart Disease and Stroke Statistics – 2003 Update. American Heart Association, TX, USA (2003).
   Google Scholar
• Katzan IL, Hammer MD, Hixson ED et al. Utilization of intravenous tissue plasminogen activator for acute ischemic stroke. Arch. Neurol. 61(3), 346–350 (2004).
   PubMed Web of Science ®Google Scholar
• The National Institutes of Neurological Disorders and Stroke rtPA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N. Engl. J. Med. 333(24), 1581–1587 (1995).
   PubMed Web of Science ®Google Scholar
• Christou I, Felberg RA, Demchuk AM et al. Intravenous tissue plasminogen activator and flow improvement in acute ischemic stroke patients with internal carotid artery occlusion. J. Neuroimaging 12(2), 119–123 (2002).
   PubMed Web of Science ®Google Scholar
• Demchuk AM, Burgin WS, Christou I et al. Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery and mortality in patients treated with intravenous tissue plasminogen activator. Stroke 32(1), 89–93 (2001).
   PubMed Web of Science ®Google Scholar
• Furlan A, Higashida R, Wechsler L et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 282(21), 2003–2011 (1999).
   PubMed Web of Science ®Google Scholar
• Rosomoff HL. Hypothermia and cerebral vascular lesions. I. Experimental interruption of the middle cerebral artery during hypothermia. J. Neurosurg. 13(4), 244–255 (1956).
   PubMedGoogle Scholar
• Dietrich WD, Busto R, Halley M, Valdes I. The importance of brain temperature in alterations of the blood–brain barrier following cerebral ischemia. J. Neuropathol. Exp. Neurol. 49(5), 486–497 (1990).
   PubMed Web of Science ®Google Scholar
• Busto R, Globus MY, Dietrich WD, Martinez E, Valdes I, Ginsberg MD. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 20(7), 904–910 (1989).
   PubMed Web of Science ®Google Scholar
• Shiozaki T, Sugimoto H, Taneda M et al. Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J. Neurosurg. 79(3), 363–368 (1993).
   PubMed Web of Science ®Google Scholar
• Baron JC. Perfusion thresholds in human cerebral ischemia: historical perspective and therapeutic implications. Cerebrovasc. Dis. 11(Suppl. 1), 2–8 (2001).
   PubMed Web of Science ®Google Scholar
• Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia – the ischemic penumbra. Stroke 12(6), 723–725 (1981).
   PubMed Web of Science ®Google Scholar
• Marchal G, Beaudouin V, Rioux P et al. Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke: a correlative PET-CT study with voxel-based data analysis. Stroke 27(4), 599–606 (1996).
   PubMed Web of Science ®Google Scholar
• Marchal G, Benali K, Iglesias S, Viader F, Derlon JM, Baron JC. Voxel-based mapping of irreversible ischaemic damage with PET in acute stroke. Brain 122( Pt 12), 2387–2400 (1999).
   PubMedGoogle Scholar
• Furlan M, Marchal G, Viader F, Derlon JM, Baron JC. Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann. Neurol. 40(2), 216–226 (1996).
   PubMed Web of Science ®Google Scholar
• Heiss WD. Ischemic penumbra: evidence from functional imaging in man. J. Cereb. Blood Flow Metab. 20(9), 1276–1293 (2000).
   PubMedGoogle Scholar
• Heiss WD, Kracht LW, Thiel A, Grond M, Pawlik G. Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia. Brain 124(Pt 1), 20–29 (2001).
   PubMed Web of Science ®Google Scholar
• Symon L, Branston NM, Strong AJ, Hope TD. The concepts of thresholds of ischaemia in relation to brain structure and function. J. Clin. Pathol. Suppl. (R. Coll. Pathol.) 11, 149–154 (1977).
   PubMedGoogle Scholar
• Raichle ME. The pathophysiology of brain ischemia and infarction. Clin. Neurosurg. 29, 379–389 (1982).
   PubMedGoogle Scholar
• Heiss WD, Forsting M, Diener HC. Imaging in cerebrovascular disease. Curr. Opin. Neurol. 14(1), 67–75 (2001).
   PubMed Web of Science ®Google Scholar
• Ginsberg MD. Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture. Stroke 34(1), 214–223 (2003).
   PubMed Web of Science ®Google Scholar
• Soukoup J, Zauner A, Doppenberg EM et al. The importance of brain temperature in patients after severe head injury: relationship to intracranial pressure, cerebral perfusion pressure, cerebral blood flow and outcome. J. Neurotrauma 19(5), 559–571 (2002).
   PubMedGoogle Scholar
• Ishikawa M, Sekizuka E, Sato S et al. Effects of moderate hypothermia on leukocyte-endothelium interaction in the rat pial microvasculature after transient middle cerebral artery occlusion. Stroke 30(8), 1679–1686 (1999).
   PubMed Web of Science ®Google Scholar
• Smith SL, Hall ED. Mild pre- and post-traumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat. J. Neurotrauma 13(1), 1–9 (1996).
   PubMed Web of Science ®Google Scholar
• Krafft P, Frietsch T, Lenz C, Piepgras A, Kuschinsky W, Waschke KF. Mild and moderate hypothermia (α-stat) do not impair the coupling between local cerebral blood flow and metabolism in rats. Stroke 31(6), 1393–1400 (2000).
   PubMed Web of Science ®Google Scholar
• Yenari MA, Palmer JT, Bracci PM, Steinberg GK. Thrombolysis with tissue plasminogen activator (tPA) is temperature dependent. Thromb. Res. 77(5), 475–481 (1995).
   PubMed Web of Science ®Google Scholar
• Kollmar R, Henninger N, Bardutzky J, Schellinger PD, Schabitz WR, Schwab S. Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke – an MRI study. Exp. Neurol. 190(1), 204–212 (2004).
   PubMed Web of Science ®Google Scholar
• Tyson RL, Sutherland GR, Peeling J. 23Na nuclear magnetic resonance spectral changes during and after forebrain ischemia in hypoglycemic, normoglycemic, and hyperglycemic rats. Stroke 27(5), 957–964 (1996).
   PubMedGoogle Scholar
• Baudry M, Bundman MC, Smith EK, Lynch GS. Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes. Science 212(4497), 937–938 (1981).
   Google Scholar
• Chen ZL, Strickland S. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell 91(7), 917–925 (1997).
   PubMed Web of Science ®Google Scholar
• Dugan LL, Choi DW. Excitotoxicity, free radicals, and cell membrane changes. Ann. Neurol. 35(Suppl.), S17–S21 (1994).
   PubMed Web of Science ®Google Scholar
• Kristian T, Siesjo BK. Calcium in ischemic cell death. Stroke 29(3), 705–718 (1998).
   PubMed Web of Science ®Google Scholar
• Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22(9), 391–397 (1999).
   PubMed Web of Science ®Google Scholar
• Ritter LS, Orozco JA, Coull BM, McDonagh PF, Rosenblum WI. Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke. Stroke 31(5), 1153–1161 (2000).
   PubMed Web of Science ®Google Scholar
• Clark RK, Lee EV, Fish CJ et al. Development of tissue damage, inflammation and resolution following stroke: an immunohistochemical and quantitative planimetric study. Brain Res. Bull. 31(5), 565–572 (1993).
   PubMed Web of Science ®Google Scholar
• Clark WM, Coull BM, Briley DP, Mainolfi E, Rothlein R. Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke. J. Neuroimmunol. 44(1), 123–125 (1993).
   PubMed Web of Science ®Google Scholar
• Rothwell NJ. Cytokines and acute neurodegeneration. Mol. Psychiatry 2(2), 120–121 (1997).
   PubMed Web of Science ®Google Scholar
• Lindsberg PJ, Hallenbeck JM, Feuerstein G. Platelet-activating factor in stroke and brain injury. Ann. Neurol. 30(2), 117–129 (1991).
   PubMed Web of Science ®Google Scholar
• Zhang Z, Chopp M, Goussev A, Powers C. Cerebral vessels express interleukin-1β after focal cerebral ischemia. Brain Res. 784(1–2), 210–217 (1998).
   PubMed Web of Science ®Google Scholar
• Gong C, Qin Z, Betz AL, Liu XH, Yang GY. Cellular localization of tumor necrosis factor α following focal cerebral ischemia in mice. Brain Res. 801(1–2), 1–8 (1998).
   PubMedGoogle Scholar
• Iadecola C, Zhang F, Casey R, Nagayama M, Ross ME. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J. Neurosci. 17(23), 9157–9164 (1997).
   PubMed Web of Science ®Google Scholar
• Chopp M, Knight R, Tidwell CD, Helpern JA, Brown E, Welch KM. The metabolic effects of mild hypothermia on global cerebral ischemia and recirculation in the cat: comparison to normothermia and hyperthermia. J Cereb. Blood Flow Metab. 9(2), 141–148 (1989).
   PubMed Web of Science ®Google Scholar
• Lee KS, Lim BV, Jang MH et al. Hypothermia inhibits cell proliferation and nitric oxide synthase expression in rats. Neurosci. Lett. 329(1), 53–56 (2002).
   PubMedGoogle Scholar
• Yenari MA, Iwayama S, Cheng D et al. Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or capsase activation after experimental stroke. J. Cereb. Blood Flow Metab. 22(1), 29–38 (2002).
   PubMed Web of Science ®Google Scholar
• Ooboshi H, Ibayashi S, Takano K et al. Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats. Brain Res. 884(1–2), 23–30 (2000).
   PubMedGoogle Scholar
• Deng H, Han HS, Cheng D, Sun GH, Yenari MH. Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation. Stroke 34(10), 2495–2501 (2003).
   PubMed Web of Science ®Google Scholar
• Hamann GF, Burggraf D, Martens HK et al. Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia. Stroke 35(3), 764–769 (2004).
   PubMed Web of Science ®Google Scholar
• Griepp RB, Stinson EB, Oyer PE, Copeland JG, Shumway NE. The superiority of aortic cross-clamping with profound local hypothermia for myocardial protection during aorta-coronary bypass grafting. J. Thorac. Cardiovasc. Surg. 70(6), 995–1009 (1975).
   PubMedGoogle Scholar
• Midulla PS, Gandas A, Sadeghi AM et al. Comparison of retrograde cerebral perfusion to antegrade cerebral perfusion and hypothermic circulatory arrest in a chronic porcine model. J. Card. Surg. 9(5), 560–574 (1994).
   PubMed Web of Science ®Google Scholar
• Griepp RB, Ergin MA, McCullough JN et al. Use of hypothermic circulatory arrest for cerebral protection during aortic surgery. J. Card. Surg. 12(Suppl. 2), 312–321 (1997).
   PubMedGoogle Scholar
• Mezrow CK, Midulla PS, Sadeghi AM et al. Evaluation of cerebral metabolism and quantitative electroencephalography after hypothermic circulatory arrest and low-flow cardiopulmonary bypass at different temperatures. J. Thorac. Cardiovasc. Surg. 107(4), 1006–1019 (1994).
   PubMed Web of Science ®Google Scholar
• Prochettino A, Cheung AT. Pro: retrograde cerebral perfusion is useful for deep hypothermic circulatory arrest. J. Cardiothorac. Vasc. Anesth. 17(6), 764–767 (2003).
   PubMedGoogle Scholar
• Kouchoukos NT. Adjuncts to reduce the incidence of embolic brain injury during operations on the aortic arch. Ann. Thorac. Surg. 57, 243–245 (1994).
   PubMed Web of Science ®Google Scholar
• Reich DL, Uysal S. Con: retrograde cerebral perfusion is not an optimal method of neuroprotection in thoracic aortic surgery. J. Cardiothorac. Vasc. Anesth. 17(6), 768–769 (2003).
   PubMedGoogle Scholar
• Di Eusanio M, Schepens MA, Morshuis WJ et al. Brain protection using antegrade selective cerebral perfusion: A multicenter study. Ann. Thorac. Surg. 76(4), 1181–1188 (2003).
   PubMed Web of Science ®Google Scholar
• Okita Y, Minatoya K, Tagusari O et al. Prospective comparative study of brain protection in total aortic arch replacement: deep hypothermic circulatory arrest with retrograde cerebral perfusion or selective antegrade cerebral perfusion. Ann. Thorac. Surg. 72, 72–79 (2001).
   PubMed Web of Science ®Google Scholar
• Schubert A. Side effects of mild hypothermia. J. Neurosurg. Anesthesiol. 7(2), 139–147 (1995).
   PubMed Web of Science ®Google Scholar
• Bernard SA, Gray TW, Buist MD et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N. Engl. J. Med. 346(8), 557–563 (2002).
   PubMed Web of Science ®Google Scholar
• Clifton GL, Miller ER, Choi SC et al. Lack of effect of induction of hypothermia after acute brain injury. N. Engl. J. Med. 344(8), 556–563 (2001).
   PubMed Web of Science ®Google Scholar
• The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N. Engl. J. Med. 346(8), 549–556 (2002).
   PubMed Web of Science ®Google Scholar
• Polderman KH, Tjong Tjin Joe R, Peerdeman SM, Vandertop WP, Girbes ARJ. Effects of artificially induced hypothermia on intracranial pressure and outcome in patients with severe traumatic head injury. Intensive Care Med. 28(11), 1563–1567 (2002).
   PubMed Web of Science ®Google Scholar
• Schwab S, Schwarz S, Spranger M, Keller E, Bertram M, Hacke W. Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke 29(12), 2461–2466 (1998).
   PubMed Web of Science ®Google Scholar
• Krieger DW, DeGeorgia MA, Abou-Chebl A et al. Cooling for acute ischemic brain damage (COOL AID): an open pilot study of induced hyothermia in acute ischemic stroke. Stroke 32(8), 1847–1854 (2001).
   PubMed Web of Science ®Google Scholar
  •Shows the feasibility of cooling in acute stroke.
   Google Scholar
• Wang H, Olivero W, Lanzino G et al. Rapid and selective cerebral hypothermia achieved using a cooling helmet. J. Neurosurg. 100(2), 272–277 (2004).
   PubMed Web of Science ®Google Scholar
• Callaway CW, Tadler SC, Katz LM, Lipinski CL, Brader E. Feasibility of external cooling during out-of-hospital cardiac arrest. Resuscitation 52(2), 159–165 (2002).
   PubMed Web of Science ®Google Scholar
• Tooley J, Satas S, Eagle R, Silver IA, Thorensen M. Significant selective head cooling can be maintained long-term after global hypoxia ischemia in newborn piglets. Pediatrics 109(4), 643–649 (2002).
   PubMedGoogle Scholar
• Laptook AR, Shalak L, Corbett RJ. Differences in brain temperature and cerebral blood flow during selective head versus whole-body cooling. Pediatrics 108(5), 1103–1110 (2001).
   PubMed Web of Science ®Google Scholar
• Schwab S, Spranger M, Aschoff A, Steiner T, Hacke W. Brain temperature monitoring and modulation in patients with severe MCA infarction. Neurology 48(3), 762–767 (1997).
   PubMed Web of Science ®Google Scholar
• Battin MR, Dezoete A, Gunn TR, Gluckman PD, Gunn AJ. Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia. Pediatrics 107(3), 480–484 (2001).
   PubMed Web of Science ®Google Scholar
• Battin MR, Penrice J, Gunn TR, Gunn AJ. Treatment of term infants with head cooling and mild systemic hypothermia (35.0°C and 34.5°C) after perinatal asphyxia. Pediatrics 111(2), 244–251 (2003).
   PubMed Web of Science ®Google Scholar
• Corbett RJ, Purdy PD, Laptook AR, Chaney C, Garcia D. Noninvasive measurement of brain temperature after stroke. AJNR Am. J. Neuroradiol. 20(10), 1851–1857 (1999).
   PubMedGoogle Scholar
• Mack WJ, Huang J, Winfree C et al. Ultrarapid, convection-enhanced intravascular hypothermia: a feasibility study in nonhuman primate stroke. Stroke 34(8), 1994–1999 (2003).
   PubMed Web of Science ®Google Scholar
• Dae MW, Gao DW, Sessler DI, Chair K, Stillson CA. Effect of endovascular cooling on myocardial temperature, infarct size and cardiac output in human-sized pigs. Am. J. Physiol. Heart Circ. Physiol. 282(5), H1584–H1591 (2002).
   Google Scholar
• DeGeorgia MA, Krieger DW, Abou-Chebl A et al. Cooling for Acute Ischemic Brain Damage (COOLAID). A feasibility trial of endovascular cooling. Neurology 63(2), 312–317 (2004).
   PubMedGoogle Scholar
• Mustafa S, Thulesius O. Cooling-induced carotid artery dilatation: an experimental study in isolated vessels. Stroke 33(1), 256–260 (2002).
   PubMed Web of Science ®Google Scholar
• Ding Y, Li J, Luan X et al. Local saline infusion into ischemic territory induces regional brain cooling and neuroprotection in rats with transient middle cerebral artery occlusion. Neurosurgery 54(4), 956–965 (2004).
   PubMed Web of Science ®Google Scholar
• Slotboom J, Kiefer C, Brekenfeld C et al. Locally induced hypothermia for treatment of acute ischaemic stroke: a physical feasibility study. Neuroradiology (2004) (In Press).
   PubMedGoogle Scholar
• Sorimachi T, Fujii Y, Tsuchiya N et al. Recanalization by mechanical embolus disruption during intra-arterial thrombolysis in the carotid territory. AJNR Am. J. Neuroradiol. 25(8), 1391–1402 (2004).
   PubMed Web of Science ®Google Scholar
• Lutsep HL, Clark WM, Nesbit GM, Kuether TA, Barnwell SL. Intraarterial suction thrombectomy in acute stroke. AJNR Am. J. Neuroradiol. 23(5), 783–786 (2002).
   PubMed Web of Science ®Google Scholar
• Jin KL, Mao XO, Goldsmith PC, Greenberg DA. CB1 cannabinoid receptor induction in experimental stroke. Ann. Neurol. 48(2), 257–261 (2000).
   PubMed Web of Science ®Google Scholar
• Ovadia H, Wohlman A, Mechoulam R, Weidenfeld J. Characterization of the hypothermic effect of the synthetic cannabinoid HU-210 in the rat: relation to the adrenergic system and endogenous pyrogens. Neuropharmacology 34(2), 175–180 (1995).
   PubMedGoogle Scholar
• Leker RR, Gai N, Mechoulam R, Ovadia H. Drug-induced hypothermia reduces ischemic damage. Effects of cannabinoid HU-210. Stroke 34(8), 2000–2006 (2003).
   PubMed Web of Science ®Google Scholar
• Thomas EA, Cravatt BF, Sutcliffe JG. The endogenous lipid oleamide activates serotnoin 5-HT7 neurons in mouse thalamus and hypothalamus. J. Neurochem. 72(6), 2370–2378 (1999).
   Google Scholar
• Hedlund PB, Danielson PE, Thomas EA, Slanina K, Carson MJ, Sutcliffe JG. No hypothermic response to serotonin in 5-HT7 receptor knockout mice. Proc. Natl Acad. Sci. USA 100(3), 1375–1380 (2003).
   PubMed Web of Science ®Google Scholar
• Zweifler RM, Voorhees ME, Mahmood A, Parnell M. Magnesium sulfate increases the rate of hypothermia via surface cooling and improves comfort. Stroke 35(10), 2331–2334 (2004).
   PubMed Web of Science ®Google Scholar
• Zausinger S, Scholler K, Plesnila N, Schmid-Elsaesser R. Combination drug therapy and mild hypothermia after transient focal cerebral ischemia in rats. Stroke 34(9), 2246–2251 (2003).
   PubMed Web of Science ®Google Scholar
• Yang Y, Shuaib A, Li Q, Siddiqui MM. Neuroprotection by delayed administration of topiramate in a rat model of middle cerebral artery embolization. Brain Res. 804(2), 169–176 (1998).
   PubMed Web of Science ®Google Scholar
• Liu Y, Barks JD, Xu G, Silverstein FS. Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats. Stroke 35(6), 1460–1465 (2004).
   PubMed Web of Science ®Google Scholar
• Damian MS, Ellenberg D, Gildmeister R et al. Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study. Circulation 110(19), 3011–3016 (2004).
   PubMedGoogle Scholar
• Barber PA, Hoyte L, Colbourne F, Buchan AM. Temperature-regulated model of focal ischemia in the mouse: a study with histopathological and behavioral outcomes. Stroke 35(7), 1720–1725 (2004).
   PubMed Web of Science ®Google Scholar
• Venn RM, Hell J, Grounds RM. Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit. Care 4(5), 302–308 (2000).
   PubMed Web of Science ®Google Scholar
• Doufas AG, Lin CM, Suleman MI et al. Dexmedetomidine and meperidine additively reduce the shivering threshold in humans. Stroke 34(3), 1218–1223 (2003).
   PubMed Web of Science ®Google Scholar
• Mokhtarani M, Mahgoub AN, Morioka N et al. Buspirone and meperidine synergistically reduce the shivering threshold. Anesth. Analg. 93(5), 1233–1239 (2001).
   PubMed Web of Science ®Google Scholar
• Huh PW, Belayev L, Zhao W, Koch S, Busto R, Ginsberg MD. Comparative neuroprotective efficacy of prolonged moderate intraischemic and postischemic hypothermia in focal cerebral ischemia. J. Neurosurg. 92(1), 91–99 (2000).
   PubMed Web of Science ®Google Scholar
• Kollmar R, Schabitz WR, Heiland S et al. Neuroprotective effect of delayed moderate hypothermia after focal cerebral ischemia: an MRI study. Stroke 33(7), 1899–1904 (2002).
   PubMed Web of Science ®Google Scholar
• Colbourne F, Corbett D, Zhao Z, Yang J, Buchan AM. Prolonged but delayed postischemic hypothermia: a long-term outcome study in the rat middle cerebral artery occlusion model. J. Cereb. Blood Flow Metab. 20(12), 1702–1708 (2000).
   PubMed Web of Science ®Google Scholar
• Krieger DW, Yenari MA. Therapeutic hypothermia for acute ischemic stroke. What do laboratory studies teach us? Stroke 35(6), 1482–1489 (2004).
   PubMed Web of Science ®Google Scholar
• Doerfler A, Schwab S, Hoffmann T, Engelhorn T, Forsting M. Combination of decompressive craniectomy and mild hypothermia ameliorates infarction volume after permanent focal ischemia in rats. Stroke 32(11), 2675–2681 (2001).
   PubMed Web of Science ®Google Scholar
• Baker CJ, Onesti ST, Solomon RA. Reduction by delayed hypothermia of cerebral infarction following middle cerebral artery occlusion in the rat: a time-course study. J. Neurosurg. 77(3), 438–444 (1992).
   PubMed Web of Science ®Google Scholar
• Hacke W, Schwab S, Horn M, Spranger M, DeGeorgia M, von Kummer R. Malignant middle cerebral artery territory infarction: clinical course and prognostic signs. Arch. Neurol. 53(4), 309–315 (1996).
   PubMed Web of Science ®Google Scholar
• Gupta R, Connolly ES, Mayer S, Elkind MS. Hemicraniectomy for massive middle cerebral artery territory infarction: a systematic review. Stroke 35(2) 539–543 (2004).
   PubMed Web of Science ®Google Scholar
• Marion DW, Penrod LE, Kelsey SF et al. Treatment of traumatic brain injury with moderate hypothermia. N. Engl. J. Med. 336(8), 540–546 (1997).
   PubMed Web of Science ®Google Scholar
• Georgiadis D, Schwarz S, Aschoff A, Schwab S. Hemicraniectomy and moderate hypothermia in patients with severe ischemic stroke. Stroke 33(6), 1584–1588 (2002).
   PubMed Web of Science ®Google Scholar
• Kammersgaard LP, Rasmussen BH, Jorgensen HS, Reith J, Weber U, Olsen TS. Feasibility and safety of inducing modest hypothermia in awake patients with acute stroke through surface cooling: a case-control study. The Copenhagen Stroke Study. Stroke 31(9), 2251–2256 (2000).
   PubMed Web of Science ®Google Scholar