317
Views
23
CrossRef citations to date
0
Altmetric
Drug Profile

Methylphenidate HCl: therapy for attention deficit hyperactivity disorder

, &
Pages 325-331 | Published online: 10 Jan 2014

References

  • Pelham WE Jr, Greenslade KE, Vodde-Hamilton M et al. Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: a comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline. Pediatrics 86(2), 226–237 (1990).
  • Markowitz JS, Straughn AB, Patrick KS. Advances in the pharmacotherapy of attention-deficit-hyperactivity disorder: focus on methylphenidate formulations. Pharmacotherapy 23(10), 1281–1299 (2003).
  • Zhang J, Deng Y, Fang J, McKay G. Enantioselective analysis of ritalinic acids in biological samples by using a protein-based chiral stationary phase. Pharm. Res. 20(11), 1881–1884 (2003).
  • Sane N, McGough JJ. MethyPatch Noven. Curr. Opin. Investig. Drugs 3(8), 1222–1224 (2002).
  • Hubbard JW, Srinivas NR, Quinn D, Midha KK. Enantioselective aspects of the disposition of D,L-threo-methylphenidate after the administration of a sustained-release formulation to children with attention deficit-hyperactivity disorder. J. Pharm. Sci. 11, 944–947 (1989).
  • Redalieu E, Bartlett MF, Waldes LM et al. A study of methylphenidate in man with respect to its major metabolite. Drug Metab. Dispos. 10, 708–709 (1982).
  • Ding YS, Gatley SJ, Thanos PK et al. Brain kinetics of methylphenidate (Ritalin®) enantiomers after oral administration. Synapse 53(3), 168–175 (2004).
  • Faraj BA, Israili ZH, Perel JM et al. Metabolism and disposition of methylphenidate-14C: studies in man and animals. J. Pharmacol. Exp. Ther. 191, 535–547 (1974).
  • Srinivas NR, Hubbard JW, Quinn D, Midha KK. Enantio-selective pharmacokinetics and pharmacodynamics of D,L-threo-methylphenidate in children with attention deficit hyperactivity disorder. Clin. Pharmacol. Ther. 52, 561–568 (1992).
  • Sun Z, Murry DJ, Sanghani SP et al. Methylphenidate is stereoselectively hydrolyzed by human caboxylesterase CES1A1. J. Pharmacol. Exp. Ther. 310(2), 469–476 (2004).
  • Bartlik B, Harmon G. Use of methylphenidate in a patient with glaucoma and attention-deficit hyperactivity disorder: a clinical dilemma. Arch. Gen. Psychiatry. 54, 188–189 (1997).
  • Feinberg SS. Combining stimulants with monoamine oxidase inhibitors: a review of uses and one possible additional indication. J. Clin. Psychiatry 65, 1520–1524 (2004).
  • Tourette's Syndrome Study Group. Treatment of ADHD in children with tics: a randomized controlled trial. Neurology 58, 527–536 (2002).
  • Palumbo D, Spencer T, Lynch J, Co-Chien H, Faraone SV. Emergence of tics in children with ADHD: impact of once-daily OROS methylphenidate therapy. J. Child Adolesc. Psychpharmacol. 14, 185–194 (2004).
  • Ahmann P, Waltonen S, Olson K, Theye F, Van Erem A, LaPlant R. Placebo-controlled evaluation of ritalin side effects. Pediatrics 91(6), 1101–1106 (1993).
  • Barkley RA, McMurray MB, Edelbrock CS, Robbins K. Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation. Pediatrics 86(2), 184–192 (1990).
  • Efron D, Jarma F, Barker M. Side effects of methylphenidate and dexamphetamine in children with attention deficit hyperactivity disorder: a double-blind, crossover trial. Pediatrics 100, 662–666 (1997).
  • Lisska MC, Rivkees SA. Daily methylphenidate use slows the growth of children: a community based study. J. Pediatr. Endocrinol. Metab. 16(5), 711–718 (2003).
  • Rapport MD, Moffitt C. Attention deficit hyperactivity disorder and methylphenidate. A review of height/weight, cardiovascular, and somatic complaint side effects. Clin. Psychol. Rev. 22(8), 1107–1131 (2002).
  • Toren P, Silbergeld A, Eldar S et al. Lack of effect of methylphenidate on serum growth hormone (GH), GH-binding protein, and insulin-like growth factor I. Clin. Neuropharmacol. 20(3), 264–269 (1997).
  • MTA Cooperative Group. National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: changes in effectiveness and growth after the end of treatment. Pediatrics 113, 762–769 (2004).
  • Tan M, Appleton R. Attention deficit and hyperactivity disorder, methylphenidate, and epilepsy. Arch. Dis. Childhood. 90, 57–59 (2005).
  • Biederman J. Pharmacotherapy for attention deficit hyperactivity disorder (ADHD) decreases the risk for substance abuse: findings from a longitudinal follow-up of youths with and without ADHD. J. Clin. Psychiatry 64(Suppl. 11), 3–8 (2003).
  • Gordon SM, Tulak F, Troncale J. Prevalence and characteristics of adolescent patients with co-occurring ADHD and substance dependence. J. Addic. Dis. 23, 31–40 (2004).
  • Swanson JM, Volkow ND. Serum and brain concentrations of methylphenidate: implications for use and abuse. Neurosci. Biobehav. Rev. 27, 615–621 (2003).
  • Brandon CL, Marinelli M, White FJ. Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons. Biol. Psych. 54, 1338–1344 (2003).
  • Wax PM. Analeptic use in clinical toxicology: a historical appraisal. J. Toxicol. Clin. Toxicol. 35, 203–209 (1997).
  • Loo SK, Specter E, Smolen A et al. Functional effects of the DAT1 polymorphism on EEG measures in ADHD. J. Am. Acad. Child Adolesc. Psychiatry 42(8), 986–993 (2003).
  • Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Madras BK, Fischman AJ. Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet 354, 2132–2133 (1999).
  • Krause KH, Dresel SH, Krause J et al. The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder. Neurosci. Biobehav. Rev. 27(7), 605–613 (2003).
  • van Dyck CH, Quinlan DM, Cretalla LM et al. Unaltered dopamine transporter availability in adult attention deficit hyperactivity disorder. Am. J. Psychiatry 159, 309–312 (2002).
  • Langley K, Marshall L, van den Bree M et al. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. Am. J. Psychiatry 161(1), 133–138 (2004).
  • LaHoste GJ, Swanson JM, Wigal SB et al. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol. Psychiatry. 1(2), 121–124 (1996).
  • Faraone SV, Doyle AE, Mick E, Biederman J. Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder. Am. J. Psychiatry 158(7), 1052–1057 (2001).
  • Avale ME, Falzone TL, Gelman DM et al. The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder. Mol. Psychiatry 9(7), 718-26 (2004).
  • Sandoval V, Riddle EL, Hanson GR, Fleckenstein AE. Methylphenidate redistributes vesicular monoamine transporter-2: role of dopamine receptors. J. Neurosci. 22(19), 8705–8710 (2002).
  • Sandoval V, Riddle EL, Hanson GR, Fleckenstein AE. Methylphenidate alters vesicular monoamine transport and prevents methamphetamine-induced dopaminergic deficits. J. Pharmacol. Exp. Ther. 304(3), 1181–1187 (2003).
  • Davids E, Zhang K, Kula NS et al. Effects of norepinephrine and serotonin transporter inhibitors on hyperactivity induced by neonatal 6-hydroxydopamine lesioning in rats. J. Pharmacol. Exp. Ther. 301(3), 1097–1102 (2002).
  • Overtoom CC, Verbaten MN, Kemner C et al. Effects of methylphenidate, desipramine, and L-dopa on attention and inhibition in children with Attention Deficit Hyperactivity Disorder. Behav. Brain Res. 145(1–2), 7–15 (2003).
  • Barrickman LL, Perry P, Allen A et al. Bupropion versus methylphenidate in the treatment of attention-deficit hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry 34(5), 649–657 (1995).
  • Kratochvil CJ, Vaughan BS, Harrington MJ, et al. Atomoxetine: a selective noradrenaline reuptake inhibitor for the treatment of attention-deficit/hyperactivity disorder. Expert Opin. Pharmacother. 4, 1165–1174 (2003).
  • Schweri M, Skolnick P, Rafferty M et al. [3H]Threo-(±)-methylphenidate binding to 3,4-dihydrophenylethylamine uptake sites in corpus striatum: correlation with the stimulant properties of ritalinic acid esters. J. Neurochem. 45(4), 1062–1070 (1985).
  • Szobot CM, Ketzer C, Cunha RD et al. The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit hyperactivity disorder. Eur. J. Nucl. Med. Mol. Imaging 30(3), 423–426 (2003).
  • Morecraft RJ, Geula C, Mesulam MM. Architecture of connectivity within a cingulo-fronto-parietal neurocognitive network for directed attention. Arch. Neurol. 50(3), 279–284 (1993).
  • Mattay VS, Berman KF, Ostrem JL et al. Dextroamphetamine enhances "neural network-specific" physiological signals: a positron-emission tomography rCBF study. J. Neurosci. 16(15), 4816–4822 (1996).
  • Mehta MA, Goodyer IM, Sahakian BJ. Methylphenidate improves working memory and set-shifting in AD/HD: relationships to baseline memory capacity. J. Child Psychol. Psyc. 45(2), 293–305 (2004).
  • Tannock R, Ickowicz A, Schachar R. Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety. J. Am. Acad.Child Adolesc. Psychiatry 34(7), 886–896 (1995).
  • Wolraich M, Greenhill L, Pelham W et al. Randomized, controlled trial of OROS methylphenidate once a day in children with attention-deficit/hyperactivity disorder. Pediatrics 108(4), 883–892 (2001).
  • Stein MA, Sarampote CS, Waldman ID et al. A dose-response study of OROS methylphenidate in children with attention-deficit/hyperactivity disorder. Pediatrics 112(5), e404 (2003).
  • Swanson JM, Wigal SB, Wigal T et al. A comparison of once-daily extended-release methylphenidate formulations in children with attention-deficit/hyperactivity disorder in the laboratory school (the COMACS Study). Pediatrics 113(3 Pt 1), e206–e216 (2004).
  • Lopez F, Silva R, Pestreich L et al. Comparative efficacy of two once-daily methylphenidate formulations (Ritalin LA and Concerta) and placebo in children with attention deficit hyperactivity disorder across the school day. Paediatr. Drugs 5, 545–555 (2003).
  • Wigal S, Swanson JM, Feifel D. A double-blind, placebo-controlled trial of dexmethylphenidate hydrochloride and D,L-threo-methylphenidate hydrochloride in children with attention deficit/hyperactivity disorder. J. Am. Acad. Child. Adolesc. Psych. 43, 1406–1414 (2004).
  • MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for Attention-Deficit/Hyperactivity Disorder. Arch. Gen. Psychiatry 56(12), 1073–1086 (1999).
  • Greenhill L, Swanson J, Vitiello B et al. Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial. J. Am. Acad. Child Adolesc. Psychiatry 40(2), 180–187 (2001).
  • MTA Cooperative Group. National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: 24 month outcomes of treatment strategies for Attention-Deficit/Hyperactivity Disorder. Pediatrics 113(4), 754–761 (2004).
  • Conners CK, Epstein JN, March JS et al. Multimodal treatment of ADHD in the MTA: an alternative outcome analysis. J. Am. Acad. Child. Adolesc. Psychiatry 40(2), 159–167 (2001).
  • Spencer T, Biederman J, Wilens T et al. A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. Biol. Psych. 57, 456–463 (2005).
  • GucuyenerK, Erdemoglu AK, Senol S, Serdaroglu A, Soysal S, Kockar AI. Use of methylphenidate for attention-deficit hyperactivity disorder in patients with epilepsy or electroencephalographic abnormalities. J. Child. Neurol. 18, 109–112 (2003).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.