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Review

Pathophysiology of complex regional pain syndrome

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Pages 669-681 | Published online: 10 Jan 2014

References

  • Harden NR, Bruehl S. Diagnostic criteria: the statistical derivation of the four criterion factors. In: CRPS: Current Diagnosis and Therapy. Wilson PR, Stanton-Hicks MD, Harden RN (Eds). IASP Press, WA, USA, 45–58 (2005).
  • Janig W, Baron R. Is CRPS I a neuropathic pain syndrome? Pain120(3), 227–279 (2006).
  • Oaklander AL, Rissmiller JG, Gelman LB, Zheng L, Chang Y, Gott R. Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy). Pain120(3), 235–243 (2006).
  • Albrecht PJ, Hines S, Eisenberg E et al. Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome. Pain120(3), 244–266 (2006).
  • Weidner C, Schmelz M, Schmidt R et al. Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J. Neurosci.19(22), 10184–10190 (1999).
  • Bernard J, Gauriau F. Brainstem and pain: a complementary role with regard to the thalamus. In: CRPS: Current Diagnosis and Therapy. Wilson PR, Stanton-Hicks M, Harden NR (Eds). IASP Press, WA, USA, 139–154 (2005).
  • Dickenson AH, Suzuki R, Mathews EA et al. Balancing excitations and inhibitions in spinal circuits. In: The Pain System in Normal and Pathological States: a Primer for Clinicians. Villanueva L, Dickenson AH; Ollat H (Eds). IASP Press, WA, USA, 79–105 (2004).
  • Hunt SP. Molecular approaches to the study of pain. In: The Pain System in Normal and Pathological States : a Primer for Clinicians. Villanueva L, Dickenson AH, Ollat H (Eds). IASP Press, WA, USA, 57–77 (2004).
  • Janig W, Baron R. Complex regional pain syndrome: mystery explained? Lancet Neurol.2(11), 687–97 (2003).
  • Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat. Rev. Neurosci.3(8), 655–666 (2002).
  • Marchand F, Perretti M, McMahon SB. Role of the immune system in chronic pain. Nat. Rev. Neurosci.6, 521–532 (2005).
  • McMahon SB, Cafferty WB, Marchand F. Immune and glial cell factors as pain mediators and modulators. Exp. Neurol.192, 444–462 (2005).
  • Watkins LR, Maier SF. Glia: a novel drug discovery target for clinical pain. Nat. Rev. Drug Discov.2, 973–985 (2003).
  • Abbadie C. Chemokines, chemokine receptors and pain. Trends Immunol.26, 529–534 (2005).
  • Tsuda M, Inoue K, Salter MW. Neuropathic pain and spinal microglia: a big problem from molecules in “small” glia. Trends Neurosci.28, 101–107 (2005).
  • Shu X, Mendell LM. Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin. Neurosci. Lett.274(3), 159–162 (1999).
  • England S, Bevan S, Docherty RJ. PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J. Physiol.495(Pt 2), 429–440 (1996).
  • Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science288(5472), 1765–1769 (2000).
  • Davies SN, Lodge D. Evidence for involvement of N-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat. Brain Res.424(2), 402–406 (1987).
  • Dickenson AH, Sullivan AF. Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology26(8), 1235–1238 (1987).
  • Kilo S, Schmelz M, Koltzenburg M, Handwerker HO. Different patterns of hyperalgesia induced by experimental inflammation in human skin. Brain117(Pt 2), 385–396 (1994).
  • Ali Z, Meyer RA, Campbell JN. Secondary hyperalgesia to mechanical but not heat stimuli following a capsaicin injection in hairy skin. Pain68(2–3), 401–411 (1996).
  • Sheng M, Kim MJ. Postsynaptic signaling and plasticity mechanisms. Science298(5594), 776–780 (2002).
  • Thompson SW, King AE, Woolf CJ. Activity-dependent changes in rat ventral horn neurons in vitro; summation of prolonged afferent evoked postsynaptic depolarizations produce a D-2-amino-5-phosphonovaleric acid sensitive windup. Eur. J. Neurosci.2(7), 638–649 (1990).
  • Hollmann M, Heinemann S. Cloned glutamate receptors. Ann. Rev. Neurosci.17, 31–108 (1994).
  • Klein T, Magerl W, Hopf HC, Sandkuhler J, Treede RD. Perceptual correlates of nociceptive long-term potentiation and long-term depression in humans. J. Neurosci.28, 24(4), 964–971 (2004).
  • Nilsson HJ, Psouni E, Schouenborg J. Long term depression of human nociceptive skin senses induced by thin fibre stimulation. Eur. J. Pain7(3), 225–233 (2003).
  • Watkins LR, Maier SF. Immune regulation of central nervous system functions: from sickness responses to pathological pain. J. Intern. Med.257, 139–155 (2005).
  • DeLeo JA, Yezierski RP. The role of neuroinflammation and neuroimmune activation in persistent pain. Pain90(1–2), 1–6 (2001).
  • Milligan ED, Mehmert KK, Hinde JL et al. Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Res.861, 105–116 (2000).
  • Milligan ED, Twining C, Chacur M et al. Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J. Neurosci.23, 1026–1040 (2003).
  • AumeerallyN, Allen G, Sawynok J. Glutamate-evoked release of adenosine and regulation of peripheral nociception. Neuroscience127, 1–11 (2004).
  • Raghavendra V, Tanga F, DeLeo JA. Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J. Pharmacol. Exp. Ther.306, 624–630 (2003).
  • Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci.19, 312–318 (1996).
  • Abbadie C, Lindia JA, Cumiskey AM et al. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc. Natl Acad. Sci. USA100, 7947–7952 (2003).
  • Inoue K. The function of microglia through purinergic receptors: Neuropathic pain and cytokine release. Pharmacol. Ther.109(1–2), 210–226 (2006).
  • Klein MA, Moller JC, Jones LL, Bluethmann H, Kreutzberg GW, Raivich G. Impaired neuroglial activation in interleukin-6 deficient mice. Glia19, 227–233 (1997).
  • Nakajima K, Kohsaka S. Microglia: activation and their significance in the central nervous system. J. Biochem.130, 169–172 (2001).
  • Nishiyori A, Minami M, Ohtani Y et al. Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia? FEBS Lett.429, 167–172 (1998).
  • Svensson CI, Marsala M, Westerlund A et al. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J. Neurochem.86, 1534–1544 (2003).
  • Watkins LR, Maier SF. The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu. Rev. Psychol.51, 29–57 (2000).
  • Wieseler-Frank J, Maier SF, Watkins LR. Glial activation and pathological pain. Neurochem. Int.45, 389–395 (2004).
  • Goebel A, Vogel H, Caneris O et al. Immune responses to Campylobacter and serum autoantibodies in patients with complex regional pain syndrome. J. Neuroimmunol.162(1–2), 184–189 (2005).
  • Muneshige H, Toda K, Kimura H, Asou T. Does a viral infection cause complex regional pain syndrome? Acupunct. Electrother. Res.28, 183–192 (2003).
  • van de Vusse AC, Goossens VJ, Kemler MA, Weber WE. Screening of patients with complex regional pain syndrome for antecedent infections. Clin. J. Pain17, 110–114 (2001).
  • Blaes F, Schmitz K, Tschernatsch M et al. Autoimmune etiology of complex regional pain syndrome (M. Sudeck). Neurology63, 1734–1736 (2004).
  • Calder JS, Holten I, McAllister RM. Evidence for immune system involvement in reflex sympathetic dystrophy. J. Hand. Surg.23, 147–150 (1998).
  • Kemler MA, van de Vusse AC, van den Berg-Loonen EM, Barendse GA, van Kleef M, Weber WE. HLA-DQ1 associated with reflex sympathetic dystrophy. Neurology53, 1350–1351 (1999).
  • van Hilten JJ, van de Beek WJ, Roep BO. Multifocal or generalized tonic dystonia of complex regional pain syndrome: a distinct clinical entity associated with HLA-DR13. Ann. Neurol.48(1), 113–116 (2000).
  • Mailis A, Wade J. Profile of Caucasian women with possible genetic predisposition to reflex sympathetic dystrophy: a pilot study. Clin. J. Pain10, 210–217 (1994).
  • Hartrick CT. Increased production of nitric oxide stimulated by interferon-γ from peripheral blood monocytes in patients with complex regional pain syndrome. Neurosci. Lett.323, 75–77 (2002).
  • van de Beek WJT, Remarque EJ, Westendorp RGJ, van Hilten JJ. Innate cytokine profile in patients with complex regional pain syndrome is normal. Pain91, 259–261 (2001).
  • Huygen FJPM, de Bruijn AGJ, de Bruin MT, Groeneweg J, Klein J, Zijlstra F. Evidence for local inflammation in complex regional pain syndrome type 1. Mediators Inflamm.11, 47–51 (2002).
  • Ribbers GM, Oosterhuis WP, VanLimbeek J, deMetz M. Reflex sympathetic dystrophy: is the immune system involved? Arch. Phys. Med. Rehabil.79(12), 1549–1952 (1998).
  • Maihofner C, Handwerker HO, Neundorfer B, Birklein F. Mechanical hyperalgesia in complex regional pain syndrome: a role for TNF-α? Neurology65, 311–313 (2005).
  • Alexander GM, van Rijn MA, van Hilten JJ, Perreault MJ, Schwartzman RJ. Changes in cerebrospinal fluid levels of pro-inflammatory cytokines in CRPS. Pain116, 213–219 (2005).
  • Huygen FJ, Niehof S, Zijlstra FJ, van Hagen PM, Van Daele PL. Successful treatment of CRPS 1 with anti-TNF. J. Pain Symptom Manage.27, 101–103 (2004).
  • Goehler LE, Gaykema RP, Hammack SE, Maier SF, Watkins LR. Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve. Brain Res.804(2), 306–310 (1998).
  • Watkins LR, Maier SF. Implications of immune-to-brain communication for sickness and pain. Proc. Natl Acad. Sci. USA96(14), 7710–7713 (1999).
  • Goehler LE, Gaykema RP, Nguyen KT et al. Interleukin-1β in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems? J. Neurosci.19(7), 2799–2806 (1999).
  • Romeo HE, Tio DL, Rahman SU, Chiappelli F, Taylor AN. The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: relevance to neuroimmune surveillance of the oral cavity. J. Neuroimmunol.115, 91–100 (2001).
  • Laye S, Bluthe RM, Kent S et al. Subdiaphragmatic vagotomy blocks induction of IL-1 β mRNA in mice brain in response to peripheral LPS. Am. J. Physiol.268, R1327–R1331 (1995).
  • Mason P. Lipopolysaccharide induces fever and decreases tail flick latency in awake rats. Neurosci. Lett.154(1–2), 134–136 (1993).
  • Watkins LR, Goehler LE, Relton J, Brewer MT, Maier SF. Mechanisms of tumor necrosis factor-α (TNF-α) hyperalgesia. Brain Res.692, 244–250 (1995).
  • Maier SF, Wiertelak EP, Martin D, Watkins LR. Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Res.623, 321–324 (1993).
  • Watkins LR, Wiertelak EP, Goehler LE, Smith KP, Martin D, Maier SF. Characterization of cytokine-induced hyperalgesia. Brain Res.654, 15–26 (1994).
  • Petrenko AB, Yamakura T, Baba H, Shimoji K. The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review. Anesth. Analg.97(4), 1108–1116 (2003).
  • Harbut RE, Correll GE. Successful treatment of a nine-year case of complex regional pain syndrome type-I (reflex sympathetic dystrophy) with intravenous ketamine-infusion therapy in a warfarin-anticoagulated adult female patient. Pain Med.3(2), 147–155 (2002).
  • Goldberg ME, Domsky R, Scaringe D et al. Multi-day low dose ketamine infusion for the treatment of complex regional pain syndrome. Pain Physician8, 175–179 (2005).
  • Rommel O, Malin JP, Zenz M, Janig W. Quantitative sensory testing, neurophysiological and psychological examination in patients with complex regional pain syndrome and hemisensory deficits. Pain93(3), 279–293 (2001).
  • Sandkuhler J, Chen JG, Cheng G, Randic M. Low-frequency stimulation of afferent Aδ-fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons inthe rat. J. Neurosci.17(16), 6483–6491 (1997).
  • Kim MJ, Dunah AW, Wang YT, Sheng M. Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking. Neuron46(5), 745–760 (2005).
  • Song I, Huganir RL. Regulation of AMPA receptors during synaptic plasticity. Trends Neurosci.25(11), 578–588 (2002).
  • Carroll RC, Beattie EC, von Zastrow M, Malenka RC. Role of AMPA receptor endocytosis in synaptic plasticity. Nat. Rev. Neurosci.2(5), 315–324 (2001).
  • Perez-Otano I, Ehlers MD. Homeostatic plasticity and NMDA receptor trafficking. Trends Neurosci.28(5), 229–238 (2005).
  • Popescu G, Auerbach A. Modal gating of NMDA receptors and the shape of their synaptic response. Nat. Neurosci.6(5), 476–483 (2003).
  • Hoeger-Bement MK, Sluka KA. Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections. J. Neurosci.23(13), 5437–5445 (2003).
  • Bridges D, Thompson SW, Rice AS. Mechanisms of neuropathic pain. Br. J. Anaesth.87(1), 12–26 (2001).
  • Bi GQ, Rubin J. Timing in synaptic plasticity: from detection to integration. Trends Neurosci.28(5), 222–228 (2005).
  • Morishita W, Marie H, Malenka RC. Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses. Nat. Neurosci.8(8), 1043–1050 (2005).
  • Liang F, Huganir RL. Coupling of agonist-induced AMPA receptor internalization with receptor recycling. J. Neurochem.77(6), 1626–1631 (2001).
  • Gaiarsa JL, Caillard O, Ben-Ari Y. Long-term plasticity at GABAergic and glycinergic synapses: mechanisms and functional significance. Trends Neurosci.25(11), 564–570 (2002).
  • Amir R, Devor M. Functional cross-excitation between afferent A- and C-neurons in dorsal root ganglia. Neuroscience95(1), 189–195 (2000).
  • Lyu YS, Park SK, Chung K, Chung JM. Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model. Brain Res.871(1), 98–103 (2000).
  • Cummins TR, Dib-Hajj SD, Black JA, Waxman SG. Sodium channels and the molecular pathophysiology of pain. In: Nervous System Plasticity and Chronic Pain. Sandhulerr J, Bromm B, Gebhart GF, (Eds). Elsevier Press, Amsterdam, Netherlands, 13–19 (2000).
  • Zhou XF, Chie ET, Deng YS et al. Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat. Neuroscience92(3), 841–853 (1999).
  • Passmore GM, Selyanko AA, Mistry M et al. KCNQ/M currents in sensory neurons: significance for pain therapy. J. Neurosci.23(18), 7227–7236 (2003).
  • Hughes DI, Scott DT, Todd AJ, Riddell JS. Lack of evidence for sprouting of Aβ afferents into the superficial laminas of the spinal cord dorsal horn after nerve section. J. Neurosci.23(29), 9491–9499 (2003).
  • Maihofner C, Handwerker HO, Birklein F. Functional imaging of allodynia in complex regional pain syndrome. Neurology66(5), 711–717 (2006).
  • Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus. Nat. Rev. Neurosci.6(7), 533–544 (2005).
  • Maihofner C, Handwerker HO, Neundorfer B, Birklein F. Cortical reorganization during recovery from complex regional pain syndrome. Neurology63(4), 693–701 (2004).
  • Moseley GL. Distorted body image in complex regional pain syndrome. Neurology65(5), 773 (2005).
  • Acerra NE, Moseley GL. Dysynchiria: watching the mirror image of the unaffected limb elicits pain on the affected side. Neurology65(5), 751–753 (2005).
  • Forss N, Kirveskari E, Gockel M. Mirror-like spread of chronic pain. Neurology65(5), 748–750 (2005).
  • McCabe CS, Haigh RC, Halligan PW, Blake DR. Referred sensations in patients with complex regional pain syndrome type 1. Rheumatology42(9), 1067–1073 (2003).
  • Drummond PD, Finch PM, Skipworth S, Blockey P. Pain increases during sympathetic arousal in patients with complex regional pain syndrome. Neurology57(7), 1296–1303 (2001).
  • Singh B, Moodley J, Shaik AS, Robbs JV. Sympathectomy for complex regional pain syndrome. J. Vasc. Surg.37(3), 508–511 (2003).
  • Baron R, Schattschneider J, Binder A, Siebrecht D, Wasner G. Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case–control study. Lancet359(9318), 1655–1660 (2002).
  • Torebjork E, Wahren L, Wallin G, Hallin R, Koltzenburg M. Noradrenaline-evoked pain in neuralgia. Pain63(1), 11–20 (1995).
  • Schwartzman RJ. Autonomic system and pain. In: Handbook of Clinical Neurology. Appenzeller O (Ed.). Elsevier, Amsterdam, Netherlands, 307–347 (2000).
  • Drummond PD, Skipworth S, Finch PM. α-1-adrenoreceptors in normal and hyperalgesic human skin. Clin. Sci.91(1), 73–77 (1996).
  • Villaneuva L, Fields HL. Endogenous central mechanisms of pain modulation. In: The Pain System in Normal and Pathological States: a Primer for Clinicians. Villanueva, Luis, Dickenson, Ollar (Eds). IASP Press, WA, USA (2004).
  • Coderre TJ, Xanthos DN, Francis L, Bennett GJ. Chronic post-ischemia pain (CPIP), a novel animal model of complex regional pain syndrome type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain112(1–2), 94–105 (2004).
  • Schurmann M, Gradl G, Andress HJ, Furst H, Schildberg FW. Assessment of peripheral sympathetic nervous function for diagnosing early post-traumatic complex regional pain syndrome type I. Pain80, 149–159 (1999).
  • Gradl G, Schurmann M. Sympathetic dysfunction as a temporary phenomenon in acute posttraumatic CRPS-1. Clin. Auton. Res.15, 29–34 (2005).
  • Wasner G, Heckmann K, Maier C, Baron R. Vascular abnormalities in acute reflex sympathetic dystrophy (CRPS-1), complete inhibition of sympathetic nerve activity with recovery. Arch. Neurol.56, 613–620 (1999).
  • Bej M, Schwartzman RJ. Abnormalities of cutaneous blood flow regulation in patients with reflex sympathetic dystrophy as measured by laser Doppler fluxmetry. Arch. Neurol.48(9), 912–915 (1991).
  • Di Benedetto M, Huston C, Sharp M, Jones B. Regional hypothermia in response to minor injury. Am. J. Phys. Med. Rehabil.75(4), 270–277 (1996).
  • Chelimsky TC, Low PA, Naessens JM. Value of autonomic testing in reflex sympathetic dystrophy. Mayo Clin. Proc.70, 1029–1040 (1995).
  • Chemali KR, Gorodeski R, Chelimsky TC. α-adrenergic supersensitivity of the sudomotor nerve in complex regional pain syndrome. Ann. Neurol.49(4), 453–459 (2001).
  • Molina PE. Noradrenergic inhibition of TNF upregulation in hemorrhagic shock. Neuroimmunomodulation9(3), 125–133 (2001).
  • Molina PE. Neurobiology of the stress response: contribution of the sympathetic nervous system to the neuroimmune axis in traumatic injury. Shock24(1), 3–10 (2005).
  • Howarth D, Burstal R, Hayes C, Lan L, Lantry G. Autonomic regulation of lymphatic flow in the lower extremity demonstrated on lymphoscintigraphy in patients with reflex sympathetic dystrophy. Clin. Nucl. Med.24(6), 383–387 (1999).
  • Schurmann M, Zaspel J, Gradl G, Wipfel A, Christ F. Assessment of the peripheral microcirculation using computer-assisted venous congestion plethysmography in post-traumatic complex regional pain syndrome type I. J. Vasc. Res.38, 453–461 (2001).
  • Leis S, Weber M, Isselmann A, Schmelz M, Birklein F. Substance-P-induced protein extravasation is increased in complex regional pain syndrome. Exp. Neurol.183, 197–204 (2003).
  • Weber M, Birklein F, Neundorfer B, Schmelz M. Facilitated neurogenic inflammation in complex regional pain syndrome. Pain91, 251–257 (2001).
  • Moseley GL. Imagined movements cause pain and swelling in a patient with complex regional pain syndrome. Neurology62(1), 1644 (2004).
  • Galer BS, Jensen M. Neglect-like symptoms in complex regional pain syndrome: results of a self-administered survey. J. Pain Symptom Manage.18(3), 213–217 (1999).
  • van Hilten JJ, Blumberg H, Schwartzman RJ. Factor IV: movement disorders and dystrophy – pathophysiology and measurement. In: CRPS: Current Diagnosis and Therapy. Progress in Pain Research and Management. Wilson P, Stanton Hicks M, Harden RN (Eds). IASP Press, WA, USA, 119–137 (2005).
  • van de Beek WJ, Schwartzman RJ, van Nes SI, Delhaas EM, van Hilten JJ. Diagnostic criteria used in studies of reflex sympathetic dystrophy. Neurology58(4), 522–526 (2002).
  • Woolf C, Wiesenfeld-Hallin Z. Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptive flexor withdrawal reflex in the rat. Neurosci. Lett.66(2), 226–230 (1986).
  • Price DD, Long S, Wilsey B, Rafii A. Analysis of peak magnitude and duration of analgesia produced by local anesthetics injected into sympathetic ganglia of complex regional pain syndrome patients. Clin. J. Pain14(3), 216–226 (1998).
  • van de Beek WJ, Vein A, Hilgevoord AA, van Dijk JG, van Hilten BJ. Neurophysiologic aspects of patients with generalized or multifocal tonicdystonia of reflex sympathetic dystrophy. J. Clin. Neurophysiol.19(1), 77–83 (2002).
  • Marilis-Gagnon A, Giannoylis I, Dowman J et al. Altered central somatosensory processing in chronic pain patients with “hysterical” anesthesia. Neurology60, 1501–1507 (2003).
  • van Hilten JJ, van de Beek WJ, Vein AA, van Dijk JG, Middelkoop HA. Clinical aspects of multifocal or generalized tonic dystonia in reflex sympathetic dystrophy. Neurology56(12), 1762–1765 (2001).
  • Schwenkreis P, Janssen F, Rommel O et al. Bilateral motor cortex disinhibition in complex regional pain syndrome (CRPS) type I of the hand. Neurology61(4), 515–519 (2003).
  • Schattschnedier J, Wenzelburger R, Deuschl G, Baron R. Kinematic analysis of the upper extremity in CRPS. In: Complex Regional Pain Syndrome. Harden RN, Baron R, Janig W (Eds). IASP Press, WA, USA, 119–128 (2001).
  • McCabe CS, Haigh RC, Ring EF, Halligan PW, Wall PD, Blake DR. A controlled pilot study of the utility of mirror visual feedback in the treatment of complex regional pain syndrome (type 1). Rheumatology42(1), 97–101 (2003).

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