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Review

Use of magnetic resonance imaging in tracking the course and treatment of schizophrenia

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Pages 1005-1016 | Published online: 10 Jan 2014

References

  • Jablensky A, Sartorius N, Ernberg G et al. Schizophrenia: manifestations, incidence and course in different cultures. A WHO ten-country study. Psychol. Med. Monogr. (Suppl. 20), 1–97 (1992).
  • Jablensky A. Schizophrenia: recent epidemiologic issues. Epidemiol. Rev.17(1), 10–20 (1995).
  • Gottesman II. Schizophrenia genesis: the origins of madness. WH Freeman and Company, NY, USA (1991).
  • Lehmann HE, Ban TA. The history of the psychopharmacology of schizophrenia. Can. J. Psychiatry42(2), 152–162 (1997).
  • Moller HJ. Antipsychotic agents. Gradually improving treatment from the traditional oral neuroleptics to the first atypical depot. Eur. Psychiatry20(5–6), 379–385 (2005).
  • Salkever D, Slade E, Karakus M. Differential effects of atypical versus typical antipsychotic medication on earnings of schizophrenia patients: estimates from a prospective naturalistic study. Pharmacoeconomics24(2), 123–139 (2006).
  • Sharma T, Antonova L. Cognitive function in schizophrenia. Deficits, functional consequences, and future treatment. Psychiatr. Clin. North Am.26(1), 25–40 (2003).
  • Davis JM, Chen N, Glick ID. A meta-analysis of the efficacy of second-generation antipsychotics. Arch. Gen. Psychiatry60(6), 553–564 (2003).
  • Glassman AH. Schizophrenia, antipsychotic drugs, and cardiovascular disease. J. Clin. Psychiatry66(Suppl. 6), 5–10 (2005).
  • Bottai T, Quintin P, Perrin E. Antipsychotics and the risk of diabetes: a general data review. Eur. Psychiatry20(Supp. 4), S349–S357 (2005).
  • Tandon R, Wolfgang Fleischhacker W. Comparative efficacy of antipsychotics in the treatment of schizophrenia: a critical assessment. Schizophr. Res.79(2–3), 145–155 (2005).
  • Kane JM. Treatment-resistant schizophrenic patients. J. Clin. Psychiatry57(Suppl. 9), 35–40 (1996).
  • Knapp M, Mangalore R, Simon J. The global costs of schizophrenia. Schizophr. Bull.30(2), 279–293 (2004).
  • Thornicroft G, Tansella M, Becker T et al. The personal impact of schizophrenia in Europe. Schizophr. Res.69(2–3), 125–132 (2004).
  • Sharma T, Chitnis X. Brain Imaging in Schizophrenia. Insights and Applications. Remedica Publishing, London, UK (2000).
  • Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophr. Res.49(1–2), 1–52 (2001).
  • Kasai K, Iwanami A, Yamasue H, Kuroki N, Nakagome K, Fukuda M. Neuroanatomy and neurophysiology in schizophrenia. Neurosci. Res.43(2), 93–110 (2002).
  • Pantelis C, Yucel M, Wood SJ et al. Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia. Schizophr. Bull.31(3), 672–696 (2005).
  • Velakoulis D, Wood SJ, Wong MT et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch. Gen. Psychiatry63(2), 139–149 (2006).
  • Nadeau SE, Crosson B. A guide to the functional imaging of cognitive processes. Neuropsychiatry. Neuropsychol. Behav. Neurol.8(3), 143–162 (1995).
  • Kraepelin E. Dementia Praecox and Paraphrenia. Livingston, Edinburgh, UK (1919).
  • Beuler E. Dementia Praecox or the Group of Schizophrenias. Zinkin J (Ed.). International University Press, NY, USA (1911; Reprinted 1950).
  • Gaser C, Schlaug G. Brain structures differ between musicians and non-musicians. J. Neurosci.23(27), 9240–9245 (2003).
  • Shah PJ, Ebmeier KP, Glabus MF, Goodwin GM. Cortical gray matter reductions associated with treatment-resistant chronic unipolar depression. Controlled magnetic resonance imaging study. Br. J. Psychiatry172, 527–532 (1998).
  • Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET. Meta-analysis of regional brain volumes in schizophrenia. Am. J. Psychiatry157(1), 16–25 (2000).
  • Gaser C, Nenadic I, Buchsbaum BR, Hazlett EA, Buchsbaum MS. Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex. Am. J. Psychiatry161(1), 154–156 (2004).
  • Honea R, Crow TJ, Passingham D, Mackay CE. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am. J. Psychiatry162(12), 2233–2245 (2005).
  • Sharma T, Kumari V. Structural and functional brain abnormalities in first-episode schizophrenia. In: Early Course of Schizophrenia. Sharma T, Harvey PD (Eds), Oxford University Press, UK (2005).
  • Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry44(7), 660–669 (1987).
  • Murray RM, Lewis SW. Is schizophrenia a neurodevelopmental disorder? Br. Med. J.295, 681–682 (1987).
  • Fannon D, Chitnis X, Doku V et al. Features of structural brain abnormality detected in first-episode psychosis. Am. J. Psychiatry157(11), 1829–1834 (2000).
  • Ettinger U, Chitnis XA, Kumari V et al. Magnetic resonance imaging of the thalamus in first-episode psychosis. Am. J. Psychiatry158(1), 116–118 (2001).
  • Sumich A, Chitnis XA, Fannon DG et al. Temporal lobe abnormalities in first-episode psychosis. Am. J. Psychiatry159(7), 1232–1235 (2002).
  • Kim JJ, Crespo-Facorro B, Andreasen NC, O’Leary DS, Magnotta V, Nopoulos P. Morphology of the lateral superior temporal gyrus in neuroleptic naive patients with schizophrenia: relationship to symptoms. Schizophr. Res.60(2–3), 173–181 (2003).
  • Joyal CC, Laakso MP, Tiihonen J et al. The amygdala and schizophrenia: a volumetric magnetic resonance imaging study in first-episode, neuroleptic-naive patients. Biol. Psychiatry54(11), 1302–1304 (2003).
  • Narr KL, Thompson PM, Szeszko P et al. Regional specificity of hippocampal volume reductions in first-episode schizophrenia. NeuroImage21(4), 1563–1575 (2004).
  • Jayakumar PN, Venkatasubramanian G, Gangadhar BN, Janakiramaiah N, Keshavan MS. Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naive schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry29(4), 587–591 (2005).
  • Crespo-Facorro B, Kim JJ, Andreasen NC, Leary DS, Magnotta V. Regional frontal abnormalities in schizophrenia: a quantitative gray matter volume and cortical surface size study. Biol. Psychiatry48(2), 110–119 (2000).
  • Hirayasu Y, Shenton ME, Salisbury DF et al. Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. Am. J. Psychiatry155(10), 1384–1391 (1998).
  • Molina V, Reig S, Sarramea F et al. Anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia. Psych. Res. Neuroimag.124(3), 153–161 (2003).
  • DeLisi LE, Sakuma M, Tew W, Kushner M, Hoff AL, Grimson R. Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia. Psych. Res. Neuroimag.74(3), 129–140 (1997).
  • DeLisi LE, Sakuma M, Ge S, Kushner M. Association of brain structural change with the heterogeneous course of schizophrenia from early childhood through five years subsequent to a first hospitalization. Psych. Res. Neuroimag.84(2–3), 75–88 (1998).
  • DeLisi LE, Sakuma M, Maurizio AM, Relja M, Hoff AL. Cerebral ventricular change over the first 10 years after the onset of schizophrenia. Psych. Res. Neuroimag.130(1), 57–70 (2004).
  • Gharaibeh WS, Rohlf FJ, Slice DE, DeLisi LE. A geometric morphometric assessment of change in midline brain structural shape following a first-episode of schizophrenia. Biol. Psychiatry48(5), 398–405 (2000).
  • Kasai K, Shenton ME, Salisbury DF et al. Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Arch. Gen. Psychiatry60(8), 766–775 (2003).
  • Ho BC, Andreasen NC, Nopoulos P, Arndt S, Magnotta V, Flaum M. Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia. Arch. Gen. Psychiatry60(6), 585–594 (2003).
  • Weinberger DR, McClure RK. Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain? Arch. Gen. Psychiatry59(6), 553–558 (2002).
  • Antonova E, Sharma T, Morris R, Kumari V. The relationship between brain structure and neurocognition in schizophrenia: a selective review. Schizophr. Res.70(2–3), 117–145 (2004).
  • Szeszko PR, Gunning-Dixon F, Goldman RS et al. Lack of normal association between cerebellar volume and neuropsychological functions in first-episode schizophrenia. Am. J. Psychiatry160(10), 1884–1887 (2003).
  • Ettinger U, Kumari V, Chitnis XA et al. Volumetric neural correlates of antisaccade eye movements in first-episode psychosis. Am. J. Psychiatry161(10), 1918–1921 (2004).
  • Salgado-Pineda P, Baeza I, Perez-Gomez M et al. Sustained attention impairment correlates to gray matter decreases in first-episode neuroleptic-naive schizophrenic patients. NeuroImage19(2), 365–375 (2003).
  • Flashman LA, Green MF. Review of cognition and brain structure in schizophrenia: profiles, longitudinal course, and effects of treatment. Psychiatr. Clin. North Am.27(1), 1–18 (2004).
  • Premkumar P, Sharma T. Neuropsychologic functioning and structural MRI of the brain in patients with schizophrenia. Expert Rev. Neurotherapeutics5(1), 85–94 (2005).
  • Weinberger DR, Lipska BK. Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground. Schizophr. Res.16(2), 87–110 (1995).
  • Buchsbaum MS. The frontal lobes, basal ganglia, and temporal lobes as sites for schizophrenia. Schizophr. Bull.16(3), 379–389 (1990).
  • Grace AA. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience41(1), 1–24 (1991).
  • Gray JA. Dopamine release in the nucleus accumbens: the perspective from aberrations of consciousness in schizophrenia. Neuropsychologia33(9), 1143–1153 (1995).
  • Gray JA. Integrating schizophrenia. Schizophr. Bull.24(2), 249–266 (1998).
  • O’Donnell P, Grace AA. Dysfunctions in multiple interrelated systems as the neurobiological bases of schizophrenic symptom clusters. Schizophr. Bull.24(2), 267–283 (1998).
  • Andreasen NC, Paradiso S, O’Leary DS. “Cognitive dysmetria” as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry? Schizophr. Bull.24(2), 203–218 (1998).
  • Andreasen NC, Nopoulos P, Leary DS, Miller DD, Wassink T, Flaum M. Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms. Biol. Psychiatry46(7), 908–920 (1999).
  • Middleton FA, Strick PL. Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science266(5184), 458–461 (1994).
  • Schmahmann JD. From movement to thought: anatomic substrates of the cerebellar contribution to cognitive processing. Hum. Brain Mapp.4(3), 174–198 (1996).
  • Schmahmann JD, Sherman JC. Cerebellar cognitive affective syndrome. Int. Rev. Neurobiol.41, 433–440 (1997).
  • Semkovska M, Bedard MA, Stip E. Hypofrontality and negative symptoms in schizophrenia: synthesis of anatomic and neuropsychological knowledge and ecological perspectives. L’Encephale27(5), 405–415 (2001).
  • Barta PE, Pearlson GD, Powers RE, Richards SS, Tune LE. Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am. J. Psychiatry147(11), 1457–1462 (1990).
  • Shenton ME, Kikinis R, Jolesz FA et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N. Engl. J. Med.327(9), 604–612 (1992).
  • Kasai K, McCarley RW, Salisbury DF et al. Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study. Schizophr. Res.71(1), 65–76 (2004).
  • DeLisi LE, Hoff AL, Neale C, Kushner M. Asymmetries in the superior temporal lobe in male and female first-episode schizophrenic patients: measures of the planum temporale and superior temporal gyrus by MRI. Schizophr. Res.12(1), 19–28 (1994).
  • Corson PW, Leary DS, Miller DD, Andreasen NC. The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorders: a comparison between the neuroleptic-naive and medicated states. Biol. Psychiatry52(9), 855–862 (2002).
  • Gunduz H, Wu H, Ashtari M et al. Basal ganglia volumes in first-episode schizophrenia and healthy comparison subjects. Biol. Psychiatry51(10), 801–808 (2002).
  • Chakos M, Lieberman J, Alvir J, Bilder R, Ashtari M. Caudate nuclei volumes in schizophrenic patients treated with typical antipsychotics or clozapine. Lancet345(8947), 456–457 (1995).
  • Chakos MH, Lieberman JA, Bilder RM et al. Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs. Am. J. Psychiatry151(10), 1430–1436 (1994).
  • Gur RE, Maany V, Mozley PD, Swanson C, Bilker W, Gur RC. Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia. Am. J. Psychiatry155(12), 1711–1717 (1998).
  • Lieberman JA, Tollefson GD, Charles C et al. Antipsychotic drug effects on brain morphology in first-episode psychosis. Arch. Gen. Psychiatry62(4), 361–370 (2005).
  • Garver DL, Holcomb JA, Christensen JD. Cerebral crtical gray expansion associated with two second-generation antipsychotics. Biol. Psychiatry58(1), 62–66 (2005).
  • Shad MU, Muddasani S, Keshavan MS. Prefrontal subregions and dimensions of insight in first-episode schizophrenia – a pilot study. Psych. Res. Neuroimag.146(1), 35–42 (2006).
  • Shad MU, Muddasani S, Prasad K, Sweeney JA, Keshavan MS. Insight and prefrontal cortex in first-episode schizophrenia. NeuroImage22(3), 1315–1320 (2004).
  • Flashman LA, McAllister TW, Johnson SC, Rick JH, Green RL, Saykin AJ. Specific frontal lobe subregions correlated with unawareness of illness in schizophrenia: a preliminary study. J. Neuropsychiatry Clin. Neurosci.13(2), 255–257 (2001).
  • Konicki PE, Kwon KY, Steele V et al. Prefrontal cortical sulcal widening associated with poor treatment response to clozapine. Schizophr. Res.48(2–3), 173–176 (2001).
  • Lieberman J, Chakos M, Wu H et al. Longitudinal study of brain morphology in first-episode schizophrenia. Biol. Psychiatry49(6), 487–499 (2001).
  • Robinson DG, Woerner MG, McMeniman M, Mendelowitz A, Bilder RM. Symptomatic and functional recovery from a first-episode of schizophrenia or schizoaffective disorder. Am. J. Psychiatry161(3), 473–479 (2004).
  • Cahn W, Hulshoff Pol HE, Lems EBTE et al. Brain volume changes in first-episode schizophrenia: a 1-year follow-up study. Arch. Gen. Psychiatry59(11), 1002–1010 (2002).
  • Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry160(4), 636–645 (2003).
  • Braff D, Freedman R. Endophenotypes in the studies of the genetics of schizophrenia. In: Neuropsychopharmacology: The 5th Generation of Progress. Davies KL, Charney D, Coyle JT, Nemeroff C (Eds,), Lippincott Williams & Wilkins, Philladelphia, USA 703–716 (2002).
  • Keltner NL. Genomic influences on schizophrenia-related neurotransmitter systems. J. Nurs. Scholarsh.37(4), 322–328 (2005).
  • Baare WF, Hulshoff Pol HE, Boomsma DI et al. Quantitative genetic modeling of variation in human brain morphology. Cereb. Cortex11(9), 816–824 (2001).
  • Bartley AJ, Jones DW, Weinberger DR. Genetic variability of human brain size and cortical gyral patterns. Brain120(2), 257–269 (1997).
  • Pfefferbaum A, Sullivan EV, Swan GE, Carmelli D. Brain structure in men remains highly heritable in the seventh and eighth decades of life. Neurobiol. Aging21(1), 63–74 (2000).
  • Reveley AM, Reveley MA, Chitkara B, Clifford C. The genetic basis of cerebral ventricular volume. Psychiatry Res.13(3), 261–266 (1984).
  • Toga AW, Thompson PM, Sowell ER. Mapping brain maturation. Trends Neurosci.29(3), 148–159 (2006).
  • Keshavan MS, Diwadkar VA, Montrose DM, Rajarethinam R, Sweeney JA. Premorbid indicators and risk for schizophrenia: a selective review and update. Schizophr. Res.79(1), 45–57 (2005).
  • Ohara K, Sato Y, Tanabu S, Yoshida K, Shibuya H. Magnetic resonance imaging study of the ventricle-brain ratio in parents of schizophrenia subjects. Prog. Neuropsychopharmacol. Biol. Psychiatry30(1), 89–92 (2006).
  • McDonald C, Marshall N, Sham PC et al. Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives. Am. J. Psychiatry163(3), 478–487 (2006).
  • McIntosh AM, Job DE, Moorhead WJ et al. Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure. Am. J. Med. Genet.141(1), 76–83 (2006).
  • Goghari VM, Rehm K, Carter CS, MacDonald AW 3rd. Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients. Cereb. Cortex (2006) (Epub ahead of print).
  • van HarenNEM, Picchioni MM, McDonald C et al. A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia. Biol. Psychiatry56(6), 454–461 (2004).
  • Rijsdijk FV, van Haren NEM, Picchioni MM et al. Brain MRI abnormalities in schizophrenia: same genes or same environment? Psychol. Med.35(10), 1399–1409 (2005).
  • Schulze K, McDonald C, Frangou S et al. Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives. Biol. Psychiatry53(7), 562–570 (2003).
  • van Erp TG, Saleh PA, Huttunen M et al. Hippocampal volumes in schizophrenic twins. Arch. Gen. Psychiatry61(4), 346–353 (2004).
  • Johnstone EC, Lawrie SM, Cosway R. What does the Edinburgh high-risk study tell us about schizophrenia? Am. J. Med. Genet.114(8), 906–912 (2002).
  • Keshavan MS, Jayakumar PN, Diwadkar VA, Singh A. Cavum septi pellucidi in first-episode patients and young relatives at risk for schizophrenia. CNS Spectrums7(2), 155–158 (2002).
  • Rajarethinam R, Sahni S, Rosenberg DR, Keshavan MS. Reduced superior temporal gyrus volume in young offspring of patients with schizophrenia. Am. J. Psychiatry161(6), 1121–1124 (2004).
  • Diwadkar VA, Sweeney JA, Montrose DM. Cognitive impairments and structural MRI abnormalities in schizotypal first-degree relatives of schizophrenia patints. Biol. Psychiatry53(Suppl. 8), 500 (2003).
  • Jou RJ, Hardan AY, Keshavan MS. Reduced cortical folding in individuals at high risk for schizophrenia: a pilot study. Schizophr. Res.75(2–3), 309–313 (2005).
  • van Rijn S, Aleman A, Swaab H, Kahn RS. Neurobiology of emotion and high risk for schizophrenia: role of the amygdala and the X-chromosome. Neurosci. Biobehav. Rev.29(3), 385–397 (2005).
  • Gilbert AR, Montrose DM, Sahni SD, Diwadkar VA, Keshavan MS. Obstetric complications correlate with neurobehavioral and brain structural alterations in young relatives at risk for schizophrenia. Ann. NY Acad. Sci.1008, 269–275 (2003).
  • McGlashan TH. Early detection and intervention in schizophrenia: editor's introduction. Schizophr. Bull.22(2), 197–199 (1996).
  • McGorry PD. ‘A stitch in time...’ The scope for preventive strategies in early psychosis. In: The Recognition and Management of Early Psychosis: A Preventive Approach. McGorry PD, Jackson HJ (Eds), Cambridge University Press, NY, USA (1999).
  • Dickerson FB. Cognitive behavioral psychotherapy for schizophrenia: a review of recent empirical studies. Schizophr. Res.43(2–3), 71–90 (2000).
  • Job DE, Whalley HC, Johnstone EC, Lawrie SM. gray matter changes over time in high-risk subjects developing schizophrenia. NeuroImage25(4), 1023–1030 (2005).
  • Callicott JH. An expanded role for functional neuroimaging in schizophrenia. Curr. Opin. Neurobiol.13(2), 256–260 (2003).
  • Callicott JH, Bertolino A, Mattay VS et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb. Cortex10(11), 1078–1092 (2000).
  • Manoach DS, Halpern EF, Kramer TS et al. Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects. Am. J. Psychiatry158(6), 955–958 (2001).
  • Ramsey NF, Koning HAM, Welles P, Cahn W, van der Linden JA, Kahn RS. Excessive recruitment of neural systems subserving logical reasoning in schizophrenia. Brain125(8), 1793–1807 (2002).
  • Callicott JH, Mattay VS, Bertolino A et al. Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb. Cortex9(1), 20–26 (1999).
  • Manoach DS. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophr. Res.60(2–3), 285–298 (2003).
  • Jansma JM, Ramsey NF, van der Wee NJA, Kahn RS. Working memory capacity in schizophrenia: a parametric fMRI study. Schizophr. Res.68(2–3), 159–171 (2004).
  • Glahn DC, Ragland JD, Abramoff A et al. Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Hum. Brain Mapp.25(1), 60–69 (2005).
  • Kumari V, Gray JA, Geyer MA et al. Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjects. Psych. Res. Neuroimag.122(2), 99–113 (2003).
  • Hempel A, Hempel E, Schonknecht P, Stippich C, Schroder J. Impairment in basal limbic function in schizophrenia during affect recognition. Psych. Res. Neuroimag.122(2), 115–124 (2003).
  • Jessen F, Scheef L, Germeshausen L et al. Reduced hippocampal activation during encoding and recognition of words in schizophrenia patients. Am. J. Psychiatry160(7), 1305–1312 (2003).
  • Leube DT, Rapp A, Erb M et al. Hippocampal dysfunction during episodic memory encoding in patients with schizophrenia – an fMRI study. Schizophr. Res.64(1), 83–85 (2003).
  • Aleman A, Kahn RS. Strange feelings: do amygdala abnormalities dysregulate the emotional brain in schizophrenia? Prog. Neurobiol.77(5), 283–298 (2005).
  • Braus DF, Ende G, Weber-Fahr W et al. Antipsychotic drug effects on motor activation measured by functional magnetic resonance imaging in schizophrenic patients. Schizophr. Res.39(1), 19–29 (1999).
  • Braus DF, Ende G, Hubrich-Ungureanu P, Henn FA. Cortical response to motor stimulation in neuroleptic-naive first-episode schizophrenics. Psych. Res. Neuroimag.98(3), 145–154 (2000).
  • Barch DM, Carter CS, Braver TS et al. Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Arch. Gen. Psychiatry58(3), 280–288 (2001).
  • Muller JL, Roder C, Schuierer G, Klein HE. Subcortical overactivation in untreated schizophrenic patients: a functional magnetic resonance image finger-tapping study. Psychiatry Clin. Neurosci.56(1), 77–84 (2002).
  • Hofer A, Weiss EM, Golaszewski SM et al. Neural correlates of episodic encoding and recognition of words in unmedicated patients during an acute episode of schizophrenia: a functional MRI study. Am. J. Psychiatry160(10), 1802–1808 (2003).
  • Mendrek A, Laurens KR, Kiehl KA, Ngan ETC, Stip E, Liddle PF. Changes in distributed neural circuitry function in patients with first-episode schizophrenia. Br. J. Psychiatry185, 205–214 (2004).
  • Boksman K, Theberge J, Williamson P et al. A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia. Schizophr. Res.75(2–3), 247–263 (2005).
  • Molina V, Sanz J, Reig S et al. Hypofrontality in men with first-episode psychosis. Br. J. Psychiatry186, 203–208 (2005).
  • Morey RA, Inan S, Mitchell TV, Perkins DO, Lieberman JA, Belger A. Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing. Arch. Gen. Psychiatry62(3), 254–262 (2005).
  • Honey GD, Bullmore ET, Soni W, Varatheesan M, Williams SC, Sharma T. Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia. Proc. Natl Acad. Sci. USA96(23), 13432–13437 (1999).
  • Miller DD, Andreasen NC, Leary DS, Watkins GL, Boles Ponto LL, Hichwa RD. Comparison of the effects of risperidone and haloperidol on regional cerebral blood flow in schizophrenia. Biol. Psychiatry49(8), 704–715 (2001).
  • Lahti AC, Holcomb HH, Weiler MA et al. Clozapine but not haloperidol re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex. Neuropsychopharmacology29(1), 171–178 (2004).
  • Davis CE, Jeste DV, Eyler LT. Review of longitudinal functional neuroimaging studies of drug treatments in patients with schizophrenia. Schizophr. Res.78(1), 45–60 (2005).
  • Gur RE, Resnick SM, Gur RC et al. Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography. Arch. Gen. Psychiatry44(2), 126–129 (1987).
  • Risch SC, McGurk S, Horner MD et al. A double-blind placebo-controlled case study of the use of donepezil to improve cognition in a schizoaffective disorder patient: functional MRI correlates. Neurocase7(2), 105–110 (2001).
  • Nahas Z, George MS, Horner MD et al. Augmenting atypical antipsychotics with a cognitive enhancer (donepezil) improves regional brain activity in schizophrenia patients: a pilot double-blind placebo controlled BOLD fMRI study. Neurocase9(3), 274–282 (2003).
  • Aasen I, Kumari V, Sharma T. Effects of rivastigmine on sustained attention in schizophrenia: an fMRI Study. J. Clin. Psychopharmacol.25(4), 311–317 (2005).
  • Kumari V, Aasen I, Ffytche D, Williams SCR, Sharma T. Neural correlates of adjunctive rivastigmine treatment to antipsychotics in schizophrenia: a randomized, placebo-controlled, double-blind fMRI study. NeuroImage29(2), 545–556 (2006).
  • Postma P, Gray JA, Sharma T et al. A behavioural and functional neuroimaging investigation into the effects of nicotine on sensorimotor gating in healthy subjects and persons with schizophrenia. Psychopharmacology (Berl).184(3–4), 589–599 (2006).
  • McGuire PK, Murray RM, Shah GMS. Increased blood flow in Broca’s area during auditory hallucinations in schizophrenia. Lancet342(8873), 703–706 (1993).
  • Suzuki M, Yuasa S, Minabe Y, Murata M, Kurachi M. Left superior temporal blood flow increases in schizophrenic and schizophreniform patients with auditory hallucination: a longitudinal case study using 123I-IMP SPECT. Eur. Arch. Psychiatry Clin. Neurosci.242(5), 257–261 (1993).
  • Dierks T, Linden DEJ, Jandl M et al. Activation of Heschl’s gyrus during auditory hallucinations. Neuron22(3), 615–621 (1999).
  • Shergill SS, Cameron LA, Brammer MJ, Williams SC, Murray RM, McGuire PK. Modality specific neural correlates of auditory and somatic hallucinations. J. Neurol. Neurosurg. Psychiatr.71(5), 688–690 (2001).
  • Lawrie SM, Buechel C, Whalley HC, Frith CD, Friston KJ, Johnstone EC. Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol. Psychiatry51(12), 1008–1011 (2002).
  • Stephane M, Barton S, Boutros NN. Auditory verbal hallucinations and dysfunction of the neural substrates of speech. Schizophr. Res.50(1–2), 61–78 (2001).
  • Frith CD. The cognitive neuropsychology of schizophrenia. Hillsdale, NJ, USA (1992).
  • Kircher TT, Liddle PF, Brammer MJ, Williams SC, Murray RM, McGuire PK. Neural correlates of formal thought disorder in schizophrenia: preliminary findings from a functional magnetic resonance imaging study. Arch. Gen. Psychiatry58(8), 769–774 (2001).
  • Perlstein WM, Carter CS, Noll DC, Cohen JD. Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. Am. J. Psychiatry158(7), 1105–1113 (2001).
  • Callicott JH, Egan MF, Mattay VS et al. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am. J. Psychiatry160(4), 709–719 (2003).
  • Thermenos HW, Seidman LJ, Breiter H et al. Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: a pilot study. Biol. Psychiatry55(5), 490–500 (2004).
  • Raemaekers M, Ramsey NF, Vink M, van den Heuvel MP, Kahn RS. Brain activation during antisaccades in unaffected relatives of schizophrenic patients. Biol. Psychiatry59(6), 530–535 (2006).
  • Habel U, Klein M, Shah NJ et al. Genetic load on amygdala hypofunction during sadness in nonaffected brothers of schizophrenia patients. Am. J. Psychiatry161(10), 1806–1813 (2004).
  • Whalley HC, Simonotto E, Flett S et al. fMRI correlates of state and trait effects in subjects at genetically enhanced risk of schizophrenia. Brain127(3), 478–490 (2004).
  • Whalley HC, Simonotto E, Marshall I et al. Functional disconnectivity in subjects at high genetic risk of schizophrenia. Brain128(9), 2097–2108 (2005).
  • Whalley HC, Simonotto E, Moorhead W et al. Functional imaging as a predictor of schizophrenia. Biol. Psychiatry (2006) (In press).
  • Hariri AR, Weinberger DR. Imaging genomics. Br. Med. Bull.65, 259–270 (2003).
  • Goldberg TE, Straub RE, Callicott JH et al. The G72/G30 gene complex and cognitive abnormalities in schizophrenia. Neuropsychopharmacology (2006) (In press).
  • Egan MF, Goldberg TE, Kolachana BS et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc. Natl Acad. Sci. USA98(12), 6917–6922 (2001).
  • Weinberger DR, Egan MF, Bertolino A et al. Prefrontal neurons and the genetics of schizophrenia. Biol. Psychiatry50(11), 825–844 (2001).
  • Fan JB, Zhang CS, Gu NF et al. Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis. Biol. Psychiatry57(2), 139–144 (2005).
  • Tunbridge EM, Harrison PJ, Weinberger DR. Catechol-O-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol. Psychiatry (2006) (In press).
  • Blasi G, Bertolino A. Imaging genomics and response to treatment with antipsychotics in schizophrenia. NeuroRX3(1), 117–130 (2006).
  • Pilling S, Bebbington P, Kuipers E et al. Psychological treatments in schizophrenia: I. Meta-analysis of family intervention and cognitive behaviour therapy. Psychol. Med.32(5), 763–782 (2002).

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