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Review

Role of androgens in epilepsy

Pages 1061-1075 | Published online: 10 Jan 2014

References

  • Hauser WA, Annegers JF, Rocca WA. Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota. Mayo Clin. Proc.71(6), 576–586 (1996).
  • Begley CE, Famular M, Annegers JF et al. The cost of epilepsy in the United States: an estimate from population-based clinical and survey data. Epilepsia.41, 342–351 (2000).
  • Kadir ZA, Chadwick DW. Principles of treatment of epilepsy. Drugs Today1, 35–41 (1999).
  • Silverman A, Livne I, Witkin JW. The gonadatropin-releasing hormone (GnRH) neuronal systems: immunocytochemistry and in situ hybridization. In: The Physiology of Reproduction. Knobil E, Neill JD (Eds), 1683–1709 (1994).
  • Everett JW. Pituitary and hypothalamus: perspectives and overview. In: The Physiology of Reproduction. Knobil E, Neill JD, (Eds), Raven Press, NY, USA 1509–1526 (1994).
  • Baulieu EE, Robel P, Schumacher M. Neurosteroids: beginning of the story. Int. Rev. Neurobiol.46, 1–32 (2001).
  • Bloch M, Rubinow DR, Berlin K, Kevala KR, Kim HY, Schmidt PJ. Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men. Arch. Gen. Psychiatry63, 450–456 (2006).
  • Mensah-Nyagan G, Do-Rego JL, Beaujean D, Luu-The V, Pelletier G, Vaudry H. Regulation of neurosteroid biosynthesis in the frog diencephalon by GABA and benzodiazepines. Horm. Behav.40, 218–225 (2001).
  • Brambilla F, Biggio G, Pisu MG et al. Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis. Neuropsychobiology50, 6–9 (2004).
  • Paul SM, Purdy RH. Neuroactive steroids. FASEB J.6, 2311–2322 (1992).
  • Patchev VK, Almeida OF. Gonadal steroids exert facilitating and “buffering” effects on glucocorticoid-mediated transcriptional regulation of corticotropin-releasing hormone and corticosteroid receptor genes in rat brain. J. Neurosci.16, 7077–7084 (1996).
  • Barbaccia ML, Serra M, Purdy RH, Biggio G. Stress and neuroactive steroids. Int. Rev. Neurobiol.46, 243–272 (2001).
  • Frye CA, Rhodes ME, Petralia SM, Walf AA, Sumida K, Edinger KL. 3e-hydroxy-5e-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Neuroscience38, 1007–1014 (2006).
  • Schumacher M, Weill-Engerer S, Liere P et al. Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Prog. Neurobiol.71, 3–29 (2003).
  • Grosso S, Luisi S, Mostardini R et al. Inter-ictal and post-ictal circulating levels of allopregnanolone, an anticonvulsant metabolite of progesterone, in epileptic children. Epilepsy Res.54, 29–34 (2003).
  • Gray GD. Changes in the levels of luteinizing hormone and testosterone in the circulation of ageing male rats. J. Endocrinol.76, 551–552 (1978).
  • Chambers KC, Phoenix CH. Testosterone and the decline of sexual behavior in aging male rats. Behav. Neural. Biol.40, 87–97 (1984).
  • Foldvary-Schaefer N, Falcone T. Catamenial epilepsy: pathophysiology, diagnosis, and management. Neurology61, S2–S15 (2003).
  • Nemeroff CB. NeuroEndocrinology. CRC Press, Ann Arbor, MI, USA 1–512 (1992)
  • Harden CL, Baker GA, Frye CA, Montouris GD, Pennell PB, Zupanc ML. Epilepsy and ovarian hormones. Neurology (Suppl.) 1–16 (2005).
  • Beyenburg S, Stoffel-Wagner B et al. Neuroactive steroids and seizure susceptibility. Epilepsy Res.44, 141–153 (2001).
  • Terasawa E, Timiras PS. Electrical activity during the estrous cycle of the rat: cyclic changes in limbic structures. Endocrinology83, 207–216 (1968).
  • Frye CA, Rhodes ME. Estrogen-priming can enhance progesterone’s antiseizure effects in part by increasing hippocampal levels of allopregnanolone. Pharmacol. Biochem. Behav.81, 907–916 (2005).
  • Schwartz-Giblin S, Korotzer A, Pfaff DW. Steroid hormone effects on picrotoxin-induced seizures in female and male rats. Brain Res.476, 240–247 (1989).
  • Veliskova J, Velisek L, Galanopoulou AS, Sperber EF. Neuroprotective effects of estrogens on hippocampal cells in adult female rats after status epilepticus. Epilepsia.41(Suppl. 6), S30–S35 (2000).
  • Bäckstrom T, Zetterlund B, Blom S, Romano M. Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with partial epilepsy. Acta Neurol. Scand.69, 240–248 (1984).
  • Rhodes ME, Harney JP, Frye CA. Gonadal, adrenal, and neuroactive steroids’ role in ictal activity. Brain Res.1000, 8–18 (2004).
  • Scharfman HE. Absence of information about hormones and absence. Epilepsy Curr.5, 101–103 (2005).
  • Herzog AG, Klein P, Ransil BJ. Three patterns of catamenial epilepsy. Epilepsia.38, 1082–1088 (1997).
  • Harden CL, Pulver MC, Ravdin L, Jacobs AR. The effect of menopause and perimenopause on the course of epilepsy. Epilepsia.40, 1402–1407 (1999).
  • Edwards HE, Burnham WM, Mendonca A, Bowlby DA, MacLusky NJ. Steroid hormones affect limbic afterdischarge thresholds and kindling rates in adult female rats. Brain Res.38, 136–150 (1999).
  • Kalkbrenner KA, Standley CA. Estrogen modulation of NMDA-induced seizures in ovariectomized and non-ovariectomized rats. Brain Res.964, 244–249 (2003).
  • Scharfman HE, Goodman JH, Rigoulot MA et al. Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine. Exp. Neurol.196, 73–86 (2005).
  • Scharfman HE, Maclusky NJ. Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue? Trends Neurosci.28, 79–85 (2005).
  • Cheng YJ, Karavolas HJ. Conversion of progesterone to 5e-pregnane3,20-dione and 3e-hydroxy-5e-pregnan-20-one by rat medical basal hypothalami and the effects of estradiol and stage of estrous cycle on the conversion. Endocrinology93, 1157–1162 (1973).
  • Vongher JM, Frye CA. Progesterone in conjunction with estradiol has neuroprotective effects in an animal model of neurodegeneration. Pharmacol. Biochem. Behav.64, 777–785 (1999).
  • Herzog AG. Progesterone therapy in women with complex partial and secondary generalized seizures. Neurology45, 1660–1662 (1995).
  • Frye CA, Bayon LE. Seizure activity is increased in endocrine states characterized by decline in endogenous levels of the neurosteroid 3e,5e-THP. Neuroendocrinol.68, 272–280 (1998).
  • Frye CA, Bayon LE. Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures. Pharmacol. Biochem. Behav.62, 315–321 (1999).
  • Frye CA, Scalise TJ. Antiseizure effects of progesterone and 3α,5α-THP in kainic acid and perforant pathway models of epilepsy. Psycho. Neuroendocrinol.4, 407–420 (2000).
  • Hoffman GE, Moore N, Fiskum G, Murphy AZ. Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment. Exp. Neurol.182, 124–134 (2003).
  • Ruusa J, Bergman B. Sex hormones and alcohol withdrawal: does a good supply of testosterone prevent serious symptoms during detoxification? Alcohol13, 139–145 (1996).
  • Badalian LO, Temin PA, Mukhin K. Effect of testenate in the treatment of epilepsy in men. ZH Nevropatol. Psikhiatr. Im. SS Korsakova91, 44–47 (1991).
  • Herzog AG, Klein P, Jacobs AR. Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism. Neurology50, 782–784 (1998).
  • Harden C, MacLusky NJ. Aromatase inhibition, testosterone and seizures. Epilepsy Behav.5, 260–263 (2004).
  • Farwell JR, Blackner G, Sulzbacher S, Adelman L, Voeller M. First febrile seizures. Characteristics of the child, the seizure, and the illness. Clin. Pediatr.33, 263–267 (1994).
  • Kokka N, Sapp DW, Witte U, Olsen RW. Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding. Pharmacol. Biochem. Behav.43, 441–447 (1992).
  • Pericic D, Manev H, Bujas M. Gonadal hormones and picrotoxin-induced convulsions in male and female rats. Brain Res.736, 174–179 (1996).
  • Rhodes ME, McCormick CM, Frye CA. 3α,5α-THP mediates progestins’ effects to protect against adrenalectomy-induced cell death in the dentate gyrus of female and male rats. Pharmacol. Biochem. Behav.78, 505–512 (2004).
  • Chakraborty TR, Gore AC. Aging-related changes in ovarian hormones, their receptors, and neuroendocrine function. Exp. Biol. Med.229, 977–987 (2004).
  • Edwards HE, Burnham WM, MacLusky NJ. Testosterone and its metabolites affect afterdischarge thresholds and the development of amygdala kindled seizures. Brain Res.838(1–2), 151–157 (1999).
  • Pesce ME, Acevedo X, Pinardi G, Miranda HF. Gender differences in diazepam withdrawal syndrome in mice. Pharmacol. Toxicol.75, 353–355 (1994).
  • Frye CA, Reed TA. Androgenic neurosteroids: antiseizure effects in an animal model of epilepsy. Psycho. Neuroendocrinol.23, 385–399 (1998).
  • Kaminski RM, Marini H, Kim WJ, Rogawski MA. Anticonvulsant activity of androsterone and etiocholanolone. Epilepsia46, 819–827 (2005).
  • Reddy DS. Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3e-androstanediol and 17f-estradiol. Neuroscience129, 195–207 (2004).
  • Iswari S, Colas AE, Karavolas HJ. Binding of 5e-dihydroprogesterone and other progestins to female rat anterior pituitary nuclear extracts. Steroids47, 189–203 (1986).
  • Smith HE, Smith RG, Toft DO, Neergaard JR, Burrows EP, O’Malley BW. Binding of steroids to progesterone receptor proteins in chick oviduct and human uterus. J. Biol. Chem.249, 5924–5932 (1974).
  • Roselli CE, Handa RJ, Resko JA. Quantitative distribution of nuclear androgen receptors in microdissected areas of the rat brain. Neuroendocrinology49, 449–453 (1989).
  • Harding SM, McGinnis MY. Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors. Physiol. Behav.81, 671–680 (2004).
  • Brown TJ, Adler GH, Sharma M, Hochberg RB, MacLusky NJ. Androgen treatment decreases estrogen receptor binding in the ventromedial nucleus of the rat brain: a quantitative in vitro autoradiographic analysis. Mol. Cell Neurosci.5, 549–555 (1994).
  • Lieberburg I, MacLusky N, McEwen BS. Cytoplasmic and nuclear estradiol-17β binding in male and female rat brain: regional distribution, temporal aspects and metabolism. Brain Res.193, 487–503 (1980).
  • Kuiper GG, Lemmen JG, Carlsson B et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology139, 4252–4263 (1998).
  • Pak TR, Chung WC, Lund TD, Hinds LR, Clay CM, Handa RJ. The androgen metabolite, 5e-androstane-3f.17f-diol (3f-Adiol), is a potent modulator of estrogen receptor-β1-mediated gene transcription in neuronal cells. Endocrinology146, 147–155 (2005).
  • Weihua Z, Lathe R, Warner M, Gustafsson JA. An endocrine pathway in the prostate, ERf, AR, 5e-androstane-3f, 17f-diol, and CYP7B1, regulates prostate growth. Proc. Natl Acad. Sci. USA99, 13589–13594 (2002).
  • Kuiper TB, Langer WD, Velusamy T. Evolutionary status of the pre-protostellar core L1498. Astrophys. J.468, 761–773 (1996).
  • Tremblay GB, Tremblay A, Copeland NG et al. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor β. Mol. Endocrinol.11, 353–365 (1997).
  • Green S, Walter P, Kumar V et al. Human oestrogen receptor cDNA: sequence, expression and homology to ERf-e. Nature320, 134–139 (1986).
  • Kuiper GG, Carlsson B, Grandien K et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology138, 863–870 (1997).
  • Paech K, Webb P, Kuiper GG et al. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science2771, 508–510 (1997).
  • Tena-Sempere M, Navarro VM, Mayen A, Bellido C, Sanchez-Criado JE. Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in the female rat pituitary. Biol. Reprod.70, 671–678 (2004).
  • Shughrue P, Scrimo P, Lane M, Askew R, Merchenthaler I. The distribution of estrogen receptor-β mRNA in forebrain regions of the estrogen receptor-α knockout mouse. Endocrinology138, 5649–5652 (1997).
  • Melcangi RC, Magnaghi V, Galbiati M, Martini L. Formation and effects of neuroactive steroids in the central and peripheral nervous system. Int. Rev. Neurobiol.46, 145–176 (2001).
  • Engel SR, Grant KA. Neurosteroids and behavior. Int. Rev. Neurobiol.46, 321–348 (2001).
  • Frye CA, Manjarrez J, Camacho-Arroyo I. Infusion of 3α,5α-THP to the pontine reticular formation attenuates PTZ-induced seizures. Brain Res.881, 98–102 (2000).
  • Herzog AG, Frye CA. Seizure exacerbation associated with inhibition of progesterone metabolism. Ann. Neurol.53, 390–391 (2003).
  • Rhodes ME, Frye CA. Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model. Epilepsia45, 1531–1538 (2004).
  • Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science232, 1004–1007 (1986).
  • Rosciszewska D, Buntner B, Guz I, Zawisza L. Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy. J. Neurol. Neurosurg. Psychiatry49, 47–51 (1986).
  • Frye CA, Scalise TJ, Bayon LE. Finasteride blocks the reduction in ictal activity produced by exogenous estrous cyclicity. J. Neuroendocrinol.10, 291–296 (1998).
  • Kokate TG, Banks MK, Magee T, Yamaguchi S, Rogawski MA. Finasteride. A 5α-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice. J. Pharmacol. Exp. Ther.288, 679–684 (1999).
  • Frye CA, Rhodes ME, Walf A, Harney J. Progesterone reduces pentylenetetrazol-induced ictal activity of wild-type mice but not those deficient in type I 5α-reductase. Epilepsia5, 14–17 (2002).
  • Gee KW. Steroid modulation of the GABA/benzodiazepine receptor-linked chloride ionophore. Mol. Neurobiol.2, 291–317 (1988).
  • Frye CA, Duncan JE, Basham M, Erskine MS. Behavioral effects of 3 α-androstanediol. II: Hypothalamic and preoptic area actions via a GABAergic mechanism. Behav. Brain Res.79, 119–130 (1996).
  • Frye CA, Van Keuren KR, Erskine MS. Behavioral effects of 3 α-androstanediol. I: Modulation of sexual receptivity and promotion of GABA-stimulated chloride flux. Behav. Brain Res.79, 109–118 (1996).
  • Frye CA, Rhodes ME, Walf AA, Harney JP. Testosterone reduces pentylenetetrazole-induced ictal activity of wild-type mice but not those deficient in type I 5α-reductase. Brain Res.918, 182–186 (2001).
  • Edeh J, Toone B. Relationship between interictal psychopathology and the type of epilepsy. Results of a survey in general practice. Br. J. Psychiatry151, 95–101 (1987).
  • Gilliam F, Hecimovic H, Sheline Y. Psychiatric comorbidity, health, and function in epilepsy. Epilepsy Behav.4, 26–30 (2003).
  • Gureje O. Interictal psychopathology in epilepsy. Prevalence and pattern in a Nigerian clinic. Br. J. Psychiatry158, 700–705 (1991).
  • Hermann BP, Seidenberg M, Bell B. Psychiatric comorbidity in chronic epilepsy: identification, consequences, and treatment of major depression. Epilepsia.41, 31–41 (2000).
  • Jacoby A, Baker GA, Steen N, Potts P, Chadwick DW. The clinical course of epilepsy and its psychosocial correlates: findings from a U.K. Community study. Epilepsia.37, 148–161 (1996).
  • Manchanda R, Schaefer B, McLachlan RS et al. Psychiatric disorders in candidates for surgery for epilepsy. J. Neurol. Neurosurg. Psychiatry61, 82–89 (1996).
  • Pariente PD, Lepine JP, Lellouch J. Lifetime history of panic attacks and epilepsy: an association from a general population survey. J. Clin. Psychiatry52, 88–89 (1991).
  • Perini GI, Tosin C, Carraro C et al. Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy. J. Neurol. Neurosurg. Psychiatry61, 601–605 (1996).
  • Scicutella A, Ettinger BA. Treatment of anxiety in epilepsy. Epilepsy Behav.5, 10–12 (2002).
  • Adamec RE. Amygdala kindling and anxiety in the rat. Neuroreport1, 255–258 (1990).
  • Swanson SJ, Rao SM, Grafman J, Salazar AM, Kraft J. The relationship between seizure subtype and interictal personality. Results from the Vietnam Head Injury Study. Brain118, 91–103 (1995).
  • Erdogan F, Golgeli A, Arman F, Ersoy AO. The effects of pentylenetetrazole-induced status epilepticus on behavior, emotional memory, and learning in rats. Addict Behav.5, 388–393 (2004).
  • File SE, Lister RG. Do the reductions in social interaction produced by picrotoxin and pentylenetetrazole indicate anxiogenic actions? Neuropharmacology23(7A), 793–796 (1984).
  • Szyndler J, Rok P, Maciejak P et al. Effects of pentylenetetrazol-induced kindling of seizures on rat emotional behavior and brain monoaminergic systems. Pharmacol. Biochem. Behav.73, 851–861 (2002).
  • File SE, Mabbutt PS, Becker A, Gonzalez LE, Fluck E. Short-term rebound anxiolytic effects and long-term changes in platelet benzodiazepine binding after pentylenetetrazole-kindling in two strains of rat. Anxiety2, 109–116 (1996).
  • Devinsky O. Introduction: managing epilepsy in special populations. Rev. Neurol. Dis.1, 3 (2004).
  • Abrahams S, Morris RG, Polkey CE et al. Hippocampal involvement in spatial and working memory: a structural MRI analysis of patients with unilateral mesial temporal lobe sclerosis. Brain Cogn.41, 39–65 (1999).
  • Helmstaedter C. Effects of chronic epilepsy on declarative memory systems. Prog. Brain Res.135, 439–453 (2002).
  • Collier TJ, Routtenberg A. Selective impairment of declarative memory following stimulation of dentate gyrus granule cells: a naloxone-sensitive effect. Brain Res.310, 384–387 (1984).
  • Mathern GW, Adelson PD, Cahan LD, Leite JP. Hippocampal neuron damage in human epilepsy: Meyer’s hypothesis revisited. Prog. Brain Res.135, 237–251 (2002).
  • Mello LE, Cavalheiro EA, Tan AM et al. Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia34, 985–995 (1993).
  • Schwarcz R, Zaczek R, Coyle JT. Microinjection of kainic acid into the rat hippocampus. Eur. J. Pharmacol.50, 209–220 (1978).
  • Franke H, Kittner H. Morphological alterations of neurons and astrocytes and changes in emotional behavior in pentylenetetrazol-kindled rats. Pharmacol. Biochem. Behav.70, 291–303 (2001).
  • Sloviter RS. “Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies. Brain Res. Bull.10, 675–697 (1983).
  • Kotloski R, Lynch M, Lauersdorf S, Sutula T. Repeated brief seizures induce progressive hippocampal neuron loss and memory deficits. Prog. Brain Res.135, 95–110 (2002).
  • Grecksch U, Becker A, Gadau C, Matthies H. Gangliosides improve a memory deficit in pentylentetrazol-kindled rats. Pharmacol. Biochem. Behav.39, 825–828 (1991).
  • Genkova-Papazova M, Lazarova-Bakarov M. Pentylenetetrazole kindling impairs long-term memory in rats. Eur. Neuropsychopharmacol.5, 53–56 (1995).
  • Genkova-Papazova B, Petkova N, Shishkova M, Lazarova-Bakarova MG. The GABA-B antagonist CGP 36742 prevent PTZ-kindling-provoked amnesia in rats. Eur. Neuropsychopharmacol.10, 273–278 (2000).
  • Morrell MJ. Epilepsy in women: the science of why it is special. Neurology53, S42–S48 (1999).
  • Morrell MJ. Hormones and epilepsy through the lifetime. Epilepsia33, S49–S61 (1992).
  • Trimble MR. Serum prolactin in epilepsy and hysteria. Br. Med. J.2, 1682 (1978).
  • Pritchard PB 3rd, Wannamaker BB, Sagel J, Nair R, DeVillier C. Endocrine function following complex partial seizures. Ann. Neurol.14, 27–32 (1983).
  • Dana-Haeri J, Trimble M, Oxley J. Prolactin and gonadotrophin changes following generalised and partial seizures. J. Neurol. Neurosurg. Psychiatry46, 331–335 (1983).
  • Bilo L, Meo R, Valentino R, Buscaino GA, Striano S, Nappi C. Abnormal pattern of luteinizing hormone pulsatility in women with epilepsy. Fertil. Steril.55, 705–711 (1991).
  • Drislane FW, Coleman AE, Schomer DL et al. Altered pulsatile secretion of luteinizing hormone in women with epilepsy. Neurology44, 306–310 (1994).
  • Herzog AG, Drislane FW, Schomer DL, et al. Abnormal pulsatile secretion of luteinizing hormone in men with epilepsy: relationship to laterality and nature of paroxysmal discharges. Neurology40, 1557–1561 (1990).
  • Molaie M, Culebras A, Miller M. Effect of interictal epileptiform discharges on nocturnal plasma prolactin concentrations in epileptic patients with complex partial seizures. Epilepsia27, 724–728 (1986).
  • Cerullo A, Tinuper P, Provini F et al. Autonomic and hormonal ictal changes in gelastic seizures from hypothalamic hamartomas. Electroencephalogr. Clin. Neurophysiol.107, 317–322 (1998).
  • Herzog AG, Coleman AE, Jacobs AR et al. Relationship of sexual dysfunction to epilepsy laterality and reproductive hormone levels in women. Epilepsy Behav.4, 407–413 (2003).
  • Herzog AG, Seibel MM, Schomer DL, Vaitukaitis JL, Geschwind N. Reproductive endocrine disorders in men with partial seizures of temporal lobe origin. Arch. Neurol.43, 347–350 (1986).
  • Bauer J, Isojarvi JI, Herzog AG et al. Reproductive dysfunction in women with epilepsy: recommendations for evaluation and management. J. Neurol. Neurosurg. Psychiatry73, 121–125 (2002).
  • Bilo L, Meo R, Valentino R, Di Carlo C, Striano S, Nappi C. Characterization of reproductive endocrine disorders in women with epilepsy. J. Clin. Endocrinol. Metab.86, 2950–2956 (2001).
  • Herzog AG. Altered reproductive endocrine regulation in men with epilepsy: implications for reproductive function and seizures. Ann. Neurol.51, 539–542 (2002).
  • Crowley WF Jr, Filicori M, Spratt DI, Santoro NF. The physiology of gonadotropin-releasing hormone (GnRH) secretion in men and women. Recent Prog. Horm. Res.41, 473–531 (1985).
  • Isojarvi JI, Lofgren E, Juntunen KS et al. Effect of epilepsy and antiepileptic drugs on male reproductive health. Neurology62, 247–253 (2004).
  • Herzog AG, Drislane FW, Schomer DL et al. Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy. Neurology65, 1016–1020 (2005).
  • Edwards HE, MacLusky NJ, Burnham WM. The effect of seizures and kindling on reproductive hormones in the rat. Neurosci. Biobehav. Rev.24, 753–762 (2000).
  • Amado D, Cavalheiro EA, Bentivoglio M. Epilepsy and hormonal regulation: the patterns of GnRH and galanin immunoreactivity in the hypothalamus of epileptic female rats. Epilepsy Res.14, 149–159 (1993).
  • Friedman MN, Geula C, Holmes GL, Herzog AG. GnRH-immunoreactive fiber changes with unilateral amygdala-kindled seizures. Epilepsy Res.52, 73–77 (2002).
  • Edwards HE, Burnham WM, MacLusky NJ. Testosterone and its metabolites affect afterdischarge thresholds and the development of amygdala kindled seizures. Brain Res.838, 151–157 (1998).
  • Locock C. Analysis of fifty-two cases of epilepsy observed by the author. Lancet527–528 (1857).
  • Cramer JA, Fisher R, Ben-Menachem E, French J, Mattson RH. New antiepileptic drugs: comparison of key clinical trials. Epilepsia40, 590–600 (1999).
  • Besag FMC. Behavioural effects of the newer antiepileptic drugs: an update. Exp. Opin. Drug Saf.3, 1–8 (2004).
  • Boylan LS, Boylan O, Devinsky JJ, Barry TA. Psychiatric uses of antiepileptic treatments. Epilepsy Behav.3, 54 (2002).
  • Rogawski MA, Loscher W. The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nat. Med.10, 685 (2004).
  • Griffith NM, Szaflarski JP, Szaflarski M et al. Measuring depressive symptoms among treatment-resistant seizure disorder patients: POMS Depression scale as an alternative to the BDI-II. Epilepsy Behav.7, 266–272 (2005).
  • Schachter SC. Improving quality of life beyond seizure control. Epileptic Disord.7, 34–38 (2005).
  • Calabrese JR, Calabrese CL, Bowden GS et al. A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J. Clin. Psychiatry60, 79–88 (1999).
  • Gilliam FG, Santos J, Vahle V, Carter J, Brown K, Hecimovic H. Depression in epilepsy: ignoring clinical expression of neuronal network dysfunction? Epilepsia.45, 28–33 (2004).
  • Kanner JJ, Barry AM. Is the psychopathology of epilepsy different from that of nonepileptic patients? Epilepsy Behav.2, 170–186 (2001).
  • Nagahata M. Neuropsychological and psychiatric problems in epileptic children. No To Hattatsu22, 143–148 (1990).
  • Stores G. Behavioural effects of anti-epileptic drugs. Dev. Med. Child Neurol.17, 647–658 (1975).
  • Meador KJ, Loring DW, Allen M et al. Comparative cognitive effects of carbamazepine and phenytoin in healthy adults. Neurology41, 1537–1540 (1991).
  • Meador KJ, Loring DW, Abney OL et al. Effects of carbamazepine and phenytoin on EEG and memory in healthy adults. Epilepsia34, 153–157 (1993).
  • Meador KJ, Loring DW, Moore EE et al. Comparative cognitive effects of phenobarbital, phenytoin and valproate in healthy subjects. Neurology45, 1494–1499 (1995).
  • Meador KJ. Cognitive and memory effects of the new antiepileptic drugs. Epilepsy Res.68, 63–67 (2006).
  • Voigt JP, Morgenstern E. Comparative effects of carbamazepine, phenytoin, diazepam and clonazepam on inhibitory avoidance learning in mice. Psychopharmacology (Berl).108, 131–135 (1992).
  • Connell JM, Rapeport WG, Beastall GH, Brodie MJ. Changes in circulating androgens during short term carbamazepine therapy. Br. J. Clin. Pharmacol.17, 347–351 (1984).
  • Barragry JM, Makin HL, Trafford DJ, Scott DF. Effect of anticonvulsants on plasma testosterone and sex hormone binding globulin levels. J. Neurol. Neurosurg. Psychiatry41, 913–914 (1978).
  • Toone BK, Wheeler M, Nanjee M, Fenwick P, Grant R. Sex hormones, sexual activity and plasma anticonvulsant levels in male epileptics. J. Neurol. Neurosurg. Psychiatry46, 824–826 (1983).
  • Vecht CJ, Wagner GL, Wilms EB. Interactions between antiepileptic and chemotherapeutic drugs. Lancet Neurol.2, 404–409 (2003).
  • Harden CL, Baker GA, Frye CA, Montouris GD, Pennell PB, Zupanc ML. Epilepsy and ovarian hormones. Neurology (Suppl.) 16–29 (2005).
  • Pennell PB. Using current evidence in selecting antiepileptic drugs for use during pregnancy. Epilepsy Curr.5, 45–51 (2005).
  • Isojärvi JI, Laatikainen TJ, Knip M, Pakarinen AJ, Juntunen KT, Myllyla VV. Obesity and endocrine disorders in women taking valproate for epilepsy. Ann. Neurol.39, 579–584 (1996).
  • Isojärvi JI, Laatikainen TJ, Pakarinen AJ, Juntunen KT, Myllyla VV. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N. Engl. J. Med.329, 1383–1388 (1993).
  • Isojarvi JI, Pakarinen AJ, Ylipalosaari PJ, Myllyla VV. Serum hormones in male epileptic patients receiving anticonvulsant medication. Arch. Neurol.47, 670–676 (1990).
  • Herzog AG, Drislane FW, Schomer DL, et al. Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs. Epilepsia45, 764–768 (2004).
  • Murialdo G, Galimberti CA, Fonzi S et al. Sex hormones and pituitary function in male epileptic patients with altered or normal sexuality. Epilepsia36, 360–365 (1995).
  • Derry PA. Psychological treatment in intractable epilepsy: approaches, evidence, and future directions. Adv. Neurol.97, 375–380 (2006).
  • Trost LF 3rd, Wender RC, Suter CC et al. National Epilepsy Management Panel. Management of epilepsy in adults. Treatment guidelines. Postgrad. Med.118, 29–33 (2005).
  • Bäckström T. Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle. Acta Neurol. Scand.54, 321–347 (1976).
  • Shavit G, Lerman P, Korczyn AD, Kivity S, Bechar M, Gitter S. Phenytoin pharmacokinetics in catamenial epilepsy. Neurology34, 959–961 (1984).
  • Krishnamurthy KB, Schomer DL. Weekly fluctuation and adjustment of antiepileptic drugs to treat catamenial epilepsy. Epilepsia39, 179 (1998).
  • Tatum WO IV, Liporace J, Benbadis SR, Kaplan PW. Updates on the treatment of epilepsy in women. Arch. Intern. Med.164, 137–145 (2004).
  • Spina E, Perucca E. Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs. Epilepsia43, 37–44 (2002).
  • Mellon SH, Griffin LD. Synthesis, regulation, and function of neurosteroids. Endocr. Res.28, 463 (2002).
  • Uzunova V, Sampson L, Uzunov DP. Relevance of endogenous 3α-reduced neurosteroids to depression and antidepressant action. Psychopharmacology (Berl.)1–11 (2006).

Website

  • Cognitive Function Survey, 2004 Cognitive Function Survey, 2004. International Bureau for Epilepsy, www.ibe-epilepsy.org/whasnewdet.asp

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