Using objective markers and imaging in the development of novel treatments of chronic pain

References

• Hill R. NK1 (substance P) receptor antagonists – why are they not analgesic in humans? Trends Pharmacol. Sci.21(7), 244–246 (2000).
   PubMed Web of Science ®Google Scholar
• Moore RA, Gavaghan D, Tramer MR, Collins SL, McQuay HJ. Size is everything – large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects. Pain78(3), 209–216 (1998).
   PubMed Web of Science ®Google Scholar
• Okuse K. Pain signalling pathways: from cytokines to ion channels. Int. J. Biochem. Cell Biol.39(3), 490–496 (2007).
   PubMed Web of Science ®Google Scholar
• Schmelz M, Michael K, Weidner C et al. Which nerve fibers mediate the axon reflex flare in human skin? Neuroreport11(3), 645–648 (2000).
   Google Scholar
• Klede M, Clough G, Lischetzki G, Schmelz M. The effect of the nitric oxide synthase inhibitor N-nitro-L-arginine-methyl ester on neuropeptide-induced vasodilation and protein extravasation in human skin. J. Vasc. Res.40(2), 105–114 (2003).
   PubMedGoogle Scholar
• Sauerstein K, Klede M, Hilliges M, Schmelz M. Electrically evoked neuropeptide release and neurogenic inflammation differ between rat and human skin. J. Physiol.529(3), 803–810 (2000).
   PubMed Web of Science ®Google Scholar
• Weidner C, Klede M, Rukwied R et al. Acute effects of substance P and calcitonin gene-related peptide in human skin – a microdialysis study. J. Invest. Dermatol.115(6), 1015–1020 (2000).
   PubMedGoogle Scholar
• Klede M, Handwerker HO, Schmelz M. Central origin of secondary mechanical hyperalgesia. J. Neurophysiol.90(1), 353–359 (2003).
   PubMed Web of Science ®Google Scholar
• Koppert W, Dern SK, Sittl R et al. A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine. Anesthesiology95(2), 395–402 (2001).
   PubMed Web of Science ®Google Scholar
• Koppert W, Zeck S, Blunk JA et al. The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction. Anesth. Analg.89(6), 1521–1527 (1999).
   PubMed Web of Science ®Google Scholar
• Chizh B, Napolitano A, O’Donnell M et al. The TRPV1 antagonist SB705498 attenuates TRPV1 receptor-mediated activity and inhibits inflammatory hyperalgesia in humans: results from a Phase 1 study. J. Pain7(Suppl. 4), S42 (2006).
   Google Scholar
• Peyron R, Laurent B, Garcia-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiol. Clin.30(5), 263–288 (2000).
   PubMed Web of Science ®Google Scholar
• Apkarian AV, Bushnell MC, Treede RD, Zubieta JK. Human brain mechanisms of pain perception and regulation in health and disease. Eur. J. Pain9(4), 463–484 (2005).
   PubMed Web of Science ®Google Scholar
• Brooks JC, Tracey I. The insula: a multidimensional integration site for pain. Pain128(1–2), 1–2 (2007).
   PubMedGoogle Scholar
• Frot M, Magnin M, Mauguiere F, Garcia-Larrea L. Human SII and posterior insula differently encode thermal laser stimuli. Cereb. Cortex17(3), 610–620 (2007).
   PubMed Web of Science ®Google Scholar
• Maihofner C, Herzner B, Otto HH. Secondary somatosensory cortex is important for the sensory-discriminative dimension of pain: a functional MRI study. Eur. J. Neurosci.23(5), 1377–1383 (2006).
   PubMed Web of Science ®Google Scholar
• Rogers R, Wise RG, Painter DJ, Longe SE, Tracey I. An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging. Anesthesiology100(2), 292–301 (2004).
   PubMed Web of Science ®Google Scholar
• Wise RG, Rogers R, Painter D et al. Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil. Neuroimage16(4), 999–1014 (2002).
   PubMed Web of Science ®Google Scholar
• Wise RG, Williams P, Tracey I. Using fMRI to quantify the time dependence of remifentanil analgesia in the human brain. Neuropsychopharmacology29(3), 626–635 (2004).
   PubMed Web of Science ®Google Scholar
• Schweinhardt P, Glynn C, Brooks J et al. An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients. Neuroimage32(1), 256–265 (2006).
   PubMedGoogle Scholar
• Schweinhardt P, Lee M, Tracey I. Imaging pain in patients: is it meaningful? Curr. Opin. Neurol.19(4), 392–400 (2006).
   PubMed Web of Science ®Google Scholar
• Iannetti GD, Zambreanu L, Wise RG et al. Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. Proc. Natl Acad. Sci. USA102(50), 18195–18200 (2005).
   PubMed Web of Science ®Google Scholar
• Zambreanu L, Wise RG, Brooks JC, Iannetti GD, Tracey I. A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging. Pain114(3), 397–407 (2005).
   PubMed Web of Science ®Google Scholar
• Shafritz KM, Collins SH, Blumberg HP. The interaction of emotional and cognitive neural systems in emotionally guided response inhibition. Neuroimage31(1), 468–475 (2006).
   PubMed Web of Science ®Google Scholar
• Luks TL, Simpson GV. Preparatory deployment of attention to motion activates higher-order motion-processing brain regions. Neuroimage22(4), 1515–1522 (2004).
   PubMedGoogle Scholar
• Nagai Y, Critchley HD, Featherstone E et al. Brain activity relating to the contingent negative variation: an fMRI investigation. Neuroimage21(4), 1232–1241 (2004).
   PubMed Web of Science ®Google Scholar
• Huettel SA, McCarthy G. What is odd in the oddball task? Prefrontal cortex is activated by dynamic changes in response strategy. Neuropsychologia42(3), 379–386 (2004).
   PubMed Web of Science ®Google Scholar
• Anderson AK, Christoff K, Panitz D, De Rosa E, Gabrieli JD. Neural correlates of the automatic processing of threat facial signals. J. Neurosci.23(13), 5627–5633 (2003).
   PubMed Web of Science ®Google Scholar
• Yarkoni T, Braver TS, Gray JR, Green L. Prefrontal brain activity predicts temporally extended decision-making behavior. J. Exp. Anal. Behav.84(3), 537–554 (2005).
   PubMedGoogle Scholar
• Fairhurst M, Wiech K, Dunckley P, Tracey I. Anticipatory brainstem activity predicts neural processing of pain in humans. Pain128(1–2), 101–110 (2007).
   PubMed Web of Science ®Google Scholar
• Iannetti GD, Niazy RK, Wise RG et al. Simultaneous recording of laser-evoked brain potentials and continuous, high-field functional magnetic resonance imaging in humans. Neuroimage28(3), 708–719 (2005).
   PubMedGoogle Scholar
• Borsook D, Burstein R, Moulton E, Becerra L. Functional imaging of the trigeminal system: applications to migraine pathophysiology. Headache46(Suppl. 1), S32–S38 (2006).
   Google Scholar
• Borsook D, Burstein R, Becerra L. Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease. J. Neurobiol.61(1), 107–125 (2004).
   PubMedGoogle Scholar
• Borsook D, DaSilva AFM, Ploghaus A, Becerra LR. Specific and somatotopic functional magnetic resonance imaging activation in the trigeminal ganglion by brush and noxious heat. J. Neurosci.23(21), 7897–7903 (2003).
   PubMed Web of Science ®Google Scholar
• DaSilva AFM, Becerra L, Markis N et al. Somatotopic activation in the human trigeminal pain pathway. J. Neurosci.22(18), 8183–8192 (2002).
   PubMed Web of Science ®Google Scholar
• Becerra L, Morris S, Bazes S et al. Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. J. Neurosci.26(42), 10646–10657 (2006).
   PubMed Web of Science ®Google Scholar
• Foss JM, Apkarian AV, Chialvo DR. Dynamics of pain: fractal dimension of temporal variability of spontaneous pain differentiates between pain states. J. Neurophysiol.95(2), 730–736 (2006).
   PubMed Web of Science ®Google Scholar
• Geha PY, Baliki MN, Chialvo DR et al. Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy. Pain128(1–2), 88–100 (2007).
   PubMed Web of Science ®Google Scholar
• Baliki MN, Chialvo DR, Geha PY et al. Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain. J. Neurosci.26(47), 12165–12173 (2006).
   PubMed Web of Science ®Google Scholar
• Chen AC. New perspectives in EEG/MEG brain mapping and PET/fMRI neuroimaging of human pain. Int. J. Psychophysiol.42(2), 147–159 (2001).
   PubMed Web of Science ®Google Scholar
• Lorenz J, Garcia-Larrea L. Contribution of attentional and cognitive factors to laser evoked brain potentials. Neurophysiol. Clin.33(6), 293–301 (2003).
   PubMedGoogle Scholar
• Kakigi R, Inui K, Tamura Y. Electrophysiological studies on human pain perception. Clin. Neurophysiol.116(4), 743–763 (2005).
   PubMedGoogle Scholar
• Garcia-Larrea L, Frot M, Valeriani M. Brain generators of laser-evoked potentials: from dipoles to functional significance. Neurophysiol. Clin.33(6), 279–292 (2003).
   PubMed Web of Science ®Google Scholar
• Hauck M, Bischoff P, Schmidt G et al. Clonidine effects on pain evoked SII activity in humans. Eur. J. Pain10(8), 757–765 (2006).
   PubMedGoogle Scholar
• Larbig W, Montoya P, Braun C, Birbaumer N. Abnormal reactivity of the primary somatosensory cortex during the experience of pain in complex regional pain syndrome: a magnetoencephalograhic case study. Neurocase12(5), 280–285 (2006).
   PubMed Web of Science ®Google Scholar
• Ploner M, Gross J, Timmermann L, Pollok B, Schnitzler A. Pain suppresses spontaneous brain rhythms. Cereb. Cortex16(4), 537–540 (2006).
   PubMedGoogle Scholar
• Garcia-Larrea L, Convers P, Magnin M et al. Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked pain. Brain125(Pt 12), 2766–2781 (2002).
   PubMed Web of Science ®Google Scholar
• Hall SD, Hillebrand A, Furlong PL, Seri S, Barnes GR. Pharmaco-MEG: the cortical oscillatory profile of benzodiazepine uptake. Presented at: 15th International Conference on Biomagnetism A3709 20–26 August 2006.
   Google Scholar
• Stern J, Jeanmonod D, Sarnthein J. Persistent EEG overactivation in the cortical pain matrix of neurogenic pain patients. Neuroimage31(2), 721–731 (2006).
   PubMed Web of Science ®Google Scholar
• Hobson AR, Aziz Q. Central nervous system processing of human visceral pain in health and disease. News Physiol. Sci.18, 109–114 (2003).
   PubMedGoogle Scholar
• Hobson AR, Sarkar S, Furlong PL, Thompson DG, Aziz Q. A cortical evoked potential study of afferents mediating human esophageal sensation. Am. J. Physiol. Gastrointest. Liver Physiol.279(1), G139–G147 (2000).
   Google Scholar
• Sarkar S, Hobson AR, Furlong PL et al. Central neural mechanisms mediating human visceral hypersensitivity. Am. J. Physiol. Gastrointest. Liver Physiol.281(5), G1196–G1202 (2001).
   PubMed Web of Science ®Google Scholar
• Hobson AR, Furlong PL, Sarkar S et al. Neurophysiologic assessment of esophageal sensory processing in noncardiac chest pain. Gastroenterology130(1), 80–88 (2006).
   PubMed Web of Science ®Google Scholar
• Hobson AR, Furlong PL, Worthen SF et al. Real-time imaging of human cortical activity evoked by painful esophageal stimulation. Gastroenterology128(3), 610–619 (2005).
   PubMed Web of Science ®Google Scholar
• Ploner M, Schmitz F, Freund HJ, Schnitzler A. Parallel activation of primary and secondary somatosensory cortices in human pain processing. J. Neurophysiol.81(6), 3100–3104 (1999).
   PubMed Web of Science ®Google Scholar
• Apkarian AV, Sosa Y, Sonty S et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J. Neurosci.24(46), 10410–10415 (2004).
   PubMed Web of Science ®Google Scholar
• Kuchinad A, Schweinhardt P, Seminowicz D et al. Accelerated brain gray-matter loss in fibromyalgia patients: premature aging of the brain? J. Neurosci.27(15) 4004–4007 (2007).
   PubMed Web of Science ®Google Scholar
• Jones AK, Watabe H, Cunningham VJ, Jones T. Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [11C]diprenorphine binding and PET. Eur. J. Pain8(5), 479–485 (2004).
   PubMed Web of Science ®Google Scholar
• Ravert HT, Bencherif B, Madar I, Frost JJ. PET imaging of opioid receptors in pain: progress and new directions. Curr. Pharm. Des.10(7), 759–768 (2004).
   PubMedGoogle Scholar
• Wood PB, Bushnell MC, Dagher A et al. Disruption of dopaminergic reactivity in fibromyalgia demonstrated by [11C]-raclopride/PET. Eur. J. Pain10(Suppl. 1), S115 (2006).
   Google Scholar
• Martikainen IK, Hagelberg N, Mansikka H et al. Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia. Neurosci. Lett.376(3), 149–153 (2005).
   PubMed Web of Science ®Google Scholar
• Hagelberg N, Jaaskelainen SK, Martikainen IK et al. Striatal dopamine D2 receptors in modulation of pain in humans: a review. Eur. J. Pharmacol.500(1–3), 187–192 (2004).
   PubMed Web of Science ®Google Scholar