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Review

Botulinum toxin in the treatment of tremors, dystonias, sialorrhea and other symptoms associated with Parkinson’s disease

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Pages 637-647 | Published online: 10 Jan 2014

References

  • Jankovic J, Tintner R. Dystonia and parkinsonism. Parkinsonism Relat. Disord.8, 109–121 (2001).
  • Nutt JG, Wooten GF. Clinical practice. Diagnosis and initial management of Parkinson’s disease. N. Engl. J. Med.353, 1021–1027 (2005).
  • Diamond A. Jankovic J. Treatment of advanced Parkinson’s disease. Expert Rev. Neurother.6(8), 1181–1197 (2006).
  • Suchowersky O, Rich S, Perlmutter J, Zesiewicz T, Gronseth G, Weiner WJ. Diagnosis and prognosis of new onset Parkinson disease: report of the Quality Standards Subcommittee of the American academy of Neurology. Neurology66, 968–975 (2006).
  • Jankovic J, Schwartz KS, Ondo W. Re-emergent tremor of Parkinson’s disease. J. Neurol. Neurosurg. Psychiatr.67, 646–650 (1999).
  • Elble RJ. Tremor and dopamine agonists. Neurology58(4 Suppl. 1), S57–S62 (2002).
  • Jankovic J, Schwartz K. Botulinum toxin treatment of tremors. Neurology41, 1185–1188 (1991).
  • Trosch RM, Pullman SC. Botulinum toxin A injections for the treatment of hand tremor. Mov. Disord.9, 601–609 (1994).
  • Henderson JM, Ghika JA, Van-Melle G, Haller E, Einstein R. Botulinum toxin A in nondystonic tremors. Eur. Neurol.36, 29–35 (1996).
  • Jankovic J, Schwartz K, Clemence W, Aswad A, Mordaunt J. A randomized double-blind, placebo controlled study to evaluate botulinum toxin A in essential hand tremor. Mov. Disord.11, 250–256 (1996).
  • Pullman SC, Greene P, Pahn S et al. Approach to the treatment of limb disorders with botulinum toxin A: experience with 187 patients. Arch. Neurol.53, 617–624 (1996).
  • Brin MF, Lyons KE, Doucette J et al. A randomized, double masked, controlled trial of botulinum toxin type A in essential hand tremor. Neurology56, 1523–1528 (2001).
  • Pahwa R, Busenbark K, Swanson-Hyland EF et al. Botulinum toxin treatment of essential head tremor. Neurology45(4), 822–824 (1995).
  • Wissel J, Masuhr F, Schelosky L, Ebersbach G, Poewe W. Quantitative assessment of botulinum toxin treatment in 43 patients with head tremor. Mov. Disord.12(5), 722–726 (1997).
  • Warrick P, Dromey C, Irish JC, Durkin L, Pakiam A, Lang A. Botulinum toxin for essential tremor of the voice with multiple anatomical sites of tremor: a crossover design study of unilateral versus bilateral injection. Laryngoscope110(8), 1366–1374 (2000).
  • Adler CH, Bansberg SF, Hentz JG et al. Botulinum toxin type A for treating voice tremor. Arch. Neurol.61(9), 1416–1420 (2004).
  • Hunker CJ, Abbs JH. Uniform frequency of parkinsonian resting tremor in the lips, jaw, tongue and index finger. Mov. Disord.5, 71–77 (1990).
  • Salamone JD, Mayorga AJ, Trevitt JT, Cousins MS, Conlan A, Nawab A. Tremulous jaw movements in rats: a model of parkinsonian tremor. Prog. Neurobiol.56(6), 591–611 (1998).
  • Schneider SA, Edwards MJ, Cordivari C, Macleod WN, Bhatia KP. Botulinum toxin A may be efficacious as treatment for jaw tremor in Parkinson’s disease. Mov. Disord.21(10), 1722–1724 (2006).
  • Kidron D, Melamed E. Forms of dystonia in patients with Parkinson’s disease. Neurology37, 1009–1011 (1987).
  • Hartmann A, Pogarell O, Oertel WH. Secondary dystonia. J. Neurol.245, 511–518 (1998).
  • Quinn NP. Parkinsonism and dystonia, pseudoparkinsonism and pseudodystonia. Adv. Neurol.60, 540–543 (1993).
  • Tabamo REJ, Fernandez HH, Friedman J, Simon DK. Young-onset Parkinson’s disease: a clinical pathologic description of two siblings. Mov. Disord.13, 744–746 (2000).
  • Poewe WH, Lees AJ, Stern GM. Dystonia in Parkinson’s disease: clinical and pharmacological features. Ann. Neurol.23, 73–78 (1988).
  • Jankovic J. Motor fluctuations and dyskinesias in Parkinson’s disease: clinical manifestations. Mov. Disord.20(Suppl. 11), S11–S16 (2005).
  • Jankovic J. Complications and limitations of drug therapy for Parkinson’s disease. Neurology55(12 Suppl. 6), S2–S6 (2000).
  • Ashour R, Tintner R, Jankovic J. Striatal deformities of the hand and foot in Parkinson’s disease. Lancet Neurol.4(7) 423–431 (2005).
  • Vidailhet M, Bonnet AM, Marconi R, Gouider-Khouja N, Agid Y. Do parkinsonian symptoms and levodopa-induced dyskinesias start in the foot? Neurology44, 1613–1616 (1994).
  • Pacchetti C, Albani G, Martignoni E, Godi L, Alfonsi E, Nappi G. “Off” painful dystonia in Parkinson’s disease treated with botulinum toxin. Mov. Disord.10(3), 333–336 (1995).
  • Limousin P, Memin B, Pollak P. Treatment of dystonia occurring in parkinsonian syndromes by botulinum toxin. Eur. Neurol.37, 66–67 (1997).
  • Jankovic J. Botulinum toxin in clinical practice. J. Neurol. Neurosurg. Psychiatr.75(7), 951–957 (2004).
  • Giladi N, Meer J, Honigman S. The use of botulinum toxin to treat “striatal” toes. J. Neurol. Neurosurg. Psychiatr.57(5), 659 (1994).
  • Cordivari C, Misra VP, Catania S, Lees AJ. Treatment of dystonic clenched fist with botulinum toxin. Mov. Disord.16, 907–913 (2001).
  • Soonawala N, Bhatia KP, Yeung JHM et al. Idiopathic blepharospasm does not lead to a parkinsonian syndrome: results of a questionnaire-based follow-up study. J. Neurol.246, 283–286 (1999).
  • Krack P, Marion MH. ‘Apraxia of lid opening.’ A focal eyelid dystonia: clinical study of 32 patients. Mov. Disord.9, 610–615 (1994).
  • Jankovic J. Apraxia of lid opening. Mov. Disord.10, 686 (1995).
  • Boghen D. Apraxia of lid opening: a review. Neurology48, 1491–1494 (1997).
  • Katz BB, Rosenberg JH. Botulinum therapy for apraxia of eyelid opening. Am. J. Ophthalmol.103, 718–719 (1987).
  • Lepore V, Defazio G, Acquistapace D et al. Botulinum A toxin for the so-called apraxia of lid opening. Mov. Disord.10, 525–526 (1995).
  • Aramideh M, Ongerboer de Visser BW, Brans JW, Koelman JH, Speelman JD. Pretarsal application of botulinum toxin for treatment of blepharospasm. J. Neurol. Neurosurg. Psychiatr.59(3), 309–311 (1995).
  • Forget R, Tozlovanu V, Iancu A, Boghen D. Botulinum toxin improves lid opening delays in blepharospasm-associated apraxia of lid opening. Neurology58(12), 1843–1846 (2002).
  • Aramideh M, Ongerboer de Visser BW, Brans JW, Koelman JH, Speelman JD. Pretarsal application of botulinum toxin for treatment of blepharospasm. J. Neurol. Neurosurg. Psychiatr.59(3), 309–311 (1995).
  • Roggenkamper P, Jost WH, Bihari K, Comes G, Grafe S; for the NT 201 Blepharospasm Study Team. Efficacy and safety of a new botulinum toxin type A free of complexing proteins in the treatment of blepharospasm. J. Neural Transm.113(3), 303–312 (2006).
  • Lobbezoo F, Lavigne GJ, Tanguay R, Montplaisir JY. The effect of the catecholamine precursor L-dopa on sleep bruxism: a controlled clinical trial. Mov. Disord.12, 73–78 (1997).
  • Lobbezoo F, Soucy JP, Hartman NG, Montplaisir JY, Lavigne GJ. Effects of the dopamine D2 receptor agonist bromocriptine on sleep bruxism: report of two single-patient clinical trials. J. Dent. Res.76, 1610–1614 (1997).
  • Magee KR. Bruxism related to levodopa therapy. JAMA214, 147 (1970).
  • Wooten-Watts MW, Tan EK, Jankovic J. Bruxism and cranial-cervical dystonia: is there a relationship? Cranio.17, 196–201 (1999).
  • Harada T, Ichiki R, Tsukiyama Y, Koyano K. The effect of oral splint devices on sleep bruxism: a 6-week observation with an ambulatory electromyographic recording device. J. Oral Rehabil.33(7), 482–488 (2006).
  • Van Zandijcke M, Marchau MM. Treatment of bruxism with botulinum toxin injections. J. Neurol. Neurosurg. Psychiatr.53(6), 530 (1990).
  • Ivanhoe CB, Lai JM, Francisco GE. Bruxism after brain injury: successful treatment with botulinum toxin-A. Arch. Phys. Med. Rehabil.78(11), 1272–1273 (1997).
  • Pidcock FS, Wise JM, Christensen JR. Treatment of severe post-traumatic bruxism with botulinum toxin-A: case report. J. Oral Maxillofac. Surg.60(1), 115–117 (2002).
  • See SJ, Tan EK. Severe amphethamine-induced bruxism: treatment with botulinum toxin. Acta Neurol. Scand.107(2), 161–163 (2003).
  • Nash MC, Ferrell RB, Lombardo MA, Williams RB. Treatment of bruxism in Huntington’s disease with botulinum toxin. J. Neuropsychiatry Clin. Neurosci.16(3), 381–382 (2004).
  • Monroy PG, da Fonseca MA. The use of botulinum toxin-A in the treatment of severe bruxism in a patient with autism: a case report. Spec. Care Dentist.26(1), 37–39 (2006).
  • Tan E-K, Jankovic J. Treating severe bruxism with botulinum toxin. J. Am. Dent. Assoc.131, 211–216 (2000).
  • Djaldetti R, Mosberg-Galili H, Sroka H, Merims D, Melamed E. Camptocormia (bent spine) in patients with Parkinson’s disease – characterization and possible pathogenesis of an unusual phenomenon. Mov. Disord.14, 443–447 (1999).
  • Azher SN, Jankovic J. Camptocormia: pathogenesis, classification, and response to therapy. Neurology65(3), 355–359 (2005).
  • Wunderlich S, Csoti I, Reiners K et al. Camptocormia in Parkinson’s disease mimicked by focal myositis of the paraspinal muscles. Mov. Disord.17(3), 598–600 (2002).
  • Feriha O, Aytul M, Hasan M. A case of camptocormia (bent spine) secondary to early motor neuron disease. Behav. Neurol.15(1–2), 51–54 (2004).
  • Diederich NJ, Goebel HH, Dooms G et al. Camptocormia associated with focal myositis in multiple-system atrophy. Mov. Disord.21(3), 390–394 (2006).
  • Ozer F, Ozturk O, Meral H, Serdaroglu P, Yayla V. Camptocormia in a patient with parkinson disease and a myopathy with nemaline rods. Am. J. Phys. Med. Rehabil.86(1), 3–6 (2007).
  • Slawek J, Derejko M, Lass P. Camptocormia as a form of dystonia in Parkinson’s disease. Eur. J. Neurol.10(1), 107–108 (2003).
  • Holler I, Dirnberger G, Pirker W, Auff E, Gerschlager W. Camptocormia in idiopathic Parkinson’s disease: [(123)I]β-CIT SPECT and clinical characteristics. Eur. Neurol.50(2), 118–120 (2003).
  • Djaldetti R, Melamed E. Camptocormia in Parkinson’s disease: new insights. J. Neurol. Neurosurg. Psychiatr.77(11), 1205 (2006).
  • Lepoutre AC, Devos D, Blanchard-Dauphin A et al. A specific clinical pattern of camptocormia in Parkinson’s disease. J. Neurol. Neurosurg. Psychiatr.77(11), 1229–1234 (2006).
  • Melamed E, Djaldetti R. Camptocormia in Parkinson’s disease. J. Neurol.253(Suppl. 7), vii14–vii16 (2006).
  • Nandi D, Parkin S, Scott R et al. Camptocormia treated with bilateral pallidal stimulation. J. Neurosurg.97(2), 461–466 (2002).
  • Micheli F, Cersosimo MG, Piedimonte F. Camptocormia in a patient with Parkinson disease: beneficial effects of pallidal deep brain stimulation. Case report. J. Neurosurg.103(6), 1081–1083 (2005).
  • Hellmann MA, Djaldetti R, Israel Z, Melamed E. Effect of deep brain subthalamic stimulation on camptocormia and postural abnormalities in idiopathic Parkinson’s disease. Mov. Disord.21(11), 2008–2010 (2006).
  • Denny-Brown D. The nature of apraxia. J. Nerv. Ment. Dis.126, 9–31 (1958).
  • Langworthy OR. A review of the studies of Derek Denny-Brown In: The Sensory Control Of Posture and Movement. Williams and Wilkins, MD, USA 121–122 (1970).
  • Giladi N, Treves TA, Simon ES et al. Freezing of gait in patients with advanced Parkinson’s disease. J. Neural Transm.108, 53–61 (2001).
  • Krack P, Batir A, Van Blercom N et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N. Engl. J. Med.349(20), 1925–1934 (2003).
  • Davis JT, Lyons KE, Pahwa R. Freezing of gait after bilateral subthalamic nucleus stimulation for Parkinson’s disease. Clin. Neurol. Neurosurg.108(5), 461–464 (2006).
  • Giladi N, Honigman S. Botulinum toxin injections to one leg alleviate freezing of gait in a patient with Parkinson’s disease. Mov. Disord.12(6), 1085–1086 (1997).
  • Giladi N, Gurevich, Shabtai H, Paleacu D, Simon ES. The effect of botulinum toxin injections to the calf muscles on freezing of gait in parkinsonism: a pilot study. J. Neurol.248, 572–576 (2001).
  • Fernandez HH, Lannon MC, Trieschmann ME, Friedman JH. Botulinum toxin type B for gait freezing in Parkinson’s disease. Med. Sci. Monit.10(7), 282–284 (2004).
  • Wieler M, Camicioli R, Jones CA, Martin WR. Botulinum toxin injections do not improve freezing of gait in Parkinson disease. Neurology65(4), 626–628 (2005).
  • Gurevich T, Peretz C, Moore O, Weizmann N, Giladi N. The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson’s disease: a double blind placebo-controlled pilot study. Mov. Disord.22(6), 880–883 (2007).
  • Kupsky WJ, Grimes MM, Sweeting J, Bertsch R, Cote LJ. Parkinson’s disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells. Neurology37, 1253–1255 (1987).
  • Proulx de Courval FP, Wiseman MA, Panisset M. Salivary production in Parkinson’s disease. Mov. Disord.20, 204–247 (2005).
  • Pinnington LL, Muhiddin KA, Ellis RE, Playford ED. Non-invasive assessment of swallowing and respiration in Parkinson’s disease. J. Neurol.247(10), 773–777 (2000).
  • Leopold NA, Kagel MC. Pharyngo-esophageal dysphagia in Parkinson’s disease. Dysphagia12, 1–18 (1997).
  • Tscheng DZ. Sialorrhea – therapeutic drug options. Ann. Pharmacother.36, 1785–1790 (2002).
  • Jos WH. Treatment of drooling in Parkinson’s disease with botulinum toxin. Mov. Disord.14(6), 1057 (1999).
  • Pal PK, Calne DB, Calne S, Tsui JK. Botulinum toxin A as treatment for drooling saliva in PD. Neurology54(1), 244–247 (2000).
  • Friedman A, Potulska A. Quantitative assessment of parkinsonian sialorrhea and results of treatment with botulinum toxin. Parkinsonism Relat. Disord.7(4), 329–332 (2001).
  • Mancini F, Zangaglia R, Cristina S et al. Double-blind, placebo-controlled study to evaluate the efficacy and safety of botulinum toxin type A in the treatment of drooling in parkinsonism. Mov. Disord.18(6), 685–688 (2003).
  • Lipp A, Trottenberg T, Schink T, Kupsch A, Arnold G. A randomized trial of botulinum toxin A for treatment of drooling. Neurology61(9), 1279–1281 (2003).
  • Racette BA, Good L, Sagitto S, Perlmutter JS. Botulinum toxin B reduces sialorrhea in parkinsonism. Mov. Disord.18(9), 1059–1061 (2003).
  • Ondo WG, Hunter C, Moore W. A double-blind placebo-controlled trial of botulinum toxin B for sialorrhea in Parkinson’s disease. Neurology62(1), 37–40 (2004).
  • Dogu O, Apaydin D, Sevim S, Talas DU, Aral M. Ultrasound-guided versus ‘blind’ intraparotid injections of botulinum toxin-A for the treatment of sialorrhoea in patients with Parkinson’s disease. Clin. Neurol. Neurosurg.106(2), 93–96 (2004).
  • Lagalla G, Millevolte M, Capecci M, Provinciali L, Ceravolo MG. Botulinum toxin type A for drooling in Parkinson’s disease: a double-blind, randomized, placebo-controlled study. Mov. Disord.21(5), 704–707 (2006).
  • Kalf JG, Smit AM, Bloem BR, Zwarts MJ, Mulleners WM, Munneke M. Botulinum toxin A for drooling in Parkinson’s disease: a pilot study to compare submandibular to parotid gland injections. Parkinsonism Relat. Disord. (2007) (Epub ahead of print).
  • Jankovic J, Hunter C, Dolimbek BZ et al. Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia. Neurology67(12), 2233–2235 (2006).
  • Edwards LL, Quigley EM, Pfeiffer RF. Gastrointestinal dysfunction in Parkinson’s disease: frequency and pathophysiology. Neurology42, 726–732 (1992).
  • Pfeiffer RF. Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol.2, 107–116 (2003).
  • Sakakibara R, Odaka T, Uchiyama T et al. Colonic transit time and rectoanal videomanometry in Parkinson’s disease. J. Neurol. Neurosurg. Psychiatr.74(2), 268–272 (2003).
  • Mathers SE, Kempster PA, Swash M, Lees AJ. Constipation and paradoxical puborectalis contraction in anismus and Parkinson’s disease: a dystonic phenomenon? J. Neurol. Neurosurg. Psychiatr.51, 1503–1507 (1988).
  • Albanese A, Brisinda G, Bentivoglio AR, Maria G. Treatment of outlet obstruction constipation in Parkinson’s disease with botulinum neurotoxin A. Am. J. Gastroenterol.98, 1439–1440 (2003).
  • Cadeddu F, Bentivoglio AR, Brandara F, Marniga G, Brisinda G, Maria G. Outlet type constipation in Parkinson’s disease: results of botulinum toxin treatment. Aliment. Pharmacol. Ther.22(10), 997–1003 (2005).
  • Barbano R, Wenqing F, Luergans S, Comella C; for the Dystonia Study Group. Utility of electromyography in botulinum toxin injection for cervical dystonia. Mov. Disord. (Suppl. 10), S19 (2005).
  • Jost WH, Blumel J, Grafe S. Botulinum neurotoxin type A free of complexing proteins (XEOMIN®) in focal dystonia. Drugs67, 669–683 (2007).
  • Rieder CR, Schestatsky P, Socal MP et al. A double-blind, randomized, crossover study of Prosigne versus Botox in patients with blepharospasm and hemifacial spasm. Clin. Neuropharmacol.30, 39–42 (2007).
  • Naumann M, Jost W. Botulinum toxin treatment of secretory disorders. Mov. Disord.19(Suppl. 8), S137–S141(2004).
  • Diamond A, Jankovic J. Botulinum toxin in dermatology – beyond wrinkles and sweat. J. Cosmet. Dermatol.5(2), 162 (2006).
  • Sahai A, Khan MS, Dasgupta P; GKT Botulinum Study Group. Efficacy of botulinum toxin-a for treating idiopathic detrusor overactivity: results from a single center, randomized, double-blind, placebo controlled trial. J. Urol.177(6), 2231–2236 (2007).

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