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Review

Co-occurrence of ADHD and autism spectrum disorders: phenomenology and treatment

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Pages 657-669 | Published online: 09 Jan 2014

References

  • Hattori J, Ogino T, Abiru K, Nakano K, Oka M, Ohtsuka Y. Are pervasive developmental disorders and attention-deficit/hyperactivity disorder distinct disorders? Brain Dev.28(6), 371–374 (2006).
  • Goldstein S, Schwebach AJ. The comorbidity of pervasive developmental disorder and attention deficit hyperactivity disorder: results of a retrospective chart review. J. Autism Dev. Disord.34(3), 329–339 (2004).
  • Sturm H, Fernell E, Gillberg C. Autism spectrum disorders in children with normal intellectual levels: associated impairments and subgroups. Dev. Med. Child Neurol.46(7), 444–447 (2004).
  • Yoshida Y, Uchiyama T. The clinical necessity for assessing attention deficit/hyperactivity disorder (AD/HD) symptoms in children with high-functioning pervasive developmental disorder (PDD). Eur. Child Adolesc. Psychiatry13(5), 307–314 (2004).
  • Gadow KD, DeVincent CJ, Pomeroy J. ADHD symptom subtypes in children with pervasive developmental disorder. J. Autism Dev. Disord.36(2), 271–283 (2006).
  • Lee DO, Ousley OY. Attention-deficit hyperactivity disorder symptoms in a clinic sample of children and adolescents with pervasive developmental disorders. J. Child Adolesc. Psychopharmacol.16(6), 737–746 (2006).
  • Holtmann M, Bolte S, Poustka F. Attention deficit hyperactivity disorder symptoms in pervasive developmental disorders: association with autistic behavior domains and coexisting psychopathology. Psychopathology40(3), 172–177 (2007).
  • de Boo GM, Prins PJ. Social incompetence in children with ADHD: possible moderators and mediators in social-skills training. Clin. Psychol. Rev.27(1), 78–97 (2007).
  • Greene RW, Biederman J, Faraone SV, Ouellette CA, Penn C, Griffin SM. Toward a new psychometric definition of social disability in children with attention-deficit hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry35(5), 571–578 (1996).
  • Greene RW, Biederman J, Faraone SV, Sienna M, Garcia-Jetton J. Adolescent outcome of boys with attention-deficit/hyperactivity disorder and social disability: results from a 4-year longitudinal follow-up study. J. Consult Clin. Psychol.65(5), 758–767 (1997).
  • Jensen PS, Hinshaw SP, Kraemer HC et al. ADHD comorbidity findings from the MTA study: comparing comorbid subgroups. J. Am. Acad. Child Adolesc. Psychiatry40(2), 147–158 (2001).
  • Diamantopoulou S, Rydell AM, Thorell LB, Bohlin G. Impact of executive functioning and symptoms of attention deficit hyperactivity disorder on children’s peer relations and school performance. Dev. Neuropsychol.32(1), 521–542 (2007).
  • Hoza B, Gerdes AC, Mrug S et al. Peer-assessed outcomes in the multimodal treatment study of children with attention deficit hyperactivity disorder. J. Clin. Child Adolesc. Psychol.34(1), 74–86 (2005).
  • Hoza B, Mrug S, Gerdes AC et al. What aspects of peer relationships are impaired in children with attention-deficit/hyperactivity disorder? J. Consult Clin. Psychol.73(3), 411–423 (2005).
  • Blachman DR, Hinshaw SP. Patterns of friendship among girls with and without attention-deficit/hyperactivity disorder. J. Abnorm. Child Psychol.30(6), 625–640 (2002).
  • Hoza B, Waschbusch DA, Pelham WE, Molina BS, Milich R. Attention-deficit/hyperactivity disordered and control boys’ responses to social success and failure. Child Dev.71(2), 432–446 (2000).
  • Clark T, Feehan C, Tinline C, Vostanis P. Autistic symptoms in children with attention deficit-hyperactivity disorder. Eur. Child Adolesc. Psychiatry8(1), 50–55 (1999).
  • Santosh PJ, Mijovic A. Social impairment in hyperkinetic disorder – relationship to psychopathology and environmental stressors. Eur. Child Adolesc. Psychiatry13(3), 141–150 (2004).
  • Constantino JN, Hudziak JJ, Todd RD. Deficits in reciprocal social behavior in male twins: evidence for a genetically independent domain of psychopathology. J. Am. Acad. Child Adolesc. Psychiatry42(4), 458–467 (2003).
  • Reiersen AM, Constantino JN, Volk HE, Todd RD. Autistic traits in a population-based ADHD twin sample. J. Child Psychol. Psychiatry48(5), 464–472 (2007).
  • Reiersen AM, Constantino JN, Todd RD. Co-occurrence of motor problems and autistic symptoms in attention-deficit/hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry48(5), 464–472(2007).
  • Constantino JN, Davis SA, Todd RD et al. Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised. J. Autism Dev. Disord.33(4), 427–433 (2003).
  • Constantino JN, Gruber CP. Social Responsiveness Scale (SRS) Manual. Western Psychological Services, CA, USA (2005).
  • Constantino JN, Przybeck T, Friesen D, Todd RD. Reciprocal social behavior in children with and without pervasive developmental disorders. J. Dev. Behav. Pediatr.21(1), 2–11 (2000).
  • Constantino JN, Lavesser PD, Zhang Y, Abbacchi AM, Gray T, Todd RD. Rapid quantitative assessment of autistic social impairment by classroom teachers. J. Am. Acad. Child Adolesc. Psychiatry46(12), 1668–1676 (2007).
  • Todd RD, Huang H, Henderson AS. Poor utility of the age of onset criterion for DSM-IV attention deficit/hyperactivity disorder: recommendations for DSM-V and ICD-11.J. Child Psychol. Psychiatry (In Press).
  • McGee R, Williams S, Feehan M. Attention deficit disorder and age of onset of problem behaviors. J. Abnorm. Child Psychol.20(5), 487–502 (1992).
  • Martin NC, Piek JP, Hay D. DCD and ADHD: a genetic study of their shared aetiology. Hum. Mov. Sci.25(1), 110–124 (2006).
  • Piek JP, Pitcher TM, Hay DA. Motor coordination and kinaesthesis in boys with attention deficit-hyperactivity disorder. Dev. Med. Child Neurol.41(3), 159–165 (1999).
  • Pitcher TM, Piek JP, Barrett NC. Timing and force control in boys with attention deficit hyperactivity disorder: subtype differences and the effect of comorbid developmental coordination disorder. Hum. Mov. Sci.21(5–6), 919–945 (2002).
  • Pitcher TM, Piek JP, Hay DA. Fine and gross motor ability in males with ADHD. Dev. Med. Child Neurol.45(8), 525–535 (2003).
  • Mahone EM, Powell SK, Loftis CW, Goldberg MC, Denckla MB, Mostofsky SH. Motor persistence and inhibition in autism and ADHD. J. Int. Neuropsychol. Soc.12(5), 622–631 (2006).
  • Mostofsky SH, Newschaffer CJ, Denckla MB. Overflow movements predict impaired response inhibition in children with ADHD. Percept. Mot. Skills97(3 Pt 2), 1315–1331 (2003).
  • Schuerholz LJ, Cutting L, Mazzocco MM, Singer HS, Denckla MB. Neuromotor functioning in children with Tourette syndrome with and without attention deficit hyperactivity disorder. J. Child Neurol.12(7), 438–442 (1997).
  • Schuerholz LJ, Singer HS, Denckla MB. Gender study of neuropsychological and neuromotor function in children with Tourette syndrome with and without attention-deficit hyperactivity disorder. J. Child Neurol.13(6), 277–282 (1998).
  • Dziuk MA, Gidley Larson JC, Apostu A, Mahone EM, Denckla MB, Mostofsky SH. Dyspraxia in autism: association with motor, social, and communicative deficits. Dev. Med. Child Neurol.49(10), 734–739 (2007).
  • Jansiewicz EM, Goldberg MC, Newschaffer CJ, Denckla MB, Landa R, Mostofsky SH. Motor signs distinguish children with high functioning autism and Asperger’s syndrome from controls. J. Autism Dev. Disord.36(5), 613–621 (2006).
  • Mostofsky SH, Dubey P, Jerath VK, Jansiewicz EM, Goldberg MC, Denckla MB. Developmental dyspraxia is not limited to imitation in children with autism spectrum disorders. J. Int. Neuropsychol. Soc.12(3), 314–326 (2006).
  • Gillberg C. Deficits in attention, motor control, and perception: a brief review. Arch. Dis. Child.88(10), 904–910 (2003).
  • Landgren M, Kjellman B, Gillberg C. Deficits in attention, motor control and perception (DAMP): a simplified school entry examination. Acta Paediatr.89(3), 302–309 (2000).
  • Sergeant JA, Piek JP, Oosterlaan J. ADHD and DCD: a relationship in need of research. Hum. Mov. Sci.25(1), 76–89 (2006).
  • Goldberg MC, Mostofsky SH, Cutting LE et al. Subtle executive impairment in children with autism and children with ADHD. J. Autism Dev. Disord.35(3), 279–293 (2005).
  • Geurts HM, Verte S, Oosterlaan J, Roeyers H, Sergeant JA. How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? J. Child Psychol. Psychiatry45(4), 836–854 (2004).
  • Sergeant JA, Geurts H, Oosterlaan J. How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder? Behav. Brain Res.130(1–2), 3–28 (2002).
  • Pennington BF, Ozonoff S. Executive functions and developmental psychopathology. J. Child Psychol. Psychiatry37(1), 51–87 (1996).
  • Livesey D, Keen J, Rouse J, White F. The relationship between measures of executive function, motor performance and externalising behaviour in 5- and 6-year-old children. Hum. Mov. Sci.25(1), 50–64 (2006).
  • Piek JP, Dyck MJ, Francis M, Conwell A. Working memory, processing speed, and set-shifting in children with developmental coordination disorder and attention-deficit-hyperactivity disorder. Dev. Med. Child Neurol.49(9), 678–683 (2007).
  • Piek JP, Dyck MJ, Nieman A et al. The relationship between motor coordination, executive functioning and attention in school aged children. Arch. Clin. Neuropsychol.19(8), 1063–1076 (2004).
  • Gilger JW, Kaplan BJ. Atypical brain development: a conceptual framework for understanding developmental learning disabilities. Dev. Neuropsychol.20(2), 465–481 (2001).
  • Kaplan B, Crawford S, Cantell M, Kooistra L, Dewey D. Comorbidity, co-occurrence, continuum: what’s in a name? Child Care Health Dev.32(6), 723–731 (2006).
  • Smalley SL, Loo SK, Yang MH, Cantor RM. Toward localizing genes underlying cerebral asymmetry and mental health. Am. J. Med. Genet. B Neuropsychiatr. Genet.135(1), 79–84 (2005).
  • Ronald A, Simonoff E, Kuntsi J, Asherson P, Plomin R. Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. J. Child Psychol. Psychiatry (2008) (Epub ahead of print).
  • Nieoullon A. Dopamine and the regulation of cognition and attention. Prog. Neurobiol.67(1), 53–83 (2002).
  • Todd RD, Botteron KN. Is attention-deficit/hyperactivity disorder an energy deficiency syndrome? Biol. Psychiatry50(3), 151–158 (2001).
  • Neuman RJ, Lobos E, Reich W, Henderson CA, Sun LW, Todd RD. Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biol. Psychiatry61(12), 1320–1328 (2007).
  • Todd RD, Neuman RJ. Gene–environment interactions in the development of combined type ADHD: evidence for a synapse-based model. Am. J. Med. Genet. B Neuropsychiatr. Genet.144(8), 971–975 (2007).
  • Vorstman JA, Morcus ME, Duijff SN et al. The 22q11.2 deletion in children: high rate of autistic disorders and early onset of psychotic symptoms. J. Am. Acad. Child Adolesc. Psychiatry45(9), 1104–1113 (2006).
  • Antshel KM, Aneja A, Strunge L et al. Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion). J. Autism Dev. Disord.37(9), 1776–1786 (2007).
  • Fine SE, Weissman A, Gerdes M et al. Autism spectrum disorders and symptoms in children with molecularly confirmed 22q11.2 deletion syndrome. J. Autism Dev. Disord.35(4), 461–470 (2005).
  • Gothelf D, Presburger G, Levy D et al. Genetic, developmental, and physical factors associated with attention deficit hyperactivity disorder in patients with velocardiofacial syndrome. Am. J. Med. Genet. B Neuropsychiatr. Genet.126(1), 116–121 (2004).
  • Murphy KC. Annotation: velo-cardio-facial syndrome. J. Child Psychol. Psychiatry46(6), 563–571 (2005).
  • Niklasson L, Rasmussen P, Oskarsdottir S, Gillberg C. Chromosome 22q11 deletion syndrome (CATCH 22): neuropsychiatric and neuropsychological aspects. Dev. Med. Child Neurol.44(1), 44–50 (2002).
  • Ousley O, Rockers K, Dell ML, Coleman K, Cubells JF. A review of neurocognitive and behavioral profiles associated with 22q11 deletion syndrome: implications for clinical evaluation and treatment. Curr. Psychiatry Rep.9(2), 148–158 (2007).
  • Farzin F, Perry H, Hessl D et al. Autism spectrum disorders and attention-deficit/hyperactivity disorder in boys with the fragile X premutation. J. Dev. Behav. Pediatr.27(2 Suppl.), S137–S144 (2006).
  • Reiersen AM. Psychopathology in 22q11 deletion syndrome. J. Am. Acad. Child Adolesc. Psychiatry46(8), 942; author reply 942–944 (2007).
  • Katragadda S, Schubiner H. ADHD in children, adolescents, and adults. Primary care34(2), 317–341 (2007).
  • Pliszka S. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry46(7), 894–921 (2007).
  • Wolraich ML. Attention-deficit hyperactivity disorder. Semin. Pediatr. Neurol.13(4), 279–285 (2006).
  • Wolraich ML, Wibbelsman CJ, Brown TE et al. Attention-deficit/hyperactivity disorder among adolescents: a review of the diagnosis, treatment, and clinical implications. Pediatrics115(6), 1734–1746 (2005).
  • Bodfish JW. Treating the core features of autism: are we there yet? Ment. Retard. Dev. Disabil. Res. Rev.10(4), 318–326 (2004).
  • Bostic JQ, King BH. Autism spectrum disorders: emerging pharmacotherapy. Expert Opin. Emerg. Drugs10(3), 521–536 (2005).
  • De Ocampo AC, Jacobs JM. Medical management of autism. J. S. C. Med. Assoc. (1975),102(8), 274–276 (2006).
  • Erickson CA, Posey DJ, Stigler KA, McDougle CJ. Pharmacologic treatment of autism and related disorders. Pediatr. Ann.36(9), 575–585 (2007).
  • Filipek PA, Steinberg-Epstein R, Book TM. Intervention for autistic spectrum disorders. NeuroRx3(2), 207–216 (2006).
  • King BH, Bostic JQ. An update on pharmacologic treatments for autism spectrum disorders. Child. Adolesc. Psychiatr. Clin. N. Am.15(1), 161–175 (2006).
  • McCracken JT. Safety issues with drug therapies for autism spectrum disorders. J. Clin. Psychiatry66(Suppl. 10), 32–37 (2005).
  • Myers SM. The status of pharmacotherapy for autism spectrum disorders. Expert Opin Pharmacother.8(11), 1579–1603 (2007).
  • Volkmar F, Cook E Jr, Pomeroy J, Realmuto G, Tanguay P. Summary of the practice parameters for the assessment and treatment of children, adolescents, and adults with autism and other pervasive developmental disorders. American Academy of Child and Adolescent Psychiatry. J. Am. Acad. Child Adolesc. Psychiatry38(12), 1611–1616 (1999).
  • Volkmar F, Cook EH Jr, Pomeroy J, Realmuto G, Tanguay P. Practice parameters for the assessment and treatment of children, adolescents, and adults with autism and other pervasive developmental disorders. American Academy of Child and Adolescent Psychiatry Working Group on Quality Issues. J. Am. Acad. Child Adolesc. Psychiatry38(12 Suppl.), 32S–54S (1999).
  • Hazell P. Drug therapy for attention-deficit/hyperactivity disorder-like symptoms in autistic disorder. J. Paediatr. Child Health43(1–2), 19–24 (2007).
  • Jaselskis CA, Cook EH, Jr, Fletcher KE, Leventhal BL. Clonidine treatment of hyperactive and impulsive children with autistic disorder. J. Clin. Psychopharmacol.12(5), 322–327 (1992).
  • Research Units on Pediatric Psychopharmacology Autism Network. Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch. Gen. Psychiatry62(11), 1266–1274 (2005).
  • Posey DJ, Wiegand RE, Wilkerson J, Maynard M, Stigler KA, McDougle CJ. Open-label atomoxetine for attention-deficit/ hyperactivity disorder symptoms associated with high-functioning pervasive developmental disorders. J. Child Adolesc. Psychopharmacol.16(5), 599–610 (2006).
  • Posey DJ, Aman MG, McCracken JT et al. Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures. Biol. Psychiatry61(4), 538–544 (2007).
  • Handen BL, Johnson CR, Lubetsky M. Efficacy of methylphenidate among children with autism and symptoms of attention-deficit hyperactivity disorder. J. Autism Dev. Disord.30(3), 245–255 (2000).
  • Posey DJ, Puntney JI, Sasher TM, Kem DL, McDougle CJ. Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases. J. Child Adolesc. Psychopharmacol.14(2), 233–241 (2004).
  • Scahill L, Aman MG, McDougle CJ et al. A prospective open trial of guanfacine in children with pervasive developmental disorders. J. Child Adolesc. Psychopharmacol.16(5), 589–598 (2006).
  • Arnold LE, Aman MG, Cook AM et al. Atomoxetine for hyperactivity in autism spectrum disorders: placebo-controlled crossover pilot trial. J. Am. Acad. Child Adolesc. Psychiatry45(10), 1196–1205 (2006).
  • Doyle RL, Frazier J, Spencer TJ, Geller D, Biederman J, Wilens T. Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: a case series. J. Atten. Disord.9(3), 543–549 (2006).
  • Santosh PJ, Baird G, Pityaratstian N, Tavare E, Gringras P. Impact of comorbid autism spectrum disorders on stimulant response in children with attention deficit hyperactivity disorder: a retrospective and prospective effectiveness study. Child Care Health Dev.32(5), 575–583 (2006).
  • Gothelf D, Gruber R, Presburger G et al. Methylphenidate treatment for attention-deficit/hyperactivity disorder in children and adolescents with velocardiofacial syndrome: an open-label study. J. Clin. Psychiatry64(10), 1163–1169 (2003).
  • Tharoor H, Lobos EA, Todd RD, Reiersen AM. Association of dopamine, serotonin, and nicotinic gene polymorphisms with methylphenidate response in ADHD. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2007) (Epub ahead of print).
  • McGough JJ. Attention-deficit/hyperactivity disorder pharmacogenomics. Biol. Psychiatry57(11), 1367–1373 (2005).
  • Bondy B, Spellmann I. Pharmacogenetics of antipsychotics: useful for the clinician? Curr. Opin. Psychiatry20(2), 126–130 (2007).

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