Lacunar stroke

References

• Marie P. Des foyers lacunaires de desintegration et de differents autres etats cavitaires du cerveau. Rev. Med. (Paris)21, 281–298 (1901).
   Google Scholar
• Ferrand J. Essai sur l’hémiplegie des vieillards. Les Lacunes de Désintégration Cérébrale. Thesis, Jules Rousset, Paris (1902).
   Google Scholar
• Hughes M, Dodgson MCH. Chronic cerebral hypertensive disease. Lancet2, 770–774 (1954).
   Google Scholar
• Poirier J, Derouesné C. Le concept de lacune cerebrale de 1838 à nos jours. Rev. Neurol.141, 3–17 (1985).
   PubMedGoogle Scholar
• Besson G, Hommel M. Historical aspects of lacunes and the lacunar controversy. In: Cerebral Small Artery Diseases. Advances in Neurology (Volume 62). Pullicino PM, Caplan LR, Hommel M (Eds). Raven Press, New York, NY, USA 1–10 (1993).
   Google Scholar
• Fisher CM, Curry HB. Pure motor hemiplegia of vascular origin. Arch. Neurol.13, 30–44 (1965).
   PubMed Web of Science ®Google Scholar
• Fisher CM. Pure sensory stroke involving face, arm and leg. Neurology15, 76–80 (1965).
   PubMedGoogle Scholar
• Fisher CM, Cole M. Homolateral ataxia and crural paresis: a vascular syndrome. J. Neurol. Neurosurg. Psychiatry28, 48–55 (1965).
   PubMedGoogle Scholar
• Fisher CM. Ataxia hemiparesis. A pathologic study. Arch. Neurol.35, 126–128 (1978).
   PubMedGoogle Scholar
• Fisher CM. A lacunar stroke: the dysarthria–clumsy hand syndrome. Neurology17, 614–617 (1967).
   PubMed Web of Science ®Google Scholar
• Fisher CM. Lacunes: small, deep cerebral infarcts. Neurology15, 774–784 (1965).
   PubMed Web of Science ®Google Scholar
• Mohr JP, Kase CS, Meckler MD, Fisher CM. Sensorimotor stroke due to thalamocapsular ischemia. Arch. Neurol.34, 739–741 (1977).
   PubMedGoogle Scholar
• Fisher CM. Lacunar infarcts. A review. Cerebrovasc. Dis.1, 311–320 (1991).
   Web of Science ®Google Scholar
• Millikan C, Futrell N. The fallacy of lacune hypothesis. Stroke21, 1251–1257 (1990).
   PubMed Web of Science ®Google Scholar
• Boiten J, Lodder J. Lacunar infarcts: pathogenesis and validity of the clinical syndromes. Stroke22, 1374–1378 (1991).
   PubMedGoogle Scholar
• Chamorro A, Sacco RL, Mohr JP et al. Clinical computed tomographic correlations of lacunar infarction in the Stroke Data Bank. Stroke22, 175–181 (1991).
   PubMed Web of Science ®Google Scholar
• Arboix A, Martí-Vilalta JL. Lacunar syndromes not due to lacunar infarcts. Cerebrovasc. Dis.2, 287–292 (1992).
   Web of Science ®Google Scholar
• Boiten J, Lodder J, Kessels F. Two clinically distinct lacunar infarct entities? A hypothesis. Stroke24, 652–656 (1993).
   PubMedGoogle Scholar
• Norrving B. Long-term prognosis after lacunar infarction. Lancet Neurol.2, 238–245 (2003).
   PubMed Web of Science ®Google Scholar
• Wardlaw JM. What causes lacunar stroke? J. Neurol. Neurosurg. Psychiatry76, 617–619 (2005).
   PubMed Web of Science ®Google Scholar
• Martí-Vilalta JL, Arboix A, Mohr JP. Lacunes. In: Stroke. Pathophysiology, Diagnosis, and Management. Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PhA (Eds). Churchill–Livingstone, PA, USA 275–299 (2004).
   Google Scholar
• Bamford JM, Sandercock P, Jones L, Warlow CP. The natural history of lacunar infarction: the Oxfordshire Community Stroke Project. Stroke18, 545–551 (1987).
   PubMed Web of Science ®Google Scholar
• Gan R, Sacco RL, Kargman DE, Roberts JK, Boden-Albala B, Gu Q. Testing the validity of the lacunar hypothesis: the Northern Manhattan Stroke Study experience. Neurology48, 1204–1211 (1997).
   PubMedGoogle Scholar
• Martí-Vilalta JL, Arboix A. The Barcelona Stroke Registry. Eur. Neurol.41, 135–142 (1999).
   PubMed Web of Science ®Google Scholar
• Mohr JP, Kase CS, Wolf PA et al. Lacunes in the NINCDS Pilot Stroke Data Bank. Ann. Neurol.12, 84 (1982).
   Google Scholar
• Arboix A, Miguel M, Císcar E, García-Eroles L, Massons J, Balcells M. Cardiovascular risk factors in patients aged 85 or older with ischemic stroke. Clin. Neurol. Neurosurg.108, 638–643 (2006).
   PubMed Web of Science ®Google Scholar
• Arboix A, Martí Vilalta JL, García JH. Clinical study of 227 patients with lacunar infarcts. Stroke21, 842–847 (1990).
   PubMed Web of Science ®Google Scholar
• Norrving B, Staaf G. Pure motor stroke from presumed lacunar infarct. Incidence, risk factors and initial course. Cerebrovasc. Dis.1, 203–209 (1991).
   Google Scholar
• De Jong G, Kessels F, Lodder J. Two types of lacunar infarcts. Further arguments from a study on prognosis. Stroke33, 2072–2076 (2002).
   PubMed Web of Science ®Google Scholar
• Benavente O, White CL, Roldan AM. Small vessel strokes. Curr. Cardiol. Rep.7, 23–28 (2005).
   PubMedGoogle Scholar
• Mast H, Thompson JLP, Lee SH, Mohr JP, Sacco RL. Hypertension and diabetes mellitus as determinants of multiple lacunar infarcts. Stroke26, 30–33 (1995).
   PubMedGoogle Scholar
• Lodder J, Bamford JM, Sandercock PAG, Jones LN, Warlow CP. Are hypertension or cardiac embolism likely causes of lacunar infarction? Stroke21, 375–381 (1990).
   PubMed Web of Science ®Google Scholar
• Arboix A, García-Eroles K, Massons J, Oliveres M, Targa C. Lacunar infarcts in patients aged 85 years and older. Acta Neurol. Scand.101, 25–29 (2000).
   PubMed Web of Science ®Google Scholar
• Arboix A, Martí-Vilalta JL. Presumed cardioembolic lacunar infarcts. Stroke23, 1841–1842 (1992).
   PubMedGoogle Scholar
• Tejada J, Díez-Tejedor E, Hernández-Echebarría L, Balboa O. Does a relationship exist between carotid stenosis and lacunar infarction? Stroke34, 1404–1411 (2003).
   PubMedGoogle Scholar
• Arboix A, García-Eroles L, Massons J, Oliveres M, Comes E, Targa C. Lacunar stroke in patients with intermittent claudication. Acta Neurol. Scand.111, 253–257 (2005).
   PubMedGoogle Scholar
• Inzitari D, Eliasziw M, Sharpe BL, Fox AJ, Barnett HJM for the North American Symptomatic Carotid Endarterectomy Trial Group. Risk factors and outcome of patients with carotid artery stenosis presenting with lacunar stroke. Neurology54, 660–666 (2000).
   PubMed Web of Science ®Google Scholar
• Arboix A, Martí-Vilalta JL. Transient ischemic attacks in lacunar infarcts. Cerebrovasc. Dis.1, 20–24 (1991).
   Web of Science ®Google Scholar
• Gandolfo C, Caponnetto C, Del Sette M, Santoloci D, Loeb C. Risk factors in lacunar síndromes: a case–control study. Acta Neurol. Scand.77, 22–26 (1988).
   PubMedGoogle Scholar
• You R, McNeil JJ, O’Malley HM, Davis SM, Donnan JA. Risk factors for lacunar infarction syndromes. Neurology45, 1483–1487 (1995).
   PubMedGoogle Scholar
• Matsui T, Arai H, Yuzuriha T et al.. Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people. Stroke32, 1116–1119 (2001).
   PubMed Web of Science ®Google Scholar
• Sasaki T, Watanabe M, Nagai Y et al. Association of plasma homocysteine concentration with atherosclerotic carotid plaques and lacunar infarction. Stroke33, 1493–1496 (2002).
   PubMed Web of Science ®Google Scholar
• Arboix A, Martí-Vilalta Jl. New concepts in lacunar stroke etiology: the constellation of small-vessel arterial disease. Cerebrovasc. Dis.17(Suppl. 1), 58–62 (2004).
   PubMed Web of Science ®Google Scholar
• Fisher CM. The arterial lesions underlying lacunes. Acta Neuropathol. (Berl.)12, 1–15 (1969).
   Web of Science ®Google Scholar
• Fisher CM. Capsular infarcts: the underlying vascular lesions. Arch. Neurol.36, 65–73 (1979).
   PubMed Web of Science ®Google Scholar
• Mohr JP. Lacunes. Neurol. Clin. North Am.1, 201–221 (1983).
   PubMedGoogle Scholar
• Chester EM, Agamanolis DP, Banker Q, Victor M. Hypertensive encephalopathy: a clinicopathologic study of 20 cases. Neurology28, 928–939 (1978).
   PubMed Web of Science ®Google Scholar
• Laloux P, Broucher JM. Lacunar infarctions due to cholesterol emboli. Stroke22, 1440–1444 (1991).
   PubMedGoogle Scholar
• Fisher CM. Lacunar strokes and infarcts: a review. Neurology32, 871–876 (1982).
   PubMed Web of Science ®Google Scholar
• Benhaiem-Sigaux N, Gherardi R, Salama J, Gray F, Amouroux J, Poirier J. Thrombosis of a saccular microanerysm causing cerebral (pontine) lacunae. Acta Neuropathol. (Berl.)69, 332–336 (1986).
   PubMedGoogle Scholar
• Fang HCH. Lacunar infarction, clinico-pathologic correlation study. J. Neuropathol. Exp. Neurol.31, 212 (1972).
   Google Scholar
• De Reuck J, Vander Eecken H. The arterial angioarchitecture in lacunar state. Acta Neurol. Belg.76, 142–149 (1976).
   PubMedGoogle Scholar
• Ishii N, Nishihara Y, Imamura T. Why do frontal lobe symptoms predominate in vascular dementia with lacunes? Neurology36, 340–345 (1986).
   PubMed Web of Science ®Google Scholar
• Mancardi GL, Romagnoli P, Tassinari T, Gandolfo V, Primavera A, Loeb C. Lacunes and cribiform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. Eur. Neurol.28, 11–17 (1988).
   PubMedGoogle Scholar
• Tuszynski MH, Petito CK, Levy DE. Risk factors and clinical manifestations of pathologically verified lacunar infarctions. Stroke20, 990–999 (1989).
   PubMed Web of Science ®Google Scholar
• Dozono K, Ishii N, Nishihara Y, Horie A. An autopsy study of the incidence of lacunes in relation to age, hypertension, and arteriosclerosis. Stroke22, 993–996 (1991).
   PubMedGoogle Scholar
• Arboix A, Ferrer I, Martí-Vilalta JL. Clinico-pathologic analysis of 25 patients with lacunar infarcts. Rev. Clin. Esp.196, 370–374 (1996).
   PubMed Web of Science ®Google Scholar
• Arboix A, Martí-Vilalta JL. A study of lacunar infarcts based on analysis of the main anatomopathological series in the literature. Rev. Neurol.26, 365–367 (1998).
   PubMedGoogle Scholar
• Derouesné C, Gray F, Escourelle R, Castaigne. Expanding cerebral lacunae in a hypertensive patient with normal pressure hydrocephalus. Neuropathol. Appl. Neurobiol.13, 309–320 (1987).
   PubMedGoogle Scholar
• Benhaiem-Sigaux N, Gray F, Gherardi R, Roucayrol AM, Poirier J. Expanding cerebellar lacunes due to dilatation of the perivascular space associated with Binswanger’s subcortical arteriosclerosis encephalopathy. Stroke18, 1087–1092 (1987).
   PubMedGoogle Scholar
• Lammie GA, Brannan F, Wardlaw JM. Incomplete lacunar infarction (type 1b lacunes). Acta Neuropathol.96, 163–171 (1998).
   PubMedGoogle Scholar
• Poirier J, Gray F, Gherardi R, Derouesné C. Cerebral lacunae. A new neuropahological classification. J. Neuropathol. Exp. Neurol.44, 312 (1985).
   Google Scholar
• Arboix A, Martí-Vilalta JL, Pujol J, Sanz M. Lacunar cerebral infarct and nuclear magnetic resonance. A review of sixty cases. Eur. Neurol.30, 47–51 (1990).
   PubMedGoogle Scholar
• Vaxman SG, Toole JF. Temporal profile resembling TIA in the setting of cerebral infarction. Stroke14, 433–437 (1983).
   PubMedGoogle Scholar
• Kappelle LJ, van Latum JC, Koudstaal PJ, van Gijn J for the Dutch TIA Study Group. Transient ischaemic attacks and small-vessel disease. Lancet337, 339–341 (1991).
   PubMedGoogle Scholar
• Arboix A, Martí-Vilalta JL. Acute stroke and circadian rhythm. Stroke21, 826 (1990).
   PubMedGoogle Scholar
• Arboix A, García-Trallero O, García-Eroles L, Massons J, Comes E, Targa C. Stroke-related headache: a clinical study in lacunar infarction. Headache45, 1345–1352 (2005).
   PubMedGoogle Scholar
• Arboix A, Grau-Olivares M, García-Eroles L, Massons J, Comes E, Targa C. Clinical implications of headache in lacunar stroke: relevance of site of infarct. Headache46, 1172–1180 (2006).
   PubMedGoogle Scholar
• Martí-Vilalta JL, Arboix A. Estúdio multicéntrico. In: Infarto Cerebral de Tipo Lacunar. Martí-Vilalta JL, Arboix A (Eds). Vila Sala, Barcelona, Spain 119–124 (1989).
   Google Scholar
• Chimowitz MI, Furlan AJ, Sila CA, Paranandi L, Beck GJ. Etiology of motor or sensory stroke: a prospective study of the predictive value of clinical and radiological features. Ann. Neurol.30, 519–525 (1991).
   PubMedGoogle Scholar
• Hommel M, Besson G, Le bas JF, Gaio JM, Pollack P, Borgei F, Ferret J. Prospective study of lacunar infarction using magnetic resonance imaging. Stroke21, 546–554 (1990).
   PubMedGoogle Scholar
• Melo TP, Bogousslavsky J, Van Melle G, Regli F. Pure motor stroke: a reappraisal. Neurology42, 789–795 (1992).
   PubMed Web of Science ®Google Scholar
• Arboix A, Padilla I, García-Eroles, Massons, Comes E, Targa C. Pure motor hemiparesis: a clinical study of 222 patients. J. Neurol. Neurosurg. Psychiatry71, 239–242 (2001).
   PubMed Web of Science ®Google Scholar
• Nighoghossian N, Ryvlin P, Trouillas P, Laharotte JC, Froment JC. Pontine versus capsular pure motor hemiparesis. Neurology43, 2197–2201 (1993).
   PubMed Web of Science ®Google Scholar
• Ho KL. Pure motor hemiplegia due to infarction of the cerebral peduncle. Arch. Neurol.39, 524–526 (1982).
   PubMedGoogle Scholar
• Ropper AH, Fisher CM, Kleinman GM. Pyramidal infarction in the medulla: a cause of pure motor hemiplegia sparing the face. Neurology29, 91–95 (1979).
   PubMed Web of Science ®Google Scholar
• Fraix V, Besson G, Hommel M, Perret J. Brachiofacial pure motor stroke. Cerebrovasc. Dis.12, 34–38 (2001).
   PubMedGoogle Scholar
• Donnan GA, Tress BM, Bladin PF. A prospective study of lacunar infarction using computerized tomography. Neurology32, 49–56 (1982).
   PubMedGoogle Scholar
• Tapia JF, Kase CS, Sawyer RH, Mohr JP. Hypertensive putaminal hemorrhage presenting as pure motor hemiparesis. Stroke14, 505–506 (1983).
   PubMedGoogle Scholar
• Arboix A, García-Eroles L, Massons J, Oliveres M, Balcells M. Haemorrhagic pure motor stroke. Eur. J. Neurol.14, 219–223 (2007).
   PubMed Web of Science ®Google Scholar
• Fisher CM. Thalamic pure sensory stroke: a pathologic study. Neurology28, 1141–1144 (1978).
   PubMedGoogle Scholar
• Shintani S. Clinical–radiologic correlations in pure sensory stroke. Neurology51, 297–302 (1998).
   PubMed Web of Science ®Google Scholar
• Kim JS, Bae YH. Pure or predominant sensory stroke due to brain stem lesion. Stroke28, 1761–1764 (1997).
   PubMed Web of Science ®Google Scholar
• Paciaroni M, Bogousslavsky J. Pure sensory syndromes in thalamic stroke. Eur. Neurol.39, 211–217 (1998).
   PubMedGoogle Scholar
• Arboix A, García-Plata C, García-Eroles L et al. Clinical study of 99 patients with pure sensory stroke. J. Neurol.252, 156–162 (2005).
   PubMed Web of Science ®Google Scholar
• Yasuda Y, Watanabe T, Tanaka H, Akiguchi I, Kimura J, Kameyama M. Unusual sensory disturbances in the thoracic region after stroke: relationship to cheiro–oral and cheiro–oral–pedal syndrome. J. Neurol. Sci.153, 68–75 (1997).
   PubMed Web of Science ®Google Scholar
• Kim JS. Restricted acral sensory syndrome following minor stroke. Further observation with special reference to differential severity of symptoms among individual digits. Stroke25, 2497–2502 (1994).
   PubMed Web of Science ®Google Scholar
• Carrera E, Michel P, Bogousslavsky J. Anteromedian, central, and posterolateral infarcts of the thalamus. Three variants types. Stroke35, 2826–2831 (2004).
   PubMed Web of Science ®Google Scholar
• Wolk DA, Messe SR, Kasner SE. Pure sensory stroke from cortical infarction. Neurology59, 783 (2002).
   PubMedGoogle Scholar
• Groothuis DR, Duncan GW, Fisher CM. The human thalamocortical sensory path in the internal capsule: evidence from a small capsular hemorrhage causing a pure sensory stroke. Ann. Neurol.2, 328–331 (1977).
   PubMed Web of Science ®Google Scholar
• Blecic SA, Bogousslavsky J, van Melle G, Regli F. Isolated SMS: a reevaluation of clinical, topographic, and etiological patterns. Cerebrovasc. Dis.3, 357–363 (1993).
   Google Scholar
• Arboix A, Oliveres M, García-Eroles L, Comes E, Balcells M, Targa C. Risk factors and clinical features of sensorimotor stroke. Cerebrovasc. Dis.16, 448–451 (2003).
   PubMedGoogle Scholar
• Arboix A, Oliveres M, Besses C. Sensorimotor stroke due to gangliocapsular hematoma as first manifestation of chronic myelocytic leukaemia. Cerebrovasc. Dis.10, 81–82 (2000).
   PubMed Web of Science ®Google Scholar
• Tei H, Uchiyama S, Maruyama S. Capsular infarcts: location, size and etiology of pure motor hemiparesis, sensorimotor stroke and ataxic hemiparesis. Acta Neurol. Scand.88, 264–268 (1993).
   PubMedGoogle Scholar
• Moulin T, Bogousslavsky J, Chopard JL, Crepin-Leblond T, Martin V, Maeder P. Vascular ataxic hemiparesis: a re-evaluation. J. Neurol. Neurosurg. Psychiatry58, 422–427 (1995).
   PubMedGoogle Scholar
• Gorman MJ, Dafer R, Levine S. Ataxic hemiparesis. Critical appraisal of a lacunar syndrome. Stroke29, 2549–2555 (1998).
   PubMed Web of Science ®Google Scholar
• Besson G, Vincent E, Hommel M, Perret. L’hémiparésie ataxique par infarctus lacunaire. Rev. Neurol.155, 209–212 (1999).
   PubMedGoogle Scholar
• Arboix A. Clinical study of 23 patients with ataxic hemiparesis. Med. Clin. (Barc.)122, 342–344 (2004).
   PubMedGoogle Scholar
• Bogousslavsky J, Regli F, Ghika J, Feldmeyer JJ. Painful ataxic hemiparesis. Arch. Neurol.41, 892–893 (1984).
   PubMedGoogle Scholar
• Hiraga A, Uzawa A, Kamitsukasa I. Diffusion weighted imaging in ataxic hemiparesis. J. Neurol. Neurosurg. Psychiatry78, 1260–1262 (2007).
   PubMed Web of Science ®Google Scholar
• Flint AC, Naley MC, Wright CB. Ataxic hemiparesis from strategic frontal white matter infarction with crossed cerebellar diaschisis. Stroke37, E1–E2 (2006).
   PubMedGoogle Scholar
• Schnapper RA. Pontine hemorrhage presenting as ataxic hemiparesis. Stroke13, 518–519 (1982).
   PubMedGoogle Scholar
• Bendheim PE, Berg BO. Ataxic hemiparesis from a midbrain mass. Ann. Neurol.9, 405–407 (1981).
   PubMedGoogle Scholar
• Barinagarementeria F, Del Brutto O, Otero E. Ataxic hemiparesis from cysticercosis. Arch. Neurol.45, 246 (1988).
   PubMedGoogle Scholar
• Arboix A, Bell Y, García-Eroles L, Massons J, Comes E, Balcells M, Targa C. Clinical study of 35 patients with dysarthria–clumsy hand syndrome. J. Neurol. Neurosurg. Psychiatry75, 231–234 (2004).
   PubMed Web of Science ®Google Scholar
• Glass JD, Levey AI, Rothstein JD. The dysarthria–clumsy hand syndrome: a distinct clinical entity related to pontine infarction. Ann. Neurol.27, 487–494 (1990).
   PubMed Web of Science ®Google Scholar
• Urban PP, Hopf HC, Visbeck A, Fleischer S, Andreas J. Dysarthria–clumsy hand syndrome due to infarction of the cerebral peduncle. J. Neurol. Neurosurg. Psychiatry60, 231–232 (1996).
   PubMedGoogle Scholar
• Iguchi Y, Kimura K, Ueno Y, Inoue T, Matusmoto N, Sunada Y. Dysarthria–clumsy hand syndrome originating in the corona radiate. Eur. J. Neurol.3, E6 (2006).
   Google Scholar
• Tougeron A, Samson Y, Schaison M, Artigou JY, Bousser MG. Dysarthria–clumsy hand syndrome caused by cerebellar infarction. Rev. Neurol. (Paris)144(10), 596–597 (1988).
   PubMedGoogle Scholar
• Thurim S, Yang WC, Rubinowitz H, Weinberger J. Primary pontine hemorrhage and the dysarthria–clumsy hand syndrome. Neurology32, 1027–1028 (1982).
   PubMedGoogle Scholar
• Seet RC, Lim EC. Dysarthria–clumsy hand syndrome associated with dengue type-2 infection. J. Neurol.254, 1129–1230 (2007).
   PubMedGoogle Scholar
• D’Olhaberriague L, Arboix A, Martí-Vilalta JL, Moral A, Massons J. Movement disorders in ischemic stroke: clinical study of 22 patients. Eur. J. Neurol.2, 553–557 (1995).
   PubMedGoogle Scholar
• Ghika-Schmid F, Ghika J, Regli F, Bogousslavsky J. Hyperkinetic movement disorders during and after acute stroke. The Lausanne Stroke Registry. J. Neurol. Sci.146, 109–116 (1997).
   PubMedGoogle Scholar
• Arboix A, Massons J, Oliveres M, Titus F. Isolated dysarthrya. Stroke22, 531 (1991).
   PubMedGoogle Scholar
• Kim JS, Pure dysarthria, isolated facial paresis or dysarthria–facial paresis syndrome. Stroke25, 1994–1998 (1994).
   PubMed Web of Science ®Google Scholar
• Luijckx GL, Boiten J, Lodder J, Heuts-van Raak L, Wilmink J. Isolated hemiataxia following supratentorial brain infarcts. J. Neurol. Neurosurg. Psychiatry57, 742–744 (1994).
   PubMedGoogle Scholar
• Arboix A, López-Grau M, Casasnovas C, García-Eroles L, Massons J, Balcells M. Clinical study of 39 patients with atypical lacunar syndrome. J. Neurol. Neurosurg. Psychiatry77, 381–384 (2006).
   PubMed Web of Science ®Google Scholar
• Besson G, Hommel M, Perret J. Risk factors for lacunar infarcts. Cerebrovasc. Dis.10, 387–390 (2000).
   PubMed Web of Science ®Google Scholar
• Kim JS, Kwon SU, Lee TG. Pure dysarthria due to small cortical stroke. Neurology60, 1178–1180 (2003).
   PubMedGoogle Scholar
• Luijckx GL, Boiten J, Lodder J, Wilmink J. Isolated hemiataxia caused by a small capsular hemorrhage. Cerebrovasc. Dis.3, 381–382 (1993).
   Google Scholar
• Erkinjuntti T. Subcortical vascular dementia. Cerebrovasc. Dis.13(Suppl 2), 58–60 (2002).
   PubMedGoogle Scholar
• Hachinski VC, Potter P, Merskey H. Leuko-araiosis. Arch. Neurol.44, 21–23 (1987).
   PubMedGoogle Scholar
• Ward NS, Brown MM. Leukoaraiosis. In: Subcortical Stroke (2nd Edition). Donnan G, Norrving B, Bamford J, Bogousslavsky J (Eds). Oxford University Press, New York, NY, USA 47–66 (2002).
   Google Scholar
• Mast H, Mohr JP. Binswanger’s disease and vascular dementia. In: Stroke. Pathophysiology, Diagnosis, and Management. Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PHA (Eds). Churchill Livingstone, PA, USA 679–686 (2004).
   Google Scholar
• Bennett DA, Wilson RS, Gilley DW, Fox JH. Clinical diagnosis of Binswanger disease. J. Neurol. Neurosurg. Psychiatry53, 961–965 (1990).
   PubMed Web of Science ®Google Scholar
• Erkinjuntti T, Inzitari D, Pantoni L et al. Research criteria for subcortical vascular dementia in clinical trials. J. Neural Transm. Suppl.59, 23–30 (2000).
   PubMedGoogle Scholar
• Tsiskaridze A, de Freitas GR, Uldry PA, Bogousslavsky J. Acute infarcts in the with matter medullary artery territory of the centrum ovale. In: Subcortical Stroke (2nd Edition). Donnan G, Norrving B, Bamford J, Bogousslavsky J (Eds). Oxford University Press, New York, NY, USA 47–66 (2002).
   Google Scholar
• Read SJ, Pettigrew L, Schimmel L et al. White matter medullary infarcts: acute subcortical infarction in the centrum ovale. Cerebrovasc. Dis.8, 289–295 (1998).
   PubMedGoogle Scholar
• Leys D, Mounier-Vehier F, Rondepierre PH et al. Small infarcts in the centrum ovale: study of predisposing factors. Cerebrovasc. Dis.4, 83–87 (1994).
   Google Scholar
• Yonemura K, Kimura K, Minematsu K, Uchino M, Yamaguchi T. Small centrum ovale infarcts on diffusion-weighted magnetic resonance imaging. Stroke33, 1541–1544 (2002).
   PubMedGoogle Scholar
• Krapf H, Widder B, Skalej M. Small rosarylike infarctions in the centrum semiovale suggest hemodynamic failure. Am. J. Neuroradiol.19, 1479–1484 (1998).
   PubMed Web of Science ®Google Scholar
• Lammie GA, Wardlaw JM. Small centrum ovale infarcts. A pathological study. Cerebrovasc. Dis.9, 82–90 (1999).
   PubMedGoogle Scholar
• Chabriat H, Vahedi K, Ina-Zizen MT et al. Clinical spectrum of CADASIL: a study of 7 families. Lancet346, 934–939 (1995).
   PubMed Web of Science ®Google Scholar
• Dichgans M. CADASIL: a monogenic condition causing stroke and subcortical vascular dementia. Cerebrovasc. Dis.13(Suppl. 2), 37–41 (2002).
   PubMedGoogle Scholar
• Razvi SS, Bone I. Single gene disorders causing ischaemic stroke. J. Neurol.253, 685–700 (2006).
   PubMed Web of Science ®Google Scholar
• Arboix A, García-Eroles L, Massons J, Oliveres M. Targa C. Hemorrhagic lacunar stroke. Cerebrovasc. Dis.10, 229–234 (2000).
   PubMed Web of Science ®Google Scholar
• Singer MB, Chong J, Lu D, Schonewille WJ, Tuhrim S, Atlas SW. Diffusion-weighted MRI in acute subcortical infarction. Stroke29, 133–136 (1998).
   PubMed Web of Science ®Google Scholar
• Schonewille WJ, Tuhrim S, Singer MB, Atlas SW. Diffusion-weighted MRI in acute lacunar syndromes. A clinical–radiological correlation study. Stroke30, 2066–2069 (1999).
   PubMed Web of Science ®Google Scholar
• Wen HM, Mok VC, Fan YH et al. Effect of white matter changes on cognitive impairment in patients with lacunar infarcts. Stroke35, 1826–1830 (2004).
   PubMed Web of Science ®Google Scholar
• Grau-Olivares M, Arboix A, Bartrés-Faz D, Junqué C. Higher severity of frontal periventricular white matter and basal ganglia hyperintensities in first-ever lacunar stroke with multiple silent lacunes. Eur. J. Neurol.15, 1002–1005 (2008).
   PubMedGoogle Scholar
• Kinoshita T, Okudera T, Tamura H, Ogawa T, Hatazawa J. Assessment of lacunar hemorrhage associated with hypertensive stroke by echo-planar gradient-echo T2*-weighted MRI. Stroke31, 1646–1650 (2000).
   PubMedGoogle Scholar
• Fiehler J. Cerebral microbleeds: old leaks and new haemorrhages. Int. J. Stroke1, 122–130 (2006).
   PubMed Web of Science ®Google Scholar
• Sweeny R, Cheng EM, Kidwell CHS et al. Incidence of intracranial large vessel disease in patients with radiologic lacunar stroke. Neurology52(Suppl. 2), 557 (1999).
   PubMedGoogle Scholar
• Thompson DW, Cruz S, Eichholz KM. Magnetic resonance angiography in patients with paramedian pontine infarcts and a lacunar syndrome. Neurology50, A215 (1998).
   Google Scholar
• Nikunan A, Barrick TR, Charlton RA, Clark CA, Markus HS. Multimodal MRI in cerebral small vessel disease. Its relation with cognition and sensitivity to change over time. Stroke39, 1999–2005 (2008).
   PubMedGoogle Scholar
• Kidwell CS, el-Saden S, Livshits Z, Martin NA, Glenn TC, Saber JL. Transcranial Doppler pulsatility indices as a measure of diffuse small-vessel disease. J. Neuroimaging11, 229–235 (2001).
   PubMedGoogle Scholar
• Chamorro A, Saiz A, Vila N et al. Contribution of arterial blood pressure to the clinical expression of lacunar infarction. Stroke27, 388–392 (1996).
   PubMedGoogle Scholar
• Molina C, Sabín JA, Montaner J, Rovira A, Abilleira S, Codina A. Impaired cerebrovascular reactivity as a risk marker for first-ever lacunar infarction. A case–control study. Stroke30, 2296–2301 (1999).
   PubMed Web of Science ®Google Scholar
• Kazui S, Levi CR, Jones EF, Quang L, Calfiore P, Donnan GA. Risk factors for lacunar stroke: a case–control transesophageal echocardiographic study. Neurology54, 1385–1387 (2000).
   PubMedGoogle Scholar
• Kazui S, Levi CR, Jones EF, Quang L, Calafiore P, Donnan GA. Lacunar stroke: transoesophageal echocardiographic factors influencing long-term prognosis. Cerebrovasc. Dis.12, 325–330 (2001).
   PubMedGoogle Scholar
• Tonk M, Haan J. A review of genetic causes of ischemic and hemorrhagic stroke. J. Neurol. Sci.257, 273–279 (2007).
   PubMed Web of Science ®Google Scholar
• Dichgans M. Genetics of ischaemic stroke. Lancet Neurol.6, 149–161 (2007).
   PubMed Web of Science ®Google Scholar
• Micheli S, Agnelli MS, Palmerini F et al. Need for extensive diagnostic work-up for patients with lacunar stroke. J. Neurol.255, 637–642 (2008).
   PubMedGoogle Scholar
• Baumgartner RW, Sidler C, Mosso M, Georgiadis D. Ischemic lacunar stroke in patients with and without potential mechanism other than small-artery disease. Stroke34, 653–659 (2003).
   PubMed Web of Science ®Google Scholar
• Steinke W, Ley SC. Lacunar stroke is the major cause of progressive motor deficits. Stroke33, 1510–1516 (2002).
   PubMed Web of Science ®Google Scholar
• Nakamura K, Saku Y, Ibayashi S, Fujishima M. Progressive motor deficits in lacunar infarction. Neurology52, 29–33 (1999).
   PubMedGoogle Scholar
• Serena J, Leira R, Castillo J, Pumar JM, Castellanos M, Davalos A. Neurological deterioration in acute lacunar infarctions. The role of excitatory and inhibitory neurotransmitters. Stroke32, 1154–1161 (2001).
   PubMedGoogle Scholar
• Audebert HJ, Pelikofer TS, Wimmer ML, Haberl RL. Progression in lacunar stroke is related to elevated acute phase parameters. Eur. Neurol.51, 125–131 (2004).
   PubMedGoogle Scholar
• Jackson C, Sudlow C. Are lacunar strokes really different? A systematic review of difference in risk factor profiles between lacunar and nonlacunar infarcts. Stroke36, 891–901 (2005).
   PubMed Web of Science ®Google Scholar
• Arboix A, Martí-Vilalta JL. Infartos cerebrales de tipo lacunar en pacientes jóvenes. Neurología5, 192–195 (1990).
   PubMedGoogle Scholar
• Bejot Y, Catteau A, Caillier M et al. Trends in incidence, risk factors, and survival in symptomatic lacunar stroke in Dijon, France, from 1989 to 2006. A population-based study. Stroke39, 1945–1951 (2008).
   PubMed Web of Science ®Google Scholar
• Staals J, van Raak L, Hilton A, Lodder J. Differences in long-term survival in two lacunar stroke types: a 15-year follow-up study in 782 cerebral infarct patients. Cerebrovasc. Dis.25, 26–31 (2008).
   PubMedGoogle Scholar
• Jackson C, Sudlow C. Comparing risks of death and recurrent vascular events between lacunar and non-lacunar infarction. Brain128, 2507–2517 (2005).
   PubMedGoogle Scholar
• Salgado AV, Ferro JM, Gouveia-Oliveira A. Long-term prognosis of first-ever lacunar infarction. A hospital-based study. Stroke27, 661–666 (1996).
   PubMed Web of Science ®Google Scholar
• Sacco S, Marini C, Totaro B, Russo T, Cerone D, Carolei A. A population-based study of the incidence and prognosis of lacunar stroke. Neurology66, 1335–1338 (2006).
   PubMed Web of Science ®Google Scholar
• Arauz A, Murillo L, Cantú C, Barinagarrementería F, Higuera J. Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging. Risk factors, recurrence, and outcome in 175 consecutive cases. Stroke34, 2453–2458 (2003).
   PubMedGoogle Scholar
• Arboix A, Font A, Garro C, Comes E, Massons J. Recurrent lacunar infarction following a previous lacunar stroke: a clinical study of 122 patients. J. Neurol. Neurosurg. Psychiatry78, 1392–1394 (2007).
   PubMed Web of Science ®Google Scholar
• Appelros P, Samuelsson M, Lindell D. Lacunar infarcts: functional and cognitive outcomes at five years in relation to MRI findings. Cerebrovasc. Dis.20, 34–40 (2005).
   PubMed Web of Science ®Google Scholar
• Tatemichi TK, Desmond DW, Prohovnik I et al. Confusion and memory loss from capsular genu infarction: a thalamocortical disconnection syndrome? Neurology42, 1966–1979 (1992).
   PubMed Web of Science ®Google Scholar
• Schneider A, Gutbrod K, Hess CW, Schroth G. Memory without context: amnesia with confabulations after infarction of the right capsular genu. J. Neurol. Neurosurg. Psychiatry61, 186–193 (1996).
   PubMedGoogle Scholar
• Gold G, Kövari E, Herrmann FR et al. Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia. Stroke36, 1184–1188 (2005).
   PubMed Web of Science ®Google Scholar
• Grau-Olivares M, Arboix A, Bartrés-Faz D, Junqué C. Neuropsychological abnormalities associated with lacunar infarction. J. Neurol. Sci.257, 160–165 (2007).
   PubMed Web of Science ®Google Scholar
• Mok VC, Wong A, Lan WW, Baum LW, Ng HK, Wong L. A case–controlled study of cognitive progression in chinese lacunar stroke patients. Clin. Neurol. Neurosurg.110, 649–656 (2008).
   PubMedGoogle Scholar
• Yamamoto Y, Akiguchi I, Oiwa K et al. Twenty-four hour blood pressure and MRI as predictive factors for different outcomes in patients with lacunar infarct. Stroke33, 2072–2076 (2002).
   PubMedGoogle Scholar
• Roman GC, Erkinjuntti T, Wallin A, Pantoni L, Chui HC. Subcortical ischaemic vascular dementia. Lancet Neurol.1, 426–436 (2002).
   PubMed Web of Science ®Google Scholar
• Wen HM, Mok VCT, Fan YH et al. Effect of white matter changes on cognitive impairment in patients with lacunar infarcts. Stroke35, 1826–1830 (2004).
   PubMed Web of Science ®Google Scholar
• Snowdon DA, Greiner LH, Mortimer JA. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA277, 813–817 (1997).
   PubMed Web of Science ®Google Scholar
• Lafosse JM, Reed BR, Mungas D, Starling SB, Wahbeh H, Jagust WJ. Fluency and memory differences between ischemic vascular dementia and Alzheimer’s disease. Neuropsychology11, 514–522 (1997).
   PubMed Web of Science ®Google Scholar
• Grau-Olivares M, Bartrés-Faz D, Arboix A et al. Mild cognitive impairment after lacunar infarction: voxel-based morphometry and neuropsychological assessment. Cerebrovasc. Dis.23, 353–361 (2007).
   PubMed Web of Science ®Google Scholar
• Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and the risk of dementia and cognitive decline. N. Engl. J. Med.348, 1215–1222 (2003).
   PubMed Web of Science ®Google Scholar
• Van Zagten M, Boiten J, Kessels F, Lodder J. Significant progression of white matter lesions and small deep (lacunar) infarcts in patients with stroke. Arch. Neurol.53, 650–655 (1996).
   PubMed Web of Science ®Google Scholar
• Van Dijk EJ, Prins ND, Vrooman HA, Hofman A, Koudstaal PJ, Breteler MM. Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences. Rotterdam Scan Study. Stroke39, 2712–2719 (2008).
   PubMed Web of Science ®Google Scholar
• Wardlaw JM, Sandercock PAG, Dennis MS, Starr J. Is breakdown of the blood–brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke34, 806–812 (2003).
   PubMed Web of Science ®Google Scholar
• Gouw AA, van der Flier WM, Fazekas F et al. Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study. Stroke39, 1414–1420 (2008).
   PubMed Web of Science ®Google Scholar
• The European Stroke Organisation (ESO) Executive Committee and the ESO Writing Committee. Guidelines for management of ischemic stroke and transient ischemic attack 2008. Cerebrovasc. Dis.25, 457–507 (2008).
   PubMed Web of Science ®Google Scholar
• Romano JG, Sacco RL. Progress in secondary stroke prevention. Ann. Neurol.63, 418–427 (2008).
   PubMedGoogle Scholar
• Frey JL, Snider RM, Jahnke H, Stoane J. rt-PA in lacunar infarction. Neurology50, 406 (1998).
   Google Scholar
• Cocho D, Belvis R, Martí-Fàbregas JM et al. Does thrombolysis benefit patients with lacunar syndrome?. Eur. Neurol.55, 70–73 (2006).
   PubMedGoogle Scholar
• Rashid P, Leonardi-Bee J, Bath P. Blood pressure reduction and secondary prevention of stroke and other vascular events: a systematic review. Stroke34, 2741–2748 (2003).
   PubMed Web of Science ®Google Scholar
• Dufouil C, Mazoyer B, Chalmers J, Tzourio C. Effects of blood pressure lowering on incidence of cerebral with matter lesions in patients with stroke. Neurology62, A172 (2004).
   PubMedGoogle Scholar
• Dufouil C, Chalmers J, Coskun O et al. Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: the PROGRESS (Perindopril Protection Against Recurrent Stroke Study) magnetic resonance imaging substudy. Circulation112, 1644–1650 (2005).
   PubMed Web of Science ®Google Scholar
• Wilcox R, Bousser MG, Betteridge DJ et al. Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: results from PROactive (PRO-spective pioglitAzone Clinical Trial in macroVascular Events 04). Stroke38, 865–873 (2007).
   PubMed Web of Science ®Google Scholar