332
Views
35
CrossRef citations to date
0
Altmetric
Original Research

Protective efficacy of two novel DNA vaccines expressing Toxoplasma gondii rhomboid 4 and rhomboid 5 proteins against acute and chronic toxoplasmosis in mice

, , , , , & show all

References

  • Dubey JP. Toxoplasmosis of animals and humans. CRC Press, Inc; Boca Raton, New York: 2010, p. 1-313
  • Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet 2004;363:1965-76
  • Weiss LM, Dubey JP. Toxoplasmosis: a history of clinical observations. Int J Parasitol 2009;39:895-901
  • Fayer R, Dubey JP, Lindsay DS. Zoonotic protozoa: from land to sea. Trends Parasitol 2004;20:531-6
  • Dubey JP, Hill DE, Jones JL, et al. Prevalence of viable Toxoplasma gondii in beef, chicken, and pork from retail meat stores in the United States: risk assessment to consumers. J Parasitol 2005;91:1082-93
  • Zhang NZ, Chen J, Wang M, et al. Vaccines against Toxoplasma gondii: new developments and perspectives. Expert Rev Vaccines 2013;12:1287-99
  • Buxton D, Thomson K, Maley S, et al. Vaccination of sheep with a live incomplete strain (S48) of Toxoplasma gondii and their immunity to challenge when pregnant. Vet Rec 1991;129:89-93
  • Gurunathan S, Klinman DM, Seder RA. DNA vaccines: immunology, application, and optimization. Annu Rev Immunol 2000;18:927-74
  • Hoft DF, Eickhoff CS, Giddings OK, et al. Trans-sialidase recombinant protein mixed with CpG motif-containing oligodeoxynucleotide induces protective mucosal and systemic Trypanosoma cruzi immunity involving CD8+ CTL and B cell-mediated cross-priming. J Immunol 2007;179:6889-900
  • Xenopoulos A, Pattnaik P. Production and purification of plasmid DNA vaccines: is there scope for further innovation? Expert Rev Vaccines 2014;13:1537-51
  • Hoffman SL, Doolan DL, Sedegah M, et al. Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use. Vaccine 1997;15:842-5
  • Chen J, Huang SY, Zhou DH, et al. DNA immunization with eukaryotic initiation factor-2α of Toxoplasma gondii induces protective immunity against acute and chronic toxoplasmosis in mice. Vaccine 2013;31:6225-31
  • Zhang NZ, Huang SY, Zhou DH, et al. Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3. BMC Infect Dis 2013;13:512
  • Chen J, Li ZY, Petersen E, et al. DNA vaccination with genes encoding Toxoplasma gondii antigens ROP5 and GRA15 induces protective immunity against toxoplasmosis in Kunming mice. Expert Rev Vaccines 2015;14:489-92
  • Dowse TJ, Soldati D. Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature. Trends Parasitol 2005;21:254-8
  • Dowse TJ, Soldati D. Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis. Curr Opin Microbiol 2004;7:388-96
  • Brossier F, Jewett TJ, Sibley LD, Urban S. A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma. Proc Natl Acad Sci USA 2005;102:4146-51
  • Buguliskis JS, Brossier F, Shuman J, Sibley LD. Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii. PLoS Pathog 2010;6:e1000858
  • Chen J, Huang SY, Li ZY, et al. Protective immunity induced by a DNA vaccine expressing eIF4A of Toxoplasma gondii against acute toxoplasmosis in mice. Vaccine 2013;25:1734-9
  • Zhang NZ, Huang SY, Xu Y, et al. Evaluation of immune responses in mice after DNA immunization with putative Toxopalsma gondii calcium-dependent protein kinase 5. Clin Vaccine Immunol 2014;21:924-9
  • Dowse TJ, Pascall JC, Brown KD, Soldati D. Apicomplexan rhomboids have a potential role in microneme protein cleavage during host cell invasion. Intl J Parasitol 2005;35:747-56
  • Kim K. Role of proteases in host cell invasion by Toxoplasma gondii and other Apicomplexa. Acta Trop 2004;91:69-81
  • Dowse TJ, Koussis K, Blackman MJ, Soldati-Favre D. Roles of proteases during invasion and egress by Plasmodium and Toxoplasma. Subcell Biochem 2008;47:121-39
  • Li J, Han Q, Gong P, et al. Toxoplasma gondii rhomboid protein 1 (TgROM1) is a potential vaccine candidate against toxoplasmosis. Vet Parasit 2012;184:154-60
  • Bessieres MH, Swierczynski B, Cassaing S, et al. Role of IFN-gamma, TNF-alpha, IL-4 and IL-10 in the regulation of experimental Toxoplasma gondii infection. J Eukaryot Microbiol 1997;44:87S
  • Sturge CR, Benson A, Raetz M, et al. TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens. Proc Natl Acad Sci USA 2013;110:10711-16
  • Sánchez-Valdéz FJ, Pérez Brandán C, Ferreira A, Basombrío MA. Gene-deleted live-attenuated Trypanosoma cruzi parasites as vaccines to protect against Chagas disease. Expert Rev Vaccines 2014;11:1-17
  • Scott P & Trinchieri G. The role of natural killer cells in host-parasite interactions. Curr Opin Immunol 1995;14:466-70
  • Denkers EY, Gazzinelli RT. Regulation and function of T-Cell-Mediated immunity during Toxoplasma gondii infection. Clin Microbiol Rev 1998;11:569-88
  • Sibley LD. Invasion and intracellular survival by protozoan parasites. Immunol Rev 2011;240:72-91
  • Gazzinelli R, Xu Y, Hieny S, et al. Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol 1992;149:175-80
  • Sayles PC, Gibson GW, Johnson LL. B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii. Infect Immun 2000;68:1026-33

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.