Progress toward norovirus vaccines: considerations for further development and implementation in potential target populations

References

• Ahmed SM , Hall AJ , Robinson AE , et al. Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis. Lancet Infect Dis 2014;14(8):725-30
   PubMed Web of Science ®Google Scholar
• Patel MM , Widdowson MA , Glass RI , et al. Systematic literature review of role of noroviruses in sporadic gastroenteritis. Emerg Infect Dis 2008;14(8):1224-31
   PubMed Web of Science ®Google Scholar
• Lanata CF , Fischer-Walker CL , Olascoaga AC , et al. Global causes of diarrheal disease mortality in children <5 years of age: a systematic review. PLoS One 2013;8(9):e72788
   PubMed Web of Science ®Google Scholar
• Hall AJ , Rosenthal M , Gregoricus N , et al. Incidence of acute gastroenteritis and role of norovirus. Georgia, USA, 2004-2005. Emerg Infect Dis 2011;17(8):1381-8
   PubMed Web of Science ®Google Scholar
• Scallan E , Hoekstra RM , Angulo FJ , et al. Foodborne illness acquired in the United States–major pathogens. Emerg Infect Dis 2011;17(1):7-15
   PubMed Web of Science ®Google Scholar
• Lopman BA , Hall AJ , Curns AT , Parashar UD . Increasing rates of gastroenteritis hospital discharges in US adults and the contribution of norovirus, 1996-2007. Clin Infect Dis 2011;52(4):466-74
   PubMed Web of Science ®Google Scholar
• Hall AJ , Curns AT , McDonald LC , et al. The roles of clostridium difficile and norovirus among gastroenteritis-associated deaths in the United States, 1999-2007. Clin Infect Dis 2012;55(2):216-23
   PubMed Web of Science ®Google Scholar
• Gastanaduy PA , Hall AJ , Curns AT , et al. Burden of norovirus gastroenteritis in the ambulatory setting–United States, 2001-2009. J Infect Dis 2013;207(7):1058-65
   PubMed Web of Science ®Google Scholar
• Batz MB , Hoffmann S , Morris JG Jr . Ranking the disease burden of 14 pathogens in food sources in the United States using attribution data from outbreak investigations and expert elicitation. J Food Prot 2012;75(7):1278-91
   PubMed Web of Science ®Google Scholar
• Hall AJ , Lopman BA , Payne DC , et al. Norovirus disease in the United States. Emerg Infect Dis 2013;19(8):1198-205
   PubMed Web of Science ®Google Scholar
• Bresee JS , Marcus R , Venezia RA , et al. The etiology of severe acute gastroenteritis among adults visiting emergency departments in the United States. J Infect Dis 2012;205(9):1374-81
   PubMed Web of Science ®Google Scholar
• Bruggink LD , Dunbar NL , Marshall JA . Norovirus genotype diversity in community-based sporadic gastroenteritis incidents: A five-year study. J Med Virol 2015;87(6):961-9
   PubMed Web of Science ®Google Scholar
• Saupe AA , Kaehler D , Cebelinski EA , et al. Norovirus surveillance among callers to foodborne illness complaint hotline, Minnesota, USA, 2011-2013. Emerg Infect Dis 2013;19(8):1293-6
   PubMed Web of Science ®Google Scholar
• Patel MM , Hall AJ , Vinje J , Parashar UD . Noroviruses: a comprehensive review. J Clin Virol 2009;44(1):1-8
   PubMed Web of Science ®Google Scholar
• Hall AJ , Wikswo ME , Pringle K , et al. Vital signs: foodborne norovirus outbreaks - United States, 2009-2012. MMWR Morb Mortal Wkly Rep 2014;63(22):491-5
   PubMed Web of Science ®Google Scholar
• Hall AJ , Wikswo ME , Manikonda K , et al. Acute gastroenteritis surveillance through the National Outbreak Reporting System, United States. Emerg Infect Dis 2013;19(8):1305-9
   PubMed Web of Science ®Google Scholar
• Richardson C , Bargatze RF , Goodwin R , Mendelman PM . Norovirus virus-like particle vaccines for the prevention of acute gastroenteritis. Expert Rev Vaccines 2013;12(2):155-67
   PubMed Web of Science ®Google Scholar
• Atmar RL , Estes MK . Norovirus vaccine development: next steps. Expert Rev Vaccines 2012;11(9):1023-5
   PubMed Web of Science ®Google Scholar
• Teunis PF , Moe CL , Liu P , et al. Norwalk virus: how infectious is it? J Med Virol 2008;80(8):1468-76
   PubMed Web of Science ®Google Scholar
• Atmar RL , Opekun AR , Gilger MA , et al. Determination of the 50% human infectious dose for norwalk virus. J Infect Dis 2014;209(7):1016-22
   PubMed Web of Science ®Google Scholar
• Glass RI , Parashar UD , Estes MK . Norovirus gastroenteritis. N Engl J Med 2009;361(18):1776-85
   PubMed Web of Science ®Google Scholar
• Mattner F , Sohr D , Heim A , et al. Risk groups for clinical complications of norovirus infections: an outbreak investigation. Clin Microbiol Infect 2006;12(1):69-74
   PubMed Web of Science ®Google Scholar
• Bok K , Green KY . Norovirus gastroenteritis in immunocompromised patients. The New England j med 2012;367(22):2126-32
   PubMed Web of Science ®Google Scholar
• Rocha-Pereira J , Neyts J , Jochmans D . Norovirus: targets and tools in antiviral drug discovery. Biochem Pharmacol 2014;91(1):1-11
   PubMed Web of Science ®Google Scholar
• Hall AJ VJ , Lopman BA , Park GW , et al. Update norovirus outbreak management and disease prevention guidelines. MMWR Morb Mortal Wkly Rep 2011;60(RR03):1-15
   Google Scholar
• Atmar RL , Opekun AR , Gilger MA , et al. Norwalk virus shedding after experimental human infection. Emerg Infect Dis 2008;14(10):1553-7
   PubMed Web of Science ®Google Scholar
• Lopman B , Gastanaduy P , Park GW , et al. Environmental transmission of norovirus gastroenteritis. Curr Opin Virol 2012;2(1):96-102
   PubMed Web of Science ®Google Scholar
• Payne DC , Vinje J , Szilagyi PG , et al. Norovirus and medically attended gastroenteritis in US. children. N Engl J Med 2013;368(12):1121-30
   PubMed Web of Science ®Google Scholar
• Hemming M , Rasanen S , Huhti L , et al. Major reduction of rotavirus, but not norovirus, gastroenteritis in children seen in hospital after the introduction of RotaTeq vaccine into the National Immunization Programme in Finland. Eur J Pediatr 2013;172(6):739-46
   PubMed Web of Science ®Google Scholar
• Phillips G , Tam CC , Conti S , et al. Community incidence of norovirus-associated infectious intestinal disease in England: improved estimates using viral load for norovirus diagnosis. Am J Epidemiol 2010;171(9):1014-22
   PubMed Web of Science ®Google Scholar
• Rockx B , De Wit M , Vennema H , et al. Natural history of human calicivirus infection: a prospective cohort study. Clin Infect Dis 2002;35(3):246-53
   PubMed Web of Science ®Google Scholar
• Saito M , Goel-Apaza S , Espetia S , et al. Multiple norovirus infections in a birth cohort in a Peruvian periurban community. Clin Infect Dis 2014;58(4):483-91
   PubMed Web of Science ®Google Scholar
• Simmons K , Gambhir M , Leon J , Lopman B . Duration of immunity to norovirus gastroenteritis. Emerg Infect Dis 2013;19(8):1260-7
   PubMed Web of Science ®Google Scholar
• Hickman D , Jones MK , Zhu S , et al. The effect of malnutrition on norovirus infection. mBio 2014;5(2):e01032-13
   PubMed Web of Science ®Google Scholar
• Trivedi TK , Desai R , Hall AJ , et al. Clinical characteristics of norovirus-associated deaths: a systematic literature review. Am J Infect Control 2013;41(7):654-7
   PubMed Web of Science ®Google Scholar
• Verhoef L , Koopmans M , Vanp W , et al. The estimated disease burden of norovirus in The Netherlands. Epidemiol Infect 2013;141(3):496-506
   PubMed Web of Science ®Google Scholar
• Harris JP , Edmunds WJ , Pebody R , et al. Deaths from norovirus among the elderly, England and Wales. Emerg Infect Dis 2008;14(10):1546-52
   PubMed Web of Science ®Google Scholar
• Kambhampati A , Koopmans M , Lopman BA . Burden of norovirus in healthcare facilities and strategies for outbreak control. J Hosp Infect 2015;89(4):296-301
   PubMed Web of Science ®Google Scholar
• Desai R , Hembree CD , Handel A , et al. Severe outcomes are associated with genogroup 2 genotype 4 norovirus outbreaks: a systematic literature review. Clin Infect Dis 2012;55(2):189-93
   PubMed Web of Science ®Google Scholar
• Trivedi TK , DeSalvo T , Lee L , et al. Hospitalizations and mortality associated with norovirus outbreaks in nursing homes, 2009-2010. Jama 2012;308(16):1668-75
   PubMed Web of Science ®Google Scholar
• Ajami NJ , Kavanagh OV , Ramani S , et al. Seroepidemiology of norovirus-associated travelers’ diarrhea. J Travel Med 2014;21(1):6-11
   PubMed Web of Science ®Google Scholar
• Ajami N , Koo H , Darkoh C , et al. Characterization of norovirus-associated traveler’s diarrhea. Clin Infect Dis 2010;51(2):123-30
   PubMed Web of Science ®Google Scholar
• Koo HL , Ajami NJ , Jiang ZD , et al. Noroviruses as a cause of diarrhea in travelers to Guatemala, India, and Mexico. J Clin Microbiol 2010;48(5):1673-6
   PubMed Web of Science ®Google Scholar
• Zlot A , Simckes M , Vines J , et al. Norovirus outbreak associated with a natural lake used for recreation - Oregon, 2014. MMWR Morb Mortal Wkly Rep 2015;64(18):485-90
   PubMed Web of Science ®Google Scholar
• Wikswo ME , Hall AJ , Centers for Disease C . Prevention. Outbreaks of acute gastroenteritis transmitted by person-to-person contact–United States, 2009-2010. MMWR Surveill Summ 2012;61(9):1-12
   PubMedGoogle Scholar
• Matthews JE , Dickey BW , Miller RD , et al. The epidemiology of published norovirus outbreaks: a review of risk factors associated with attack rate and genogroup. Epidemiol Infect 2012;140(7):1161-72
   PubMed Web of Science ®Google Scholar
• Verhoef L , Depoortere E , Boxman I , et al. Emergence of new norovirus variants on spring cruise ships and prediction of winter epidemics. Emerg Infect Dis 2008;14(2):238-43
   PubMed Web of Science ®Google Scholar
• Kirking HL , Cortes J , Burrer S , et al. Likely transmission of norovirus on an airplane, October 2008. Clinical infectious diseases : an official publication of the Infectious. Clin Infect Dis 2010;50(9):1216-21
   PubMed Web of Science ®Google Scholar
• Riddle MS , Sanders JW , Putnam SD , Tribble DR . Incidence, etiology, and impact of diarrhea among long-term travelers (US military and similar populations): a systematic review. Am J Trop Med Hyg 2006;74(5):891-900
   PubMed Web of Science ®Google Scholar
• Thornton SA , Sherman SS , Farkas T , et al. Gastroenteritis in US Marines during operation Iraqi freedom. Clin Infect Dis 2005;40(4):519-25
   PubMed Web of Science ®Google Scholar
• Aronson NE , Sanders JW , Moran KA . In harm’s way: infections in deployed American military forces. Clin Infect Dis 2006;43(8):1045-51
   PubMed Web of Science ®Google Scholar
• Ye X , Van JN , Munoz FM , et al. Noroviruses as a cause of diarrhea in immunocompromised pediatric hematopoietic stem cell and solid organ transplant recipients. Am J Transplant 2015;15(7):1874-81
   PubMed Web of Science ®Google Scholar
• Woodward JM , Gkrania-Klotsas E , Cordero-Ng AY , et al. The role of chronic norovirus infection in the enteropathy associated with common variable immunodeficiency. Am J Gastroenterol 2015;110(2):320-7
   PubMed Web of Science ®Google Scholar
• Hoffmann D , Hutzenthaler M , Seebach J , et al. Norovirus GII.4 and GII.7 capsid sequences undergo positive selection in chronically infected patients. Infect Genet Evol 2012;12(2):461-6
   PubMed Web of Science ®Google Scholar
• Vega E , Donaldson E , Huynh J , et al. RNA populations in immunocompromised patients as reservoirs for novel norovirus variants. J Virol 2014;88(24):14184-96
   PubMed Web of Science ®Google Scholar
• Munir N , Liu P , Gastanaduy P , et al. Norovirus infection in immunocompromised children and children with hospital-acquired acute gastroenteritis. J Med Virol 2014;86(7):1203-9
   PubMed Web of Science ®Google Scholar
• Hall AJ , Eisenbart VG , Etingue AL , et al. Epidemiology of foodborne norovirus outbreaks, United States, 2001-2008. Emerg Infect Dis 2012;18(10):1566-73
   PubMed Web of Science ®Google Scholar
• Fankhauser RL , Monroe SS , Noel JS , et al. Epidemiologic and molecular trends of "Norwalk-like viruses" associated with outbreaks of gastroenteritis in the United States. J Infect Dis 2002;186(1):1-7
   PubMed Web of Science ®Google Scholar
• Meakins SM , Adak GK , Lopman BA , O’Brien SJ . General outbreaks of infectious intestinal disease (IID) in hospitals, England and Wales, 1992-2000. J Hosp Infect 2003;53(1):1-5
   PubMed Web of Science ®Google Scholar
• Bruggink LD , Oluwatoyin O , Sameer R , et al. Molecular and epidemiological features of gastroenteritis outbreaks involving genogroup I norovirus in Victoria, Australia, 2002-2010. J Med Virol 2012;84(9):1437-48
   PubMed Web of Science ®Google Scholar
• Kroneman A , Verhoef L , Harris J , et al. Analysis of integrated virological and epidemiological reports of norovirus outbreaks collected within the Foodborne Viruses in Europe network from 1 July 2001 to 30 June 2006. J Clin Microbiol 2008;46(9):2959-65
   PubMed Web of Science ®Google Scholar
• Sukhrie FH , Teunis P , Vennema H , et al. Nosocomial transmission of norovirus is mainly caused by symptomatic cases. Clin Infect Dis 2012;54(7):931-7
   PubMed Web of Science ®Google Scholar
• Kapikian AZ , Wyatt RG , Dolin R , et al. Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious nonbacterial gastroenteritis. J Virol 1972;10(5):1075-81
   PubMed Web of Science ®Google Scholar
• Vinje J . Advances in laboratory methods for detection and typing of norovirus. J Clin Microbiol 2015;53(2):373-81
   PubMed Web of Science ®Google Scholar
• Kroneman A , Vega E , Vennema H , et al. Proposal for a unified norovirus nomenclature and genotyping. Arch Virol 2013;158(10):2059-68
   PubMed Web of Science ®Google Scholar
• Jiang X , Wang M , Graham DY , Estes MK . Expression, self-assembly, and antigenicity of the Norwalk virus capsid protein. J Virol 1992;66(11):6527-32
   PubMed Web of Science ®Google Scholar
• Jones MK , Watanabe M , Zhu S , et al. Enteric bacteria promote human and mouse norovirus infection of B cells. Science 2014;346(6210):755-9
   PubMed Web of Science ®Google Scholar
• Hoa Tran TN , Trainor E , Nakagomi T , et al. Molecular epidemiology of noroviruses associated with acute sporadic gastroenteritis in children: global distribution of genogroups, genotypes and GII.4 variants. J Clin Virol 2013;56(3):185-93
   PubMed Web of Science ®Google Scholar
• Vega E , Barclay L , Gregoricus N . Genotypic and epidemiologic trends of norovirus outbreaks in the United States, 2009 to 2013. J Clin Microbiol 2014;52(1):147-55
   PubMed Web of Science ®Google Scholar
• Siebenga JJ , Vennema H , Zheng DP , et al. Norovirus illness is a global problem: emergence and spread of norovirus GII.4 variants, 2001-2007. J Infect Dis 2009;200(5):802-12
   PubMed Web of Science ®Google Scholar
• Debbink K , Lindesmith LC , Donaldson EF , et al. Emergence of new pandemic GII.4 Sydney norovirus strain correlates with escape from herd immunity. J Infect Dis 2013;208(11):1877-87
   PubMed Web of Science ®Google Scholar
• van Beek J , Ambert-Balay K , Botteldoorn N , et al. Indications for worldwide increased norovirus activity associated with emergence of a new variant of genotype II.4, late 2012. Euro Surveill 2013;18(1):8-9
   PubMedGoogle Scholar
• Sakon N , Yamazaki K , Nakata K , et al. Impact of genotype-specific herd immunity on the circulatory dynamism of norovirus: a 10-year longitudinal study of viral acute gastroenteritis. J Infect Dis 2015;211(6):879-88
   PubMed Web of Science ®Google Scholar
• Donaldson EF , Lindesmith LC , Lobue AD , Baric RS . Norovirus pathogenesis: mechanisms of persistence and immune evasion in human populations. Immunol Rev 2008;225:190-211
   PubMed Web of Science ®Google Scholar
• Lindesmith LC , Donaldson EF , Baric RS . Norovirus GII.4 strain antigenic variation. J Virol 2011;85(1):231-42
   PubMed Web of Science ®Google Scholar
• Cannon JL , Lindesmith LC , Donaldson EF , et al. Herd immunity to GII.4 noroviruses is supported by outbreak patient sera. J virol 2009;83(11):5363-74
   PubMed Web of Science ®Google Scholar
• Lindesmith LC , Beltramello M , Donaldson EF , et al. Immunogenetic mechanisms driving norovirus GII.4 antigenic variation. PLoS Pathog 2012;8(5):e1002705
   PubMed Web of Science ®Google Scholar
• Huhti L , Blazevic V , Puustinen L , et al. Genetic analyses of norovirus GII.4 variants in Finnish children from 1998 to 2013. Infect Genet Evol 2014;26:65-71
   PubMed Web of Science ®Google Scholar
• Leshem E , Barclay L , Wikswo M , et al. Genotype GI.6 norovirus, United States, 2010-2012. Emerg Infect Dis 2013;19(8):1317-20
   PubMed Web of Science ®Google Scholar
• Ahmed SF , Klena JD , Mostafa M , et al. Viral gastroenteritis associated with genogroup II norovirus among US. military personnel in Turkey, 2009. PloS One 2012;7(5):e35791
   PubMed Web of Science ®Google Scholar
• Fu J , Ai J , Jin M , et al. Emergence of a new GII.17 norovirus variant in patients with acute gastroenteritis in Jiangsu, China, September 2014 to March 2015. Euro Surveill 2015;20:24
   PubMedGoogle Scholar
• Lu J , Sun L , Fang L , et al. Gastroenteritis Outbreaks Caused by Norovirus GII.17, Guangdong Province, China, 2014-2015. Emerg Infect Dis 2015;21(7):1240-2
   PubMed Web of Science ®Google Scholar
• Lindesmith L , Moe C , Marionneau S , et al. Human susceptibility and resistance to Norwalk virus infection. Nat med 2003;9(5):548-53
   PubMed Web of Science ®Google Scholar
• Frenck R , Bernstein DI , Xia M , et al. Predicting susceptibility to norovirus GII.4 by use of a challenge model involving humans. J Infect Dis 2012;206(9):1386-93
   PubMed Web of Science ®Google Scholar
• Yazawa S , Yokobori T , Ueta G , et al. Blood group substances as potential therapeutic agents for the prevention and treatment of infection with noroviruses proving novel binding patterns in human tissues. PLoS ONE 2004;9(2):e89071
   Web of Science ®Google Scholar
• Thorven M , Grahn A , Hedlund KO , et al. A homozygous nonsense mutation (428G–>A) in the human secretor (FUT2) gene provides resistance to symptomatic norovirus (GGII) infections. J virol 2005;79(24):15351-5
   PubMed Web of Science ®Google Scholar
• Currier RL , Payne DC , Staat MA , et al. Innate susceptibility to norovirus infections influenced by FUT2 genotype in a united states pediatric population. Clin Infect Dis 2015;60(11):1631-8
   PubMed Web of Science ®Google Scholar
• Lopman BA , Trivedi T , Vicuna Y , et al. Norovirus infection and disease in an Ecuadorian birth cohort: Association of certain norovirus genotypes with host FUT2 secretor status. J Infect Dis 2015;211(11):1813-21
   PubMed Web of Science ®Google Scholar
• Murakami K , Kurihara C , Oka T , et al. Norovirus binding to intestinal epithelial cells is independent of histo-blood group antigens. PLoS One 2013;8(6):e66534
   PubMed Web of Science ®Google Scholar
• Ryder RW , Singh N , Reeves WC , et al. Evidence of immunity induced by naturally acquired rotavirus and Norwalk virus infection on two remote Panamanian islands. J Infect Dis 1985;151(1):99-105
   PubMed Web of Science ®Google Scholar
• Nurminen K , Blazevic V , Huhti L , et al. Prevalence of norovirus GII-4 antibodies in Finnish children. J Med Virol 2011;83(3):525-31
   PubMed Web of Science ®Google Scholar
• Lew JF , Valdesuso J , Vesikari T , et al. Detection of norwalk virus or norwalk-like virus infections in finnish infants and young children. J Infect Dis 1994;169(6):1364-7
   PubMed Web of Science ®Google Scholar
• Malm M , Uusi-Kerttula H , Vesikari T , Blazevic V . High serum levels of norovirus genotype-specific blocking antibodies correlate with protection from infection in children. J Infect Dis 2014;210(11):1755-62
   PubMed Web of Science ®Google Scholar
• Parker SP , Cubitt WD , Jiang XJ , Estes MK . Seroprevalence studies using a recombinant Norwalk virus protein enzyme immunoassay. J Med Virol 1994;42(2):146-50
   PubMed Web of Science ®Google Scholar
• Johnson PC , Mathewson JJ , DuPont HL , Greenberg HB . Multiple-challenge study of host susceptibility to Norwalk gastroenteritis in US adults. J Infect Dis 1990;161(1):18-21
   PubMed Web of Science ®Google Scholar
• Reeck A , Kavanagh O , Estes MK , et al. Serological correlate of protection against norovirus-induced gastroenteritis. J Infect Dis 2010;202(8):1212-18
   PubMed Web of Science ®Google Scholar
• Wyatt RG , Dolin R , Blacklow NR , et al. Comparison of three agents of acute infectious nonbacterial gastroenteritis by cross-challenge in volunteers. J Infect Dis 1974;129(6):709-14
   PubMed Web of Science ®Google Scholar
• Treanor JJ , Jiang X , Madore HP , Estes MK . Subclass-specific serum antibody responses to recombinant Norwalk virus capsid antigen (rNV) in adults infected with Norwalk, Snow Mountain, or Hawaii virus. J Clin Microbiol 1993;31(6):1630-4
   PubMed Web of Science ®Google Scholar
• Noel JS , Ando T , Leite JP , et al. Correlation of patient immune responses with genetically characterized small round-structured viruses involved in outbreaks of nonbacterial acute gastroenteritis in the United States, 1990 to 1995. J Med Virol 1997;53(4):372-83
   PubMed Web of Science ®Google Scholar
• Ramani S , Neill FH , Opekun AR , et al. Mucosal and Cellular Immune Responses to Norwalk Virus. J Infect Dis 2015;212(3):397-405
   PubMed Web of Science ®Google Scholar
• Parrino TA , Schreiber DS , Trier JS , et al. Clinical immunity in acute gastroenteritis caused by Norwalk agent. N Engl J Med 1977;297(2):86-9
   PubMed Web of Science ®Google Scholar
• El-Kamary SS , Pasetti MF , Mendelman PM , et al. Adjuvanted intranasal Norwalk virus-like particle vaccine elicits antibodies and antibody-secreting cells that express homing receptors for mucosal and peripheral lymphoid tissues. J Infect Dis 2010;202(11):1649-58
   PubMed Web of Science ®Google Scholar
• Tacket CO , Sztein MB , Losonsky GA , et al. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clinical Immunology 2003;108(3):241-7
   PubMed Web of Science ®Google Scholar
• Zhu S , Regev D , Watanabe M , et al. Identification of immune and viral correlates of norovirus protective immunity through comparative study of intra-cluster norovirus strains. PLoS pathog 2013;9(9):e1003592
   PubMed Web of Science ®Google Scholar
• LoBue AD , Lindesmith L , Yount B , et al. Multivalent norovirus vaccines induce strong mucosal and systemic blocking antibodies against multiple strains. Vaccine 2006;24(24):5220-34
   PubMed Web of Science ®Google Scholar
• Tamminen K , Lappalainen S , et al. Trivalent combination vaccine induces broad heterologous immune responses to norovirus and rotavirus in mice. PloS One 2013;8(7):e70409
   PubMed Web of Science ®Google Scholar
• Sundararajan A , Sangster MY , Frey S , et al. Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine. Vaccine 2015;33(4):568-76
   PubMed Web of Science ®Google Scholar
• Lindesmith LC , Ferris MT , Mullan CW , et al. Broad blockade antibody responses in human volunteers after immunization with a multivalent norovirus VLP candidate vaccine: immunological analyses from a phase I clinical trial. PLoS med 2015;12(3):e1001807
   PubMed Web of Science ®Google Scholar
• Czako R AR , Opekun AR , Gilger MA , et al. Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity. Clinical and Vaccine Immunology 2015;22(2):221-8
   PubMed Web of Science ®Google Scholar
• Atmar RL , Bernstein DI , Harro CD , et al. Norovirus vaccine against experimental human Norwalk virus illness. N Engl J Med 2011;365(23):2178-87
   PubMed Web of Science ®Google Scholar
• Ruuska T , Vesikari T . Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes. Scand J Infect Dis 1990;22(3):259-67
   PubMed Web of Science ®Google Scholar
• Bok K , Parra GI , Mitra T , et al. Chimpanzees as an animal model for human norovirus infection and vaccine development. Proc Natl Acad Sci USA 2011;108(1):325-30
   PubMed Web of Science ®Google Scholar
• Bernstein DI , Atmar RL , Lyon GM , et al. Norovirus vaccine against experimental human GII.4 Virus illness: A challenge study in healthy adults. J Infect Dis 2014;211(6):870-8
   PubMed Web of Science ®Google Scholar
• Patel MM , Steele D , Gentsch JR , et al. Real-world impact of rotavirus vaccination. Pediatr Infect Dis J 2011;30(1 Suppl):S1-5
   PubMed Web of Science ®Google Scholar
• Bartsch SM , Lopman BA , Hall AJ , et al. The potential economic value of a human norovirus vaccine for the United States. Vaccine 2012;30(49):7097-104
   PubMed Web of Science ®Google Scholar
• Mirelman AJ , Ballard SB , Saito M , et al. effectiveness of norovirus vaccination in children in Peru. Vaccine 2015;33(27):3084-91
   PubMed Web of Science ®Google Scholar
• (ACIP) ACoIP. General Recommendations on Immunization. MMWR Morb Mortal Wkly Rep 2011;60:2
   Google Scholar
• Lu PJ , Euler GL , Jumaan AO , Harpaz R . Herpes zoster vaccination among adults aged 60 years or older in the United States, 2007: uptake of the first new vaccine to target seniors. Vaccine 2009;27(6):882-7
   PubMed Web of Science ®Google Scholar
• O’Reilly FW , Cran GW , Stevens AB . Factors affecting influenza vaccine uptake among health care workers. Occup Med (Chic Ill) 2005;55(6):474-9
   Web of Science ®Google Scholar