37
Views
47
CrossRef citations to date
0
Altmetric
Review

Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity

, , , , &
Pages S161-S168 | Published online: 09 Jan 2014

References

  • UNAIDS--WHO. AIDS epidemic update (2003).
  • Stanecki IKA. The AIDS Pandemic in the 21th Century. The US Census Bureau (www.census.gov/ipc/prod/wp02/wp02-2.pdf) (2004).
  • Daniel MD, Kirchhoff F, Czajak SC, Sehgal PK, Desrosiers RC. Protective effects of a live attenuated SW vaccine with a deletion in the nef gene. Science 258, 1938–1941 (1992).
  • Cao Y, Qin L, Zhang L, Safrit J and Ho DD. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus Type 1 infection. N Engl. Med 332, 201–208 (1995).
  • Cecilia D, Kleeberger C, Munoz A, Giorgi JV, Zolla-Pazner S. A longitudinal study of neutralizing antibodies and disease progression in HIV-1-infected subjects. Infect. Dis. 179, 1365–1374 (1999).
  • Kaul R, Plummer FA, Kimani J et al HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1- resistant prostitutes in Nairobi. J. immuno/.164, 1602–1611 (2000).
  • Rowland-Jones S, Sutton J, Ariyoshi K et al. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nature Med. 1, 59–64 (1995).
  • Barouch DH, Santra S, Schmitz JE et al Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 290, 486–492 (2000).
  • •Demonstrates that the when augmented by interleukin (10-2/immunoglobulin (Ig), DNA vaccines of SIVmac239 Gag and HIV-I 89.6P Env can control the SHIV 89.6P viral replication to undetectable levels in blood.
  • Amara RR, Villinger F, Altman JD et al Control of a mucosal challenge and prevention of AIDS by a multi-protein DNA/MVA vaccine. Science 292, 69–74 (2001).
  • •Demonstrates that the heterologous DNA prime and modified vaccinia Ankara boost strategy with multiple HIV/SIV genes can induce immune responses that control vim! replication after SHIV 89.6 challenge.
  • Shiver JW, Fu TM, Chen L et al. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 415, 331–335 (2002).
  • •Demonstrates that the replication incompetent adenovirus Type 5 (Ad5) vector-expressing the SIV Gag protein can exhibit the pronounced attenuation of the SHIV infection.
  • Veazey RS, Shattock RJ, Pope M et al. Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120. Nature Merl 9, 343–346 (2003).
  • •Demonstrates that administration of the broadly neutralizing human monoclonal antibody b12 can protect macaques from SHIV-162P4 infection through the vagina.
  • Peeters M, Toure-Kane C, Nkengasong JN. Genetic diversity of HIV in Africa: impact on diagnosis, treatment, vaccine development and trials. AIDS17, 2547–2560 (2003).
  • •Reviews extensive genetic diversity and recombination in Africa and discusses its impact on vaccine development.
  • Walker BD, Korber BT Immune control of HIV: the obstacles of HLA and viral diversity. Nature ImmunoI2, 473–475 (2001).
  • ••Reviews and discusses the important impactof human HLA types and genetic diversity of HIV on AIDS vaccine development.
  • Korber B, Foley B, Gaschen B, Kuiken C. Epidemiological and immunological implications of the global variability of HIV-I. In: Retroviral Immunology Pantaleo G, Walker B (Eds). Humana Press, Inc., NJ, USA, 1–32 (2001).
  • Korber B, Gaschen B, Yusim K, Thakallapally R, Kesmir C, Detours V. Evolutionary and immunological implications of contemporary HIV-1 variation. BE Merl Bull. 58, 19–42 (2001).
  • Gaschen B, Taylor J, Yusim K et al. Diversity considerations in HIV-1 vaccineselection. Science 296, 2354–2360 (2002).
  • ••Proposes the use of consensus and ancestralviral gene sequences for the induction of broader T- and B-cell immune responses and discusses the advantages of consensus and ancestral sequences over wild-type viral gene sequences.
  • Gao F, Bhattacharya T, Gaschen B et al. Consensus and Ancestral State HIV Vaccines (Letter). Science 299, 1517–1518 (2003).
  • Nickle DC, Jensen MA, Gottlieb GS et al Consensus and Ancestral State HIV Vaccines (Letter). Science 299, 1515–1517 (2003).
  • ••Proposes the COT method as a centralizedgene vaccine approach.
  • Novitsky V, Smith UR, Gilbert P et al. Human immunodeficiency virus Type 1 subtype C molecular phylogeny: consensus sequence for an AIDS vaccine design? Vino'. 76, 5435–5451 (2002).
  • Ellenberger DL, Li B, Lupo LD et al Generation of a consensus sequence from prevalent and incident HIV-1 infections in West Africa to guide AIDS vaccine development. Virelogy302, 155–163 (2002).
  • Kuiken CL, Foley B, Freed E et al. HIV sequence compendium 2002. Los Alamos, New Mexico: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, USA (2002).
  • Vidal N, Peeters M, Mulanga-Kabeya C et al Unprecedented degree of human immunodeficiency virus Type 1 (HIV-1) group M genetic diversity in the Democratic Republic of Congo suggests that the HIV-1 pandemic originated in Central Africa.Viral. 74,10498–10507 (2000).
  • Robertson DL, Sharp PM, McCutchan FE and Hahn BH. Recombination in HIV-1. Nature 374,124–126 (1995).
  • Comelissen M, Kampinga G, Zorgdrager F, Goudsmit J. Human immunodeficiency virus Type 1 subtypes defined by env show high frequency of recombinant gag genes. The UNAIDS Network for HIV Isolation and Characterization. j Viral. 70, 8209–8212 (1996).
  • Dowling WE, Kim B, Mason CJ et al. Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. AIDS 16,1809–1820 (2002).
  • Hoelscher M, Dowling WE, Sanders-Buell E et al. Detection of HIV-1 subtypes, recombinants and dual infections in east Africa by a multi-region hybridization assay. AIDS16,2055–2064 (2002).
  • Hoelscher M, Kim B, Maboko L et al High proportion of unrelated HIV-1 intersubtype recombinants in the Mbeya region of southwest Tanzania. AIDS15, 1461–1470 (2001).
  • Carr JK, Foley BT, Leitner T, Salminen MO, Korber BT, McCutchan E Reference sequences representing the principal genetic diversity of HIV-1 in the pandemic. In: Human Retroviruses andAIDS 1998: a Compilation and Analysis of Nucleic Acicl andAm/no Acid Sequence. Korber B, Kuiken C, Foley B et al., (Eds), Los Alamos, New Mexico, USA. Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, III-10-III-19 (1998).
  • Robertson DL, Anderson JP, Bradac JA et al. HIV-1 nomenclature proposal. Science 288,55–56 (2000).
  • Bartlett JA, Wasserman SS, Hicks CB et al. Safety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen. DATRI 010 Study Group. Division of AIDS Treatment Research Initiative. AIDS12, 1291–1300 (1998).
  • Cho MW, Kim YB, Lee MK et al Polyvalent envelope glycoprotein vaccine elicits a broader neutralizing antibody response but is unable to provide sterilizing protection against heterologous Simian/human immunodeficiency virus infection in pigtailed macaques. j Viral 75,2224–2234 (2001).
  • •Demonstrates that administration of multiple subtype B Env proteins can induce broader neutralizing spectrum against a number of subtype B isolates than any single subtype B Env protein.
  • Kong VVP, Huang Y, Yang ZY, Chakrabarti BK, Moodie Z, Nabel GJ. Immunogenicity of multiple gene and dade human immunodeficiency virus Type 1 DNA vaccines.' Virol 77,12764–12772 (2003).
  • ••Demonstrates that a multigene andmulticlade vaccine that consists of subtype A, B and C Env and Gag—Pol—Nef can broaden antiviral immune responses without immune interference.
  • Haynes B, Ma B, Montefiori D et al. Analysis of HIV-1 subtype B and C envelope third variable region peptide motifs for induction of neutralizing antibodies against HIV-1 primary isolates. Viral (Submitted) 2004.
  • Fouts T, Godfrey K, Bobb K et al Crosslinked HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaques. Proc. Natl Acad. Sci. USA 99,11842–11847 (2002).
  • Roben P, Moore JP, Thai M, Sodroski J, Barbas CF 3rd, Burton DR. Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus Type 1. j Virol 68,4821–4828 (1994).
  • Saphire EO, Parren PW, Pantophlet R et al Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science 293,1155–1159 (2001).
  • Burton DR, Pyati J, Koduri R et al Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. Science 266, 1024–1027 (1994).
  • Moore JP, McCutchan FE, Poon SW et al Exploration of antigenic variation in gp120 from clades A through F of human immunodeficiency virus Type 1 by using monoclonal antibodies. j Viral. 68, 8350–8364 (1994).
  • Moulard M, Phogat SK, Shu Y et al Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes. Roc. Nat! Acad. Sci. USA 99,6913–6918 (2002).
  • Trkola A, Pomales AB, Yuan H et al Cross- clade neutralization of primary isolates of human immunodeficiency virus Type 1 by human monoclonal antibodies and tetrameric CD4-IgG. j Viral. 69, 6609–6617 (1995).
  • Zwick MB, Labrijn AF, Wang M et al. Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus Type 1 glycoprotein gp41. j Viral. 75, 10892–10905 (2001).
  • Burton DR, Desrosiers RC, Doms RVV et al HIV vaccine design and the neutralizing antibody problem. Nature Immunol 5,233–236 (2004).
  • ••Reviews the current challenges andpotential new approaches to induce neutralizing antibodies against HIV.
  • Gauduin MC, Parren PW, Weir R, Barbas CF, Burton DR, Koup RA. Passive immunization with a human monoclonal antibody protects hu-PBL- SCID mice against challenge by primary isolates of HIV-1. Nature Med. 3,1389–1393 (1997).
  • Letvin NL, Montefiori DC, Yasutomi Y et al Potent, protective antiHR/ immune responses generated by bimodal HIV envelope DNA plus protein vaccination. Proc. Natl Acad. Sci USA 94,9378–9383 (1997).
  • Mascola JR, Stiegler G, VanCott TC et al Protection of macaques against vaginal transmission of a pathogenic HIV- 1/SW chimeric virus bypassive infusion of neutralizing antibodies. Nature Med. 6, 207–210 (2000).
  • •Demonstrates that passive infusion of the most potent combinations of broadly neutralizing antibodies into monkeys can confer the highest level of protection against vaginal exposure to a pathogenic SHIV89.6PD.
  • Desrosiers RC. Prospects for an AIDS vaccine. Nature Med. 10,221–223 (2004).
  • ••Reviews the current challenges for vaccinedevelopment and appeal for more fundamental basic research for a possible AIDS vaccine.
  • Hanke T, Schneider J, Gilbert SC, Hill AV, McMichael A. DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparurd immunogenicity in mice. Vaccine 16,426–435 (1998).
  • Hanke T, Samuel RV, Blanchard TJ et al Effective induction of simian immunodeficiency virus-specific cytotoxic T-lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen. j Viral. 73, 7524–7532 (1999).
  • Hanke T, McMichael A. Preclinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS. Immunol Lett. 66,177–181 (1999).
  • Hanke T, Blanchard TJ, Schneider J et al. Immunogenicities of iv. and im. administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus Type 1 in mice.' Gen. Vim'. 79\(Pt 1), 83–90 (1998).
  • Korber B, Muldoon M, Theiler J et al. Timing the ancestor of the HIV-1 pandemic strains. Science 288, 1789–1796 (2000).
  • Yusim K, Kesmir C, Gaschen B et al Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus Type 1 (HiV-1) proteins reveal imprints of immune evasion on HIV-1 global variation. J. Viral. 76, 8757–8768 (2002).
  • Korber B, Brander C, Haynes B et al. HIV Molecular Immunology 2002 Los Alamos, New Mexico, USA. Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, USA (2002).
  • Gao F, Weaver EA, Lu Z et al Antigenicity and Immunogenicity of a synthetic HIV-1 group M consensus envelope glycoprotein. (Submitted) (2004).
  • Center RJ, Earl PL, Lebowitz J, Schuck P, Moss B. The human immunodeficiency virus Type 1 gp120 V2 domain mediates gP41-independent intersubunit contacts. Viml 74, 4448–4455 (2000).
  • Weaver EA, Lu Z, Li Y et al. Immunogenicity of HIV-1 group M consensus Env immunogens. AIDS Vaccine 2003 (Abstract #43).
  • Weaver EA, Lu Z, Li Y et al Cross-subtype immune responses of HIV-1 group M consensus Env immunogens. The 11th Confemnce on Retro viruses and Opportunistic Infections (Abstract #164) (2004).
  • Liao HX, Alam M, Mascola J et al Immunogenicity of Constrained Monoclonal Antibody A32- HIV Env gp120 Complexes Compared to Recombinant HIV-1 gp 120 Envelope Glycoproteins. j Viral. (In Press) (2004).
  • Ogg GS, Jin X, Bonhoeffer S et al. Quantitation of HIV-1-specific cytotoxic T-lymphocytes and plasma load of viral RNA. Science 279, 2103–2106 (1998).
  • Yu XG, Addo MM, Rosenberg ES et al Consistent patterns in the development and immunodominance of human immunodeficiency virus Type 1 (HIV-1)-specific CD8* T-cell responses following acute HIV-1 infection. J Viral. 76, 8690–8701 (2002).
  • Cao J, McNevin J, Holte S, Fink L, Corey L, McElrath MJ. Comprehensive analysis of human immunodeficiency virus Type 1 (HIV-1) -specific)' interferon-secreting CD8*T-cel1s in primary HIV-1 infection. J. Viral. 77, 6867–6878 (2003).
  • Haynes BE HIV vaccines: where we are and where we are going. Lancet 348, 933–937 (1996).
  • ••Reviews the concept of epitope-based vaccines for HIV-1.
  • Ward FE, Tuan S, Haynes B. Analysis of HLA frequencies in population cohorts for design of HLA-based HIV vaccines. In: HIV Molecular Immunology Database 1995 Korber B, Brander C, Walker B et al (Eds), Los Alamos National Laboratory, USA, IV10-1V16 (1995).
  • Yasutomi Y, Koenig S, Woods RM et al. A vaccine-elicited, single viral epitope-specific cytotoxic T-lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge. J. Viral 69, 2279–2284 (1995).
  • Barouch DH, Kunstman J, Kuroda MJ et al Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T-lymphocytes. Nature 415, 335–339 (2002).
  • Barouch DH, Kunstman J, Glowczwskie J et al. Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T-lymphocytes in DNA-vaccinated rhesus monkeys. J. Viral. 77, 7367–7375 (2003).
  • Borrow P, Lewicki H, Wei X et al Antiviral pressure exerted by HIV-1-specific cytotoxic T-lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nature Med. 3, 205–211 (1997).
  • Moore CB, John M, James IR, Christiansen FT, Witt CS and Mallal SA. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science 296, 1439–1443 (2002).
  • Graham BS, Ottinger J, Weinhold KJ et al Phase I clinical trial of a multivalent HIV-1 peptide vaccine containing B and T epitopes formulated in incomplete Freund's adjuvant. AIDS' Vaccine 2001 (Abstract #46) (2001).
  • Bansal A, Sabbaj S, Edwards BH et al T- cell responses in HIV Type 1-infected adolescent minorities share similar epitope specificities with whites despite significant differences in HLA class I alleles. AIDS Res. Hum. Retroviruses 19, 1017–1026 (2003).
  • Frahm N, Korber BT, Adams CM et al Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. Vim!. 78, 2187–2200 (2004).
  • Liao HX, Cianciolo GJ, Staats HF et al Increased immunogenicity of HIV envelope subunit complexed with alpha2-macroglobulin when combined with monophosphoryl lipid A and GM-CSE Vaccine 20, 2396–2403 (2002).
  • Egan MA, Chong SY, Hagen M et al A Comparative Evaluation of Nasal and Parenteral Vaccine Adjuvants to Elicit Systemic and Mucosal HIV-1 peptide-specific Humoral Immune Responses in Cynomolgus Macaques. Vaccine (In Press) 2004.
  • Connor RI, Sheridan KE, Ceradini D, Choe S and Landau NR. Change in coreceptor use coreceptor use correlates with disease progression in HIV-1-infected individuals. J. Exp. Med. 185, 621–628 (1997).
  • Shankarappa R, Margolick JB, Gange SJ et al Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus Type 1 infection. J. Viral. 73, 10489–10502 (1999).
  • Derdeyn CA, Decker J, Bibollet-Ruche F et al. envelope-constrained neutralization-sensitiveH[v-1 after heterosexual transmission. Science 303, 2019–2022 (2004).
  • Johnson RP, Trocha A, Buchanan TM, Walker BD, Identification of overlapping HLA class I-restricted cytotoxic T-cell epitopes in a conserved region of the human immunodeficiency virus Type I envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation. Exp. Med. 175, 961–971 (1992).
  • Goulder PJ, Reid SW Price DA et al Combined structural and immunological refinement of HIV-1 HLA-B8-restricted cytotoxic T-lymphocyte epitopes. Eur. Immunol 27, 1515–1521 (1997).

Website

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.