Vaccination for atherosclerosis: a novel therapeutic paradigm

References

• Libby P Inflammation in atherosclerosis. Nature 420,868–874 (2002).
   Google Scholar
• •Excellent overview of the role of inflammation in atherosclerosis.
   Google Scholar
• Shah PK. Mechanisms of plaque vulnerability and rupture. J Am. Coll. Cardio]. 41 (Suppl. 4) S15-S22 (2003).
   Google Scholar
• •Reviews the link between inflammation, plaque rupture and thrombosis.
   Google Scholar
• Ross R. Atherosclerosis - an inflammatory disease. N Engl. Med. 340,115–126 (1999).
   PubMed Web of Science ®Google Scholar
• Hansson GK, Libby P, Schonbeck U, Yan ZQ. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ. Res. 91,281–291 (2002).
   PubMed Web of Science ®Google Scholar
• Binder CJ, Chang MK, Shaw PX et al. Innate and acquired immunity in atherogenesis. Nature Med. 8,1218–1226 (2002).
   PubMed Web of Science ®Google Scholar
• •Highlights the immune aspects of atherogenesis.
   Google Scholar
• Gordon S. Pattern recognition receptors: doubling up for the innate immuneresponse. Ce11111, 927–930 (2002).
   Google Scholar
• Xu XH, Shah PK, Faure E et al. Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and unregulated by oxidized LDL. Circulation104, 3103–3108 (2001).
   PubMed Web of Science ®Google Scholar
• Edfeldt K, Swedenborg J, Hansson GK, Yan ZQ. Expression of Toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation 105,1158–1161 (2002).
   PubMed Web of Science ®Google Scholar
• Michelsen KS, Wong MH, Shah PK et al. Lack of TLR4 or MyD88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc. Natl Acad. Sci. USA 101(29), 10679–10684 (2004).
   Google Scholar
• •Key paper demonstrating the involvement of innate immune signaling via the Toll-like receptor in murine atherosclerosis.
   Google Scholar
• Shaw PX, Horkko S, Chang MK et al. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J Clin. Invest. 105,1731-1740 (2000).
   Google Scholar
• Briles DE, Forman C, Hudak S, Claflin JL. Antiphosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneurnoniae. J Exp. Med. 156,1177-1185 (1982).
   Google Scholar
• Binder CJ, Horkko S, Dewan A et al. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneurnoniae and oxidized LDL. Nature Med. 9, 736–743 (2003).
   PubMed Web of Science ®Google Scholar
• Constant SL, Bottomly K. Induction of Thl and Th2 CDC T-cell responses: the alternative approaches. Ann. Rev Irnmunol. 15,297-322 (1997).
   Google Scholar
• Frostegard J, Ulfgren AK, Nyberg P et al. Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Thl) and macrophage-stimulating cytokines. Atherosclerosis 145, 33–43 (1999).
   PubMed Web of Science ®Google Scholar
• Zhou X, Paulsson G, Stemme S, Hansson GK. Hypercholesterolemia is associated with a T-helper (D) 1/Th2 switch of the autoimmune response in atherosclerotic apoE-knockout mice. J Clin. Invest. 101, 1717–1725 (1998).
   Google Scholar
• Zhou X, Nicoletti A, Elhage R, Hansson GK. Transfer of CDC T-cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice. Clirulation 102,2919–2922 (2000).
   PubMed Web of Science ®Google Scholar
• Sakaguchi S. Regulatory T-cells: key controllers of immunologic self-tolerance. Ce11101, 455–458 (2000).
   Google Scholar
• Groux H, O'Garra A, Bigler M et al. A CDC T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389,737–742 (1997).
   Google Scholar
• Mallat Z, Gojova A, Brun V et al. Induction of a regulatory T-cell Type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice. Circulation 108, 1232–1237 (2003).
   PubMed Web of Science ®Google Scholar
• Mallat Z, Besnard S, Duriez M et al. Protective role of interleukin-10 in atherosclerosis. Circ. Res. 85, E17-24 (1999).
   Google Scholar
• Pinderski Oslund LJ, Hedrick CC, Olvera T et al. Interleukin-10 blocks atherosclerotic events in vitro and in vivo. Arterioscler. Thromb. Vag. Biol. 19, 2847–2853 (1999).
   Google Scholar
• Caligiuri G, Rudling M, O11ivier V et al. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol. Med. 9,10-17 (2003).
   Google Scholar
• Robertson AK, Rudling M, Zhou X et al. Disruption of TGF-13 signalling in T-cells accelerates atherosclerosis. j Clin. Invest. 112,1342-1350 (2003).
   Google Scholar
• Kronenberg M, Brossay L, Kurepa Z, Forman J. Conserved lipid and peptide presentation functions of nonclassical class I molecules. Irnmunol. Today20,515–521 (1999).
   Google Scholar
• Tupin E, Nicoletti A, Elhage R et al. CD1- dependent activation of NK T-cells aggravates atherosclerosis. J Exp. Med. 199, 417–422 (2004).
   Google Scholar
• Nakai Y, Iwabuchi K, Fujii S et al. Natural killer T-cells accelerate atherogenesis in mice. Blood 104 (7), 2051–2059 (2004).
   Google Scholar
• Frostegard J. Autoimmunity, oxidized LDL and cardiovascular disease. Autoirnmun. Rev 1,233–237 (2002).
   PubMedGoogle Scholar
• Lehtimaki T, Lehtinen S, Solakivi T et al. Autoantibodies against oxidized low-density lipoprotein in patients with angiographically verified coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 19, 23–27 (1999).
   PubMed Web of Science ®Google Scholar
• Hulthe J, Wiklund O, Hurt-Camejo E, Bondjers G. Antibodies to oxidized LDL in relation to carotid atherosclerosis, cell adhesion molecules, and phospholipase A(2). Arterioscler. Thromb. Vasc. Biol. 21,269-274 (2001).
   Google Scholar
• Hulthe J, Bokemark L, Fagerberg B. Antibodies to oxidized LDL in relation to intima—media thickness in carotid and femoral arteries in 58-year-old subjectively clinically healthy men. Arterioscler. Thromb. Vasc. Biol. 21, 101–107 (2001).
   Google Scholar
• Tornvall P, Waeg G, Nilsson J, Hamsten A, Regnstrom J. Autoantibodies against modified low-density lipoproteins in coronary artery disease. Atherosclerosis167, 347–353 (2003).
   Google Scholar
• Salonen JT, Yla-Herttuala S, Yamamoto R et al. Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet 339,883–887 (1992).
   PubMed Web of Science ®Google Scholar
• Perschinka H, Mayr M, Millonig G et al. Crossreactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 23,1060-1065 (2003).
   Google Scholar
• Afek A, George J, Gilburd B et al. Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP65) promotes early atherosclerosis. J Autoirnmun. 14, 115–121 (2000).
   PubMed Web of Science ®Google Scholar
• Xu Q, Dietrich H, Steiner HJ et al. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler. Thromb. 12,789-799 (1992).
   Google Scholar
• Lamb DJ, Ferns GA. The magnitude of the immune response to heat shock protein 65 following BCG immunization is associated with the extent of experimental atherosclerosis. Atherosclerosis 165, 231–240 (2002).
   PubMedGoogle Scholar
• Xu Q, Willeit J, Marosi M et al. Association of serum antibodies to heat shock protein 65 with carotid atherosclerosis. Lancet 341, 255–259 (1993).
   PubMed Web of Science ®Google Scholar
• Stemme S, Faber B, Holm J et al. T-lymphocytes from human atherosclerotic plaques recognize oxidized low-density lipoprotein. Proc. Natl Acad. Sci USA 92, 3893–3897 (1995).
   PubMed Web of Science ®Google Scholar
• Ameli S, Hultgardh-Nilsson A, Regnström J et al. Effect of immunization with homologous LDL on early atherosclerosis in hypercholesterolemic rabbits. Arterioscler. Thromb. Vasc. Biol. 16,1074–1079 (1996).
   PubMed Web of Science ®Google Scholar
• •One of the earliest demonstrations of the atheroprotective role of oxidized low-density lipoprotein (LDL) immunization.
   Google Scholar
• Nilsson J, Calara F, Regnström J et al. Immunization with homologous oxidized low-density lipoprotein reduces neointimal formation after balloon in hypercholesterolemic rabbits. J Am. Coll. Cardiol. 30,1886–1891 (1997).
   PubMedGoogle Scholar
• Palinski W, Miller E, Witztum JL. Immunization of low-density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc. Natl Acad. Sci. USA 92,821–825 (1995).
   Google Scholar
• •One of the earliest demonstrations of the atheroprotective role of oxidized LDL immunization.
   Google Scholar
• Freigang S, Horkko S, Miller E, Witztum JL, Palinski W. Immunization of LDL-receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes. Arterioscler. Thromb. Vase. Biol. 18,1972–1982 (1998).
   Google Scholar
• Zhou X, Caligiuri G, Hamsten A, Lefvert AK, Hansson GK. LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis. Arterioscler. Thrornb. Vase. Biol. 21,108–114 (2001).
   Google Scholar
• Chyu KY, Reyes OS, Zhao X et al. Timing affects the efficacy of LDL immunization on atherosclerotic lesions in apoE mice. Atherosclerosis 176 (1), 27–35 (2004).
   Google Scholar
• Fredrikson GN, Hedblad B, Berglund G et al. Identification of immune responses against aldehyde-modified peptide sequences in ApoB associated with cardiovascular disease. Arterioscler. Thrornb. Vase. Biol. 23,872–878 (2003).
   PubMed Web of Science ®Google Scholar
• Fredrikson GN, Soderberg I, Lindholm M et al. Inhibition of atherosclerosis in ApoE-null mice by immunization with ApoB-100 peptide sequences. Arterioscler. Thrornb. Vase. Biol. 23,879-884 (2003).
   Google Scholar
• •Proof-of-concept study demonstrating the atheroprotective effects of immunization with specific apolipoprotein (apo)B-related peptide mixtures as antigens.
   Google Scholar
• Reyes OS, Chyu KY, Yano J et al. Immunization with a novel human apoB-100-related peptide reduces atherosclerosis and inflammation in apoE null mice. J. Am. Coll. Cardio]. 39 (Suppl. A), 5 (2002).
   Google Scholar
• •Proof-of-concept study demonstrating the atheroprotective effects of immunization with specific apoB-related single peptide as antigens.
   Google Scholar
• Schipou A, Bengtsson J, Soderberg I et al. Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis. Circulation 110 (14), 2047-2052 (2004).
   Google Scholar
• Chen Y, Kuchroo VK, Inobe JI, Hafler DA, Weiner HL. Regulatory T-cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265,1237–1240 (1994).
   PubMed Web of Science ®Google Scholar
• Miller A, Lider O, Weiner HL. Antigen- driven bystander suppression following oral administration of antigens. J. Exp. Med. 174, 791–798 (1991).
   Google Scholar
• Chen Y, Inobe JI, Marks R et al. Peripheral deletion of antigen-reactive T-cells in oral tolerance. Nature 376,177–180 (1995).
   PubMed Web of Science ®Google Scholar
• Whitacre CC, Gienapp IE, Orosz CG, Bitar D. Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy. j Irnmunol. 147,2155–2163 (1991).
   PubMed Web of Science ®Google Scholar
• Friedman A, Weiner H. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Nail Acad. Sci. USA 91,6688–6692 (1994).
   PubMed Web of Science ®Google Scholar
• Harats D, Yacov N, Gilburd B et al. Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions. J. Am. Coll. Cardio]. 40(7), 1333–1338 (2002).
   Google Scholar
• •Key report demonstrating atheroprotective effects of oral tolerization to heat shock protein.
   Google Scholar
• George J, Yacov N, Breitbart E et al. Suppression of early atherosclerosis in LDL-receptor-deficient mice by oral tolerance with 132-glycoprotein I. Cardiovasc. Res. 62(3), 603–609 (2004).
   Google Scholar
• Maron R, Sukhova G, Faria AM et al. Mucosal administration of heat shock protein 65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 106(13), 1708–1715 (2002).
   Google Scholar
• Rittershaus CVV, Miller DP, Thomas LJ et al. Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis. Arterioscler. Thrornb. Vasc. Biol. 20, 2106–2112 (2000).
   PubMed Web of Science ®Google Scholar
• Davidson MH, Maki K, Umporowicz D et al. The safety and immunogenicity of a CETP vaccine in healthy adults. Atherosclerosis 169,113–120 (2003).
   PubMed Web of Science ®Google Scholar
• Naghavi M, Barlas Z, Siadaty S et al. Association of influenza vaccination and reduced risk of recurrent myocardial infarction. Circulation 102,3039–3045 (2000).
   PubMed Web of Science ®Google Scholar
• •First report suggesting cardiovascular risk reduction with influenza vaccination.
   Google Scholar
• Siscovick DS, Raghunathan TE, Lin D et al. Influenza vaccination and the risk of primary cardiac arrest. Am. J. Epiderniol. 152,674–677 (2000).
   PubMed Web of Science ®Google Scholar
• Nichol KL, Nordin J, Mullooly J et al. Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly. N Engl. J. Med. 348,1322–1332 (2003).
   PubMed Web of Science ®Google Scholar
• Gurfinkel EP, de la Fuente RU, Mendiz O, Mautner B. Influenza vaccine pilot study in acute coronary syndromes and planned percutaneous coronary interventions: the FLU Vaccination Acute Coronary Syndromes (FLUVACS) Study. Circulation 105,2143–2147 (2002).
   PubMed Web of Science ®Google Scholar
• Madjid M, Naghavi M, Litovsky S, Casscells SW. Influenza and cardiovascular disease: a new opportunity for prevention and the need for further studies. Circulation 108,2730–2736 (2003).
   PubMed Web of Science ®Google Scholar
• Jackson LA, Yu O, Heckbert SR et al. Influenza vaccination is not associated with a reduction in the risk of recurrent coronary events. Am. J. Epiderniol. 156,634–640 (2002).
   PubMed Web of Science ®Google Scholar