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Review

Cell-mediated immune responses induced by BHV-1: rational vaccine design

Pages 369-380 | Published online: 09 Jan 2014

References

  • Engels M, Ackermann M. Pathogenesis of ruminant herpesvirus infections. Vet. Microbiol.53, 3–15 (1996).
  • Jones C. Herpes simplex virus type 1 and bovine herpesvirus 1 latency. Clin. Microbiol. Rev.16, 79–95 (2003).
  • Ackermann M, Engels M. Pro and contra IBR-eradication. Vet. Microbiol.113, 293–302 (2006).
  • Schwyzer M, Ackermann M. Molecular virology of ruminant herpesviruses. Vet. Microbiol.53, 17–29 (1996).
  • Janssen EM, Lemmens EE, Wolfe T, Christen U, von Herrath MG, Schoenberger SP. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature421, 852–856 (2003).
  • Shedlock DJ, Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science300, 337–339 (2003).
  • van Drunen Littel-van den Hurk S, Babiuk LA. Polypeptide specificity of the antibody response after primary and recurrent infection with bovine herpesvirus 1. J. Clin. Microbiol.23, 274–282 (1986).
  • Marshall RL, Israel BA, Letchworth GJ 3rd. Monoclonal antibody analysis of bovine herpesvirus-1 glycoprotein antigenic areas relevant to natural infection. Virology165, 338–347 (1988).
  • Leary TP, Splitter GA. Recombinant herpesviral proteins produced by cell-free translation provide a novel approach for the mapping of T lymphocyte epitopes. J. Immunol.145, 718–723 (1990).
  • Tikoo SK, Campos M, Popowych YI, van Drunen Littel-van den Hurk S, Babiuk LA. Lymphocyte proliferative responses to recombinant bovine herpes virus type 1 (BHV-1) glycoprotein gD (gIV) in immune cattle: identification of a T cell epitope. Viral Immunol.8, 19–25 (1995).
  • Deshpande MS, Ambagala TC, Hegde NR, Hariharan MJ, Navaratnam M, Srikumaran S. Induction of cytotoxic T-lymphocytes specific for bovine herpesvirus-1 by DNA immunization. Vaccine20, 3744–3751 (2002).
  • Huang Y, Babiuk LA, van Drunen Littel- van den Hurk S. Immunization with a bovine herpesvirus-1 glycoprotein B DNA vaccine induces cytotoxic T lymphocyte responses in mice and cattle. J. Gen. Virol.88, 887–898 (2005).
  • Denis M, Slaoui M, Keil G et al. Identification of different target glycoproteins for bovine herpes virus type 1-specific cytotoxic T lymphocytes depending on the method of in vitro stimulation. Immunology78, 7–13 (1993).
  • Hopkins JI, Fiander AN, Evans AS, Delchambre M, Gheysen D, Borysiewicz LK. Cytotoxic T cell immunity to human cytomegalovirus glycoprotein B. J. Med. Virol.49, 124–131 (1996).
  • Tigges MA, Koelle D, Hartog K, Sekulovich RE, Corey L, Burke RL. Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens. J. Virol.66, 1622–1634 (1992).
  • Yasukawa M, Zarling JM. Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. III. Analysis of viral glycoproteins recognized by CTL clones by using recombinant herpes simplex viruses. J. Immunol.134, 2679–2682 (1985).
  • Koelle DM, Chen HB, Gavin MA, Wald A, Kwok WW, Corey L. CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells. J. Immunol.166, 4049–4058 (2001).
  • Mikloska Z, Ruckholdt M, Ghadiminejad I, Dunckley H, Denis M, Cunningham AL. Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-γ and IL-12 production. J. Immunol.164, 5167–5176 (2000).
  • Breinig F, Heintel T, Schumacher A, Meyerhans A, Schmitt MJ. Specific activation of CMV-primed human T lymphocytes by cytomegalovirus pp65 expressed in fission yeast. FEMS Immunol. Med. Microbiol.38, 231–239 (2003).
  • Sadzot-Delvaux C, Rentier B. The role of varicella zoster virus immediate-early proteins in latency and their potential use as components of vaccines. Arch. Virol. Suppl.17, 81–89 (2001).
  • Bergen RE, Sharp M, Sanchez A, Judd AK, Arvin AM. Human T cells recognize multiple epitopes of an immediate early/tegument protein (IE62) and glycoprotein I of varicella zoster virus. Viral Immunol.4, 151–166 (1991).
  • Hanon E, Keil G, van Drunen Littel-van den Hurk S et al. Bovine herpesvirus 1-induced apoptotic cell death: role of glycoprotein D. Virology257, 191–197 (1999).
  • Winkler MT, Doster A, Jones C. Bovine herpesvirus 1 can infect CD4(+) T lymphocytes and induce programmed cell death during acute infection of cattle. J. Virol.73, 8657–8668 (1999).
  • Devireddy LR, Jones CJ. Activation of caspases and p53 by bovine herpesvirus 1 infection results in programmed cell death and efficient virus release. J. Virol.73, 3778–3788 (1999).
  • Gopinath RS, Ambagala AP, Hinkley S, Srikumaran S. Effects of virion host shut-off activity of bovine herpesvirus 1 on MHC class I expression. Viral Immunol.15, 595–608 (2002).
  • Koppers-Lalic D, Rijsewijk FA, Verschuren SB et al. The UL41-encoded virion host shutoff (vhs) protein and vhs-independent mechanisms are responsible for down-regulation of MHC class I molecules by bovine herpesvirus 1. J. Gen. Virol.82, 2071–2081 (2001).
  • Koppers-Lalic D, Rychlowski M, van Leeuwen D et al. Bovine herpesvirus 1 interferes with TAP-dependent peptide transport and intracellular trafficking of MHC class I molecules in human cells. Arch. Virol.148, 2023–2037 (2003).
  • Koppers-Lalic D, Reits EA, Ressing ME et al. Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing. Proc. Natl Acad. Sci. USA102, 5144–5149 (2005).
  • Bryant NA, Davis-Poynter N, Vanderplasschen A, Alcami A. Glycoprotein G isoforms from some αherpesviruses function as broad-spectrum chemokine binding proteins. EMBO J.22, 833–846 (2003).
  • Salerno-Goncalves R, Sztein MB. Cell-mediated immunity and the challenges for vaccine development. Trends Microbiol.14, 536–542 (2006).
  • Pulendran B, Ahmed R. Translating innate immunity into immunological memory: implications for vaccine development. Cell124, 849–863 (2006).
  • Kaech SM, Ahmed R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol.2, 415–422 (2001).
  • Hayday A, Tigelaar R. Immunoregulation in the tissues by γδ T cells. Nat. Rev. Immunol.3, 233–242 (2003).
  • Hayday AC. [γ][δ] cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol.18, 975–1026 (2000).
  • Chen ZW, Letvin NL. Adaptive immune response of Vγ2Vδ2 T cells: a new paradigm. Trends Immunol.24, 213–219 (2003).
  • Naiman BM, Alt D, Bolin CA, Zuerner R, Baldwin CL. Protective killed Leptospira borgpetersenii vaccine induces potent Th1 immunity comprising responses by CD4 and γδ T lymphocytes. Infect. Immun.69, 7550–7558 (2001).
  • Robinson HL, Amara RR. T cell vaccines for microbial infections. Nat. Med.11, S25–S32 (2005).
  • Platt R, Burdett W, Roth JA. Induction of antigen-specific T-cell subset activation to bovine respiratory disease viruses by a modified-live virus vaccine. Am. J. Vet. Res.67, 1179–1184 (2006).
  • Hein WR, Mackay CR. Prominence of γ δ T cells in the ruminant immune system. Immunol. Today12, 30–34 (1991).
  • Braun RP, Babiuk LA, Loehr BI, van Drunen Littel-van den Hurk S. Particle-mediated DNA immunization of cattle confers long-lasting immunity against bovine herpesvirus-1. Virology265, 46–56 (1999).
  • Ioannou XP, Griebel P, Hecker R, Babiuk LA, van Drunen Littel-van den Hurk S. The immunogenicity and protective efficacy of bovine herpesvirus 1 glycoprotein D plus Emulsigen are increased by formulation with CpG oligodeoxynucleotides. J. Virol.76, 9002–9010 (2002).
  • Loehr BI, Willson P, Babiuk LA, van Drunen Littel-van den Hurk S. Gene gun-mediated DNA immunization primes development of mucosal immunity against bovine herpesvirus 1 in cattle. J. Virol.74, 6077–6086 (2000).
  • van Drunen Littel-van den Hurk S, Braun RP, Lewis PJ et al. Intradermal immunization with a bovine herpesvirus-1 DNA vaccine induces protective immunity in cattle. J. Gen. Virol.79, 831–839 (1998).
  • Quade MJ, Roth JA. Antigen-specific in vitro activation of T-lymphocyte subsets of cattle immunized with a modified live bovine herpesvirus 1 vaccine. Viral Immunol.12, 9–21 (1999).
  • Platt R, Roth JA, Royer RL, Thoen CO. Monitoring responses by use of five-color flow cytometry in subsets of peripheral T cells obtained from cattle inoculated with a killed Mycobacterium avium subsp paratuberculosis vaccine. Am. J. Vet. Res.67, 2050–2058 (2006).
  • Patel JR. Relative efficacy of inactivated bovine herpesvirus-1 (BHV-1) vaccines. Vaccine23, 4054–4061 (2005).
  • Endsley JJ, Quade MJ, Terhaar B, Roth JA. BHV-1-specific CD4+, CD8+, and γδ T cells in calves vaccinated with one dose of a modified live BHV-1 vaccine. Viral Immunol.15, 385–393 (2002).
  • Woolums AR, Siger L, Johnson S, Gallo G, Conlon J. Rapid onset of protection following vaccination of calves with multivalent vaccines containing modified-live or modified-live and killed BHV-1 is associated with virus-specific interferon γ production. Vaccine21, 1158–1164 (2003).
  • Corr M, Lee DJ, Carson DA, Tighe H. Gene vaccination with naked plasmid DNA: mechanism of CTL priming. J. Exp. Med.184, 1555–1560 (1996).
  • Corr M, von Damm A, Lee DJ, Tighe H. In vivo priming by DNA injection occurs predominantly by antigen transfer. J. Immunol.163, 4721–4727 (1999).
  • van Drunen Littel-van den Hurk S. Rationale and perspectives on the success of vaccination against bovine herpesvirus-1. Vet. Microbiol.113, 275–282 (2006).
  • van Oirschot JT. Diva vaccines that reduce virus transmission. J. Biotechnol.73, 195–205 (1999).
  • Kaashoek MJ, Moerman A, Madic J et al. An inactivated vaccine based on a glycoprotein E-negative strain of bovine herpesvirus 1 induces protective immunity and allows serological differentiation. Vaccine13, 342–346 (1995).
  • Kaashoek MJ, Rijsewijk FA, Ruuls RC et al. Virulence, immunogenicity and reactivation of bovine herpesvirus 1 mutants with a deletion in the gC, gG, gI, gE, or in both the gI and gE gene. Vaccine16, 802–809 (1998).
  • Mars MH, de Jong MC, van Oirschot JT. A gE-negative BHV1 vaccine virus strain cannot perpetuate in cattle populations. Vaccine18, 2120–2124 (2000).
  • Mars MH, de Jong MC, van Oirschot JT. A gE-negative bovine herpesvirus 1 vaccine strain is not re-excreted nor transmitted in an experimental cattle population after corticosteroid treatments. Vaccine18, 1975–1981 (2000).
  • Lemaire M, Meyer G, Baranowski E et al. Production of bovine herpesvirus type 1-seronegative latent carriers by administration of a live-attenuated vaccine in passively immunized calves. J. Clin. Microbiol.38, 4233–4238 (2000).
  • Lemaire M, Weynants V, Godfroid J et al. Effects of bovine herpesvirus type 1 infection in calves with maternal antibodies on immune response and virus latency. J. Clin. Microbiol.38, 1885–1894 (2000).
  • Rijsewijk FA, Kaashoek MJ, Langeveld JP et al. Epitopes on glycoprotein E and on the glycoprotein E/glycoprotein I complex of bovine herpesvirus 1 are expressed by all of 222 isolates and 11 vaccine strains. Arch. Virol.145, 921–936 (2000).
  • Makoschey B, Keil GM. Early immunity induced by a glycoprotein E-negative vaccine for infectious bovine rhinotracheitis. Vet. Rec.147, 189–191 (2000).
  • Lemaire M, Schynts F, Meyer G et al. Latency and reactivation of a glycoprotein E negative bovine herpesvirus type 1 vaccine: influence of virus load and effect of specific maternal antibodies. Vaccine19, 4795–4804 (2001).
  • Konig P, Beer M, Makoschey B et al. Recombinant virus-expressed bovine cytokines do not improve efficacy of a bovine herpesvirus 1 marker vaccine strain. Vaccine22, 202–212 (2003).
  • Zakhartchouk AN, Pyne C, Mutwiri GK et al. Mucosal immunization of calves with recombinant bovine adenovirus-3: induction of protective immunity to bovine herpesvirus-1. J. Gen. Virol.80, 1263–1269 (1999).
  • Reddy PS, Idamakanti N, Pyne C et al. The immunogenicity and efficacy of replication-defective and replication-competent bovine adenovirus-3 expressing bovine herpesvirus-1 glycoprotein gD in cattle. Vet. Immunol. Immunopathol.76, 257–268 (2000).
  • Gogev S, de Fays K, Versali MF, Gautier S, Thiry E. Glycol chitosan improves the efficacy of intranasally administrated replication defective human adenovirus type 5 expressing glycoprotein D of bovine herpesvirus 1. Vaccine22, 1946–1953 (2004).
  • Gogev S, Vanderheijden N, Lemaire M et al. Induction of protective immunity to bovine herpesvirus type 1 in cattle by intranasal administration of replication-defective human adenovirus type 5 expressing glycoprotein gC or gD. Vaccine20, 1451–1465 (2002).
  • Cox GJ, Zamb TJ, Babiuk LA. Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA. J. Virol.67, 5664–5667 (1993).
  • Lewis PJ, van Drunen Littel-van den Hurk S, Babiuk LA. Altering the cellular location of an antigen expressed by a DNA-based vaccine modulates the immune response. J. Virol.73, 10214–10223 (1999).
  • Braun RP, Babuik LA, van Drunen Littel-van den Hurk S. Enhanced immune responses to an intradermally delivered DNA vaccine expressing a secreted form of BHV-1 gD. Vaccine Research6, 151–164 (1997).
  • van Drunen Littel-van den Hurk S, Braun RP, Karvonen BC, King T, Yoo D, Babiuk LA. Immune responses and protection induced by DNA vaccines encoding bovine parainfluenza virus type 3 glycoproteins. Virology260, 35–46 (1999).
  • Caselli E, Boni M, Di Luca D, Salvatori D, Cassai E. A combined bovine herpesvirus 1 gB-gD DNA vacccine induces immune responses in mice. Comp. Immunol. Microbiol. Infect. Dis.28, 155–166 (2005).
  • van Drunen Littel-van den Hurk S, Braun RP, Lewis PJ, Karvonen BC, Babiuk LA, Griebel PJ. Immunization of neonates with DNA encoding a bovine herpesvirus glycoprotein is effective in the presence of maternal antibodies. Viral Immunol.12, 67–77 (1999).
  • Oliveira SC, Harms JS, Rosinha GM, Rodarte RS, Rech EL, Splitter GA. Biolistic-mediated gene transfer using the bovine herpesvirus-1 glycoprotein D is an effective delivery system to induce neutralizing antibodies in its natural host. J. Immunol. Methods245, 109–118 (2000).
  • Gupta PK, Saini M, Gupta LK et al. Induction of immune responses in cattle with a DNA vaccine encoding glycoprotein C of bovine herpesvirus-1. Vet. Microbiol.78, 293–305 (2001).
  • Toussaint JF, Coen L, Letellier C et al. Genetic immunisation of cattle against bovine herpesvirus 1: glycoprotein gD confers higher protection than glycoprotein gC or tegument protein VP8. Vet. Res.36, 529–544 (2005).
  • Loehr BI, Rankin R, Pontarollo R et al. Suppository-mediated DNA immunization induces mucosal immunity against bovine herpesvirus-1 in cattle. Virology289, 327–333 (2001).
  • Gerdts V, Babiuk LA, van Drunen Littel-van den Hurk S, Griebel PJ. Fetal immunization by a DNA vaccine delivered into the oral cavity. Nat. Med.6, 929–932 (2000).
  • Gerdts V, Snider M, Brownlie R, Babiuk LA, Griebel PJ. Oral DNA vaccination in utero induces mucosal immunity and immune memory in the neonate. J. Immunol.168, 1877–1885 (2002).
  • Pontarollo RA, Babiuk LA, Hecker R, van Drunen Littel-van den Hurk S. Augmentation of cellular immune responses to bovine herpesvirus-1 glycoprotein D by vaccination with CpG-enhanced plasmid vectors. J. Gen. Virol.83, 2973–2981 (2002).
  • Loehr BI, Pontarollo R, Rankin R et al. Priming by DNA immunization augments T-cell responses induced by modified live bovine herpesvirus vaccine. J. Gen. Virol.82, 3035–3043 (2001).
  • Tsang C, Babiuk S, van Drunen Littel- van den Hurk S, Babiuk LA, Griebel P. A single DNA immunization in combination with electroporation prolongs the primary immune response and the duration of immune memory. Vaccine DOI:10.1016/j.vaccine.2007.03.009 (2007) (Epub ahead of print).
  • Toussaint JF, Dubois A, Dispas M, Paquet D, Letellier C, Kerkhofs P. Delivery of DNA vaccines by agarose hydrogel implants facilitates genetic immunization in cattle. Vaccine25(7), 1167–1174 (2006).
  • van Drunen Littel-van den Hurk S, Van Donkersgoed J, Kowalski J et al. A subunit gIV vaccine, produced by transfected mammalian cells in culture, induces mucosal immunity against bovine herpesvirus-1 in cattle. Vaccine12, 1295–1302 (1994).
  • Van Donkersgoed J, McCartney D, van Drunen Littel-van den Hurk S. Efficacy of an experimental BHV-1 subunit gIV vaccine in beef calves challenged with BHV-1 in aerosol. Can. J. Vet. Res.60, 55–58 (1996).
  • Krieg A. Therapeutic potential of Toll-like receptor-9 activation. Nat. Rev. Drug Discov.5, 471–484 (2006).
  • Rankin R, Pontarollo R, Ioannou X et al. CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved. Antisense Nucleic Acid Drug Dev.11, 333–340 (2001).
  • Romera SA, Hilgers LA, Puntel M et al. Adjuvant effects of sulfolipo-cyclodextrin in a squalane-in-water and water-in-mineral oil emulsions for BHV-1 vaccines in cattle. Vaccine19, 132–141 (2000).
  • Kerkhofs P, Renjifo X, Toussaint JF, Letellier C, Vanopdenbosch E, Wellemans G. Enhancement of the immune response and virological protection of calves against bovine herpesvirus type 1 with an inactivated gE-deleted vaccine. Vet. Rec.152, 681–686 (2003).
  • Dale CJ, Thomson S, De Rose R et al. Prime–boost strategies in DNA vaccines. Methods Mol. Med.127, 171–197 (2006).
  • Estcourt MJ, Ramsay AJ, Brooks A, Thomson SA, Medveckzy CJ, Ramshaw IA. Prime-boost immunization generates a high frequency, high-avidity CD8(+) cytotoxic T lymphocyte population. Int. Immunol.14, 31–37 (2002).
  • Ramshaw IA, Ramsay AJ. The prime–boost strategy: exciting prospects for improved vaccination. Immunol. Today21, 163–165 (2000).
  • Galloway D, Liner A, Legutki J, Mateczun A, Barnewall R, Estep J. Genetic immunization against anthrax. Vaccine22, 1604–1608 (2004).
  • Li Z, Zhang H, Fan X et al. DNA electroporation prime and protein boost strategy enhances humoral immunity of tuberculosis DNA vaccines in mice and non-human primates. Vaccine24, 4565–4568 (2006).
  • Liang R, van den Hurk JV, Babiuk LA, van Drunen Littel-van den Hurk S. Priming with DNA encoding E2 and boosting with E2 protein formulated with CpG oligodeoxynucleotides induces strong immune responses and protection from bovine viral diarrhea virus in cattle. J. Gen. Virol.87, 2971–2982 (2006).
  • Toussaint JF, Letellier C, Paquet D, Dispas M, Kerkhofs P. Prime–boost strategies combining DNA and inactivated vaccines confer high immunity and protection in cattle against bovine herpesvirus-1. Vaccine23, 5073–5081 (2005).
  • Scarselli M, Giuliani MM, Adu-Bobie J, Pizza M, Rappuoli R. The impact of genomics on vaccine design. Trends Biotechnol.23, 84–91 (2005).
  • Braga-Neto UM, Marques ET Jr. From functional genomics to functional immunomics: new challenges, old problems, big rewards. PLoS Comput. Biol.2, e81 (2006).

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