Immunomodulatory treatment strategies in inflammatory cardiomyopathy: current status and future perspectives

References

• Richardson P, McKenna W, Bristow M et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. Circulation 93(5), 841–842 (1996).
   Google Scholar
• D'Ambrosio A, Patti G, Manzoli A et al. The fate of acute myocarditis between spontaneous improvement and evolution to dilated cardiomyopathy: a review. Heart 85(5), 499–504 (2001).
   Google Scholar
• Anker SD, Rauchhaus M. Insights into the pathogenesis of chronic heart failure: immune activation and cachexia. Curr. Opin. Cardiol. 14(3), 211–216 (1999).
   Google Scholar
• Olbrich HG. Epidemiology-etiology of dilated cardiomyopathy. Z. Kardiol. 90(Suppl.) 12–19 (2001).
   Google Scholar
• Karjalainen J, Heikkila J. Incidence of three presentations of acute myocarditis in young men in military service. A 20-year experience. Eur. Heart J. 20(15), 1120–1125 (1999).
   Google Scholar
• Hosenpud JD, Bennett LE, Keck BM, Fiol B, Boucek MM, Novick RJ. The Registry of the International Society for Heart and Lung Transplantation: sixteenth official report – 1999. J. Heart Lung Transplant. 18(7), 611–626 (1999).
   Google Scholar
• Michels VV, Driscoll DJ, Miller FA et al. Progression of familial and nonfamilial dilated cardiomyopathy: long term follow up. Heart 89(7), 757–761 (2003).
   Google Scholar
• McCarthy RE 3rd, Boehmer JP, Hruban RH et al. Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis. N. Engl. J. Med. 342(10), 690–695 (2000).
   Google Scholar
• Sinagra G, Maras P, D'Ambrosio A et al. Clinical polymorphic presentation and natural history of active myocarditis: experience in 60 cases. G. Ital. Cardiol. 27(8), 758–774. (1997)
   Google Scholar
• Schannwell CM, Schoebel FC, Marx R et al. Prognostic relevance of left ventricular diastolic function parameters in dilated cardiomyopathy. Z. Kardiol. 90(4), 269–279 (2001).
   Google Scholar
• Ammann P, Naegeli B, Schuiki E et al. Long–term outcome of acute myocarditis is independent of cardiac enzyme release. Int. J. Cardiol. 89(2–3), 217–222 (2003).
   Google Scholar
• Kuhl U, Lauer B, Souvatzoglu M, Vosberg H, Schultheiss HP. Antimyosin scintigraphy and immunohistologic analysis of endomyocardial biopsy in patients with clinically suspected myocarditis – evidence of myocardial cell damage and inflammation in the absence of histologic signs of myocarditis. J. Am. Coll. Cardiol. 32(5), 1371–1376 (1998).
   Google Scholar
• Why HJ, Meany BT, Richardson PJ et al. Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy. Circulation 89(6), 2582–2589 (1994).
   Google Scholar
• Fujioka S, Kitaura Y, Ukimura A et al. Evaluation of viral infection in the myocardium of patients with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 36(6), 1920–1926 (2000).
   Google Scholar
• Calabrese F, Rigo E, Milanesi O et al. Molecular diagnosis of myocarditis and dilated cardiomyopathy in children: clinicopathologic features and prognostic implications. Diagn. Mol. Pathol. 11(4), 212–221 (2002).
   Google Scholar
• Kanzaki Y, Terasaki F, Okabe M et al. Myocardial inflammatory cell infiltrates in cases of dilated cardiomyopathy as a determinant of outcome following partial left ventriculectomy. Jpn. Circ. J. 65(9), 797–802 (2001).
   Google Scholar
• Baboonian C, Treasure T. Meta-analysis of the association of enteroviruses with human heart disease. Heart 78(6), 539–543 (1997).
   Google Scholar
• Pauschinger M, Doerner A, Kuehl U et al. Enteroviral RNA replication in the myocardium of patients with left ventricular dysfunction and clinically suspected myocarditis. Circulation 99(7), 889–895 (1999).
   Google Scholar
• Pauschinger M, Bowles NE, Fuentes-Garcia FJ et al. Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction. Circulation 99(10), 1348–1354 (1999).
   Google Scholar
• Poller W, Fechner H, Noutsias M, Tschoepe C, Schultheiss HP. Highly variable expression of virus receptors in the human cardiovascular system Implications for cardiotropic viral infections and gene therapy. Z. Kardiol. 91(12), 978–991 (2002).
   Google Scholar
• Klingel K, Stephan S, Sauter M et al. Pathogenesis of murine enterovirus myocarditis: virus dissemination and immune cell targets. J. Virol. 70(12), 8888–8895 (1996).
   Google Scholar
• Noutsias M, Fechner H, de Jonge H et al. Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and a(v)b(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. Circulation 104(3), 275–280 (2001).
   Google Scholar
• Ito M, Kodama M, Masuko M et al. Expression of coxsackievirus and adenovirus receptor in hearts of rats with experimental autoimmune myocarditis. Circ. Res. 86(3), 275–280 (2000).
   Google Scholar
• Fechner H, Noutsias M, Tschoepe C et al. Induction of coxsackievirus-adenovirus-receptor expression during myocardial tissue formation and remodeling: identification of a cell-to-cell contact-dependent regulatory mechanism. Circulation 107(6), 876–882 (2003).
   Google Scholar
• Bowles NE, Javier FG F, Makar KA et al. Analysis of the coxsackievirus B-adenovirus receptor gene in patients with myocarditis or dilated cardiomyopathy. Mol. Genet. Metab. 77(3), 257–259 (2002).
   Google Scholar
• Badorff C, Lee GH, Lamphear BJ et al. Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat. Med. 5(3), 320–326 (1999).
   Google Scholar
• Wessely R, Henke A, Zell R, Kandolf R, Knowlton KU. Low-level expression of a mutant coxsackieviral cDNA induces a myocytopathic effect in culture: an approach to the study of enteroviral persistence in cardiac myocytes. Circulation 98(5), 450–457 (1998).
   Google Scholar
• Liu PP, Mason JW. Advances in the understanding of myocarditis. Circulation 104(9), 1076–1082 (2001).
   Google Scholar
• Noutsias M, Pauschinger M, Schultheiss HP, Kuhl U. Advances in the immunohistological diagnosis of inflammatory cardiomyopathy. Eur. Heart. J. 4(Suppl. I), 54–62 (2002).
   Google Scholar
• Carlquist JF, Menlove RL, Murray MB, O'Connell JB, Anderson JL. HLA class II (DR and DQ) antigen associations in idiopathic dilated cardiomyopathy. Validation study and meta-analysis of published HLA association studies. Circulation 83(2), 515–522 (1991).
   Google Scholar
• Maisch B, Ristic AD, Hufnagel G, Pankuweit S. Pathophysiology of viral myocarditis: the role of humoral immune response. Cardiovasc. Pathol. 11(2), 112–122 (2002).
   Google Scholar
• Warraich RS, Noutsias M, Kasac I et al. Immunoglobulin G3 cardiac myosin autoantibodies correlate with left ventricular dysfunction in patients with dilated cardiomyopathy: Immunoglobulin G3 and clinical correlates. Am. Heart J. 143(6), 1076–1084 (2002).
   Google Scholar
• Matsumori A. Cytokines in myocarditis and cardiomyopathies. Curr. Opin. Cardiol. 11(3), 302–309 (1996).
   Google Scholar
• Hunter JJ, Chien KR. Signaling pathways for cardiac hypertrophy and failure. N. Engl. J. Med. 341(17), 1276–1283 (1999).
   Google Scholar
• Noutsias M, Seeberg B, Schultheiss HP, Kuhl U. Expression of cell adhesion molecules in dilated cardiomyopathy: evidence for endothelial activation in inflammatory cardiomyopathy. Circulation 99(16), 2124–2131 (1999).
   Google Scholar
• Noutsias M, Pauschinger M, Schultheiss HP, Kuhl U. Cytotoxic perforin+ and TIA-1+ infiltrates are associated with cell adhesion molecule expression in dilated cardiomyopathy. Eur. J. Heart Fail. 5(4), 469–479 (2003).
   Google Scholar
• Kuhl U, Noutsias M, Seeberg B, Schultheiss HP. Immunohistological evidence for a chronic intramyocardial inflammatory process in dilated cardiomyopathy. Heart 75(3), 295–300 (1996).
   Google Scholar
• Kuhl U, Pauschinger M, Bock T et al. Parvovirus B19 infection mimicking acute myocardial infarction. Circulation 108(8), 945–950 (2003).
   Google Scholar
• Li J, Schwimmbeck PL, Tschope C et al. Collagen degradation in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction. Cardiovasc. Res. 56(2), 235 (2002).
   Google Scholar
• Frustaci A, Pieroni M, Chimenti C. The role of endomyocardial biopsy in the diagnosis of cardiomyopathies. Ital. Heart J. 3(6), 348–353 (2002).
   Google Scholar
• Maisch B. Myokardbiopsien und Perikardioskopien. In: Hess OM, Simon RW, eds. Herzkatheter, Einsatz in Diagnostik und Therapie. Springer, Berlin-Heidelberg-NY, 309–349 (1999).
   Google Scholar
• Aretz HT. Myocarditis: the Dallas criteria. Hum. Pathol. 18(6), 619–624 (1987).
   Google Scholar
• Strauer BE, Kandolf R, Mall G et al. Myocarditis – cardiomyopathy. Consensus Report of the German Association for Internal Medicine, presented at the 100th annual meeting, Wiesbaden, 13 April 1994. Acta Cardiol. 51(4), 347–371 (1996).
   Google Scholar
• Mason JW, O'Connell JB, Herskowitz A et al. A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. N. Engl. J. Med. 333(5), 269–275 (1995).
   Google Scholar
• Veinot JP. Diagnostic endomyocardial biopsy pathology – general biopsy considerations, and its use for myocarditis and cardiomyopathy: a review. Can. J. Cardiol. 18(1), 55–65 (2002).
   Google Scholar
• Shanes JG, Ghali J, Billingham ME et al. Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation 75(2), 401–405 (1987).
   Google Scholar
• Hauck AJ, Kearney DL, Edwards WD. Evaluation of postmortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implications for role of sampling error. Mayo Clin. Proc. 64(10), 1235–1245 (1989).
   Google Scholar
• Chander S, Talwar KK, Chopra P. Immunohistochemical characterisation and quantitative evaluation of lymphomononuclear cells in dilated cardiomyopathy – an endomyocardial biopsy study. Indian Heart J. 47(4), 360–364 (1995).
   Google Scholar
• Devaux B, Scholz D, Hirche A, Klovekorn WP, Schaper J. Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure. Eur. Heart J. 18(3), 470–479 (1997).
   Google Scholar
• Kolbeck PC, Steenbergen C, Wolfe JA, Sanfilippo F, Jennings RB. The correlation of mononuclear cell phenotype in endomyocardial biopsies with clinical history and cardiac dysfunction. Am. J. Clin. Pathol. 91(1), 37–44 (1989).
   Google Scholar
• Mues B, Brisse B, Zwadlo G et al. Phenotyping of macrophages with monoclonal antibodies in endomyocardial biopsies as a new approach to diagnosis of myocarditis. Eur. Heart J. 11(7), 619–627 (1990).
   Google Scholar
• Noutsias M, Pauschinger M, Schultheiss H, Kuhl U. Phenotypic characterization of infiltrates in dilated cardiomyopathy – diagnostic significance of T-lymphocytes and macrophages in inflammatory cardiomyopathy. Med. Sci. Monit. 8(7), CR478–CR487 (2002).
   Google Scholar
• Mahon NG, Madden BP, Caforio AL et al. Immunohistologic evidence of myocardial disease in apparently healthy relatives of patients with dilated cardiomyopathy. J. Am. Coll. Cardiol. 39(3), 455–462 (2002).
   Google Scholar
• Dettmeyer R, Reith K, Madea B. Alcoholic cardiomyopathy versus chronic myocarditis – immunohistological investigations with LCA, CD3, CD68 and tenascin. Forensic Sci. Int. 126(1), 57–62 (2002).
   Google Scholar
• Springer TA. Adhesion receptors of the immune system. Nature 346(6283) 425?434 (1990).
   Google Scholar
• Herskowitz A, Ahmed-Ansari A, Neumann DA et al. Induction of major histocompatibility complex antigens within the myocardium of patients with active myocarditis: a nonhistologic marker of myocarditis. J. Am. Coll. Cardiol. 15(3), 624–632 (1990).
   Google Scholar
• Ino T, Kishiro M, Okubo M et al. Late persistent expressions of ICAM–1 and VCAM–1 on myocardial tissue in children with lymphocytic myocarditis. Cardiovasc. Res. 34(2), 323–328 (1997).
   Google Scholar
• Wojnicz R, Nowalany-Kozielska E, Wojciechowska C et al. Randomized, Placebo-Controlled Study for Immunosuppressive Treatment of Inflammatory Dilated Cardiomyopathy : Two-Year Follow-Up Results. Circulation 104(1), 39–45 (2001).
   Google Scholar
• Noutsias M, Pauschinger M, Ostermann K et al. Digital image analysis system for the quantification of infiltrates and cell adhesion molecules in inflammatory cardiomyopathy. Med. Sci. Monit. 8(5), MT59–MT71 (2002).
   Google Scholar
• Parrillo JE. Inflammatory cardiomyopathy (myocarditis): which patients should be treated with anti-inflammatory therapy? Circulation 104(1), 4–6 (2001).
   Google Scholar
• Braimbridge MV, Darracott S, Chayen J, Bitensky L, Poulter LW. Possibility of a new infective aetiological agent in congestive cardiomyopathy. Lancet 1(7483), 171–176 (1967).
   Google Scholar
• Keeling PJ, Jeffery S, Caforio AL et al. Similar prevalence of enteroviral genome within the myocardium from patients with idiopathic dilated cardiomyopathy and controls by the polymerase chain reaction. Br. Heart J. 68(6), 554–559 (1992).
   Google Scholar
• Andreoletti L, Bourlet T, Moukassa D et al. Enteroviruses can persist with or without active viral replication in cardiac tissue of patients with end-stage ischemic or dilated cardiomyopathy. J. Infect. Dis. 182(4), 1222–1227 (2000).
   Google Scholar
• Chimenti C, Frustaci A, Pieroni M, Maseri A. Histologically proven myocarditis in patients with biventricular dysfunction and severe asymptomatic coronary artery disease. Cardiologia 44(2), 177–180 (1999).
   Google Scholar
• Bowles NE, Ni J, Kearney DL et al. Detection of viruses in myocardial tissues by polymerase chain reaction. evidence of adenovirus as a common cause of myocarditis in children and adults. J. Am. Coll. Cardiol. 42(3), 466–472 (2003).
   Google Scholar
• Frustaci A, Chimenti C, Calabrese F et al. Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. Circulation 107(6), 857–863 (2003).
   Google Scholar
• Bultmann BD, Klingel K, Sotlar K, Bock CT, Kandolf R. Parvovirus B19: a pathogen responsible for more than hematologic disorders. Virchows Arch. 442(1), 8–17 (2003).
   Google Scholar
• Li Y, Bourlet T, Andreoletti L et al. Enteroviral capsid protein VP1 is present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy. Circulation 101(3), 231–234 (2000).
   Google Scholar
• Kuhl U, Pauschinger M, Schwimmbeck PL et al. Interferon–beta treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction. Circulation 107(22), 2793–2798 (2003).
   Google Scholar
• Maisch B, Camerini F, Schultheiss HP. Immunosuppressive therapy for myocarditis [letter; comment]. N. Engl. J. Med. 333(25), 1713–1714 (1995).
   Google Scholar
• McNamara DM, Holubkov R, Starling RC et al. Controlled trial of intravenous immune globulin in recent–onset dilated cardiomyopathy. Circulation 103(18), 2254–2259 (2001).
   Google Scholar
• Staudt A, Schaper F, Stangl V et al. Immunohistological changes in dilated cardiomyopathy induced by immunoadsorption therapy and subsequent immunoglobulin substitution. Circulation 103(22), 2681–2686 (2001).
   Google Scholar
• Kuhl U, Schultheiss HP. Treatment of chronic myocarditis with corticosteroids. Eur. Heart J. 16(Suppl. O), O168–O172 (1995).
   Google Scholar
• Felix SB, Staudt A, Dorffel WV et al. Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy: three-month results from a randomized study. J. Am. Coll. Cardiol. 35(6), 1590–1598 (2000).
   Google Scholar
• Schimke I, Muller J, Priem F et al. Decreased oxidative stress in patients with idiopathic dilated cardiomyopathy one year after immunoglobulin adsorption. J. Am. Coll. Cardiol. 38(1), 178–183 (2001).
   Google Scholar
• Heim A, Grumbach I, Pring-Akerblom P et al. Inhibition of coxsackievirus B3 carrier state infection of cultured human myocardial fibroblasts by ribavirin and human natural interferon-a. Antiviral Res. 34(3), 101–111 (1997).
   Google Scholar
• Rosen FS. Putative mechanisms of the effect of intravenous g–globulin. Clin. Immunol. Immunopathol. 67(3 Pt 2), S41–S43 (1993).
   Google Scholar
• Takada H, Kishimoto C, Hiraoka Y. Therapy with immunoglobulin suppresses myocarditis in a murine coxsackievirus B3 model. Antiviral and anti-inflammatory effects. Circulation 92(6), 1604–1611 (1995).
   Google Scholar
• McNamara DM, Rosenblum WD, Janosko KM et al. Intravenous immune globulin in the therapy of myocarditis and acute cardiomyopathy. Circulation 95(11), 2476–2478 (1997).
   Google Scholar
• Gullestad L, Aass H, Fjeld JG et al. Immunomodulating Therapy With Intravenous Immunoglobulin in Patients With Chronic Heart Failure. Circulation 103(2), 220–225 (2001).
   Google Scholar
• Noutsias M, Hohmann C, Pauschinger M et al. sICAM–1 correlates with myocardial ICAM–1 expression in dilated cardiomyopathy. Int. J. Cardiol. 91(2–3), 153–161 (2003).
   Google Scholar
• Ghosh S, Goldin E, Gordon FH et al. Natalizumab for active Crohn's disease. N. Engl. J. Med. 348(1), 24–32 (2003).
   Google Scholar
• Matsumoto Y, Jee Y, Sugisaki M. Successful TCR-based immunotherapy for autoimmune myocarditis with DNA vaccines after rapid identification of pathogenic TCR. J. Immunol. 164(4), 2248–2254 (2000).
   Google Scholar
• Heim A, Pfetzing U, Muller G, Grumbach IM. Antiviral activity of WIN 54954 in coxsackievirus B2 carrier state infected human myocardial fibroblasts. Antiviral Res. 37(1), 47–56. (1998).
   Google Scholar