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Perspectives

Can the sum of pooled data from observational studies better evaluate outcome measures for therapies in coronary artery disease?

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Pages 155-162 | Received 22 Jun 2015, Accepted 24 Nov 2015, Published online: 27 Dec 2015

References

• First historical trial to have used randomization for selection of cases and controls.

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•• Article provides strong arguments for the superiority of cabg in multivessel disease.

•• Discusses pci against cabg with arguments for the superiority of cabg in multivessel disease as opposed to historical trials.

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•• This famous lecture looks at historical data for revascularization and how results from previous trials were skewed against cabg.

•• Discusses shortcomings of RCTs.

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•• Historical trial comparing onpump and offpump.

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•• Article analyses predictive risk of mortality scores for cabg patients and shows that only high risk patients are likely to benefit, a possible explanation why trials have not shown much survival differences between offpump and onpump results.

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•• Landmark trial comparing pci and cabg.

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•• Landmark review paper that shows superior survival for bilateral internal thoracic arteries despite lack of recommendations.

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•• Landmark observational study of bilateral internal thoracic arteries.

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•• Landmark observational study of bilateral internal thoracic arteries.

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•• Landmark observational study of bilateral internal thoracic arteries.

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•• Important study for quality of evidence.

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