References
- Powers DJ, Derdeyn CP, Biller J, et al. 2015 AHA/ASA focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment. Stroke. 2015;46(10):3020–3035.
- Jung JE, Kim GS, Chen H, et al. Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Mol Neurobiol. 2010;41(2–3):172–179.
- Fabian RH, DeWitt DS, Kent TA. In vivo detection of superoxide anion production by the brain using a cytochrome c electrode. J Cereb Blood Flow Metab. 1995;15(2):242–247.
- Leinonen JS, Ahonen JP, Lonnrot K, et al. Low plasma antioxidant activity is associated with high lesion volume and neurological impairment in stroke. Stroke. 2000;31(1):33–39.
- Llull L, Amaro S, Chamorro A. Administration of uric acid in the emergency treatment of acute ischemic stroke. Curr Neurol Neurosci Rep. 2016;16(1):4.
- Ames BN, Cathcart R, Schwiers E, et al. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA. 1981;78(11):6858–6862.
- Yu ZF, Bruce-Keller AJ, Goodman Y, et al. Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo. J Neurosci Res. 1998;53(5):613–625.
- Romanos E, Planas AM, Amaro S, et al. Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. J Cereb Blood Flow Metab. 2007;27(1):14–20.
- Onetti Y, Dantas AP, Pérez B, et al. Middle cerebral artery remodeling following transient brain ischemia is linked to early postischemic hyperemia: a target of uric acid treatment. Am J Physiol Heart Circ Physiol. 2015;308(8):862–874.
- Yildiz BS, Ozkan E, Esin F, et al. Does high serum uric acid level cause aspirin resistance? Blood Coagul Fibrinolysis. 2015;1. Epub 2015 Dec 11. doi:10.1097/MBC.0000000000000466.
- Wang Z, Lin Y, Liu Y, et al. Serum uric acid levels and outcomes after acute ischemic stroke. Mol Neurobiol. 2015. Epub 2015 Mar 7. doi:10.1007/s12035-015-9134-1.
- Brouns R, Wauters A, Van De Vijver G, et al. Decrease in uric acid in acute ischemic stroke correlates with stroke severity, evolution and outcome. Clin Chem Lab Med. 2010;48(3):383–390.
- Amaro S, Urra X, Gomez-Choco M, et al. Uric acid levels are relevant in patients with stroke treated with thrombolysis. Stroke. 2011;42(1 Suppl):S28–32.
- Hong JM, Bang OY, Chung CS, et al. Influence of recanalization on uric acid patterns in acute ischemic stroke. Cerebrovasc Dis. 2010;29(5):431–439.
- Amaro S, Soy D, Obach V, et al. A pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic stroke. Stroke. 2007;38(7):2173–2175.
- Amaro S, Obach V, Cervera A, et al. Course of matrix metalloproteinase-9 isoforms after the administration of uric acid in patients with acute stroke: a proof-of-concept study. J Neurol. 2009;256(4):651–656.
- Chamorro A, Amaro S, Castellanos M, et al. Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind, phase 2b/3 trial. Lancet Neurol. 2014;13(5):453–460.
- Fisher M, Albers GW, Donnan GA, et al. Stroke Therapy Academic Industry Roundtable IV. Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable. Stroke. 2005;36(8):1808–1813.
- Amaro S, Llull L, Renú A, et al. Uric acid improves glucose-driven oxidative stress in human ischemic stroke. Ann Neurol. 2015;77(5):775–783.
- Llull L, Laredo C, Renú A, et al. Uric acid therapy improves clinical outcome in women with acute ischemic stroke. Stroke. 2015;46(8):2162–2167.