1,417
Views
235
CrossRef citations to date
0
Altmetric
Special Report

Neutrophil to lymphocyte ratio (NLR) and cardiovascular diseases: an update

&
Pages 573-577 | Received 17 Jan 2016, Accepted 12 Feb 2016, Published online: 04 Mar 2016

References

  • Stoner L, Lucero AA, Palmer BR, et al. Inflammatory biomarkers for predicting cardiovascular disease. Clin Biochem. 2013;46:1353–1371. doi:10.1016/j.clinbiochem.2013.05.070.
  • Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther. 2013;11:55–59. doi:10.1586/erc.12.159.
  • Bruins P, te Velthuis H, Yazdanbakhsh AP, et al. Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves c-reactive protein and is associated with postoperative arrhythmia. Circulation. 1997;96:3542–3548.
  • Gibson PH, Cuthbertson BH, Croal BL, et al. Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol. 2010;105:186–191. doi:10.1016/j.amjcard.2009.09.007.
  • Frustaci A, Chimenti C, Bellocci F, et al. Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation. 1997;96:1180–1184.
  • Shao Q, Chen K, Rha SW, et al. Usefulness of neutrophil/lymphocyte ratio as a predictor of atrial fibrillation: a meta-analysis. Arch Med Res. 2015;46:199–206. doi:10.1016/j.arcmed.2015.03.011.
  • Canpolat U, Aytemir K, Yorgun H, et al. Role of preablation neutrophil/lymphocyte ratio on outcomes of cryoballoon-based atrial fibrillation ablation. Am J Cardiol. 2013;112:513–519. doi:10.1016/j.amjcard.2013.04.015.
  • Im SI, Shin SY, Na JO, et al. Usefulness of neutrophil/lymphocyte ratio in predicting early recurrence after radiofrequency catheter ablation in patients with atrial fibrillation. Int J Cardiol. 2013;168:4398–4400. doi:10.1016/j.ijcard.2013.05.042.
  • Arıbaş A, Akıllı H, Gül EE, et al.Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion? Anadolu kardiyoloji dergisi: AKD = ‎Anatol J Cardiol. 2013;13:123–130. doi:10.5152/akd.2013.036.
  • Chatterjee S, Chandra P, Guha G, et al. Pre-procedural elevated white blood cell count and neutrophil-lymphocyte (n/l) ratio are predictors of ventricular arrhythmias during percutaneous coronary intervention. Cardiovasc Hematol Disord Drug Targets. 2011;11:58–60. doi:10.2174/187152911798346981.
  • Aydin M, Yildiz A, Yuksel M, et al. Assessment of the neutrophil/lymphocyte ratio in patients with supraventricular tachycardia. Anatol J Cardiol. 2015. doi:10.5152/akd.2015.5927.
  • Libby P, Ridker PM, Hansson GK, Leducq Transatlantic Network on A. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol. 2009;54:2129–2138. doi:10.1016/j.jacc.2009.09.009.
  • Guasti L, Dentali F, Castiglioni L, et al. Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularisation. A systematic review on more than 34,000 subjects. Thromb Haemost. 2011;106:591–599. doi:10.1160/TH11-02-0096.
  • Tamhane UU, Aneja S, Montgomery D, et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008;102:653–657. doi:10.1016/j.amjcard.2008.05.006.
  • Oncel RC, Ucar M, Karakas MS, et al. Relation of neutrophil-to-lymphocyte ratio with grace risk score to in-hospital cardiac events in patients with st-segment elevated myocardial infarction. Clin Applied Thrombosis/Hemostasis. 2015;21:383–388. doi:10.1177/1076029613505763.
  • Arbel Y, Shacham Y, Ziv-Baran T, et al. Higher neutrophil/lymphocyte ratio is related to lower ejection fraction and higher long-term all-cause mortality in st-elevation myocardial infarction patients. Can J Cardiol. 2014;30:1177–1182. doi:10.1016/j.cjca.2014.05.010.
  • Yildiz A, Yuksel M, Oylumlu M, et al. The utility of the platelet-lymphocyte ratio for predicting no reflow in patients with st-segment elevation myocardial infarction. Clin Applied Thrombosis/Hemostasis. 2015;21:223–228. doi:10.1177/1076029613519851.
  • Kurtul A, Murat SN, Yarlioglues M, et al. Increased neutrophil-to-lymphocyte ratio predicts persistent coronary no-flow after wire insertion in patients with st-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Clinics. 2015;70:34–40. doi:10.6061/clinics/2015(01)07.
  • Baysal E, Cetin M, Yaylak B, et al. Roles of the red cell distribution width and neutrophil/lymphocyte ratio in predicting thrombolysis failure in patients with an st-segment elevation myocardial infarction. Blood Coagul Fibrinolysis. 2015;26:274–278. doi:10.1097/MBC.0000000000000227.
  • Kurtul S, Sarli B, Baktir AO, et al. Neutrophil to lymphocyte ratio predicts syntax score in patients with non-st segment elevation myocardial infarction. Int Heart J. 2015;56:18–21. doi:10.1536/ihj.14-175.
  • Gul M, Uyarel H, Ergelen M, et al. Predictive value of neutrophil to lymphocyte ratio in clinical outcomes of non-st elevation myocardial infarction and unstable angina pectoris: a 3-year follow-up. Clin Applied Thrombosis/Hemostasis. 2014;20:378–384. doi:10.1177/1076029612465669.
  • Cho KI, Ann SH, Singh GB, et al. Combined usefulness of the platelet-to-lymphocyte ratio and the neutrophil-to-lymphocyte ratio in predicting the long-term adverse events in patients who have undergone percutaneous coronary intervention with a drug-eluting stent. PLoS One. 2015;10:e0133934. doi:10.1371/journal.pone.0133934.
  • Ayça B, Akın F, Celik O, et al. Neutrophil to lymphocyte ratio is related to stent thrombosis and high mortality in patients with acute myocardial infarction. Angiology. 2015;66:545–552. doi:10.1177/0003319714542997.
  • Horne BD, Anderson JL, John JM, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol. 2005;45:1638–1643. doi:10.1016/j.jacc.2005.02.054.
  • Kalay N, Dogdu O, Koc F, et al. Hematologic parameters and angiographic progression of coronary atherosclerosis. Angiology. 2012;63:213–217. doi:10.1177/0003319711412763.
  • Verdoia M, Barbieri L, Giovine GD, et al. Neutrophil to lymphocyte ratio and the extent of coronary artery disease: results from a large cohort study. Angiology. 2016;67(1):75–82.
  • Kaya A, Kurt M, Tanboga IH, et al. Relation of neutrophil to lymphocyte ratio with the presence and severity of stable coronary artery disease. Clin Applied Thrombosis/Hemostasis. 2014;20:473–477. doi:10.1177/1076029612473517.
  • Chen J, Chen MH, Li S, et al. Usefulness of the neutrophil-to-lymphocyte ratio in predicting the severity of coronary artery disease: a gensini score assessment. J Atheroscler Thromb. 2014;21:1271–1282.
  • Demir K, Avci A, Altunkeser BB, et al. The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions. BMC Cardiovasc Disord. 2014;14:130. doi:10.1186/1471-2261-14-130.
  • Prabhu SD. Cytokine-induced modulation of cardiac function. Circ Res. 2004;95:1140–1153. doi:10.1161/01.RES.0000150734.79804.92.
  • Uthamalingam S, Patvardhan EA, Subramanian S, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol. 2011;107:433–438. doi:10.1016/j.amjcard.2010.09.039.
  • Benites-Zapata VA, Hernandez AV, Nagarajan V, et al. Usefulness of neutrophil-to-lymphocyte ratio in risk stratification of patients with advanced heart failure. Am J Cardiol. 2015;115:57–61. doi:10.1016/j.amjcard.2014.10.008.
  • Durmus E, Kivrak T, Gerin F, et al. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are predictors of heart failure. Arq Bras Cardiol. 2015;105:606–613. doi:10.5935/abc.20150126.
  • Cakici M, Cetin M, Dogan A, et al. Neutrophil to lymphocyte ratio predicts poor functional capacity in patients with heart failure. Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir. 2014;42:612–620.
  • Agacdiken A, Celikyurt U, Sahin T, et al. Neutrophil-to-lymphocyte ratio predicts response to cardiac resynchronization therapy. Med Sci Monit. 2013;19:373–377. doi:10.12659/MSM.883915.
  • Yost GL, Joseph CR, Tatooles AJ, et al. Neutrophil-to-lymphocyte ratio predicts outcomes in patients implanted with left ventricular assist devices. Asaio J. 2015;61:664–669. doi:10.1097/MAT.0000000000000267.
  • Baysal E, Burak C, Cay S, et al. The neutrophil to lymphocyte ratio is associated with severity of rheumatic mitral valve stenosis. J Blood Med. 2015;6:151–156. doi:10.2147/JBM.S82423.
  • Polat N, Yildiz A, Yuksel M, et al. Association of neutrophil-lymphocyte ratio with the presence and severity of rheumatic mitral valve stenosis. Clin Applied Thrombosis/Hemostasis. 2014;20:793–798. doi:10.1177/1076029613514131.
  • Varol E, Aksoy F, Ozaydin M, et al. Association between neutrophil-lymphocyte ratio and mitral annular calcification. Blood Coagul Fibrinolysis. 2014;25:557–560.
  • Avci A, Elnur A, Göksel A, et al. The relationship between neutrophil/lymphocyte ratio and calcific aortic stenosis. Echocardiography. 2014;31:1031–1035. doi:10.1111/echo.12534.
  • Castro-Dominguez Y, Mathur AP, Angeli D, et al. Impact of neutrophil to lymphocyte ratio in patients undergoing transcatheter aortic valve replacement. J Am Coll Cardiol. 2015;66(15_S).
  • Kounis NG, Soufras GD, Tsigkas G, et al. White blood cell counts, leukocyte ratios, and eosinophils as inflammatory markers in patients with coronary artery disease. Clin Applied Thrombosis/Hemostasis. 2015;21:139–143. doi:10.1177/1076029614531449.
  • Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol. 2008;8:802–815. doi:10.1038/nri2415.
  • Azab B, Zaher M, Weiserbs KF, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-st-elevation myocardial infarction. Am J Cardiol. 2010;106:470–476. doi:10.1016/j.amjcard.2010.03.062.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.