Chronotherapy in hypertensive patients: administration–time dependent effects of treatment on blood pressure regulation

References

• Chobanian AV, Bakris GL, Black HR et al. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. JAMA289, 2560–2571 (2003).
   PubMed Web of Science ®Google Scholar
• Guidelines Committee. 2003 European Society of Hypertension – European Society of Cardiology guidelines for the management of arterial hypertension. J. Hypertens.21, 1011–1053 (2003).
   PubMed Web of Science ®Google Scholar
• O’Brien A, Asmar R, Beilin L et al. European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement. J. Hypertens.21, 821–848 (2003).
   PubMed Web of Science ®Google Scholar
• Pickering TG, Hall JE, Appel LJ et al. Recommendations for blood pressure measurement in humans and experimental animals. Part 1: blood pressure measurement in humans. Hypertension45, 142–161 (2005).
   PubMed Web of Science ®Google Scholar
• Pickering TG, James GD, Boddie C, Harshfield GA, Blank S, Laragh JH. How common is white-coat hypertension? JAMA259, 225–228 (1998).
   Google Scholar
• Pickering TG. White coat hypertension. In: Hypertension: Pathophysiology, Diagnosis and Management. Laragh JH, Brenner BM (Eds). Raven Press, NY, USA 1913–1927 (1995).
   Google Scholar
• Staessen JA, Beilin L, Parati G, Waeber B, White W, and the Participants of the 1999 Consensus Conference on Ambulatory Blood Pressure Monitoring. Task Force IV: clinical use of ambulatory blood pressure monitoring. Blood Press. Monit.4, 319–331 (1999).
   PubMedGoogle Scholar
• Hermida RC. Time-qualified reference values for 24h ambulatory blood pressure monitoring. Blood Press. Monit.4, 137–147 (1999).
   PubMedGoogle Scholar
• Perloff D, Sokolow M, Cowan R. The prognostic value of ambulatory blood pressures. JAMA249, 2792–2798 (1983).
   PubMed Web of Science ®Google Scholar
• Staessen JA, Thijs L, Fagard R et al. Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. JAMA282, 539–546 (1999).
   PubMed Web of Science ®Google Scholar
• Clement DL, De Buyzere ML, De Bacquer DA et al. Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension. N. Engl. J. Med.348, 2407–2415 (2003).
   PubMed Web of Science ®Google Scholar
• Degaute JP, van de Borne P, Kerkhofs M, Dramaix M, Linkowski P. Does non-invasive ambulatory blood pressure monitoring disturb sleep? J. Hypertens.10, 879–885 (1992).
   PubMed Web of Science ®Google Scholar
• Palatini P, Mormino P, Canali C et al. Factors affecting ambulatory blood pressure reproducibility. Results of the HARVEST trial. Hypertension and Ambulatory Recording VEnetia STudy. Hypertension23, 211–216 (1994).
   PubMed Web of Science ®Google Scholar
• Mansoor GA, McCabe EJ, White WB. Long-term reproducibility of ambulatory blood pressure. J. Hypertens.12, 703–708 (1994).
   PubMed Web of Science ®Google Scholar
• Guidelines Subcommittee: Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2004). Hypertens. Res.29, S1–S106 (2006).
   Web of Science ®Google Scholar
• Portaluppi F, Smolensky MH. Circadian rhythm and environmental determinants of blood pressure regulation in normal and hypertensive conditions. In: Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. White WB (Ed.). Humana Press, NJ, USA 79–118 (2000).
   Google Scholar
• Portaluppi F, Smolensky MH. Time-dependent and control of arterial blood pressure. Ann. NY Acad. Sci.783, 1–342 (1996).
   PubMed Web of Science ®Google Scholar
• Sica DA, Wilson DK. Sodium, potassium, the sympathetic nervous system, and the renin–angiotensin system: impact on the circadian variability in blood pressure. In: Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. White WB (Ed.). Humana Press, NJ, USA 171–190 (2000).
   Google Scholar
• James GD, Pickering TG. The influence of behavioral factors on the daily variation of blood pressure. Am. J. Hypertens.6, 170S–173S (1993).
   Google Scholar
• Clark LA, Denby L, Pregibon D et al. A quantitative analysis of the effects of activity and time of day on the diurnal variations of blood pressure. J. Chronic Dis.40(7), 671–681 (1987).
   PubMedGoogle Scholar
• Degaute JP, Van Cauter E, van de Borne P, Linkowski P. Twenty-four-hour blood pressure and heart rate profiles in humans. A twin study. Hypertension23(2), 244–253 (1994).
   PubMed Web of Science ®Google Scholar
• Sundberg S, Kohvakka A, Gordin A. Rapid reversal of circadian blood pressure rhythm in shift workers. J. Hypertens.6(5), 393–396 (1988).
   PubMed Web of Science ®Google Scholar
• Goto T, Yokoyama K, Araki T et al. Identical blood pressure levels and slower heart rates among nurses during night work and day work. J. Hum. Hypertens.8(1), 11–14 (1994).
   PubMed Web of Science ®Google Scholar
• Portaluppi F, Waterhouse J, Minors D. Overview. The rhythms of blood pressure in humans. Exogenous and endogenous components and implications for diagnosis and treatment. Ann. NY Acad. Sci.783, 1–9 (1996).
   PubMed Web of Science ®Google Scholar
• Janssen BJ, Tyssen CM, Duindam H, Rietveld WJ. Suprachiasmatic lesions eliminate 24-h blood pressure variability in rats. Physiol. Behav.55(2), 307–311 (1994).
   PubMed Web of Science ®Google Scholar
• Witte K, Schnecko A, Buijs R, Lemmer B. Circadian rhythms in blood pressure and heart rate in SCN-lesioned and unlesioned transgenic hypertensive rats. Biol. Rhythm Res.26(4), 458–459 (1995) (Abstract).
   Google Scholar
• Bartter FC, Chan JCM, Simpson HW. Chronobiological aspect of plasma renin activity, plasma aldosterone and urinary electrolytes. In: Endocrine Rhythms. Krieger DT (Ed.). Raven Press, NY, USA 49–132 (1979).
   Google Scholar
• Angeli A, Gatti G, Masera R. Chronobiology of the hypothalamic-pituitary-adrenal and renin–angiotensin–aldosterone systems. In: Biologic Rhythms in Clinical and Laboratory Medicine. Touitou Y, Haus E (Eds). Springer-Verlag, Berlin, Germany 292–314 (1992).
   Google Scholar
• Sothern RB, Vesely DL, Kanabrocki EL et al. Temporal (circadian) and functional relationship between atrial natriuretic peptides and blood pressure. Chronobiol. Int.12, 106–120 (1995).
   PubMed Web of Science ®Google Scholar
• Cowley AW Jr, Liard JF, Guyton AC. Role of baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ. Res.32(5), 564–576 (1973).
   PubMed Web of Science ®Google Scholar
• van de Borne P, Nguyen H, Biston P, Linkowski P, Degaute JP. Effects of wake and sleep stages on the 24-h autonomic control of blood pressure and heart rate in recumbent men. Am. J. Physiol.266(2 Pt 2), H548–H554 (1994).
   PubMed Web of Science ®Google Scholar
• O’Brien E, Atkins N, O’Malley K. Defining normal ambulatory blood pressure. Am. J. Hypertens.6, 201S–206S (1993).
   Web of Science ®Google Scholar
• Burt VL, Whelton P, Roccella EJ et al. Prevalence of hypertension in the US adult population: results of the Third National Health and Nutrition Examination Survey, 1988–1991. Hypertension25, 305–313 (1995).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Fernández JR, Mojón A, Alonso I, Calvo C. Modeling the circadian variability of ambulatorily monitored blood pressure by multiple-component analysis. Chronobiol. Int.19, 461–481 (2002).
   PubMed Web of Science ®Google Scholar
• O’Brien E, Sheridan J, O’Malley K. Dippers and non-dippers. Lancet13, 397 (1988) (Letter).
   Google Scholar
• Chau NP, Bauduceau B, Chanudet X, Larroque P, Gautier D. Ambulatory blood pressure in diabetic subjects. Am. J. Hypertens.7, 487–491 (1994).
   PubMed Web of Science ®Google Scholar
• van de Borne P, Tielemans C, Vanherweghem JL, Degaute JP. Twenty-four hour blood pressure and heart rate patterns in chronic hemodialisys patients. Am. J. Kidney Dis.22, 419–425 (1993).
   PubMed Web of Science ®Google Scholar
• Bell DS. Heart failure: the frequent, forgotten, and often fatal complication of diabetes. Diabetes Care26(8), 2433–2441 (2003).
   PubMed Web of Science ®Google Scholar
• Verdecchia P, Schillaci G, Guerrieri M et al. Prevalence and determinants of left ventricular diastolic filling abnormalities in an unselected hypertensive population. Eur. Heart J.11(8), 679–691 (1990).
   PubMed Web of Science ®Google Scholar
• Galderisi M, Petrocelli A, Alfieri A, Garofalo M, de Divitiis O. Impact of ambulatory blood pressure on left ventricular diastolic dysfunction in uncomplicated arterial systemic hypertension. Am. J. Cardiol.77(8), 597–601 (1996).
   PubMed Web of Science ®Google Scholar
• Andersen NH, Poulsen SH, Poulsen PL et al. Left ventricular dysfunction in hypertensive patients with Type 2 diabetes mellitus. Diabet. Med.22(9), 1218–1225 (2005).
   PubMed Web of Science ®Google Scholar
• Bode-Boger SM, Boger RH, Kielstein JT, Loffler M, Schaffer J, Frolich JC. Role of endogenous nitric oxide in circadian blood pressure regulation in healthy humans and in patients with hypertension or atherosclerosis. J. Investig. Med.48, 125–132 (2000).
   PubMed Web of Science ®Google Scholar
• Higashi Y, Nakagawa K, Kimura M et al. Circadian variation of blood pressure and endothelial function in patients with essential hypertension: a comparison of dippers and non-dippers. J. Am. Coll. Cardiol.40(11), 2039–2043 (2002).
   PubMed Web of Science ®Google Scholar
• von Kanel R, Jain S, Mills PJ et al. Relation of nocturnal blood pressure dipping to cellular adhesion, inflammation and hemostasis. J. Hypertens.22(11), 2087–2093 (2004).
   PubMed Web of Science ®Google Scholar
• Lee KW, Blann AD, Lip GY. High pulse pressure and nondipping circadian blood pressure in patients with coronary artery disease: relationship to thrombogenesis and endothelial damage/dysfunction. Am. J. Hypertens.18(1), 104–115 (2005).
   PubMed Web of Science ®Google Scholar
• Chong AY, Blann AD, Patel J, Freestone B, Hughes E, Lip GY. Endothelial dysfunction and damage in congestive heart failure: relation of flow-mediated dilation to circulating endothelial cells, plasma indexes of endothelial damage, and brain natriuretic peptide. Circulation110(13), 1794–1798 (2004).
   PubMed Web of Science ®Google Scholar
• Tousoulis D, Charakida M, Stefanadis C. Inflammation and endothelial dysfunction as therapeutic targets in patients with heart failure. Int. J. Cardiol.100(3), 347–353 (2005).
   PubMed Web of Science ®Google Scholar
• Pickering TG. The clinical significance of diurnal blood pressure variations: dippers and nondippers. Circulation81, 700–702 (1990).
   PubMed Web of Science ®Google Scholar
• Kario K, Motai K, Mitsuhashi T et al. Autonomic nervous dysfunction in elderly hypertensive patients with abnormal diurnal blood pressure variation: relation to silent cerebrovascular disease. Hypertension30, 1504–1510 (1997).
   PubMed Web of Science ®Google Scholar
• Ragot S, Herpin D, Siché JP, Ingrand P, Maillon JM. Autonomic nervous system activity in dipper and non-dipper essential hypertensive patients. What about sex differences? J. Hypertens.17, 1805–1811 (1999).
   PubMed Web of Science ®Google Scholar
• Uzu T, Kazembe FS, Ishikawa K, Nakamura S, Ikenaga T, Kimura G. High sodium sensitivity implicates nocturnal hypertension in essential hypertension. Hypertension28, 139–142 (1996).
   PubMed Web of Science ®Google Scholar
• Uzu T, Fujii T, Nishimura M et al. Determinants of circadian blood pressure rhythm in essential hypertension. Am. J. Hypertens.12, 35–39 (1999).
   PubMed Web of Science ®Google Scholar
• James GD, Toledano T, Datz G, Pickering TG. Factors influencing the awake–sleep difference in ambulatory blood pressure: main effects and sex differences. J. Hum. Hypertens.9, 821–826 (1995).
   PubMed Web of Science ®Google Scholar
• Pickering TG, James GD. Determinants and consequences of the diurnal rhythm of blood pressure. Am. J. Hypertens.6, 166S–169S (1993).
   PubMed Web of Science ®Google Scholar
• Kario K, Schwartz JE, Pickering TG. Ambulatory physical activity as a determinant of diurnal blood pressure variation. Hypertension34, 685–691 (1999).
   PubMed Web of Science ®Google Scholar
• Leary AC, Donnan PT, MacDonald TM, Murphy MB. Physical activity is an independent predictor of the diurnal variation in blood pressure. J. Hypertens.18, 405–410 (2000).
   PubMed Web of Science ®Google Scholar
• Mansoor GA, White WB, McCabe EJ, Giacco S. The relationship of electronically monitored physical activity to blood pressure, heart rate, and the circadian blood pressure profile. Am. J. Hypertens.13, 262–267 (2000).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE, Mojón A, López JE. Relationship between physical activity and blood pressure in dipper and nondipper hypertensive patients. J. Hypertens.20, 1097–1104 (2002).
   PubMed Web of Science ®Google Scholar
• Dolan E, Stanton A, Thijs L et al. Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study. Hypertension46(1), 156–161 (2005).
   PubMed Web of Science ®Google Scholar
• Shimada K, Kario K. Altered circadian rhythm of blood pressure and cerebrovascular damage. Blood Press. Monit.2, 333–338 (1997).
   PubMedGoogle Scholar
• Bianchi S, Bigazzi R, Baldari G, Sgherri G, Campese VM. Diurnal variations of blood presure and microalbuminuria in essential hypertension. Am. J. Hypertens.7, 23–29 (1994).
   PubMed Web of Science ®Google Scholar
• Timio M, Venanzi S, Lolli S et al. “Non-dipper” hypertensive patients and progressive renal insufficiency: a 3-year longitudinal study. Clin. Nephrol.43, 382–387 (1995).
   PubMed Web of Science ®Google Scholar
• Goto N, Uchida K, Morozumi K et al. Circadian blood pressure rhythm is disturbed in nephrectomy. Hypertens. Res.28, 301–306 (2005).
   PubMed Web of Science ®Google Scholar
• Davidson MB, Hix JK, Vidt DG, Brotman DJ. Association of impaired diurnal blood pressure variation with a subsequent decline in glomerular filtration rate. Arch. Intern. Med.166(8), 846–852 (2006).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE et al. Seasonal variation of fibrinogen in dipper and nondipper hypertensive patients. Circulation108, 1101–1106 (2003).
   PubMed Web of Science ®Google Scholar
• Wilhelmsen L, Svardsudd K, Korsan-Bengtsen K, Larsson B, Welin L, Tibblin G. Fibrinogen as a risk factor for stroke and myocardial infarction. N. Engl. J. Med.311, 501–505 (1984).
   PubMed Web of Science ®Google Scholar
• Verdecchia P, Porcellati C, Schillaci G et al. Ambulatory blood pressure: an independent predictor of prognosis in essential hypertension. Hypertension24, 793–801 (1994).
   PubMed Web of Science ®Google Scholar
• Ohkubo T, Imai Y, Tsuji I et al. Prediction of mortality by ambulatory blood pressure monitoring versus screening blood pressure measurements: a pilot study in Ohasama. J. Hypertens.15, 357–364 (1997).
   PubMed Web of Science ®Google Scholar
• Kario K, Pickering TG, Matsuo T, Hoshide S, Schwartz JE, Shimada K. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Hypertension38, 852–857 (2001).
   PubMed Web of Science ®Google Scholar
• Ohkubo T, Hozawa A, Yamaguchi J et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J. Hypertens.20, 2183–2189 (2002).
   PubMed Web of Science ®Google Scholar
• Ingelsson E, Bjorklund-Bodegard K, Lind L, Arnlov J, Sundstrom J. Diurnal blood pressure pattern and risk of congestive heart failure. JAMA295, 2859–2866 (2006).
   PubMed Web of Science ®Google Scholar
• Kikuya M, Ohkubo T, Asayama K et al. Ambulatory blood pressure and 10-year risk of cardiovascular and noncardiovascular mortality. The Ohasama study. Hypertension45, 240–245 (2005).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Smolensky MH. Chronotherapy of hypertension. Curr. Opin. Nephrol. Hypertens.13, 501–505 (2004).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Calvo C. Administration time-dependent effects of antihypertensive treatment on the circadian pattern of blood pressure. Curr. Opin. Nephrol. Hypertens.14, 453–459 (2005).
   PubMed Web of Science ®Google Scholar
• Lemmer B. Cardiovascular chronobiology and chronopharmacology. In: Biologic Rhythms in Clinical and Laboratory Medicine. Touitou Y, Haus E (Eds). Springer-Verlag, Berlin, Germany 418–427 (1992).
   Google Scholar
• Lemmer B. The importance of circadian rhythms on drug response in hypertension and coronary heart disease – from mice and man. Pharmacol. Ther.111, 629–651 (2006).
   PubMed Web of Science ®Google Scholar
• Smolensky MH. Chronobiology and chronotherapeutics. Applications to cardiovascular medicine. Am. J. Hypertens.9, 11S–21S (1996).
   PubMed Web of Science ®Google Scholar
• Smolensky MH, Hermida RC, Portaluppi F, Haus E, Reinberg A. Chronotherapeutics in the treatment of hypertension. In: Hypertension: A Companion to Brenner and Rector's the Kidney. (Second edition). Oparil S, Weber MA (Eds). Elsevier Saunders, PA, USA 530–542 (2005).
   Google Scholar
• Cutler NR, Anders RJ, Sanford S et al. Placebo-controlled evaluation of three doses of a controlled-onset, extended-release formulation of verapamil in the treatment of stable angina pectoris. Am. J. Cardiol.75, 1102–1106 (1995).
   PubMed Web of Science ®Google Scholar
• Frishman WH, Glasser S, Stone P, Deedwania PC, Johnson M, Fakouhi TD. Comparison of controlled-onset, extended-release verapamil with amlodipine and amlodipine plus atenolol on exercise performance and ambulatory ischemia with chronic stable angina pectoris. Am. J. Cardiol.83(4), 507–514 (1999).
   PubMed Web of Science ®Google Scholar
• Gupta SK, Yih BM, Atkinson L, Longstreth J. The effect of food, time of dosing and body composition on the pharmacokinetics and pharmacodynamics of verapamil and norverapamil. J. Clin. Pharmacol.35, 1083–1093 (1995).
   PubMed Web of Science ®Google Scholar
• White WB, Anders RJ, MacInyre JM, Black HR, Sica DA. Nocturnal dosing of a novel delivery system of verapamil for systemic hypertension. Am. J. Cardiol.76, 375–380 (1995).
   PubMed Web of Science ®Google Scholar
• White W, Mehrotra D, Black HR, Kakouhi DT. Effects of controlled-onset extended-release verapamil on nocturnal blood pressure (dippers versus nondippers). Am. J. Cardiol.80(4), 469–474 (1997).
   PubMed Web of Science ®Google Scholar
• White WB, Black HR, Weber M, Elliott WJ, Bryzinski B, Fakouhi TD. Comparison of effects of controlled onset extended release verapamil at bedtime and nifedipine gastrointestinal therapeutic system on arising on early morning blood pressure, heart rate, and heart rate-blood pressure product. Am. J. Cardiol.81, 424–431 (1998).
   PubMed Web of Science ®Google Scholar
• Prisant LM, Devane JG, Butler J. A steady state evaluation of the bioavailability of chronotherapeutic oral drug absorption system verapamil PM after nighttime dosing versus immediate-acting verapamil dosed every eight hours. Am. J. Ther.7(6), 345–251 (2000).
   PubMedGoogle Scholar
• Smith DHG, Neutel JM, Weber MA. A new chronotherapeutic oral drug absorption system for verapamil optimizes blood pressure control in the morning. Am. J. Hypertens.14, 14–19 (2001).
   PubMed Web of Science ®Google Scholar
• Prisant LM, Weber M, Black HR. The role of circadian rhythm in cardiovascular function – efficacy of a chronotherapeutic approach to controlling hypertension with Veralan PM (verapamil HCL). Today’s Therapeutic Trends21(2), 201–213 (2003).
   Google Scholar
• Prisant LM, Black HR, Messerli F, Weber M. CHRONO: a community-based hypertension trial of a chronotherapeutic formulation of verapamil. Am. J. Ther.9(6), 476–483 (2002).
   PubMedGoogle Scholar
• Sista S, Chi-Keung Lai J, Eradiri O, Albert K. Pharmacokinetics of a novel diltiazem HCL extended-release tablet formulation for evening administration. J. Clin. Pharmacol.43, 1149–1157 (2003).
   PubMed Web of Science ®Google Scholar
• Glasser SP, Neutel JM, Gana TJ, Albert KS. Efficacy and safety of a once daily graded-release diltiazem formulation in essential hypertension. Am. J. Hypertens.16, 51–58 (2003).
   PubMed Web of Science ®Google Scholar
• Pool PE. Anomalies in the dosing of diltiazem. Clin. Card.23, 18–23 (2000).
   PubMed Web of Science ®Google Scholar
• White WB, Lacourciere Y, Gana T, Pascual MG, Smith DH, Albert KS. The effects of graded-release diltiazem versus ramapril, dosed at bedtime, on the early morning blood pressure, heart rate, and the rate-pressure product. Am. Heart J.148, 628–634 (2004).
   PubMed Web of Science ®Google Scholar
• Sica D, Frishman WH, Manowitz N. Pharmacokinetics of propranolol after single and multiple dosing with sustained released propranolol or propranolol CR (Innopran XL™), a new chronotherapeutic formulation. Heart Disease5(3), 176–181 (2003).
   PubMedGoogle Scholar
• Neutel JM, Rotemberg K. Comparison of a chronotherapeutically administered β blocker vs. a traditionally administered β blocker in patients with hypertension. J. Clin. Hypertens. (Greenwich)7(7), 395–400 (2005).
   PubMedGoogle Scholar
• Mengden T, Binswanger B, Gruene S. Dynamics of drug compliance and 24-hour blood pressure control of once daily morning vs evening amlodipine. J. Hypertens.10(Suppl. 4), S136 (1992) (Abstract).
   Google Scholar
• Nold G, Strobel G, Lemmer B. Morning vs evening amlodipine treatment: effect on circadian blood pressure profile in essential hypertensive patients. Blood Press. Monit.3, 17–25 (1998).
   PubMedGoogle Scholar
• Qiu YG, Chen JZ, Zhu JH, Yao XY. Differential effects of morning or evening dosing of amlodipine on circadian blood pressure and heart rate. Cardiovasc. Drugs Ther.17, 335–341 (2003).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE, López JE. Rodríguez M, Covelo M. Administration time-dependent effects of amlodipine on ambulatory blood pressure in patients with essential hypertension. Am. J. Hypertens.18(5 Pt 2), 61A (2005) (Abstract).
   Web of Science ®Google Scholar
• Kitahara Y, Saito F, Akao M et al. Effect of morning and bedtime dosing with cilnidipine on blood pressure, heart rate, and sympathetic nervous activity in essential hypertensive patients. J. Cardiovasc. Pharmacol.43, 68–73 (2004).
   PubMed Web of Science ®Google Scholar
• Kohno I, Iwasaki H, Okutani M et al. Administration-time-dependent effects of diltiazem on the 24-hour blood pressure profile of essential hypertension patients. Chronobiol. Int.14, 71–84 (1997).
   PubMed Web of Science ®Google Scholar
• Fogari R, Malacco E, Tettamanti F, Gnemmi AE, Milani M. Evening vs. morning isradipine sustained release in essential hypertension: a double-blind study with 24 h ambulatory monitoring. Br. J. Clin. Pharmacol.35, 51–54 (1993).
   PubMed Web of Science ®Google Scholar
• Portaluppi F, Vergnani L, Manfredini R, degli Uberti EC, Fersini C. Time-dependent effect of isradipine on the nocturnal hypertension in chronic renal failure. Am. J. Hypertens.8, 719–726 (1995).
   PubMed Web of Science ®Google Scholar
• Greminger P, Suter PM, Holm D, Kobelt R, Vetter W. Morning versus evening administration of nifedipine gastrointestinal therapeutic system in the management of essential hypertension. Clin. Invest.72, 864–869 (1994).
   PubMedGoogle Scholar
• Hermida RC, Calvo C, Ayala DE et al. Dose and administration-time-dependent effects of nifedipine GITS on ambulatory blood pressure in hypertensive subjects. Chronobiol. Int. In press (2007).
   Google Scholar
• White WB, Mansoor GA, Pickering TG et al. Differential effects of morning and evening dosing of nisoldipine ER on circadian blood pressure and heart rate. Am. J. Hypertens.12, 806–814 (1999).
   PubMed Web of Science ®Google Scholar
• Meilhac B, Mallion JM, Carre A et al. Study of the influence of the time of administration on the antihypertensive effect and nitrendipine tolerance in mild to moderate essential hypertensive patients. Value of ambulatory recording of blood pressure on 24 hours. Therapie47, 205–210 (1992).
   PubMed Web of Science ®Google Scholar
• Umeda T, Naomi S, Iwaoka T et al. Timing for administration of an antihypertensive drug in the treatment of essential hypertension. Hypertension23(Suppl. 1), I211–I214 (1994).
   Google Scholar
• Palatini P, Mos L, Motolese M et al. Effect of evening versus morning benazepril on 24-hour blood pressure: a comparative study with continuous intraarterial monitoring. Int. J. Clin. Pharmacol. Ther. Toxicol.31, 295–300 (1993).
   PubMed Web of Science ®Google Scholar
• Witte K, Weisser K, Neubeck M et al. Cardiovascular effects, pharmacokinetics and converting enzyme inhibition of enalapril after morning versus evening administration. Clin. Pharmacol. Ther.54, 177–186 (1993).
   PubMed Web of Science ®Google Scholar
• Morgan T, Anderson A, Jones E. The effect on 24 h blood pressure control of an angiotensin converting enzyme inhibitor (perindopril) administered in the morning or at night. J. Hypertens.15, 205–211 (1997).
   PubMed Web of Science ®Google Scholar
• Palatini P. Can an angiotensin-converting enzyme inhibitor with a short half-life effectively lower blood pressure for 24 hours? Am. Heart J.123, 1421–1425 (1992).
   PubMed Web of Science ®Google Scholar
• Palatini P, Racioppa A, Raule G, Zaninotto M, Penzo M, Pessina AC. Effect of timing of administration on the plasma ACE inhibitory activity and the antihypertensive effect of quinapril. Clin. Pharmacol. Ther.52, 378–383 (1992).
   PubMed Web of Science ®Google Scholar
• Myburgh DP, Verho M, Botes JH, Erasmus ThP, Luus HG. 24-hour pressure control with ramipril: comparison of once-daily morning and evening administration. Curr. Ther. Res.56, 1298–1306 (1995).
   Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE, Chayán L, Rodríguez M, López JE. Chronotherapy with spirapril in hypertensive patients: changes in the diurnal/nocturnal blood pressure ratio as a function of the circadian time of administration. J. Hypertens.24(Suppl. 4), S88 (2006) (Abstract).
   Google Scholar
• Kuroda T, Kario K, Hoshide S et al. Effects of bedtime vs. morning administration of the long-acting lipophilic angiotensin-converting enzyme inhibitor trandolapril on morning blood pressure in hypertensive patients. Hypertens. Res.27, 15–20 (2004).
   PubMed Web of Science ®Google Scholar
• Middeke M, Kluglich M, Holzgreve H. Chronopharmacology of captopril plus hydrochlorothiazide in hypertension: morning versus evening dosing. Chronobiol. Int.8, 506–510 (1991).
   PubMed Web of Science ®Google Scholar
• Kohno I, Ijiri H, Takusagawa M et al. Effect of imidapril in dipper and nondipper hypertensive patients: comparison between morning and evening administration. Chronobiol. Int.17, 209–219 (2000).
   PubMed Web of Science ®Google Scholar
• Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients: the Heart Outcomes Prevention Evaluation Study Investigators. N. Engl. J. Med.342, 145–153 (2000).
   PubMed Web of Science ®Google Scholar
• Svensson P, de Faire U, Sleight P, Yusuf S, Östergren J. Comparative effects of ramipril on ambulatory and office blood pressures. A HOPE substudy. Hypertension38, e28–e32 (2001).
   PubMed Web of Science ®Google Scholar
• Panza JA, Epstein SE, Quyyumi AA. Circadian variation in vascular tone and its relation to α-sympathetic vasoconstrictor activity. N. Engl. J. Med.325, 986–990 (1991).
   PubMed Web of Science ®Google Scholar
• Pickering TG, Levenstein M, Walmsley P, for the Hypertension and Lipid Trial Study Group. Night-time dosing of doxazosin has peak effect on morning ambulatory blood pressure. Results of the HALT study. Am. J. Hypertens.7, 844–847 (1994).
   PubMed Web of Science ®Google Scholar
• Lemmer B, Nold G, Behne S, Kaiser R. Chronopharmacokinetics and cardiovascular effects of nifedipine. Chronobiol. Int.8, 485–494 (1991).
   PubMed Web of Science ®Google Scholar
• Langner B, Lemmer B. Circadian changes in the pharmacokinetics and cardiovascular effects of oral propranolol in healthy subjects. Eur. J. Clin. Pharmacol.33, 619–624 (1988).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE et al. Administration-time-dependent effects of doxazosin GITS on ambulatory blood pressure of hypertensive subjects. Chronobiol. Int.21, 277–296 (2004).
   PubMed Web of Science ®Google Scholar
• Stanton A, O’Brien E. Auswirkungen der Therapie auf das zirkadiane Blutdruckprofil. Kar-dio3, 1–8 (1994).
   Google Scholar
• Lemmer B, Portaluppi F. Chronopharmacology of cardiovascular diseases. In: Handbook of Experimental Pharmacology, Vol 125, Physiology and Pharmacology of Biological Rhythms. Redfern P, Lemmer B (Eds). Springer Verlag, Heidelberg, Germany 251–297 (1997).
   Google Scholar
• de Leeuw PW, Falke HE, Kho TL, Vandongen R, Wester A, Birkenhäger WH. Effects of β-agrenergic blockade on diurnal variability of blood pressure and plasma noradrenaline levels. Acta Med. Scand.202, 389–392 (1977).
   PubMedGoogle Scholar
• Calvo C, Hermida RC, Ayala DE, López JE, Domínguez MJ, Covelo M. Effects of nebivolol monotherapy on ambulatory blood pressure in patients with grade 1–2 essential hypertension. J. Hypertens.22(Suppl. 2), S386 (2004) (Abstract).
   Google Scholar
• Hermida RC, Calvo C, Ayala DE, Rodríguez M, Chayán L, López JE. Administration time-dependent effects of nebivolol on the diurnal/nocturnal blood pressure ratio in hypertensive patients. J. Hypertens.24(Suppl. 4), S89 (2006) (Abstract).
   Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE et al. Administration time-dependent effects of valsartan on ambulatory blood pressure in hypertensive subjects. Hypertension42, 283–290 (2003).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE et al. Administration time-dependent effects of valsartan on ambulatory blood pressure in elderly hypertensive subjects. Chronobiol. Int.22, 755–776 (2005).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE et al. Treatment of non-dipper hypertension with bedtime administration of valsartan. J. Hypertens.23, 1913–1922 (2005).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE, López JE. Decrease in urinary albumin excretion associated to the normalization of nocturnal blood pressure in hypertensive subjects. Hypertension46, 960–968 (2005).
   PubMed Web of Science ®Google Scholar
• Calvo C, Hermida RC, Ayala DE et al. Chronotherapy with torasemide in hypertensive patients: increased efficacy and therapeutic coverage with bedtime administration. Med. Clin. (Barc.)127, 721–729 (2006).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Calvo C et al. Administration-time dependent effects of aspirin on blood pressure in untreated hypertensive patients. Hypertension41, 1259–1267 (2003).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Calvo C, López JE. Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients. J. Am. Coll. Cardiol.46, 975–983 (2005).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Calvo C et al. Differing administration time-dependent effects of aspirin on blood pressure in dipper and non-dipper hypertensives. Hypertension46, 1060–1068 (2005).
   PubMed Web of Science ®Google Scholar
• Aboy M, Fernández JR, McNames J, Hermida RC. The individual RDH index: a novel vector index for statistical assessment of antihypertensive treatment reduction, duration, and homogeneity. Blood Press. Monit.11, 69–78 (2006).
   PubMed Web of Science ®Google Scholar
• Aboy M, Fernández JR, Hermida RC. The population RDH index. A novel vector index and graphical method for statistical assessment of antihypertensive treatment reduction, duration, and homogeneity. Blood Press. Monit.11, 143–155 (2006).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Calvo C et al. Effects of the time of day of antihypertensive treatment on the ambulatory blood pressure pattern of patients with resistant hypertension. Hypertension46, 1053–1059 (2005).
   PubMed Web of Science ®Google Scholar
• Nozawa M, Sugimoto K, Ohmori M, Ando H, Fujimura A. Dosing time-dependent effect of temocapril on the mortality of stroke-prone spontaneously hypertensive rats. J. Pharmacol. Exp. Ther.316, 176–181 (2006).
   PubMed Web of Science ®Google Scholar
• Eguchi K, Kario K, Shimada K. Differential effects of a long-acting angiotensin converting enzyme inhibitor (temocapril) and a long-acting calcium antagonist (amlodipine) on ventricular ectopic beats in older hypertensive patients. Hypertens. Res.25, 329–333 (2002).
   PubMed Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE et al. Prediction of cardiovascular events by ambulatory blood pressure and effects of chronotherapy: The MAPEC study. J. Hypertens.24(Suppl. 4), S180 (2006) (Abstract).
   Google Scholar