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Review

Functional foods for the prevention and treatment of cardiovascular diseases: cholesterol and beyond

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Pages 477-490 | Published online: 10 Jan 2014

References

  • Fernandez ML. Soluble fiber and nondigestible carbohydrate effects on plasma lipids and cardiovascular risk. Curr. Opin. Lipidol.12(1), 35–40 (2001).
  • Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am. J. Clin. Nutr.69(1), 30–42 (1999).
  • Kris-Etherton PM, Hecker KD, Bonanome A et al. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med.113(Suppl. 9B), 71S–88S (2002).
  • Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N. Engl. J. Med.348(26), 2599–2608 (2003).
  • Esposito K, Marfella R, Ciotola M et al. Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA292(12), 1440–1446 (2004).
  • Estruch R, Martinez-Gonzalez MA, Corella D et al. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann. Intern. Med.145(1), 1–11 (2006).
  • Law M. Plant sterol and stanol margarines and health. Br. Med. J.320, 861–864 (2000).
  • Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R; Stresa Workshop Participants. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin. Proc.78, 965–978 (2003).
  • Berger A, Jones PJ, Abumweis SS. Plant sterols: factors affecting their efficacy and safety as functional food ingredients. Lipids Health Dis.7, 3–5 (2004).
  • Jones PJ, Ntanios FY, Raeini-Sarjaz M, Vanstone CA. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am. J. Clin. Nutr.69(6), 1144–1150 (1999).
  • Tikkanen MJ, Hogstrom P, Tuomilehto J, Keinanen-Kiukaanniemi S, Sundvall J, Karppanen H. Effect of a diet based on low-fat foods enriched with nonesterified plant sterols and mineral nutrients on serum cholesterol. Am. J. Cardiol.88, 1157–1162 (2001).
  • De Graaf J, De Sauvage Nolting PR, Van Dam M et al. Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. Br. J. Nutr.88, 479–488 (2002).
  • Polagruto JA, Wang-Polagruto JF, Braun MM, Lee L, Kwik-Uribe C, Keen CL. Cocoa flavanol-enriched snack bars containing phytosterols effectively lower total and low-density lipoprotein cholesterol levels. J. Am. Diet. Assoc.106(11), 1804–1813 (2006).
  • Tapola NS, Lyyra ML, Karvonen HM, Uusitupa MI, Sarkkinen ES. The effect of meat products enriched with plant sterols and minerals on serum lipids and blood pressure. Int. J. Food Sci. Nutr.55, 389–397 (2004).
  • Clifton PM, Noakes M, Sullivan D et al. Cholesterol-lowering effects of plant sterol esters differ in milk, yoghurt, bread and cereal. Eur. J. Clin. Nutr.58, 503–509 (2004).
  • Volpe R, Niittynen L, Korpela R et al. Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia. Br. J. Nutr.86(2), 233–239 (2001).
  • Thomsen AB, Hansen HB, Christiansen C, Green H, Berger A. Effect of free plant sterols in low-fat milk on serum lipid profile in hypercholesterolemic subjects. Eur. J. Clin. Nutr.58, 860–870 (2004).
  • Devaraj S, Jialal I, Vega-Lopez S. Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arterioscler. Thromb. Vasc. Biol.24, e25–e28 (2004).
  • Mensink RP, Ebbing S, Lindhout M, Plat J, van Heugten MM. Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. Atherosclerosis160, 205–213 (2002).
  • Korpela R, Tuomilehto J, Högström P et al. Safety aspects and cholesterol-lowering efficacy of low-fat dairy products containing plant sterols. Eur. J. Clin. Nutr.60(5), 633–642 (2006).
  • Devaraj S, Autret BC, Jialal I. Reduced-calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers. Am. J. Clin. Nutr.84(4), 756–761 (2006).
  • Noakes M, Clifton PM, Doornbos AM, Trautwein EA. Plant sterol ester-enriched milk and yoghurt effectively reduce serum cholesterol in modestly hypercholesterolemic subjects. Eur. J. Nutr.44, 214–222 (2005).
  • Jones PJ, Vanstone CA, Raeini-Sarjaz M, St-Onge MP. Phytosterols in low- and nonfat beverages as part of a controlled diet fail to lower plasma lipid levels. J. Lipid Res.44, 1713–1719 (2003).
  • Doornbos AM, Meynen EM, Duchateau GS, van der Knaap HC, Trautwein EA. Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects. Eur. J. Clin. Nutr.60(3), 325–333 (2005).
  • Bray GA, Lee M, Bray TL. Weight gain of rats fed medium-chain triglycerides is less than rats fed long-chain triglycerides. Int. J. Obes.4, 27–32 (1980).
  • Baba N, Bracco EF, Hashim SA. Enhanced thermogenesis and diminished deposition of fat in response to overfeeding with diet containing medium chain triglyceride. Am. J. Clin. Nutr.35, 678–682 (1982).
  • Nosaka N, Maki H, Suzuki Y et al. Effects of margarine containing medium-chain triacylglycerols on body fat reduction in humans. J. Atheroscler. Thromb.10, 290–298 (2003).
  • St-Onge MP, Jones PJH, Ross R, Parsons WE. Medium chain triglycerides increase energy expenditure and decrease adiposity in overweight men. Obes. Res.11, 395–402 (2003).
  • St-Onge MP, Jones PJ. Greater rise in fat oxidation with medium-chain triglyceride consumption relative to long-chain triglyceride is associated with lower initial body weight and greater loss of subcutaneous adipose tissue. Int. J. Obes. Relat. Metab. Disord.27, 1565–1571 (2003).
  • von Bonsdorff-Nikander A, Christiansen L, Huikko L et al. A comparison of the effect of medium- vs. long-chain triglycerides on the in vitro solubilization of cholesterol and/or phytosterol into mixed micelles. Lipids40, 181–190 (2005).
  • Hill JO, Peters JC, Swift LL et al. Changes in blood lipids during six days of overfeeding with medium or long chain triglycerides. J. Lipids Res.31, 407–416 (1990).
  • Tholstrup T, Ehnholm C, Jauhiainen M et al. Effects of medium-chain fatty acids and oleic acid on blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities. Am. J. Clin. Nutr.79, 564–569 (2004).
  • St-Onge MP, Lamarche B, Mauger JF, Jones PJ. Consumption of a functional oil rich in phytosterols and medium-chain triglyceride oil improves plasma lipid profiles in men. J. Nutr.133, 1815–1820 (2003).
  • Bourque C, St-Onge MP, Papamandjaris AA, Cohn JS, Jones PJ. Consumption of an oil composed of medium chain triacyglycerols, phytosterols, and N-3 fatty acids improves cardiovascular risk profile in overweight women. Metabolism52, 771–777 (2003).
  • Rudkowska I, Roynette CE, Nakhasi DK, Jones PJ. Phytosterols mixed with medium chain triglycerides and high oleic canola oil decrease plasma lipids in overweight men. Metabolism55, 391–395 (2006).
  • Rudkowska I, Roynette CE, Demonty I, Vanstone CA, Jew S, Jones PJ. Diacylglycerol: efficacy and mechanism of action of an anti-obesity agent. Obes. Res.13, 1864–1876 (2005).
  • Meguro S, Higashi K, Hase T et al. Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect. Eur. J. Clin. Nutr.55, 513–517 (2001).
  • Jakulj L, Trip MD, Sudhop T, von Bergmann K, Kastelein JJ, Vissers MN. Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels. J. Lipid Res.46(12), 2692–2698 (2005).
  • Hu FB, Stampfer MJ, Manson JE, Rimm EB, Colditz GA, Rosner B. Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. Br. Med. J.317, 1341–1345 (1999).
  • Kelly JH Jr, Sabate J. Nuts and coronary heart disease: an epidemiological perspective. Br. J. Nutr.96(Suppl. 2), S61–S67 (2006).
  • Griel AE, Kris-Etherton PM. Tree nuts and the lipid profile: a review of clinical studies. Br. J. Nutr.96(Suppl. 2), S68–S78 (2006).
  • Fraser GE, Sabate J, Beeson WL, Strahan TM. A possible protective effect of nut consumption on risk of coronary heart disease: the Adventist Health Study. Arch. Intern. Med.152, 1416–1424 (1992).
  • Sabate J, Fraser GE, Burke K, Knutsen SF, Bennett H, Lindsted KD. Effects of walnuts on serum lipid levels and blood pressure in normal men. N. Engl. J. Med.328(9), 603–607 (1993).
  • Mann GV, Mirkin G, Mogadam M et al. Walnuts and serum lipids. N. Engl. J. Med.329, 358–360 (1993).
  • Ros E, Nunez I, Perez-Heras A et al. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation109(13), 1609–1614 (2004).
  • Tapsell LC, Gillen LJ, Patch CS et al. Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with Type 2 diabetes. Diabetes Care27(12), 2777–2783 (2004).
  • Zibaeenezhad MJ, Shamsnia SJ, Khorasani M. Walnut consumption in hyperlipidemic patients. Angiology56(5), 581–583 (2005).
  • Hyson DA, Schneeman BO, Davis PA. Almonds and almond oil have similar effects on plasma lipids and LDL oxidation in healthy men and women. J. Nutr.132(4), 703–707 (2002).
  • Morgan WA, Clayshulte BJ. Pecans lower low-density lipoprotein cholesterol in people with normal lipid levels. J. Am. Diet. Assoc.100(3), 312–318 (2000).
  • Rajaram S, Burke K, Connell B, Myint T, Sabate J. A monounsaturated fatty acid-rich pecan-enriched diet favorably alters the serum lipid profile of healthy men and women. J. Nutr.131(9), 2275–2279 (2001).
  • Edwards K, Kwaw I, Matud J, Kurtz I. Effect of pistachio nuts on serum lipid levels in patients with moderate hypercholesterolemia. J. Am. Coll. Nutr.18(3), 229–232 (1999).
  • Kocyigit A, Koylu AA, Keles H. Effects of pistachio nuts consumption on plasma lipid profile and oxidative status in healthy volunteers. Nutr. Metab. Cardiovasc. Dis.16(3), 202–209 (2006).
  • Curb JD, Wergowske G, Dobbs JC, Abbott RD, Huang B. Serum lipid effects of a high-monounsaturated fat diet based on macadamia nuts. Arch. Intern. Med.160(8), 1154–1158 (2000).
  • Garg ML, Blake RJ, Wills RB. Macadamia nut consumption lowers plasma total and LDL cholesterol levels in hypercholesterolemic men. J. Nutr.133(4), 1060–1063 (2003).
  • Jenkins DJ, Kendall CW, Marchie A et al. Dose response of almonds on coronary heart disease risk factors: blood lipids, oxidized low-density lipoproteins, lipoprotein(a), homocysteine, and pulmonary nitric oxide: a randomized, controlled, crossover trial. Circulation106(11), 1327–1332 (2002).
  • Sabate J, Haddad E, Tanzman JS, Jambazian P, Rajaram S. Serum lipid response to the graduated enrichment of a Step I diet with almonds: a randomized feeding trial. Am. J. Clin. Nutr.77(6), 1379–1384 (2003).
  • Zambon D, Sabate J, Munoz S et al. Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial. Ann. Intern. Med.132(7), 538–546 (2000). Erratum in: Ann. Intern. Med.133(8), 659 (2000).
  • Iwamoto M, Imaizumi K, Sato M et al. Serum lipid profiles in Japanese women and men during consumption of walnuts. Eur. J. Clin. Nutr.56(7), 629–637 (2002).
  • Chisholm A, Mc Auley K, Mann J, Williams S, Skeaff M. Cholesterol lowering effects of nuts compared with a Canola oil enriched cereal of similar fat composition. Nutr. Metab. Cardiovasc. Dis.15(4), 284–292 (2005).
  • Lovejoy JC, Most MM, Lefevre M, Greenway FL, Rood JC. Effect of diets enriched in almonds on insulin action and serum lipids in adults with normal glucose tolerance or Type 2 diabetes. Am. J. Clin. Nutr.76(5), 1000–1006 (2002).
  • Steinberg FM, Bearden MM. Keen CL. Cocoa and chocolate flavonoids: implications for cardiovascular health. J. Am. Diet. Assoc.103(2), 215–223 (2003).
  • Huxley RR, Neil HA. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. Eur. J. Clin. Nutr.57, 904–908 (2003).
  • Osakabe N, Yasuda A, Natsume M, Takizawa T, Terao J, Kondo K. Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. Exp. Biol. Med.227(1), 51–56 (2002).
  • Hirano R, Osakabe N, Iwamoto A et al. Antioxidant effects of polyphenols in chocolate on low-density lipoprotein both in vitro and ex vivo. J. Nutr. Sci. Vitaminol.46(4), 199–204 (2000).
  • Rein D, Lotito S, Holt RR, Keen CL, Schmitz HH, Fraga CG. Epicatechin in human plasma: in vivo determination and effect of chocolate consumption on plasma oxidation status. J. Nutr.130(Suppl. 8S), 2109S–2114S (2000).
  • Wang JF, Schramm DD, Holt RR et al. A dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage. J. Nutr.130, 2115S–2119S (2000).
  • Wiswedel I, Hirsch D, Kropf S et al. Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane concentrations in humans. Free Radic. Biol. Med.37(3), 411–421 (2004).
  • Engler MB, Engler MM, Chen CY et al. Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J. Am. Coll. Nutr.23(3), 197–204 (2004).
  • Murphy KJ, Chronopoulos AK, Singh I et al. Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. Am. J. Clin. Nutr.77(6), 1466–1473 (2003).
  • Mathur S, Devaraj S, Grundy SM, Jialal I. Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans J. Nutr.132(12), 3663–3667 (2002).
  • Wan Y, Vinson JA, Etherton TD, Proch J, Lazarus SA, Kris-Etherton PM. Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am. J. Clin. Nutr.74(5), 596–602 (2001).
  • Fraga CG, Actis-Goretta L, Ottaviani JI et al. Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players. Clin. Dev. Immunol.12(1), 11–17 (2005).
  • Mursu J, Voutilainen S, Nurmi T et al. Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Radic. Biol. Med.37(9), 1351–1359 (2004).
  • Vlachopoulos C, Aznaouridis K, Alexopoulos N, Economou E, Andreadou I, Stefanadis C. Effect of dark chocolate on arterial function in healthy individuals. Am. J. Hypertens.18(6), 785–791 (2005).
  • Wang-Polagruto JF, Villablanca AC, Polagruto JA et al. Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women. J. Cardiovasc. Pharmacol.47(Suppl. 2), S177–S186 (2006).
  • Schramm DD, Wang JF, Holt RR et al. Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells. Am. J. Clin. Nutr.73(1), 36–40 (2001).
  • Keen CL, Holt RR, Oteiza PI, Fraga CG, Schmitz HH. Cocoa antioxidants and cardiovascular health. Am. J. Clin. Nutr.81(Suppl. 1), 298S–303S (2005).
  • Engler MB, Engler MM. The emerging role of flavonoid-rich cocoa and chocolate in cardiovascular health and disease. Nutr. Rev.64(3), 109–118 (2006).

Website

  • WHO. Global Strategy on Diet, Physical Activity and Health – Facts sheets. www.who.int/hpr/gs.fs.cvds.shtml (2003).
  • US FDA. FDA consumer staking a claim to good health FDA and science stand behind health claims on foods. November–December 1998 www.cfsan.fda.gov/∼dms/fdhclm.html.

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