53
Views
5
CrossRef citations to date
0
Altmetric
Drug Profile

Efficacy and safety of fondaparinux in patients with acute coronary syndromes

, &
Pages 1013-1026 | Published online: 10 Jan 2014

References

  • Braunwald E, Antman EM, Beasley JW et al. ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction – 2002: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina). Circulation106, 1893–1900 (2002).
  • Antman EM, Anbe DT, Armstrong PW et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). Circulation110, 282–292 (2004).
  • Steg PG, Goldberg RJ, Gore JM et al. Baseline characteristics, management practices, and in-hospital outcomes of patients hospitalized with acute coronary syndromes in the Global Registry of Acute Coronary Events (GRACE). Am. J. Cardiol.90, 358–363 (2002).
  • Bertrand ME, Simoons ML, Fox KA et al. Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur. Heart J.23, 1809–1840 (2002).
  • van de Werf F, Ardissino D, Betriu A et al. Management of acute myocardial infarction in patients presenting with ST-segment elevation. The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology. Eur. Heart J.24, 28–66 (2003).
  • Petersen JL, Mahaffey KW, Hasselblad V et al. Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-segment elevation acute coronary syndromes: a systematic overview. JAMA292, 89–96 (2004).
  • Ferguson JJ, Califf RM, Antman EM et al. Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial. JAMA292, 45–54 (2004).
  • Eikelboom JW, Quinlan DJ, Mehta SR et al. Unfractionated and low-molecular-weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction: a meta-analysis of the randomized trials. Circulation112, 3855–3867 (2005).
  • Yusuf S, Mehta SR, Xie C et al. Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation. JAMA293, 427–435 (2005).
  • Antman EM, Morrow DA, McCabe CH et al. Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction. N. Engl. J. Med.354, 1477–1488 (2006).
  • White H, Hirulog and Early Reperfusion or Occlusion (HERO)-2 Trial Investigators. Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial. Lancet358, 1855–1863 (2001).
  • Goldberg RJ, Currie K, White K et al. Six-month outcomes in a multinational registry of patients hospitalized with an acute coronary syndrome (the Global Registry of Acute Coronary Events [GRACE]). Am. J. Cardiol.93, 288–293 (2004).
  • Rao SV, O’Grady K, Pieper KS et al. Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes. Am. J. Cardiol.96, 1200–1206 (2005).
  • Eikelboom JW, Mehta SR, Anand SS, Xie C, Fox KA, Yusuf S. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation114, 774–782 (2006).
  • Yang X, Alexander KP, Chen AY et al. The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative. J. Am. Coll. Cardiol.46, 1490–1495 (2005).
  • Alexander KP, Chen AY, Roe MT et al. Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes. JAMA294, 3108–3116 (2005).
  • Gore JM, Spencer FA, Goldberg RJ et al. Use of heparins in non-ST-elevation acute coronary syndromes. Am. J. Med.120, 63–71 (2007).
  • Alexander JH, Singh KP. Inhibition of Factor Xa: a potential target for the development of new anticoagulants. Am. J. Cardiovasc. Drugs.5, 279–290 (2005).
  • Weitz JI, Linkins LA. Beyond heparin and warfarin: the new generation of anticoagulants. Expert Opin. Investig. Drugs16, 271–282 (2007).
  • Herbert JM, Petitou M, Lormeau JC et al. SR 90107/Org 31540, a novel anti-Factor Xa antithrombotic agent. Cardiovasc. Drug Rev.15, 1–26 (1997).
  • Béguin S, Choay J, Hemker HC. The action of a synthetic pentasaccharide on thrombin generation in whole plasma. Thromb. Haemost.61, 397–401 (1989).
  • Donat F, Duret JP, Santoni A et al. The pharmacokinetics of fondaparinux sodium in healthy volunteers. Clin. Pharmacokinet.41(Suppl), 1–9 (2002).
  • Turpie AG. The safety of fondaparinux for the prevention and treatment of venous thromboembolism. Expert Opin. Drug Saf.4, 707–721 (2005).
  • Turpie AG, Gallus AS, Hoek JA, Pentasaccharide Investigators 2001. A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement. N. Engl. J. Med.344, 619–625 (2001).
  • Bauer KA, Eriksson BI, Lassen MR, Turpie AGG. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery. N. Engl. J. Med.345, 1305–1310 (2001).
  • Eriksson BI, Bauer KA, Lassen MR, Turpie AG. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N. Engl. J. Med.345, 1298–1304 (2001).
  • Lassen MR, Bauer KA, Eriksson BI, Turpie AG. Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip-replacement surgery: a randomised double-blind comparison. Lancet359, 1715–1720 (2002).
  • Turpie AG, Bauer KA, Eriksson BI, Lassen MR. Postoperative fondaparinux versus postoperative enoxaparin for prevention of venous thromboembolism after elective hip-replacement surgery: a randomised double-blind trial. Lancet359, 1721–1726 (2002).
  • Turpie AG, Bauer KA, Eriksson BI, Lassen MR. Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery: a meta-analysis of 4 randomized double-blind studies. Arch. Intern. Med.162, 1833–1840 (2002).
  • Eriksson BI, Lassen MR on behalf of the PENTHIFRA-PLUS investigators. Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery. A multicenter, randomized, placebo-controlled, double-blind study. Arch. Intern. Med.163, 1337–1342 (2003).
  • Turpie AGG, Bauer KA, Caprini JA, Comp PP, Gent M, Muntz JE. Fondaparinux combined with intermittent pneumatic compression versus intermittent pneumatic compression alone for prevention of venous thromboembolism after abdominal surgery: a randomized, double-blind comparison. J. Thromb. Haemost. (2007) (In Press).
  • Agnelli G, Bergqvist D, Cohen AT, Gallus AS, Gent M, PEGASUS investigators. Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery. Br. J. Surg.92, 1212–1220 (2005).
  • Cohen AT, Davidson BL, Gallus AS et al. Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial. Br. Med. J.332, 325–329 (2006).
  • Buller HR, Davidson BL, Decousus H et al. Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: a randomized trial. Ann. Intern. Med.140, 867–873 (2004).
  • Buller HR, Davidson BL, Decousus H et al. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. N. Engl. J. Med.349, 1695–1702 (2003).
  • Warkentin TE, Maurer BT, Aster RH. Heparin-induced thrombocytopenia associated with fondaparinux. N. Engl. J. Med.356, 2653–2655 (2007).
  • Efird LE, Kockler DR. Fondaparinux for thromboembolic treatment and prophylaxis of heparin-induced thrombocytopenia. Ann. Pharmacother.40, 1383–1387 (2006).
  • Simoons ML, Bobbink IW, Boland J et al. A dose-finding study of fondaparinux in patients with non-ST-segment elevation acute coronary syndromes; The Pentasaccharide in Unstable Angina (PENTUA) study. J. Am. Coll. Cardiol.43, 2183–2190 (2004).
  • MICHELANGELO OASIS 5 Steering Committee. Design and rationale of the MICHELANGELO Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS)-5 trial program evaluating fondaparinux, a synthetic Factor Xa inhibitor, in patients with non-ST-segment elevation acute coronary syndromes. Am. Heart J.150, 1107 (2005).
  • Yusuf S, Mehta SR, Chrolavicius S et al. Comparison of fondaparinux and enoxaparin in acute coronary syndromes. N. Engl. J. Med.354, 1464–1476 (2006).
  • Coussement PK, Bassand JP, Convens C et al. A synthetic factor-Xa inhibitor (ORG31540/SR9017A) as an adjunct to fibrinolysis in acute myocardial infarction. The PENTALYSE study. Eur. Heart J.22, 1716–1724 (2001).
  • Yusuf S, Mehta SR, Chrolavicius S et al. Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. JAMA295, 1519–1530 (2006).
  • Mehta SR, Steg PG, Granger CB et al. Randomized, blinded trial comparing fondaparinux with unfractionated heparin in patients undergoing contemporary percutaneous coronary intervention: Arixtra Study in Percutaneous Coronary Intervention: a Randomized Evaluation (ASPIRE) Pilot Trial. Circulation111, 1390–1397 (2005).
  • Rupprecht H-J, vom Dahl J, Mehta SR. Benefit of fondaparinux in patients with non-ST elevation acute coronary syndromes undergoing early percutaneous coronary intervention: insights from the OASIS-5 trial. Clin. Res. Cardiol.96(Suppl. 1), 869 (2007).
  • Mehta RH, Roe MT, Chen AY et al. Recent trends in the care of patients with non-ST-segment elevation acute coronary syndromes: insights from the CRUSADE initiative. Arch. Intern. Med.166, 2027–2034 (2006).
  • Mandelzweig L, Battler A, Boyko V et al. The second Euro Heart Survey on acute coronary syndromes: characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004. Eur. Heart J.27, 2285–2293 (2006).
  • Fox KAA, Anderson FA, Dabbous OH et al. Intervention in acute coronary syndromes: do patients undergo intervention on the basis of their risk characteristics? The Global Registry of Acute Coronary Events (GRACE). Heart93, 177–182 (2007).
  • Yusuf S, Granger CB, Mehta SR. Fondaparinux versus enoxaparin in acute coronary syndromes. N. Engl. J. Med.354, 2829–2830 (2006).
  • Bassand JP, Hamm CW, Ardissino D et al. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: The Task Force for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of the European Society of Cardiology.Eur. Heart J.28, 598–660 (2007).
  • Carruthers KF, Dabbous OH, Flather MD et al. Contemporary management of acute coronary syndromes: does the practice match the evidence? The global registry of acute coronary events (GRACE). Heart91, 290–298 (2005).
  • Steg PG, Lopez-Sendon J, Lopez de Sa E et al. External validity of clinical trials in acute myocardial infarction. Arch. Intern. Med.167, 68–73 (2007).
  • Chen ZM, Jiang LX, Chen YP et al. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet366, 1607–1621 (2005).
  • Gibbons RJ, Fuster V. Therapy for patients with acute coronary syndromes – new opportunities. N. Engl. J. Med.354, 1524–1527 (2006).
  • Eagle KA, Goodman SG, Avezum A et al. Practice variation and missed opportunities for reperfusion in ST-segment-elevation myocardial infarction: findings from the Global Registry of Acute Coronary Events (GRACE). Lancet359, 373–377 (2002).
  • Cohen M, Gensini GF, Maritz F et al. The safety and efficacy of subcutaneous enoxaparin versus intravenous unfractionated heparin and tirofiban versus placebo in the treatment of acute ST-segment elevation myocardial infarction patients ineligible for reperfusion (TETAMI): a randomized trial. J. Am. Coll. Cardiol.42, 1348–1356 (2003).
  • Yatskar L, Selzer F, Feit F et al. Access site hematoma requiring blood transfusion predicts mortality in patients undergoing percutaneous coronary intervention: Data from the National Heart, Lung, and Blood Institute Dynamic Registry. Catheter. Cardiovasc. Interv.69, 961–966 (2007).
  • Kereiakes DJ, Kleiman NS, Fry E et al. Dalteparin in combination with abciximab during percutaneous coronary intervention. Am. Heart J.141, 348–352 (2001).
  • Buller CE, Pate GE, Armstrong PW et al. Catheter thrombosis during primary percutaneous coronary intervention for acute ST elevation myocardial infarction despite subcutaneous low-molecular-weight heparin, acetylsalicylic acid, clopidogrel and abciximab pretreatment. Can. J. Cardiol.22, 511–515 (2006).
  • Madan M, Radhakrishnan S, Reis M et al. Comparison of enoxaparin versus heparin during elective percutaneous coronary intervention performed with either eptifibatide or tirofiban (the ACTION trial). Am. J. Cardiol.95, 1295–1301 (2005).
  • Silber S, Albertsson P, Aviles FF et al. Guidelines for percutaneous coronary interventions. The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology. Eur. Heart J.26, 804–847 (2005).
  • Smith SC Jr, Feldman TE, Hirshfeld JW Jr et al. ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to Update 2001 Guidelines for Percutaneous Coronary Intervention). Circulation113, e166–286 (2006).

Website

  • Budaj A, Eikelboom JW, Wallentin L et al. Bleeding complications predict major cardiovascular outcomes in non ST-elevation acute coronary syndromes: results from the OASIS-5 trial. American College of Cardiology (2006). (Abstract 972–224) www.acc.org/2006ann_meeting/home/home.htm

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.