225
Views
48
CrossRef citations to date
0
Altmetric
Drug Profile

Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity

Pages 1311-1317 | Published online: 10 Jan 2014

References

  • Jones RL, Swanton C, Ewer MS. Anthracycline cardiotoxicity. Exp. Opin. Drug Saf.5(6), 791–809 (2006).
  • Myers C, Bonow R, Palmeri S et al. A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by N-acetylcysteine. Semin. Oncol.10(1 Suppl. 1), 53–55 (1983).
  • Wouters KA, Kremer LC, Miller TL, Herman EH, Lipshultz SE. Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br. J. Haematol.131(5), 561–578 (2005).
  • Tanabe K, Ikegami Y, Ishida R, Andoh T. Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives. Cancer Res.51(18), 4903–4908 (1991).
  • Hasinoff BB, Kuschak TI, Yalowich JC, Creighton AM. A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane). Biochem. Pharmacol.50(7), 953–958 (1995).
  • Gorbsky GJ. Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and ICRF-159 (Razoxane). Cancer Res.54(4), 1042–1048 (1994).
  • Sehested M, Jensen PB. Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle. Biochem. Pharmacol.51(7), 879–886 (1996).
  • Hellmann K, Burrage K. Control of malignant metastases by ICRF l59. Nature224(5216), 273–275 (1969).
  • Salsbury AJ, Burrage K, Hellmann K. Inhibition of metastatic spread by I.C.R.F. 159: selective deletion of a malignant characteristic. Br. Med. J.4(5731), 344–346 (1970).
  • Le Serve AW, Hellmann K. Metastases and the normalization of tumour blood vessels by ICRF 159: a new type of drug action. Br. Med. J.1(5800), 597–601 (1972).
  • Popelová O, Sterba M, Simunek T et al. Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo. J. Pharmacol. Exp. Ther.326(1), 259–269 (2008).
  • Bruynzeel AM, Niessen HW, Bronzwaer JG et al. The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a Phase II study. Br. J. Cancer97(8), 1084–1089 (2007).
  • Herman E, Ardalan B, Bier C, Waravdekar V, Krop S. Reduction of daunorubicin lethality and myocardial cellular alterations by pretreatment with ICRF-187 in Syrian golden hamsters. Cancer Treat. Rep.63(1), 89–92 (1979).
  • Herman EH, Ferrans VJ. Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+/-)-1,2-bis (3,5-dioxopiperazinyl-1-yl)propane (ICRF-187). Cancer Res.41(9 Pt 1), 3436–3440 (1981).
  • Hasinoff BB, Hellmann K, Herman EH, Ferrans VJ. Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines. Curr. Med. Chem.5(1), 1–28 (1998).
  • Hasinoff BB. Stereoselective hydrolysis of ICRF-187 (dexrazoxane) and ICRF-186 by dihydropyrimidine amidohydrolase. Chirality6(3), 213–215 (1994).
  • Hasinoff BB, Kala SV. The removal of metal ions from transferrin, ferritin and ceruloplasmin by the cardioprotective agent ICRF-187 [ (+)-1,2-bis (3,5-dioxopiperazinyl-1-yl)propane] and its hydrolysis product ADR-925. Agents Actions39(1–2), 72–81 (1993).
  • Gianni L, Herman EH, Lipshultz SE, Minotti G, Sarvazyan N, Sawyer DB. Anthracycline cardiotoxicity: from bench to bedside. J. Clin. Oncol.26(22), 3777–3784 (2008).
  • Holcenberg JS, Tutsch KD, Earhart RH et al. Phase I study of ICRF-187 in pediatric cancer patients and comparison of its pharmacokinetics in children and adults. Cancer Treat. Rep.70(6), 703–709 (1986).
  • Wiseman LR, Spencer CM. Dexrazoxane. A review of its use as a cardioprotective agent in patients receiving anthracycline-based chemotherapy. Drugs56(3), 385–403 (1998).
  • Vogel CL, Gorowski E, Davila E et al. Phase I clinical trial and pharmacokinetics of weekly ICRF-187 (NSC 169780) infusion in patients with solid tumors. Invest. New Drugs5(2), 187–198 (1987).
  • Earhart RH, Tutsch KD, Koeller JM et al. Pharmacokinetics of (+)-1,2-di(3,5-dioxopiperazin-1-yl)propane intravenous infusions in adult cancer patients. Cancer Res.42(12), 5255–5261 (1982).
  • Hochster H, Liebes L, Wadler S et al. Pharmacokinetics of the cardioprotector ADR-529 (ICRF-187) in escalating doses combined with fixed-dose doxorubicin. J. Natl Cancer Inst.84(22), 1725–1730 (1992).
  • Liesmann J, Belt R, Haas C, Hoogstraten B. Phase I evaluation of ICRF-187 (NSC-169780) in patients with advanced malignancy. Cancer47(8), 1959–1962 (1981).
  • Von Hoff DD, Howser D, Lewis BJ, Holcenberg J, Weiss RB, Young RC. Phase I study of ICRF-187 using a daily for 3 days schedule. Cancer Treat. Rep.65(3–4), 249–252 (1981).
  • Koeller JM, Earhart RH, Davis HL. Phase I trial of ICRF-187 by 48-hour continuous infusion. Cancer Treat. Rep.65(5–6), 459–463 (1981).
  • Natale RB, Wheeler RH, Liepman MK, Sauder A, Bricker L. Phase II trial of ICRF-187 in non-small-cell lung cancer. Cancer Treat. Rep.67(3), 311–313 (1983).
  • Brubaker LH, Vogel CL, Einhorn LH, Birch R. Treatment of advanced adenocarcinoma of the kidney with ICRF-187: a Southeastern Cancer Study Group Trial. Cancer Treat. Rep.70(7), 915–916 (1986).
  • Wheeler RH, Bricker LJ, Natale RB, Baker SR. Phase II trial of ICRF-187 in squamous cell carcinoma of the head and neck. Cancer Treat. Rep.68(2), 427–428 (1984).
  • Chachoua A, Green M, Wernz J, Muggia F. Phase II trial of ICRF-187 in patients with acquired immune deficiency related Kaposi’s sarcoma (AIDS-KS). Invest. New Drugs17(4), 327–331 (1989).
  • Speyer JL, Green MD, Zeleniuch-Jacquotte A et al. ICRF-187 permits longer treatment with doxorubicin in women with breast cancer. J. Clin. Oncol.10(1), 117–127 (1992).
  • Swain SM, Whaley FS, Gerber MC et al. Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer. J. Clin. Oncol.15(4), 1318–1332 (1997).
  • Swain SM, Whaley FS, Gerber MC, Ewer MS, Bianchine JR, Gams RA. Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapy. J. Clin. Oncol.15(4), 1333–1340 (1997).
  • Venturini M, Michelotti A, Del Mastro L et al. Multicenter randomized controlled clinical trial to evaluate cardioprotection of dexrazoxane versus no cardioprotection in women receiving epirubicin chemotherapy for advanced breast cancer. J. Clin. Oncol.14(12), 3112–3120 (1996).
  • Marty M, Espié M, Llombart A, Monnier A, Rapoport BL, Stahalova V; Dexrazoxane Study Group. Multicenter randomized Phase III study of the cardioprotective effect of dexrazoxane (Cardioxane) in advanced/metastatic breast cancer patients treated with anthracycline-based chemotherapy. Ann. Oncol.17(4), 614–622 (2006).
  • Lopez M, Vici P, Di Lauro K et al. Randomized prospective clinical trial of high-dose epirubicin and dexrazoxane in patients with advanced breast cancer and soft tissue sarcomas. J. Clin. Oncol.16(1), 86–92 (1998).
  • Wexler LH, Andrich MP, Venzon D et al. Randomized trial of the cardioprotective agent ICRF-187 in pediatric sarcoma patients treated with doxorubicin. J. Clin. Oncol.14(2), 362–372 (1996).
  • Lipshultz SE, Rifai N, Dalton VM et al. The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N. Engl. J. Med.351(2), 145–153 (2004).
  • Feldman JE, Jones SE, Weisberg SR et al. Advanced small cell lung cancer treated with CAV (cyclophosphamide, adriamycin, vincristine) chemotherapy and the cardioprotective agent dexrazoxane (ADR-529, ICRF-187, Zinecard). Proc. Am. Soc. Clin. Oncol.11, 296 (Abstract 993) (1992).
  • Moghrabi A, Levy DE, Asselin B et al. Results of the Dana–Farber Cancer Institute ALL Consortium Protocol 95–01 for children with acute lymphoblastic leukemia. Blood109(3), 896–904 (2007).
  • Kolaric K, Bradamante V, Cervek J et al. A Phase II trial of cardioprotection with Cardioxane (ICRF-187) in patients with advanced breast cancer receiving 5-fluorouracil, doxorubicin and cyclophosphamide. Oncology52(3), 251–255 (1995).
  • Bu’Lock FA, Gabriel HM, Oakhill A, Mott MG, Martin RP. Cardioprotection by ICRF187 against high dose anthracycline toxicity in children with malignant disease. Br. Heart J.70(2), 185–188 (1993).
  • van Dalen EC, Caron HN, Dickinson HO, Kremer LC. Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane Database Syst. Rev.2, CD003917 (2008).
  • Seymour L, Bramwell V, Moran LA; The Provincial Systemic Treatment Disease Site Group. Use of dexrazoxane as a cardioprotectant in patients receiving doxorubicin or epirubicin chemotherapy for the treatment of cancer. Cancer Prev. Control3(2), 145–159 (1999).
  • Bates M, Lieu D, Zagari M, Spiers A, Williamson T. A pharmacoeconomic evaluation of the use of dexrazoxane in preventing anthracycline-induced cardiotoxicity in patients with stage IIIB or IV metastatic breast cancer. Clin. Ther.19(1), 167–184 (1997).
  • Tonkin K, Bates M, Lieu D, Arundell E, Williamson T, Zagari M. Dexrazoxane cardioprotection for patients receiving FAC chemotherapy: a pharmacoeconomic evaluation. Can. J. Oncol.6(2), 458–473 (1996).
  • Tebbi CK, London WB, Friedman D et al. Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin’s disease. J. Clin. Oncol.25(5), 493–500 (2007).
  • Barry EV, Vrooman LM, Dahlberg SE et al. Absence of secondary malignant neoplasms in children with high-risk acute lymphoblastic leukemia treated with dexrazoxane. J. Clin. Oncol.26(7), 1106–1111 (2008).
  • Mouridsen HT, Langer SW, Buter J et al. Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies. Ann. Oncol.18(3), 546–550 (2007).
  • Steiner R, Hellman K. Cytoprotection by dexrazoxane. Presented at: 19th International Congress on Anti Cancer Treatment. Paris, France, 5–8 February 2008.

Website

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.