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Review

Overview of antiviral and anti-inflammatory treatment for severe acute respiratory syndrome

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Pages 251-262 | Published online: 10 Jan 2014

References

  • Zhong NS, Zheng BJ, Li YM et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China, in Feburary, 2003. Lancet 363, 1353–1358 (2003).
  • Centers for Disease Control and Prevention. Update: outbreak of severe acute respiratory syndrome – worldwide. Morbid. Mortal. Wkly Rep. 52, 241–248 (2003).
  • Lau JTF, Tsui H, Lau M, Yang X. SARS transmission, risk factors, and prevention in Hong Kong. Emerg. Infect. Dis. 10(4), 587–592 (2004).
  • Guan Y, Zheng BJ, He YQ et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science 302, 276–278 (2003).
  • Peiris JS, Lai ST, Poon LL et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361, 1319–1325 (2003).
  • The Chinese SARS Molecular Epidemiology Consortium. Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China. Science 303, 1666–1669 (2004).
  • Zheng B, Guan Y, Wong K et al. SARS-related virus predating SARS outbreak, Hong Kong. Emerg. Infect. Dis. 10, 176–178 (2004).
  • Peiris JS, Chu CM, Cheng VC et al. Clinical progression and viral load in an outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet 361, 1767–1772 (2003).
  • Christian MD, Loutfy M, McDonald LC et al. Possible SARS coronavirus transmission during cardiopulmonary resuscitation. Emerg. Infect. Dis. 10(2), 287–293 (2004).
  • Yu IGT, Li Y, Wong TW et al. Evidence of airborne transmission of the severe acute respiratory virus. N. Engl. J. Med. 350, 1731–1739 (2004).
  • Riley S, Fraser C, Donnelly C et al. Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions. Science 300, 1961–1966 (2003).
  • Edmunds WJ, Gay NJ, Kretzschmar M, Pebody RG, Wachmann H. The prevaccination epidemiology of measles, mumps and rubella in Europe: implications for modelling studies. Epidemiol. Infect. 125, 635–650 (2000).
  • Svoboda T, Henry B, Shulman L. Public health measures to control the spread of the severe acute respiratory syndrome during the outbreak in Toronto. N. Engl. J. Med. 350(23), 2352–2361 (2004).
  • Lau J, Fung K, Wong T et al. SARS transmission among hospital workers in Hong Kong. Emerg. Infect. Dis. 10, 280–286 (2004).
  • Booth CM, Matukas LM, Tomlinson GA et al. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. J. Am. Med. Assoc. 289(21), 2801–2809 (2003).
  • Avendano M, Derkach P, Swan S. Clinical course and management of SARS in healthcare workers in Toronto: a case series. Can. Med. Assoc. J. 168(13), 1649–1660, (2003).
  • Lee N, Hui D, Wu A et al. A major outbreak of severe acute respiratory syndrome in Hong Kong. N. Engl. J. Med. 348(20), 1986–1994 (2003).
  • Chan TY, Miu KY, Tsui CK, Yee KS, Chan MH. A comparative study of clinical features and outcomes in young and older adults with severe acute respiratory syndrome. J. Am. Geriat. Soc. 52, 1321–1325 (2004).
  • Karlberg J, Chong DSY, Lai WYY. Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? Am. J. Epidemiol. 159, 229–231 (2004).
  • Chan JW, Ng CK, Chan YH et al. Short-term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome. Thorax 58, 686–689 (2003).
  • Lam CM, Wong SF, Leung TN et al. A case-controlled study comparing clinical course and outcomes of pregnant and nonpregnant women with severe acute respiratory syndrome. Br. J. Obstet. Gynaecol. 111, 771–774 (2004).
  • Chan KH, Poon LLM, Cheng VCC et al. Detection of SARS coronavirus (SCoV) by RT-PCR, culture, and serology in patients with acute respiratory syndrome (SARS). Emerg. Infect. Dis. 10, 294–299 (2003).
  • Ng EKO, Hui DS, Chan KCA et al. Quantitative analysis and prognostic implication of sars coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome. Clin. Chem. 49(12), 1976–1980 (2003).
  • Poon LLM, Wong BW, Chan KH et al. A one step quantitative RT-PCR for detection of SARS coronavirus with an internal control for PCR inhibitors. J. Clin. Virol. 30, 214–217 (2004).
  • Mandell LA, Bartlett JG, Dowell S, File TM, Musher D, Whitney C. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin. Infect. Dis. 37, 1405–1433 (2003).
  • Lew TWK, Kewk TK, Tai D et al. Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome. J. Am. Med. Assoc. 290, 374–380 (2003).
  • Zhao Z, Zhang F, Xu M et al. Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangdong, PR China. J. Med. Microbiol. 52(8), 715–720 (2003).
  • Pearlman BL. Hepatitis C treatment update. Am. J. Med. 117(5), 344–352 (2004).
  • Chen F, Chan KH, Jiang Y et al. In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds. J. Clin. Virol. 31, 69–75 (2004).
  • Chu CM, Cheng VCC, Hung IFN et al. Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings. Thorax 59, 252–256 (2004).
  • Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 361, 2045–2046 (2003).
  • Tan ELC, Ooi EE, Lin CY et al. Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs. Emerg. Infect. Dis. 10(4), 581–586 (2004).
  • Mazzulli T, Farcas GA, Poutanen SM et al. Severe acute respiratory syndrome-associated coronavirus in lung tissue. Emerg. Infect. Dis. 10(1), 20–24 (2004).
  • Samuel CE. Antiviral action of IFNs. Clin. Microbiol. Rev. 14, 778–809 (2001).
  • Poynard T. Treatment of hepatitis C virus: the first decade. Semin. Liver Dis. 24(S2), 19–24 (2004).
  • Biron CA. Interferons-α and -β as immune regulators – a new look. Immunity 14, 661–664 (2001).
  • Loutfy MR, Blatt L, Siminovitch K et al. Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome. J. Am. Med. Assoc. 290(24), 3222–3228 (2003).
  • Okanoue T, Sakamoto S, Itoh Y et al. Side effects of high-dose interferon therapy for chronic hepatitis C. J. Hepatol. 25, 283–291 (1996).
  • Bruno S, Camma C, Di Marco V et al. Peginterferon-α2b plus ribavirin for naive patients with genotype 1 chronic hepatitis C: a randomized controlled trial. J. Hepatol. 41(3), 474–481 (2004).
  • Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW. Treatment of SARS with human interferons. Lancet 362, 293–294 (2003).
  • Hensley LE, Fritz EA, Jahrling PB, Karp CL, Huggins JW, Geisbert TW. Interferon β1a and SARS coronavirus replication. Emerg. Infect. Dis. 10(2), 317–319 (2004).
  • Tanabe Y, Sakamoto N, Enomoto N et al. Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-α. J. Infect. Dis. 189(7), 1129–1139 (2004).
  • Morgenstern B, Michaelis M, Baer PC, Doerr HW, Cinatl J. Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines. Biochem. Biophys. Res. Comm. 326, 905–908 (2005).
  • Cooper CL, van Heeswijk RP, Gallicano K, Cameron DW. A review of low-dose ritonavir in protease inhibitor combination therapy. Clin. Infect. Dis. 36(12), 1585–1592 (2003).
  • Chen XP, Cao Y. Consideration of highly active antiretroviral therapy in the prevention and treatment of severe acute respiratory syndrome. Clin. Infect. Dis. 38, 1030–1032 (2004).
  • Hurst M, Faulds D. Lopinavir. Drugs 60, 1371–1379 (2000).
  • Chan KS, Lai ST, Chu CM et al. Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicenter retrospective matched cohort study. Hong Kong Med. J. 9, 399–406 (2003).
  • De Clercq E. Antiviral drugs in current clinical use. J. Clin. Virol. 30(2), 115–133 (2004).
  • Yamamoto N, Yang R, Yoshinaka Y et al. HIV protease inhibitor neflinavir inhibits replication of SARS-associated coronavirus. Biochem. Biophys. Res. Commun. 318(3), 719–725 (2004).
  • Arase Y, Ikeda K, Murashima N et al. The long-term efficacy of glycyrrhizin in chronic hepatitis C patients. Cancer 79, 1494–1500 (1997).
  • van Rossum TG, Vulto AG, de Man RA, Brouwer JT, Schalm SW. Glycyrrhizin as a potential treatment for chronic hepatitis C. Ail. Pharmacol. Ther. 12, 199–205 (1998).
  • Wu CJ, Jan JT, Chen CM et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob. Agents Chemother. 48(7), 2693–2696 (2004).
  • Chen L, Lui P, Gao H et al. Inhalation of nitric oxide in the treatment of SARS: a rescue study in Beijing. Clin. Infect. Dis. 39(10), 1531–1535 (2004).
  • Movahed P, Hogestatt ED, Petersson J. Effect of hypoxia on vasodilator responses to S-nitroso-N-acetylpenicillamine and levcromakalim in guinea-pig basilar artery. Naunyn. Schmiedebergs Arch. Pharmacol. 367(5), 532–557 (2003).
  • Keyaerts E, Vijgen L, Chen L, Maes P, Hedenstierna G, Van Ranst M. Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound. Int. J. Infect. Dis. 8(4), 223–226 (2004).
  • Keyaerts E, Vijgen L, Maes P, Neyts J, Van Ranst M. In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine. Biochem. Biophys. Res. Comm. 323, 264–268 (2004).
  • Taylor WR, White NJ. Antimalarial drug toxicity: a review. Drug Saf. 27(1), 25–61 (2004).
  • Yuan K, Yi L, Chen J. Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein. Biochem. Biophys. Res. Commun. 319(3), 746–752 (2004).
  • Hardy H, Skolnik PR. Enfuvirtide, a new fusion inhibitor for therapy of human immunodeficiency virus infection. Pharmacotherapy 24(2), 198–211 (2004).
  • Wang Z, Ren L, Zhao X et al. Inhibition of severe acute respiratory syndrome virus replication by small interfering RNAs in mammalian cells. J. Virol. 78(14), 7523–7527 (2004).
  • Shi Y, Luo H, Jia J et al. Antisense downregulation of SARS-CoV gene expression in Vero E6 cells. J. Genet. Med. 7, 97–107 (2005).
  • Novina CD, Murrary MF, Dykxhoorn DM et al. siRNA-directed inhibition of HIV-1 infection. Nature Med. 8, 681–686 (2002).
  • Wong CK, Lam CW, Wu AK et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin. Exp. Immunol. 136(1), 95–103 (2004).
  • Charles M. Severe acute respiratory syndrome (SARS) and coronavirus testing – USA, 2003. The CDC SARS Investigative Team. Morb. Mortal. Wkly Rep. 52, 297–302 (2003).
  • Lamberts SW, Bruining HA, de Jong FH. Corticosteroid therapy in severe illness. N. Engl. J. Med. 337, 1285–1292 (1997).
  • Montaner JS, Lawson LM, Levitt N et al. Corticosteroids prevent early deterioration in patients with moderately severe Pneumocystis carinii pneumonia and the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med. 113, 14–20 (1990).
  • Smego RA, Ahmed N. A systematic review of the adjunctive use of systemic corticosteroids for pulmonary tuberculosis. Int. J. Tuberc. Lung Dis. 7, 208–213 (2003).
  • Delclaux C, Zahar JR, Amraoui G et al. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in nonhuman immunodeficiency virus-infected patients: retrospective study of 31 patients. Clin. Infect. Dis. 29(3), 670–672 (1999).
  • Wong KT, Antonio GE, Hui DSC et al. Severe acute respiratory syndrome: radiographic appearances and pattern of progression in 138 patients. Radiology 228, 401–406 (2003).
  • Tse GMK, To KF, Chan PKS et al. Pulmonary pathological features in coronavirus associated severe acute respiratory syndrome (SARS). J. Clin. Pathol. 57, 260–265 (2004).
  • Bernard GR. Corticosteroids: the ‘terminator’ of all untreatable serious pulmonary illness. Am. J. Respir. Crit. Care Med. 168(12), 1409–1410 (2003).
  • Ho JC, Ooi GC, Mok TY et al. High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome. Am. J. Respir. Crit. Care Med. 168, 1449–1456 (2003).
  • Gomersall CD, Joynt GM, Lam P et al. Short-term outcome of critically ill patients with severe acute respiratory syndrome. Intensive Care Med. 30, 381–387 (2004).
  • Sheen IS, Liaw YF, Lin SM, Chu CM. Severe clinical rebound upon withdrawal of corticosteroid before interferon therapy: incidence and risk factors. J. Gastroenterol. Hepatol. 11(2), 143–147 (1996).
  • Buckingham SC, Jafri HS, Bush AJ et al. A randomized, double-blind, placebo-controlled trial of dexamethasone in severe respiratory syncytial virus (RSV) infection: effects on RSV quantity and clinical outcome. J. Infect. Dis. 185, 1222–1228 (2002).
  • Lee N, Chan KCA, Hui DS et al. Effects of early treatment on plasma SARS-associated coronavirus RNA concentrations in adult patients. J. Clin. Virol. 31, 304–309 (2004).
  • Hong N, Du XK. Avascular necrosis of bone in severe acute respiratory syndrome. Clin. Radiol. 59, 602–608 (2004).
  • Epstein NN, Tuffanelli DL, Epstein JH. Avascular bone necrosis. A complication of long-term corticosteroid therapy. Arch. Dermatol. 92(2), 178–180 (1965).
  • Wong VW, Dai D, Wu AK et al. Treatment of severe acute respiratory syndrome with convalescent plasma. Hong Kong Med. J. 9, 199–210 (2003).
  • Soo YO, Cheng Y, Wong R et al. Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients. Clin. Microbiol. Infect. 10(7), 676–678 (2004).
  • Cheng Y, Wong R, Soo Y et al. Use of convalescent plasma therapy in SARS patients in Hong Kong. Eur. J. Clin. Microbiol. Infect. Dis. 24, 44–46 (2005).
  • Navas-Martin S, Weiss SR. Coronavirus replication and pathogenesis: implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. J. Neurovirol. 10, 75–85 (2004).
  • Denison MR. Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update. Pedeatr. Infect. Dis. J. 23(11), S207–S214 (2004).
  • Lau YL. SARS: future research and vaccine. Pedeatr. Resp. Rev. 5, 300–303 (2004).
  • Bukreyev A, Lamirande EW, Buchholz UJ. Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS. Lancet 363, 22–27 (2004).
  • Marshall E, Enserink M. Caution urged on SARS vaccines. Science 303, 944–946 (2004).
  • Sung JJ, Wu A, Joynt GM et al. Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak. Thorax 59(5), 414–420 (2004).

Websites

  • World Health Organization: summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003 www.who.int/csr/sars/country/table2004_04_21/en/ (Accessed March 2005)
  • World Health Organization: SARS – breaking the chains of transmission www.who.int/features/2003/07/en/ (Accessed March 2005)
  • World Health Organization: China’s latest SARS outbreak has been contained, but biosafety concerns remain – Update 7 www.who.int/csr/don/2004_05_18a/en/ (Accessed March 2005)
  • World Health Organization: inadequate plumbing systems likely contributed to SARS transmission www.who.int/mediacentre/news/releases/2003/pr70/en (Accessed March 2005)

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