Prevention of infectious complications in severe acute pancreatitis with systemic antibiotics: where are we now?

References

• Bradley EL III. A clinically based classification system for acute pancreatitis. Arch. Surg. 128, 586–590 (1993).
   PubMed Web of Science ®Google Scholar
• Büchler MW, Gloor B, Müller CA, Friess H, Seiler ChA, Uhl W. Acute necrotizing pancreatitis: treatment strategy according to the status of infection. Ann. Surg. 232, 619–626 (2000).
   PubMed Web of Science ®Google Scholar
• Bradley EL III. A fifteen year experience with open drainage for infected pancreatic necrosis. Surg. Gynecol. Obstet. 177, 215–222 (1993).
   PubMedGoogle Scholar
• Rattner DW, Dink A, Legermate DA, Lee MJ, Mueller PR, Warshaw AL. Early surgical debridement of symptomatic pancreatic necrosis is beneficial irrespective of infection. Am. J. Surg. 163, 105–110 (1992).
   PubMed Web of Science ®Google Scholar
• Tsiotos GG, Luque-de Leon E, Söreide JA et al. Management of necrotizing pancreatitis by repeated operative necrosectomy using a zipper technique. Am. J. Surg. 175, 91–98 (1998).
   PubMed Web of Science ®Google Scholar
• Fernandez Del-Castillo C, Rattner DW, Makary MA, Mostafavi A, McGrath D, Warshaw A. Debridement and closed packing for the treatment of necrotizing pancreatitis. Ann. Surg. 228, 676–684 (1998).
   PubMed Web of Science ®Google Scholar
• Beger HG, Isenmann R. Surgical management of necrotizing pancreatitis. Surg. Clin. North Am. 79, 783–800 (1999).
   PubMed Web of Science ®Google Scholar
• Beger HG, Bittner R, Block S, Büchler M. Bacterial contamination of pancreatic necrosis – a prospective clinical study. Gastroenterology 91, 433–438 (1986).
   PubMed Web of Science ®Google Scholar
• Widdison AL, Karanjia ND. Pancreatic infection complicating acute pancreatitis. Br. J. Surg. 80, 148–154 (1993).
   PubMed Web of Science ®Google Scholar
• Baron TH, Morgan DE. Acute necrotizing pancreatitis. N. Engl. J. Med. 340, 1412–1417 (1999).
   PubMed Web of Science ®Google Scholar
• Karimgani I, Porter KA, Langevin RE, Banks PA. Prognostic factors in sterile pancreatic necrosis. Gastroenterology 103, 1636–1640 (1992).
   PubMed Web of Science ®Google Scholar
• Gerzof SG, Banks PA, Robbins AH et al. Early diagnosis of pancreatic infection by computed tomography-guided aspiration. Gastroenterology 93, 1315–1320 (1987).
   PubMed Web of Science ®Google Scholar
• Bassi C, Falconi M, Girelli R et al. Microbiological findings in severe pancreatitis. Surg. Res. Comm. 5, 1–4 (1989).
   Google Scholar
• Lange JF, van Gool J, Tytgat GNJ. The protective effect of a reduction in intestinal flora on mortality of acute haemorrhagic pancreatitis in the rat. Hepatogastroenterology 34, 28–30 (1987).
   PubMedGoogle Scholar
• Widdison AL, Karanjia ND, Reber HA. Routes of spread of pathogens into the pancreas in a feline model of acute pancreatitis. Gut 35, 1306–1310 (1994).
   PubMed Web of Science ®Google Scholar
• Foitzik T, Fernandez Del-Castillo C, Ferraro MJ, Mithöfer K, Rattner DW, Warshaw A. Pathogenesis and prevention of early pancreatic infection in experimental acute necrotizing pancreatitis. Ann. Surg. 222, 179–185 (1995).
   PubMed Web of Science ®Google Scholar
• Wang XD, Andersson R, Soltesz V, Leveau P, Ihse I. Gut origin sepsis, macrophage function, and oxygen extraction associated with acute pancreatitis in the rat. World J. Surg. 20, 299–308 (1996).
   PubMed Web of Science ®Google Scholar
• Wang XD, Wang Q, Andersson R, Ihse I. Alterations in intestinal function in acute pancreatitis in an animal model. Br. J. Surg. 83, 1537–1542 (1996).
   PubMed Web of Science ®Google Scholar
• Hotz H, Foitzik T, Hotz B, Runkel N, Buhr HJ. Impairment of intestinal capillary perfusion correlates with severity of acute pancreatitis. Int. J. Microcirc. 16(Suppl. 1), 255 (1996).
   Google Scholar
• Andersson R, Wang X, Sun Z, Deng X, Soltesz V, Ihse I. Effect of a platelet-activating factor antagonist on pancreatitis-associated gut barrier dysfunction in rats. Pancreas 17, 107–119 (1998).
   PubMed Web of Science ®Google Scholar
• Gloor B, Müller CA, Worni M, Uhl W, Büchler MW. Pancreatic infection in severe pancreatitis. The role of fungus and multiresistant organisms. Arch. Surg. 136, 592–596 (2001).
   PubMed Web of Science ®Google Scholar
• Isenmann R, Schwarz M, Rau B, Trautmann M, Schober W, Beger HG. Characteristics of infection with Candida species in patients with necrotizing pancreatitis. World J. Surg. 26, 372–376 (2002).
   PubMed Web of Science ®Google Scholar
• Hoerauf A, Hammer ST, Müller-Myhsok B, Rupprecht H. Intra-abdominal Candida infection during acute necrotizing pancreatitis has a high prevalence and is associated with increased mortality. Crit. Care Med. 26, 2010–2015 (1998).
   PubMed Web of Science ®Google Scholar
• Grewe M, Tsiotos GG, Luque-de Leon E, Sarr MG. Fungal infection in acute necrotizing pancreatitis. J. Am. Coll. Surg. 188, 408–414 (1999).
   PubMed Web of Science ®Google Scholar
• Mai G, Gloor B, Uhl W, Mueller CA, Tcholakov O, Büchler MW. Routine antibiotic prophylaxis in necrotizing pancreatitis increased Gram-positive infections. Digestion 60, 367 (1999).
   Google Scholar
• Olah A, Belagyi T, Issekutz A, Gamal ME, Bengmark S. Randomized clinical trial of specific lactobacillus and fibre supplement on early enteral nutrition in patients with acute pancreatitis. Br. J. Surg. 89, 1103–1107 (2002).
   PubMed Web of Science ®Google Scholar
• Mangiante G, Colucci G, Canepari P et al. Lactobacillus plantarum reduces infection of pancreatic necrosis in experimental acute pancreatitis. Dig. Surg. 18, 47–50 (2001).
   PubMed Web of Science ®Google Scholar
• Powell JJ, Murchinson JT, Fearon KC, Ross JA, Siriwardena AK. Randomized controlled trial of the effect of early enteral nutrition on markers of the inflammatory response in predicted severe acute pancreatitis. Br. J. Surg. 87, 1375–1381 (2000).
   PubMed Web of Science ®Google Scholar
• Marik PE, Zaloga GP. Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis. Br. Med. J. 328, 1407–1413 (2004).
   PubMed Web of Science ®Google Scholar
• Bradley EL III, Allen KA. Prospective longitudinal study of observation versus surgical intervention in the management of necrotizing pancreatitis. Am. J. Surg. 161, 19–25 (1991).
   PubMed Web of Science ®Google Scholar
• Warshaw AL. Pancreatic necrosis. To debride or not to debride – that is the question. Ann. Surg. 232, 627–629 (2000).
   PubMed Web of Science ®Google Scholar
• Rau B, Pralle U, Uhl W, Schoenberg MH, Beger HG. Management of sterile necrosis in instances of severe acute pancreatitis. J. Am. Coll. Surg. 181, 279–288 (1995).
   PubMed Web of Science ®Google Scholar
• Beger HG, Isenmann R. Acute pancreatitis: who needs an operation? J. Hepatobiliary Pancreatic Surg. 9, 436–442 (2002).
   PubMedGoogle Scholar
• Balthazar EJ, Robinson DL, Megibow AJ, Ranson JC. Acute pancreatitis: value of CT in establishing prognosis. Radiology 174, 331–336 (1990).
   PubMed Web of Science ®Google Scholar
• Mitchell RMS, Byrne MF, Baillie J. Pancreatitis. Lancet 361, 1447–1455 (2003).
   PubMed Web of Science ®Google Scholar
• Yousaf M, McCallion K, Diamond T. Management of severe acute pancreatitis. Br. J. Surg. 90, 407–420 (2003).
   PubMed Web of Science ®Google Scholar
• Kemppainen E, Sainio V, Haapiainen R, Kivisaari L, Kivilaasko E, Puolakkainen P. Early localization of necrosis by contrast-enhanced computed tomography can predict outcome in severe acute pancreatitis. Br. J. Surg. 83, 924–929 (1996).
   PubMed Web of Science ®Google Scholar
• London NJM, Leese T, Lavelle JM et al. Rapid-bolus contrast-enhanced dynamic computed tomography in acute pancreatitis: a prospective study. Br. J. Surg. 78, 1452–1456 (1991).
   PubMed Web of Science ®Google Scholar
• Büchler MW, Uhl W, Malfertheiner P. Therapie der akuten Pankreatitis. Dtsch. Med. Wschr. 119, 1739–1744 (1994).
   PubMed Web of Science ®Google Scholar
• Rau B, Pralle U, Mayer JM, Beger HG. Role of ultrasonographically guided fine-needle aspiration cytology in the diagnosis of infected pancreatic necrosis. Br. J. Surg. 85, 179–184 (1998).
   PubMedGoogle Scholar
• Paye F, Rotman N, Radier C, Nouira R, Fagniez P-L. Percutaneous aspiration for bacteriological studies in patients with necrotizing pancreatitis. Br. J. Surg. 85, 755–759 (1998).
   PubMed Web of Science ®Google Scholar
• Uhl W, Büchler M, Malfertheiner P, Martini M, Beger HG. PMN-elastase in comparison with CRP, antiproteases and LDH as indicators of necrosis in human acute pancreatitis. Pancreas 6, 253–259 (1991).
   PubMed Web of Science ®Google Scholar
• Wilson C, Heads A, Shenkin A, Imrie CW. C-reactive protein, antiproteases and complement factors as objective markers of severity in acute pancreatitis. Br. J. Surg. 76, 177–181 (1989).
   PubMed Web of Science ®Google Scholar
• Rau B, Steinbach G, Gansauge F, Mayer JM, Grünert A, Beger HG. The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis. Gut 41, 832–840 (1997).
   PubMed Web of Science ®Google Scholar
• Müller CA, Uhl W, Printzen G et al. Role of procalcitonin and granulocyte colony stimulating factor in the early prediction of infected necrosis in severe acute pancreatitis. Gut 46, 233–238 (2000).
   PubMed Web of Science ®Google Scholar
• Kylänpää-Bäck M-L, Takala A, Kemppainen E et al. Procalcitonin, soluble interleukin-2 receptor, and soluble E-selectin in predicting the severity of acute pancreatitis. Crit. Care Med. 29, 63–69 (2001).
   PubMed Web of Science ®Google Scholar
• Riche FC, Cholley BP, Laisne MJ et al. Inflammatory cytokines, C reactive protein, and procalcitonin as early predictors of necrosis infection in acute necrotizing pancreatitis. Surgery 133, 257–259 (2003).
   PubMed Web of Science ®Google Scholar
• Cameron JL, Howes R, Zuidema GD. Antibiotic therapy in acute pancreatitis. Surg. Clin. North Am. 55, 1319–1324 (1975).
   PubMed Web of Science ®Google Scholar
• Howes R, Zuidema GD, Cameron JL. Evaluation of prophylactic antibiotics in acute pancreatitis. J. Surg. Res. 18, 197–201 (1975).
   PubMed Web of Science ®Google Scholar
• Kim SL, Goldschmid S. Antibiotics in acute pancreatitis: the debate revisited. Am. J. Gastroenterol. 90, 666–667 (1995).
   PubMedGoogle Scholar
• Götzinger P, Wamser P, Barian M, Sautner T, Jakesz R, Függer R. Candida infection of local necrosis in severe acute pancreatitis is associated with increased mortality. Shock 14, 320–324 (2000).
   PubMed Web of Science ®Google Scholar
• Raty S, Scand J, Nordback I. Difference in microbes contaminating pancreatic necrosis in biliary and alcoholic pancreatitis. Int. J. Pancreatol. 24, 187–191 (1998).
   PubMedGoogle Scholar
• Bradley EL III. Antibiotics in acute pancreatitis. Current status and future directions. Am. J. Surg. 158, 472–477 (1989).
   PubMed Web of Science ®Google Scholar
• Shrikhande S, Friess H, Issenegger C et al. Fluconazole penetration into the pancreas. Antimicrob. Agents Chemother. 44, 2569–2571 (2000).
   PubMed Web of Science ®Google Scholar
• He Y-M, Lv X, Ai Z et al. Prevention and therapy of fungal infection in severe acute pancreatitis: a prospective clinical study. World J. Gastroenterol. 9, 2619–2621 (2003).
   PubMed Web of Science ®Google Scholar
• Büchler M, Malfertheiner P, Friess H et al. Human pancreatic tissue concentrations of bactericidal antibiotics. Gastroenterology 103, 1902–1908 (1992).
   PubMed Web of Science ®Google Scholar
• Bassi C, Pederzoli P, Vesentini S et al. Behaviour of antibiotics during human necrotizing pancreatitis. Antimicrob. Agents Chemother. 38, 830–836 (1994).
   PubMed Web of Science ®Google Scholar
• Koch K, Drewelow B, Liebe S, Reding R, Riethling A-K. Die Pankreasgängigkeit von Antibiotika. Chirurg 62, 317–322 (1991).
   PubMed Web of Science ®Google Scholar
• Spicak J, Martinek J, Zavada F, Moravek J, Melenovsky V. Penetration of antibiotics into the pancreas in rats: an effect of acute necrotizing pancreatitis. Scand. J. Gastroent. 34, 92–97 (1999).
   PubMed Web of Science ®Google Scholar
• Mithöfer K, Fernandez Del-Castillo C, Ferraro MJ, Lewandrowski K, Rattner DW, Warshaw A. Antibiotic treatment improves survival in experimental acute necrotizing pancreatitis. Gastroenterology 110, 232–240 (1996).
   PubMed Web of Science ®Google Scholar
• Pederzoli P, Bassi C, Vesentini S, Campedelli AA. Randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem. Surg. Gynecol. Obstet. 176, 480–483 (1993).
   PubMedGoogle Scholar
• Sainio V, Kemppainen E, Puolakkainen P et al. Early antibiotic treatment in acute necrotizing pancreatitis. Lancet 346, 663–667 (1995).
   PubMed Web of Science ®Google Scholar
• Schwarz M, Isenmann R, Meyer H, Beger HG. Antibiotika bei nekrotisierender pankreatitis. Ergebnisse einer kontrollierten studie. Dtsch. Med. Wschr. 122, 356–361 (1997).
   PubMed Web of Science ®Google Scholar
• Spicak J, Hejtmankova S, Cech P et al. Antibiotic prophylaxis in severe acute pancreatitis: randomized multicenter prospective trial with meropenem. Pancreatology 3, 220 (2003).
   Google Scholar
• Delcenserie R, Yzet T, Duccroix JP. Prophylactic antibiotics in treatment of severe acute alcoholic pancreatitis. Pancreas 13, 198–201 (1996).
   PubMed Web of Science ®Google Scholar
• Isenmann R, Rünzi M, Kron M et al and the German Antibiotics in Severe Acute Pancreatitis (ASAP) Study Group. Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis – a placebo-controlled, double-blind trial. Gastroenterology 126(4), 997–1004 (2004).
   PubMed Web of Science ®Google Scholar
• Luiten EJT, Hop WCJ, Lange JF, Bruining HA. Controlled clinical trial of selective decontamination for the treatment of severe acute pancreatitis. Ann. Surg. 222, 57–65 (1995).
   PubMed Web of Science ®Google Scholar
• Solomkin JS, Dellinger PE, Christou NV, Busuttil RW. Results of a multicenter trial comparing imipenem/cilastatin to tobramycin/clindamycin for intra-abdominal infections. Ann. Surg. 212, 581–591 (1990).
   PubMed Web of Science ®Google Scholar
• Solomkin JS, Reinhart HH, Dellinger PE et al. Results of a randomized trial comparing sequential intravenous/oral treatment with ciprofloxacin plus metronidazole vs. imipenem/cilastatin for intra-abdominal infections. Ann. Surg. 223, 303–315 (1996).
   PubMed Web of Science ®Google Scholar
• Bassi C, Falconi M, Talamini G et al. Controlled clinical trial of pefloxacin versus imipenem in severe acute pancreatitis. Gastroenterology 115, 1513–1517 (1998).
   PubMed Web of Science ®Google Scholar
• Nordback I, Scand J, Saaristo R, Paajanen H. Early treatment with antibiotics reduces the need for surgery in acute necrotizing pancreatitis – a single-center randomized study. J. Gastrointest. Surg. 5, 113–120 (2001).
   PubMed Web of Science ®Google Scholar
• Manes G, Rabitti PG, Menchise A, Riccio E, Balzano A, Uomo G. Prophylaxis with meropenem of septic complications in acute pancreatitis: a randomized, controlled trial versus imipenem. Pancreas 27, E79–E83 (2003).
   Google Scholar
• Maravi-Poma E, Gener J, Alvarez-Loma F, Olaechea P, Blanco A, Dominguez-Munoz JE and Spanish Group for the Study of Septic Complications in Severe Acute Pancreatitis. Early antibiotic treatment (prophylaxis) of septic complications in severe acute necrotizing pancreatitis: a prospective, randomized, multicenter study comparing two regimes with imipenem-cilastatin. Intensive Care Med. 29, 1974–1980 (2003).
   PubMed Web of Science ®Google Scholar
• Sharma VK, Howden CW. Prophylactic antibiotic administration reduces sepsis and mortality in acute necrotizing pancreatitis: a meta-analysis. Pancreas 22, 28–31 (2001).
   PubMed Web of Science ®Google Scholar
• Golub R, Siddiqi F, Pohl D. Role of antibiotics in acute pancreatitis: a meta-analysis. J. Gastrointest. Surg. 2, 496–502 (1998).
   PubMedGoogle Scholar
• Bassi C, Larvin M, Villatoro E. Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. Cochrane Database Syst. Rev. 4, CD002941 (2003).
   Google Scholar
• Nathens AB, Curtis JR, Beale RJ et al. Management of the critically ill patient with severe acute pancreatitis. Crit. Care Med. 32, 2524–2536 (2004).
   PubMed Web of Science ®Google Scholar
• Uhl W, Warshaw A, Imrie CW et al. IAP-guidelines for the surgical management of acute pancreatitis. Pancreatology 2, 565–573 (2002).
   PubMed Web of Science ®Google Scholar
• Société Nationale Francaise de Gastro-Entérologie. French Consensus Conference on Acute Pancreatitis: Conclusions and Recommendations. Eur. J. Gastroent. Hepatol. 13, S1–S13 (2001).
   PubMed Web of Science ®Google Scholar