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Review

Epidemiology, pathogenesis and treatment of pelvic inflammatory disease

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Pages 235-247 | Published online: 10 Jan 2014

References

  • Sexually Transmitted Disease Surveillance, 1997. 1998. Division of STD Prevention. US Department of Health and Human Services, Public Health Service, GA, USA: Centers for Disease Control and Prevention (CDC).
  • Washington AE, Katz P. Cost and payment source for pelvic inflammatory disease. Trends and projections, 1983 through 2000. JAMA266,2565 (1991).
  • Rein DB, Kassler WJ, Irwin KL, Rabiee L. Direct medical cost of pelvic inflammatory disease and its sequelae: decreasing, but still substantial. Obstet. Gynecol.95, 397–402 (2000).
  • Westrom L. Decrease in incidence of women treated in hospital for acute salpingitis in Sweden. Genitourin. Med.64, 59–63 (1988).
  • Kildea S, Bowden FJ. Reproductive health, infertility and sexually transmitted infections in indigenous women in a remote community in the Northern Territory. Aust. NZ J. Public Health24, 382–386 (2000).
  • Westrom L. Effect of acute pelvic inflammatory disease on fertility. Am. J. Obstet. Gynecol.121, 707–713 (1975).
  • Westrom L, Joesoef R, Reynolds G, Hagdu A, Thompson SE. Pelvic inflammatory disease and fertility. Sex. Transm. Dis.19, 185–192 (1992).
  • Punnonen R, Terho P, Nikkanen V, Meurman O. Chlamydial serology in infertile women by immunofluorescence. Fertil. Steril.31, 656–659 (1979).
  • Kane JL, Woodland RM, Forsey T, Darougar S, Elder MG. Evidence of chlamydial infection in infertile women with and without fallopian tube obstruction. Fertil. Steril.42, 843–848 (1984).
  • Miettinen A, Heinonen PK, Teisala K, Hakkarainen K, Punnonen R. Serologic evidence for the role of Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma hominis in the etiology of tubal factor infertility and ectopic pregnancy. Sex. Transm. Dis.17, 10–14 (1990).
  • Anestad G, Lunde O, Moen M, Dalaker K. Infertility and chlamydial infection. Fertil. Steril.48, 787–790 (1987).
  • World Health Organization Task Force on the Prevention and Management of Infertility. Tubal infertility: serologic relationship to past chlamydial and gonococcal infection. Sex. Transm. Dis.22, 71–77 (1995).
  • Haggerty CL, Peipert JF, Weitzen S et al. Predictors of chronic pelvic pain in an urban population of women with symptoms and signs of pelvic inflammatory disease. Sex. Transm. Dis.32, 293–299 (2005).
  • Steege JF. Chronic Pelvic Pain: an Integrated Approach. Steege JF, Metzger DA, Levy BS (Eds). W.B. Saunders Company, PA, USA, 2 (1998).
  • Haggerty CL, Schulz R, Ness RB. Lower quality of life among women with chronic pelvic pain following pelvic inflammatory disease. Obstet. Gynecol.102, 934–939 (2003).
  • Eschenbach DA. Epidemiology of pelvic inflammatory disease. In: Pelvic Inflammatory Disease. Landers DV, Sweet RL (Eds). Springer-Verlag, NY, USA, 1–20 (1997).
  • Westrom L, Mardh P-A. Acute pelvic inflammatory disease (PID). In: Sexually Transmitted Diseases. Holmes KK, Mardh P-A, Sparling PF (Eds). McGraw-Hill Company, NY, USA, 593 (1990).
  • Svenstrup HF, Fedder J, Abraham-Peskir J, Birkelund S, Christiansen G. Mycoplasma genitalium attaches to human spermatozoa. Hum. Reprod.18, 2103–2109 (2003).
  • IJland MM, Evers JL, Dunselman GA, Hoogland HJ. Subendometrial contractions in the nonpregnant uterus: an ultrasound study. Eur. J. Obstet. Gynecol. Reprod. Biol.70, 23–24 (1996).
  • Ness RB, Hillier SL, Richter HE et al. Douching in relation to bacterial vaginosis, lactobacilli, and facultative bacteria in the vagina. Obstet. Gynecol.100, 765 (2002).
  • Simms I, Mallinson H, Peeling RW et al. Risk factors associated with pelvic inflammatory disease: a UK study. Int. J. STD AIDS13, 18 (2002).
  • Hillier SL, Kiviat NB, Hawes SE et al. Role of bacterial vaginosis-associated microorganisms in endometritis. Am. J. Obstet. Gynecol.175, 435–441 (1996).
  • Kiviat NB, Wolner-Hanssen P, Eschenbach DA, Wasserheit JN, Paavonen JA, Bell TA. Endometrial histopathology in patients with culture-proven upper genital tract infection and laparoscopically diagnosed acute salpingitis. Am. J. Surg. Pathol.167–175 (1990).
  • Crombleholme WR, Schachter J, Ohm-Smith M, Luft J, Whidden R, Sweet RL. Efficacy of single-agent therapy for the treatment of acute pelvic inflammatory disease with ciprofloxacin. Am. J. Med.87, 142S–147S (1989).
  • Monif GR, Welkos SL, Baer H, Thompson RJ. Cul-de-sac isolates from patients with endometritis-salpingitis-peritonitis and gonococcal endocervicitis. Am. J. Obstet. Gynecol.126, 158–161 (1976).
  • Sweet RL, Draper DL, Schachter J, Hadley WK, Brooks GF. Microbiology and pathogenesis of acute salpingitis as determined by laparoscopy: what is the appropriate site to sample? Am. J. Obstet. Gynecol.138, 985–989 (1980).
  • Thompson SE, Hager WD, Wong KH et al. The microbiology and therapy of acute pelvic inflammatory disease in hospitalized patients. Am. J. Obstet. Gynecol.136, 179–186 (1980).
  • Sweet RL, Mills J, Hadley KW et al. Use of laparoscopy to determine the micobiologic etiology of acute salpingitis. Am. J. Obstet. Gynecol.134, 68–74 (1979).
  • Kiviat NB, Wolner-Hanssen P, Peterson M et al. Localization of Chlamydia trachomatis infection by direct immunofluorescence and culture in pelvic inflammatory disease. Am. J. Obstet. Gynecol.154, 865–873 (1986).
  • Eschenbach DA, Buchanan TM, Pollock HM et al. Polymicrobial etiology of acute pelvic inflammatory disease. N. Engl. J. Med.293, 166–171 (1975).
  • Brunham RC, Binns B, Guijon F et al. Etiology and outcome of acute pelvic inflammatory disease. J. Infect. Dis.158, 510–517 (1988).
  • Heionen PK, Teisala K, Punnonen R, Miettinen A, Lehtinen M, Paavonen J. Anatomic sites of upper genital tract infection. Obstet. Gynecol.66, 384–390 (1985).
  • Cunningham FG, Hauth JC, Gilstrap LC, Herbert WN, Kappus SS. The bacterial pathogenesis of acute pelvic inflammatory disease. Obstet. Gynecol.52, 161–164 (1978).
  • Lip J, Burgoyne X. Cervical and peritoneal bacterial flora associated with salpingitis. Obstet. Gynecol.28, 561–563 (1966).
  • Soper DE, Brockwell NJ, Dalton HP, Johnson D. Observations concerning the microbial etiology of acute salpingitis. Am. J. Obstet. Gynecol.170, 1008–1017 (1994).
  • Wasserheit JN, Bell TA, Kiviat NB et al. Microbial causes of proven pelvic inflammatory disease and efficacy of clindamycin and tobramycin. Ann. Intern. Med.104, 187–193 (1986).
  • Paavonen J, Teisala K, Heinonen PK et al. Microbiological and histopathological findings in acute pelvic inflammatory disease. Br. J. Obstet. Gynaecol.94, 454–460 (1987).
  • Hong S, Xin C, Qianhong Y et al. Pelvic inflammatory disease in the People’s Republic of China: aetiology and management. Int. J. STD AIDS13, 568–572 (2002).
  • Peipert JF, Montagno AB, Cooper AS, Sung CJ. Bacterial vaginosis as a risk factor for upper genital tract infection.Am. J. Obstet. Gynecol.177, 1184–1187 (1997).
  • Gogate A. Mycoplasmal pelvic inflammatory disease. In: Advances in Mycoplasmology. Proceedings of the 7th Congress of the International Organization for Mycoplasmology, Baden near Vienna, 1988. Stanek G, Cassell GH, Tully JG, Whitcomb RF (Eds), Gustav Fischer Verlag, NY, USA, 239–241 (1990).
  • Chow AW, Malkasian KL, Marshall JR, Guze LB. The bacteriology of acute pelvic inflammatory disease. Am. J. Obstet. Gynecol.122, 876–879 (1974).
  • Korn AP, Bolan G, Padian N, Ohm-Smith M, Schachter J, Landers DV. Plasma cell endometritis in women with symptomatic bacterial vaginosis. Obstet. Gynecol.85, 387–390 (1995).
  • Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized Gram stain interpretation. J. Clin. Microbiol.29, 297–301 (1991).
  • Haggerty CL, Hillier SL, Bass DC, Ness RB. Bacterial vaginosis and anaerobic bacteria are associated with endometritis. Clin. Infect. Dis.39, 990–995 (2004).
  • Wiesenfeld HC, Hillier SL, Krohn MA et al. Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease. Obstet. Gynecol.100, 456–463 (2003).
  • Eschenbach DA, Hillier S, Critchlow C, Stevens C, DeRouen T, Holmes KK. Diagnosis and clinical manifestations of bacterial vaginosis. Am. J. Obstet. Gynecol.158, 819–828 (1988).
  • Ness RB, Kip KE, Hillier SL et al. A cluster analysis of bacterial vaginosis-associated microflora and pelvic inflammatory disease. Am. J. Epidemiol.162, 585–590 (2005).
  • Tully JG, Taylor-Robinson D, Cole RM, Rose DL. A newly discovered mycoplasma in the human urogenital tract. Lancet1288–1291 (1981).
  • Carlberg H, Bjornelius E, Jensen JS. Mycoplasma genitalium – the search for effective treatment. Int. J. STD AIDS13, 30 (2002).
  • Totten PA, Schwartz MA, Sjostrom KE et al. Association of Mycoplasma genitalium with nongonococcal urethritis in heterosexual men. J. Infect. Dis.183, 269–276 (2001).
  • Maeda S, Tamaki M, Nakano M, Uno M, Deguchi T, Kawada Y. Detection of Mycoplasma genitalium in patients with urethritis. J. Urol.159, 405–407 (1998).
  • Jensen JS. Mycoplasma genitalium: a cause of non-gonococcal urethritis? Genitourin. Med.70, 363 (1994).
  • Taylor-Robinson D, Furr PM, Hanna NF. Microbiological and serological study of non-gonococcal urethritis with special reference to Mycoplasma genitalium.Genitourin. Med.61, 319–324 (1985).
  • Janier M, Lassau F, Casin I et al. Male urethritis with and without discharge: a clinical and microbiological study. Sex. Transm. Dis.22, 244–252 (1995).
  • Mena L, Wang X, Mroczkowski TF, Martin DH. Mycoplasma genitalium infections in asymptomatic men and men with urethritis attending a sexually transmitted disease clinic in New Orleans. Clin. Infect. Dis.35, 1167–1173 (2002).
  • Horner P, Thomas B, Gilroy CB, Egger M, Taylor-Robinson D. Role of Mycoplasma genitalium and Ureaplasma urealyticum in acute and chronic nongonococcal urethritis. Clin. Infect. Dis.32, 995–1003 (2001).
  • Gambini D, Decleva I, Lupica L, Ghislanzoni M, Cusini M, Alessi E. Mycoplasma genitalium in males with nongonococcal urethritis: prevalence and clinical efficacy of eradication. Sex. Transm. Dis.27, 226–229 (2000).
  • Horner PJ, Gilroy CB, Thomas BJ, Naidoo RO, Taylor-Robinson D. Association of Mycoplasma genitalium with acute non-gonococcal urethritis. Lancet342, 582–585 (1993).
  • Taylor-Robinson D, Jensen JS, Fehler G, Radebe F, Ballard RC. Observations on the microbiology of urethritis in black South African men. Int. J. STD AIDS13, 323–325 (2002).
  • Horner PJ, Thomas B, Gilroy CB, Egger M, Taylor-Robinson D. Do all men attending departments of genitourinary medicine need to be screened for non-gonococcal urethritis? Int. J. STD AIDS13, 667–673 (2002).
  • Morency P, Dubois MJ, Gresenguet G et al. Aetiology of urethral discharge in Bangui, Central African Republic. Sex. Transm. Infect.77, 125–129 (2001).
  • Keane FE, Thomas BJ, Gilroy CB, Renton A, Taylor-Robinson D. The association of Chlamydia trachomatis and Mycoplasma genitalium with non-gonococcal urethritis: observations on heterosexual men and their female partners. Int. J. STD AIDS11, 435–439 (2000).
  • Bjornelius E, Lidbrink P, Jensen JS. Mycoplasma genitalium in non-gonococcal urethritis – a study in Swedish male STD patients. Int. J. STD AIDS11, 292–296 (2000).
  • Johannisson G, Enstrom Y, Lowhagen G et al. Occurrence and treatment of Mycoplasma genitalium in patients visiting STD clinics in Sweden. Int. J. STD AIDS11, 324–326 (2000).
  • Busolo F, Camposampiero D, Bordignon G, Bertollo G. Detection of Mycoplasma genitalium and Chlamydia trachomatis DNAs in male patients with urethritis using the polymerase chain reaction. Microbiologica20, 325–332 (1997).
  • Haggerty CL, Totten P, Astete SG, Ness RB. Mycoplasma genitalium among women with non-gonococcal, non-chlamydial pelvic inflammatory disease. Infect. Dis. Obstet. Gynecol. (2006) (In press).
  • Uno M, Deguchi T, Komeda H et al. Mycoplasma genitalium in the cervices of Japanese Women.Sex. Transm. Dis.24, 284–286 (1997).
  • Manhart LE, Critchlow CW, Holmes KK et al. Mucopurulent cervicitis and Mycoplasma genitalium. J. Infect. Dis.187, 650–657 (2003).
  • Pepin J, Labbe AC, Khonde N et al. Mycoplasma genitalium: an organism commonly associated with cervicitis among west African sex workers. Sex. Transm. Infect.81, 67–72 (2005).
  • Falk L, Fredlund H, Jensen JS. Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection. Sex. Transm. Infect.81, 73–78 (2005).
  • Simms I, Eastick K, Mallinson H et al. Associations between Mycoplasma genitalium, Chlamydia trachomatis, and pelvic inflammatory disease. Int. J. STD AIDS13, 18 (2002).
  • Cohen CR, Manhart LE, Bukusi EA et al. Association between Mycoplasma genitalium and acute endometritis. Lancet359, 765–766 (2002).
  • Moller BR, Taylor-Robinson D, Furr PM, Freundt EA. Acute upper genital-tract disease in female monkeys provoked experimentally by Mycoplasma genitalium.Br. J. Exp. Pathol.66, 417–426 (1985).
  • Taylor-Robinson D, Furr PM, Tully JG, Barile MF, Moller BR. Animal models of Mycoplasma genitalium urogenital infection. Isr. J. Med. Sci.23, 561–564 (1987).
  • Collier AM, Carson JL, Hu PC, Hu SS, Huang CH, Barile MF. Attachment of Mycoplasma genitalium to the ciliated epithelium of human fallopian tubes. In: Recent Advances in Mycoplasmology. Proceedings of the 7th Congress of the International Organization for Mycoplasmology, Baden near Vienna, 1988. Stanek G, Cassell GH, Tully JG, Whitcomb RF (Eds), Gustav Fischer Verlag, Stuttgart, NY, USA, 730–732 (1990).
  • Korn AP, Ehrlich S. Images in infectious diseases in obstetrics and gynecology. Endometrial tuberculosis. Infect. Dis. Obstet. Gynecol.8, 118 (2000).
  • Avan BI, Fatmi Z, Rashid S. Comparison of clinical and laparascopic features of infertile women suffering from genital tuberculosis (TB) or pelvic inflammatory disease (PID) or endometriosis. J. Pak. Med. Assoc.51, 393–399 (2001).
  • Yang Y, Hao M, Zhu Y. Laparoscopic diagnosis of tubal infertility and fallopian tube lesions. Chin. J. Obstet. Gynecol.31, 327–329 (1996).
  • Wiesenfeld HC, Hillier SL, Krohn MA et al. Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease. Obstet. Gynecol.100, 456–463 (2002).
  • Eckert LO, Thwin SS, Hillier SL, Kiviat NB, Eschenbach DA. The antimicrobial treatment of sub-acute endometritis: a proof of concept study. Am. J. Obstet. Gynecol.190(2), 305–313 (2004).
  • CDC. Sexually transmitted diseases treatment guidelines. Morbid. Mortal. Wkly Rep.51(RR-6) 5–10 (2002).
  • Peipert JF, Ness RB, Blume J et al. Clinical predictors of endometritis in women with symptoms and signs of pelvic inflammatory disease. Am. J. Obstet. Gynecol.184, 856–863 (2001).
  • WHO. Sexually transmitted and other reproductive tract infections: a guide to essential practice. (2005).
  • Westrom L. Sexually transmitted diseases and infertility. Sex. Transm. Dis.21, S32–S37 (1994).
  • Safrin S, Schachter J, Dahrouge D, Sweet RL. Long-term sequelae of acute pelvic inflammatory disease. A retrospective cohort study. Am. J. Obstet. Gynecol.166, 1300–1305 (1992).
  • Hillis SD, Joesoef R, Marchbanks PA, Wasserheit JN, Cates W Jr, Westrom L. Delayed care of pelvic inflammatory disease as a risk factor for impaired fertility. Am. J. Obstet. Gynecol.168, 1503–1509 (1993).
  • Simms I, Eastick K, Mallinson H et al. Associations between Mycoplasma genitalium, Chlamydia trachomatis, and pelvic inflammatory disease. Sex. Transm. Infect.79, 154–156 (2003).
  • Peipert JF, Boardman L, Hogan JW, Sung J, Mayer KH. Laboratory evaluation of acute upper genital tract infection. Obstet. Gynecol.87, 730–736 (1996).
  • Paavonen J, Aine R, Teisala K, Heinonen PK, Punnonen R. Comparison of endometrial biopsy and peritoneal fluid cytologic testing with laparoscopy in the diagnosis of acute pelvic inflammatory disease. Am. J. Obstet. Gynecol.151, 645–650 (1985).
  • Molander P, Finne P, Sjoberg J, Sellors J, Paavonen J. Observer agreement with laparoscopic diagnosis of pelvic inflammatory disease using photographs. Obstet. Gynecol.101, 875–880 (2003).
  • Sellors J, Mahony J, Goldsmith C et al. The accuracy of clinical findings and laparoscopy in pelvic inflammatory disease. Am. J. Obstet. Gynecol.164, 113–120 (1991).
  • Tukeva TA, Aronen HJ, Karjalainen PT, Molander P, Paavonen T, Paavonen J. MR imaging in pelvic inflammatory disease: comparison with laparoscopy and US. Radiology210, 209–216 (1999).
  • Boardman LA, Peipert JF, Brody JM, Cooper AS, Sung J. Endovaginal sonography for the diagnosis of upper genital tract infection. Obstet. Gynecol.90, 54–57 (1997).
  • Molander P, Sjoberg J, Paavonen J, Cacciatore B. Transvaginal power Doppler findings in laparoscopically proven acute pelvic inflammatory disease. Ultrasound Obstet. Gynecol.17, 233–238 (2001).
  • Ness RB, Soper DE, Holley RL et al. Effectiveness of inpatient and outpatient treatment strategies for women with pelvic inflammatory disease: results from the PID Evaluation and Clinical Health (PEACH) randomized trial. Am. J. Obstet. Gynecol.186, 929–937 (2002).
  • Walker CK, Kahn JG, Washington AE, Peterson HB, Sweet RL. Pelvic inflammatory disease: meta-analysis of antimicrobial regimen efficacy. J. Infect. Dis.168, 969–978 (1993).
  • Walker EA, Katon WJ, Hansom J et al. Medical and psychiatric symptoms in women with childhood sexual abuse. Psychosom. Med.54, 658–664 (1992).
  • Martens MG, Gordon S, Yarborough DR, Faro S, Binder D, Berkeley A. Multicenter randomized trial of ofloxacin versus cefoxitin and doxycycline in outpatient treatment of pelvic inflammatory disease. Ambulatory PID Research Group. South. Med. J.86, 604–610 (1993).
  • Peipert JF, Sweet RL, Walker CK, Kahn J, Rielly-Gauvin K. Evaluation of ofloxacin in the treatment of laparoscopically documented acute pelvic inflammatory disease (salpingitis). Infect. Dis. Obstet. Gynecol.7, 138–144 (1999).
  • Arredondo JL, Diaz V, Gaitan H et al. Oral clindamycin and ciprofloxacin versus intramuscular ceftriaxone and oral doxycycline in the treatment of mild-to-moderate pelvic inflammatory disease in outpatients. Clin. Infect. Dis.24, 170–178 (1997).
  • Hemsell DL, Martens MG, Faro S, Gall S, McGregor JA. A multicenter study comparing intravenous meropenem with clindamycin plus gentamicin for the treatment of acute gynecologic and obstetric pelvic infections in hospitalized women. Clin. Infect. Dis.24(Suppl. 2), S222–S230 (1997).
  • Rustomjee R, Kharsany AB, Connolly CA, Karim SS. A randomized controlled trial of azithromycin versus doxycycline/ciprofloxacin for the syndromic management of sexually transmitted infections in a resource-poor setting. J. Antimicrob. Chemother.49, 875–878 (2002).
  • Malhotra M, Sharma JB, Batra S, Arora R, Sharma S. Ciprofloxacin–tinidazole combination, fluconazole–azithromicin–secnidazole-kit and doxycycline–metronidazole combination therapy in syndromic management of pelvic inflammatory disease: a prospective randomized controlled trial. Indian J. Med. Sci.57, 549–555 (2003).
  • Bevan CD, Ridgway GL, Rothermel CD. Efficacy and safety of azithromycin as monotherapy or combined with metronidazole compared with two standard multidrug regimens for the treatment of acute pelvic inflammatory disease. J. Int. Med. Res.31, 45–54 (2003).
  • Witte EH, Peters AA, Smit IB et al. A comparison of pefloxacin/metronidazole and doxycycline/metronidazole in the treatment of laparoscopically confirmed acute pelvic inflammatory disease. Eur. J. Obstet. Gynecol. Reprod. Biol.50, 153–158 (1993).
  • Piyadigamage A, Wilson J. Improvement in the clinical cure rate of outpatient management of pelvic inflammatory disease following a change in therapy. Sex. Transm. Infect.81, 233–235 (2005).
  • Haggerty CL, Ness RB, Amortegui A et al. Endometritis does not predict reproductive morbidity following pelvic inflammatory disease. Am. J. Obstet. Gynecol.188, 140–147 (2003).
  • Heinonen PK, Leinonen M. Fecundity and morbidity following acute pelvic inflammatory disease treated with doxycycline and metronidazole. Arch. Gynecol. Obstet.268, 284–288 (2003).
  • Tuffrey M, Woods C, Inman C, Ward M. The effect of a single oral dose of azithromycin on chlamydial infertility and oviduct ultrastructure in mice. J. Antimicrob. Chemother.34, 989–999 (1994).
  • Patton DL, Sweeney YT, Stamm WE. Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment. J. Infect. Dis.192, 129–135 (2005).
  • Beckmann KR, Melzer-Lange MD, Gorelick MH. Emergency department management of sexually transmitted infections in US adolescents: results from the National Hospital Ambulatory Medical Care Survey. Ann. Emerg. Med.43, 333–338 (2004).
  • Kane BG, Degutis LC, Sayward HK, D’Onofrio G. Compliance with the Centers for Disease Control and Prevention recommendations for the diagnosis and treatment of sexually transmitted diseases. Acad. Emerg. Med.11, 371–377 (2004).
  • CDC. Sexually transmitted disease surveillance, 2004. 2005. GA, US Department of Health and Human Services.
  • Rosenberg MJ, Davidson AJ, Chen JH, Judson FN, Douglas JM. Barrier contraceptives and sexually transmitted diseases in women: a comparison of female-dependent methods and condoms. Am. J. Public Health82, 669–674 (1992).
  • Austin H, Louv WC, Alexander WJ. A case-control study of spermicides and gonorrhea. JAMA251, 2822–2824 (1984).
  • Peters SE, Beck-Sague CM, Farshy CE et al. Behaviors associated with Neisseria gonorrhoeae and Chlamydia trachomatis: cervical infection among young women attending adolescent clinics. Clin. Pediatr.39, 173–177 (2000).
  • Gaydos CA, Howell MR, Pare B et al. Chlamydia trachomatis infections in female military recruits. N. Engl. J. Med.339, 739–744 (1998).
  • Radcliffe KW, Ahmad S, Gilleran G, Ross JD. Demographic and behavioural profile of adults infected with chlamydia: a case-control study. Sex. Transm. Infect.77, 265–270 (2001).
  • Zenilman JM, Weisman CS, Rompalo AM et al. Condom use to prevent incident STDs: the validity of self-reported condom use. Sex. Transm. Dis.22, 15–21 (1995).
  • Joesoef MR, Linnan M, Barakbah Y, Idajadi A, Kambodji A, Schulz K. Patterns of sexually transmitted diseases in female sex workers in Surabaya, Indonesia. Int. J. STD AIDS8, 576–580 (1997).
  • Paris M, Gotuzzo E, Goyzueta G et al. Prevalence of gonococcal and chlamydial infections in commercial sex workers in a Peruvian Amazon city. Sex. Transm. Dis.26, 103–107 (1999).
  • Fortenberry JD, Brizendine EJ, Katz BP, Wools KK, Blythe MJ, Orr DP. Subsequent sexually transmitted infections among adolescent women with genital infection due to Chlamydia trachomatis, Neisseria gonorrhoeae, or Trichomonas vaginalis. Sex. Transm. Dis.26, 26–32 (1999).
  • Kelaghan J, Rubin GL, Ory HW, Layde PM. Barrier-method contraceptives and pelvic inflammatory disease. JAMA248, 184–187 (1982).
  • Marks C, Tideman RL, Estcourt CS, Berry G, Mindel A. Assessment of risk for pelvic inflammatory disease in an urban sexual health population. Sex. Transm. Infect.76, 470–473 (2000).
  • Ness RB, Soper DE, Holley RL et al. Hormonal and barrier contraception and risk of upper genital tract disease in the PID Evaluation and Clinical Health (PEACH) study. Am. J. Obstet. Gynecol.185, 121–127 (2001).
  • Howell MR, Quinn TC, Gaydos CA. Screening for Chlamydia trachomatis in asymptomatic women attending family planning clinics. A cost-effectiveness analysis of three strategies. Ann. Intern. Med.128, 277–284 (1998).
  • Scholes D, Stergachis A, Heidrich FE, Andrilla H, Holmes KK, Stamm WE. Prevention of pelvic inflammatory disease by screening for cervical chlamydial infection. N. Engl. J. Med.334, 1362–1366 (1996).
  • Watt B, Brown FV. Is ciprofloxacin active against clinically important anaerobes? J. Antimicrob. Chemother.17, 605–613 (1986).
  • Sutter VL, Kwok YY, Bulkacz J. Comparative activity of ciprofloxacin against anaerobic bacteria. Antimicrob. Agents Chemother.27, 427–428 (1985).
  • Goldstein EJ, Citron DM. Comparative activity of the quinolones against anaerobic bacteria isolated at community hospitals. Antimicrob. Agents Chemother.27, 657–659 (1985).
  • Fernandes PB, Shipkowitz N, Bower RR, Jarvis KP, Weisz J, Chu DT. In-vitro and in-vivo potency of five new fluoroquinolones against anaerobic bacteria. J. Antimicrob. Chemother.18, 693–701 (1986).
  • Goldstein EJ, Citron DM, Hunt GS, Hudspeth M, Merriam CV. Activities of HMR 3004 (RU 64004) and HMR 3647 (RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin, and eight other antimicrobial agents against unusual aerobic and anaerobic human and animal bite pathogens isolated from skin and soft tissue infections in humans. Antimicrob. Agents Chemother.42, 1127–1132 (1998).
  • Sefton AM, Maskell JP, Beighton D et al. Azithromycin in the treatment of periodontal disease. Effect on microbial flora. J. Clin. Periodontol.23, 998–1003 (1996).
  • Goldstein EJ, Nesbit CA, Citron DM. Comparative in vitro activities of azithromycin, Bay y 3118, levofloxacin, sparfloxacin, and 11 other oral antimicrobial agents against 194 aerobic and anaerobic bite wound isolates. Antimicrob. Agents Chemother.39, 1097–1100 (1995).
  • Spangler SK, Jacobs MR, Appelbaum PC. Susceptibilities of 201 anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin by oxyrase agar dilution and E test methodologies. J. Clin. Microbiol.33, 1366–1367 (1995).
  • Williams JD, Maskell JP, Shain H et al. Comparative in vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms. J. Antimicrob. Chemother.30, 27–37 (1992).
  • Johnson SR, Sandul AL, Parekh M, Wang SA, Knapp JS, Trees DL. Mutations causing in vitro resistance to azithromycin in Neisseria gonorrhoeae.Int. J. Antimicrob. Agents21, 414–419 (2003).
  • McLean CA, Wang SA, Hoff GL et al. The emergence of Neisseria gonorrhoeae with decreased susceptibility to azithromycin in Kansas City, Missouri, 1999 to 2000. Sex. Transm. Dis.31, 73–78 (2004).
  • Sosa J, Ramirez-Arcos S, Ruben M et al. High percentages of resistance to tetracycline and penicillin and reduced susceptibility to azithromycin characterize the majority of strain types of Neisseria gonorrhoeae isolates in Cuba, 1995–1998. Sex. Transm. Dis.30, 443–448 (2003).
  • Arreaza L, Vazquez F, Alcala B, Otero L, Salcedo C, Vazquez JA. Emergence of gonococcal strains with resistance to azithromycin in Spain. J. Antimicrob. Chemother.51, 190–191 (2003).
  • Castor D, Prabhakar P, Furlonge C et al. Antibiotic resistant N. gonorrhoeae in Trinidad and Tobago. Cell. Mol. Biol.47, 987–995 (2001).
  • Dillon JA, Rubabaza JP, Benzaken AS et al. Reduced susceptibility to azithromycin and high percentages of penicillin and tetracycline resistance in Neisseria gonorrhoeae isolates from Manaus, Brazil, 1998. Sex. Transm. Dis.28, 521–526 (2001).
  • Dillon JA, Li H, Sealy J, Ruben M, Prabhakar P, Caribbean GASP Network. Gonococcal Antimicrobial Surveillance Program. Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from three Caribbean countries: Trinidad, Guyana, and St. Vincent. Sex. Transm. Dis.28, 508–514 (2001).
  • Deguchi T, Yoshida T, Yokoi S et al. Longitudinal quantitative detection by real-time PCR of Mycoplasma genitalium in first-pass urine of men with recurrent nongonococcal urethritis. J. Clin. Microbiol.40, 3854–3856 (2002).
  • Maeda SI, Tamaki M, Kojima K et al. Association of Mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis. Sex. Transm. Dis.28, 472–476 (2001).
  • Falk L, Fredlund H, Jensen JS. Tetracycline treatment does not eradicate Mycoplasma genitalium. Sex. Transm. Infect.79, 318–319 (2003).
  • Hannan PC. Comparative susceptibilities of various AIDS-associated and human urogenital tract mycoplasmas and strains of Mycoplasma pneumoniae to 10 classes of antimicrobial agent in vitro. J. Med. Microbiol.47, 1115–1122 (1998).
  • Hamasuna R, Osada Y, Jensen JS. New antibiotic susceptibility test of Mycoplasma genitalium by using real-time PCR. Program and Book of Abstracts, 16th Biennial meeting of the International Society for Sexually Transmitted Disease Research (ISSTDR).303 (2005).

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