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Review

Echinocandin antifungals: review and update

Pages 325-342 | Published online: 10 Jan 2014

References

  • Denning DW. Echinocandins and pneumocandins – a new antifungal class with a novel mode of action. J. Microb. Chemother.40, 611–614 (1997).
  • Nyfeler R, Keller SW. Metabolites of microorganisms, echinocandin B, a novel polypeptide antibiotic from Aspergillus nidulans var echinulatus – isolation and structural components. Helv. Chim. Acta57, 2459–2477 (1974).
  • Masurekar PS, Fountoulakis JM, Hallada TC et al. Pneumocandins from Zalerion arboricola, II: modification of product spectrum by mutation and medium manipulation. J. Antibiot. (Tokyo)45, 1867–1874 (1992).
  • Iwamoto T, Fujie A, Sakamoto K et al. WF11899A, B, and C, novel antifungal lipopeptides, I: taxonomy, fermentation, isolation, and physico-chemical properties.J. Antibiot. (Tokyo)47, 1084–1091 (1994).
  • Wong-Beringer A, Lambros M, Johnson D. Aerosolization potential of caspofungin (CAS). Proceedings of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA (2003).
  • Denning DW. Echinocandin antifungal drugs. Lancet362, 1142–1151 (2003).
  • Stone JA, Li S, Winchell S et al. Population pharmocokinetics of caspofungin in candidiasis patients. Program and Abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA, Abstract A-1571 (2003).
  • Walsh TJ, Adamson PC, Seibel NL et al. Pharmacokinetics, safety, and tolerability of caspofungin in children and adolescents. Antimicrob. Agents Chemother.49, 4536–4545 (2005).
  • Stone JA, Holland SD, Wickersham PJ et al. Single- and multiple-dose pharmacokinetics of caspofungin in healthy men. Antimicrob. Agents Chemother.46, 739–745 (2002).
  • Hajdu R, Thompson R, Sundelof JG et al. Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872). Antimicrob. Agents Chemother.41, 2339–2344 (1997).
  • Townsend R, Bekersky I, Buell DN et al. Pharmacokinetic (PK) evaluation of echinocandin FK463 in pediatric and adult patients. Proceedings of the 11th Focus on Fungal Infections Meeting. Washington, DC, USA, Abstract 24 (2001).
  • Azuma J, Yamamoto I, Ogura M et al. Phase I study of FK463, a new antifungal agent, in healthy adult male volunteers. Proceedings of the 38th Interscience Conference on Antimicrob Agents and Chemother. CA, USA, Abstract F-146 (1998).
  • Townsend R, Terakawa M, Bekersky I. PK/disposition of 14C/FK463, a novel echinocandin antifungal, in male volunteers. J. Clin. Pharmacol.40, 1048 (2000).
  • Fromtling RA. Micafungin sodium (FK-463). Drugs Today38, 245–257 (2002).
  • Suzuki S, Terakawa M, Yokobayashi F et al. Pharmacokinetics of FK 463, a novel water-soluble echinocandin-like lipopeptide in animals. 38th Interscience Conference on Antimicrobial Agents and Chemotherapy. CA, USA, Abstract 144 (1998).
  • Townsend R, Terakawa M, Bekersky I. Pharmacokinetics of FK463, a novel echinocandin antifungal, in bone marrow or peripheral stem cell transplant patients. J. Clin. Pharmacol.40, 1049 (2000).
  • Seibel N, Schwartz C, Arrieta A et al. A Phase I study to determine the safety and pharmacokinetics (PK) of FK463 (echinocandin) in febrile neutropenic pediatric patients. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario, Abstract 18 (2000).
  • Mukai T, Ohkuma T, Nakahara K et al. Pharmacokinetics of FK463, a novel echinocandin analogue, in elderly and non-elderly subjects. Proceedings of the 41st Interscience Conference on Antimicrob Agents and Chemother. IL, USA (2001).
  • Seibel NL, Schwartz C, Arrieta A et al. Safety, tolerability, and pharmacokinetics of micafungin (FK463) in febrile neutropenic pediatric patients. Antimicrob. Agents Chemother.49, 3317–3324 (2005).
  • Townsend R, Hebert M, Dessimoz M et al. Pharmacokinetics (PK) of micafungin, an echinocandin antifungal, in subjects with moderate hepatic dysfunction (MHD). Proceedings of the 31st Annual Meeting of the American College of Clinical Pharmacology. CA, USA (2002).
  • Townsend R, Hebert M, Dessimoz M et al. Pharmacokinetics (PK) of micafungin, an echinocandin antifungal, in subjects with severe renal dysfuntion. Proceedings of the 31st Annual Meeting of the American College of Clinical Pharmacology. CA, USA (2002).
  • Powles R, Sirohi B, Choppa R et al. Assessment of maximum tolerated dose (MTD) of FK463 in cancer patients undergoing haematopoietic stem cell transplantation. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA, Abstract J-676 (2001).
  • Odio CM, Araya R, Pinto LE et al. Caspofungin therapy of neonates with invasive candidiasis. Pediatr: Infect. Dis. J.23, 1093–1097 (2004).
  • Hesseling M, Weindling M, Neal T. First reported use of caspofungin in an extremely low-birth-weight neonate. J. Matern. Fetal Neonatal Med.14, 212 (2003).
  • Cancidas® (caspofungin acetate) prescribing information. Merck & Co. (2005).
  • Jarvis B, Figgitt DP, Scott LJ. Micafungin. Drugs64, 969–982 (2004).
  • Funguard® for infusion 50 mg. Funguard® for infusion 75mg (prescribing information). Fujisawa Pharmaceutical Co., Ltd., Japan (2003).
  • Thirty-First Annual Meeting American College of Clinical Pharmacology September 21–23, 2002 San Francisco, California. J. Clin. Pharmacol.42, 1051–1071 (2002).
  • Thye D, Kilfoil T, Kilfoil G, Henkel T. Anidulafungin: safety and pharmacokinetics in subjects receiving concomitant cyclosporine. Program and Abstracts of the 42th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. CA, USA, American Society of Microbiology, September 27–30, Abstract A-1836 (2002).
  • Townsend R, Hebert M, Wisemandle W et al. Concomitant pharmacokinetics (PK) of micafungin, an echinocandin antifungal, and tacrolimus in healthy volunteers. Proceedings of the 31st Annual Meeting of the American College of Clinical Pharmacology. CA, USA (2002).
  • Townsend R, Hebert M, Wisemandle W et al. Concomitant pharmacokinetics (PK) of micafungin, an echinocandin antifungal, and cyclosporine in healthy volunteers. Proceedings of the 31st Annual Meeting of the American College of Clinical Pharmacology. CA, USA (2002).
  • Sanz-Rodriguez C, Lopez-Duarte M, Jurado M et al. Safety of the concomitant use of caspofungin and cyclosporin A in patients with invasive fungal infections. Bone Marrow Transpl.34, 1–8 (2004).
  • Marr KA, Hachem R, Papanicolaou G et al. Retrospective study of the hepatic safety profile of patients concomitantly treated with caspofungin and cyclosporin A. Transpl. Infect. Dis.6, 110–116 (2004).
  • Trenschel R, Ditschkowski M, Elmaagacli AH et al. Caspofungin as second line therapy for fever of unknown origin or invasive fungal infection following allogeneic stem cell transplantation. Bone Marrow Transplant.35, 583–586 (2005).
  • Odds FC, Motyl M, Andrade R et al. Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species. J. Clin. Microbiol.42, 3475–3482 (2004).
  • Pfaller MA, Messer SA, Boyken L et al. Further standardization of broth microdilution methodology for the in vitro susceptibility testing of caspofungin against Candida species by use of an international collection of more than 3,000 clinical isolates. J. Clin. Microbiol.42, 3117–3119 (2004).
  • Pfaller MA, Messer SA, Boyken L et al. Geographic variation in the susceptibilities of invasive isolates of Candida glabrata to seven systemically active antifungal agents: a global assessment from the ARTEMIS Antifungal Survelillance Program conducted in 2001 and 2002. J. Clin. Microbiol.42, 3142–3146 (2004).
  • Marco F, Pfaller MA, Messer SA et al. Activity of MK-0991 (L-743,872), a new echinocandin, compared with those of LY303366 and four other antifungal agents tested against blood stream isolates of Candida spp. Diagn. Microbiol. Infect. Dis.31, 33–37 (1998).
  • Bartizal K, Gill CJ, Abruzzo GK et al. In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872). Antimicrob. Agents Chemother.41, 2326–2332 (1997).
  • Barchiesi F, Schimizzi AM, Fothergill AW et al. In vitro activity of the new echinocandin antifungal, MK-0991, against common and uncommon clinical isolates of Candida species. Eur. J. Clin. Microbiol. Infect. Dis.18, 302–304 (1999).
  • Ernst EJ, Klepser ME, Ernst ME et al. In vitro pharmacodynamic properties of MK-0991 determined by time-kill methods. Diagn. Microbiol. Infect. Dis.33, 75–80 (1999).
  • Espinel-Ingroff A. Comparison of in vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts. J. Clin. Microbiol.36, 2950–2956 (1998).
  • Vazquez JA, Lynch M, Biokov D et al. In vitro activity of a new pneumocandin antifungal, L-743,872, against azole-susceptible and -resistant Candida species. Antimicrob. Agents Chemother.41, 1612–1614 (1997).
  • Pfaller MA, Jones RN, Doern GV et al. International surveillance of blood stream infections due to Candida species in European SENTRY program: species distribution and antifungal susceptibility including the investigational triazole and echinocandin agents. Diagn. Microbiol. Infect. Dis.35, 19–25 (1999).
  • Krishnarao TV, Galgiani JN. Comparison of the in vitro activities of the echinocandin LY303366, the pneumocandin MK-0991, and fluconazole against Candida species and Cryptococcus neoformans.Antimicrob. Agents Chemother.41, 1957–1960 (1997).
  • Colombo AL, Perfect J, DiNubile M et al. Global distribution and outcomes for Candida species causing invasive candidiasis: results from an international randomized double-blind study of caspofungin versus amphotericin B for the treatment of invasive candidiasis. Eur. J. Clin. Microbiol. Infect. Dis.22, 470–474 (2003).
  • Deresinski SC, Stevens DA. Caspofungin. Clin. Infect. Dis.36, 1445–1457 (2003).
  • Kartsonis N, Killar J, Mixson L et al. Caspofungin susceptibility testing of isolates from patients with esophageal candidiasis or invasive candidiasis: relationship of MIC to treatment outcome. Antimicrob. Agents Chemother.49, 3616–3623 (2005).
  • Kuhn DM, George T, Chandra J et al. Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins. Antimicrob. Agents Chemother.46, 1773–1780 (2002).
  • Bowman JC, Hicks PS, Kurtz MB et al. The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro. Antimicrob. Agents Chemother.46, 3001–3012 (2002).
  • Flattery AM, Hicks PS, Wilcox A et al. In vitro susceptibility of clinical trial isolates of Aspergillus spp. to the echinocandin antifungal Caspofungin (Cancidas™, MK-0991). 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario, Abstract 936 (2000).
  • Simmons EJ, Abruzzo G, Bowman J et al. Activity of caspofungin acetate against Aspergillus flavus, Asperillus terreus, and Aspergillus nidulans. Proceedings of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA (2003).
  • Chiller T, Farrokhshad K, Brummer E et al. The interaction of human monocytes, monocyte-derived macrophages, and polymorphonuclear neutrophils with caspofungin (MK-0991), an echinocandin, for antifungal activity against Aspergillus fumigatus. Diagn. Microbiol. Infect. Dis. 39, 99–103 (2001).
  • Chiller T, Farrokhshad K, Brummer E et al. Influence of human sera on the in vitro activity of the echinocandin caspofungin (MK-0991) against Aspergillus fumigatus.Antimicrob. Agents Chemother.44, 3302–3305 (2000).
  • Petraitiene R, Petraitis V, Groll AH et al. Antifungal efficacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: pharmacokinetics, drug disposition, and relationship to galactomannan antigenemia. Antimicrob. Agents Chemother.46, 12–23 (2002).
  • Mora-Duarte J, Betts R, Rotstein C et al. for the caspofungin invasive candidiasis study group. Comparison of caspofungin and amphotericin B for invasive candidiasis. N. Engl. J. Med.347, 2020–2029 (2002).
  • Louie A, Deziel M, Liu W et al. Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: importance of persistence of caspofungin in tissues to understanding drug activity. Antimicrob. Agents Chemother.49, 5058–5068 (2005).
  • Graybill JR, Najvar LK, Montalbo EM et al. Treatment of histoplasmosis with MK-0991 (L-743,872). Antimicrob. Agents Chemother.42, 151–153 (1998).
  • Graybill JR, Bocanegra R, Luther M et al. Treatment of murine Candida krusei or Candida glabrata infection with L-743,872. Antimicrob. Agents Chemother.41, 1937–1939 (1997).
  • Kohler S, Wheat LJ. Connolly P et al. Comparison of the echinocandin casofungin with amphotericin B for the treatment of histoplasmosis following pulmonary challenge in a murine model. Antimicrob. Agents Chemother.44, 1850–1854 (2000).
  • Gonzalez GM, Tijerina R, Najyar LK et al. Efficacies of amphotericin B (AMB) lipid complex, AMB colloidal dispersion, liposimal AMB, and conventional AMB in treatment of murine coccidioidomycosis. Antimicrob. Agents Chemother.48, 2140–2143 (2004).
  • Pfaller MA, Marco F, Messer SA et al. In vitro activity of two echinocandin derivatives, LY202255 and MK-0991 (L-473,792) against clinical isolates of Aspergillus, Fusarium, Rhizopus, and other filamentous fungi. Diagn. Microbiol. Infect. Dis.30, 251–255 (1998).
  • Spellberg B, Fu Y, Edwards JE Jr et al. Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice. Antimicrob. Agents Chemother.49, 830–832 (2005).
  • Bocanegra R, Najvar LK, Hernandez S et al. Novel antifungal agents in murine scedosporiosis. Proceedings of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA (2003).
  • Spellberg B, Fu Y, Avanesian V et al. Treatment of experimental fusariosis using liposomal amphotericin B (LAmB), amphotericin B lipid complex (ABLC), amphotericin B deoxycholate (AmB), or caspofungin (CAS). Proceedings of the 45th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington DC, USA, Abstract B-49 (2005).
  • Motyl MR, Nielsen Kahn J, Giacobbe RA. In vitro susceptibility of dermatophytes to CANCIDAS (caspofungin acetate). Proceedings of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA (2003).
  • Powles MA, Liberator P, Anderson J et al. Efficiacy of MK-0991 (L-743,872), a semisynthetic pneumocandin, in murine models of Pneumocystis carinii.Antimicrob. Agents Chemother.42, 1985–1989 (1998).
  • Moudgal V, Little T, Boikov D et al. Multiechinocandin- and multiazole-resistant Candida parapsilosis isolates serially obtained during therapy for prosthetic valve endocarditis. Antimicrob. Agents Chemother.49, 767–769 (2005).
  • Hernandez J, Lopez-Ribot JL, Najvar LK et al. Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis. Antimicrob. Agents Chemother.48, 1382–1383 (2004).
  • Breit SM, Hariprasad SM, Mieler WF et al. Management of endogenous fungal endophthalmitis with voriconazole and caspofungin. Am. J. Ophthalmol.139, 135–140 (2005).
  • Edlind TD, Katiyar SK. Caspofungin-tolerant mutants of Candida albicans and Candida glabrata. Proceedings of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA (2003).
  • Park S, Kelly R, Kahn JN et al. Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida spp. isolates. Antimicrob. Agents Chemother.49, 3264–3273 (2005).
  • Osherov N, May GS, Albert ND et al. Overexpression of Sbe2p, a Golgi protein, results in resistance to caspofungin in Saccharomyces cerevisiae.Antimicrob. Agents Chemother.46, 2462–2469 (2002).
  • Schuetzer-Muehlbauer M, Willinger B, Krapf G et al. The Candida albicans Cdr2p ATP-binding cassette (ABC) transporter confers resistance to caspofungin. Mol. Microbiol.48, 225–235 (2003).
  • Stevens DA, Espiritu M, Parmar R. Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations. Antimicrob. Agents Chemother.48, 3407–3411 (2004).
  • Maertens J, Raad I, Sable CA et al. Multicenter, noncomparative study to evaluate safety and efficacy of caspofungin in adults with invasive aspergillosis refractory or intolerant to amphotericin B, amphotericin B lipid formulations, or azoles. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario, Abstract 1103 (2000).
  • Maertens J, Raad I, Petrikkos G et al. Efficacy and safety of caspofungin for treatent of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapy. Clin. Infect. Dis.39, 1563–1571 (2004).
  • Kartsonis N, Saah A, Lipka J et al. Salvage therapy with caspofungin for invasive aspergillosis: results from the caspofungin compassionate use study. J. Infect.50, 196–205 (2005).
  • Walsh TJ, Teppler H, Donowitz GR et al. Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia. N. Engl. J. Med.351, 1391–1402 (2004).
  • Villanueva A, Arathoon EG, Gotuzzo E et al. A randomized, double-blind study of caspofungin versus amphotericin for the treatment of candidal esophagitis. Clin. Infect. Dis.33, 1529–1535 (2001).
  • Caspofungin (Cancidas) for aspergillosis. The Medical Letter43, 58–59 (2001).
  • Villanueva A, Gotuzzo E, Arathoon EG et al. A randomized double-blind study of caspofungin versus fluconazole for the treatment of esophageal candidiasis. Am. J. Med.113, 294–299 (2002).
  • Mrowczynski W, Wojtalik M. Caspofungin for Candida endocarditis. Pediatr. Infect. Dis. J.23, 376 (2004).
  • Karsonis NA, Saah A, Lipka CJ et al. Second-line therapy with caspofungin for mucosal or invasive candidiasis: results from the caspofungin compassionate-use study. J. Antimicrob. Chemother.53, 878–881 (2004).
  • Mattiuzzi GN, Alvarado G, Giles FJ et al. Open-label, randomized comparison of itraconazole versus caspofungin for prophylaxis in patients with hematologic malignancies. Antimicrob. Agents Chemother.50, 143–147 (2006).
  • Ernst EJ, Roling EE, Petzold CR et al. In vitro activity of micafungin (FK-463) against Candida spp.: microdilution, time-kill, and postantifungal-effect studies. Antimicrob. Agents Chemother.46, 3846–3853 (2002).
  • Laverdiere M, Hoban D, Restieri C et al. In vitro activity of three new triazoles and one echinocandin against Candida bloodstream isolates from cancer patients. J. Antimicrob. Chemother.50, 119–123 (2002).
  • Iwamoto T, Sakamoto N, Yamashita M et al. FR901379, a novel antifungal antibiotic. 33rd Interscience Conference of Antimicrobial Agents and Chemotherapy. LA, USA, Abstract 371 (1993).
  • Ostrosky-Zeichner L, Paetznick VL, Mohr J et al. In vitro antifungal activity of FK-463 against Candida spp. 40th Interscience Conference of Antimicrobial Agents and Chemotherapy. Toronto, Ontario, Abstract 197 (2000).
  • Muller FC, Kurzai O, Bautsch W et al. In vitro comparative activity of FK463, fluconazole (FCZ), flucytosine (5-FC), amphotericin B (AMB), and voriconazole (VCZ), against clinical Candida albicans and Candida dubliniensis isolates and a comparison of RPMI 2%, AM3 2%, and HR medium. 40th Interscience Conference of Antimicrobial Agents and Chemotherapy. Toronto, Ontario, Abstract 195 (2000).
  • Muller FM, Kurzai O, Hacker J et al. Effect of the growth medium on the in vitro antifungal activity of micafungin (FK-463) against clinical isolates of Candida dubliniensis.J. Antimicrob. Chemother.48, 713–715 (2001).
  • Ernst EJ, Petzold CR, Roling EE et al. Effects of protein binding and in vitro activity of FK463. Pharmacotherapy21, 383 (2001).
  • Mikamo H, Sata Y, Tamaya T. In vitro antifungal activity of FK463, a new water-soluble echinocandin-like lipopeptide. J. Antimicrob. Chemother.46, 485–487 (2000).
  • Takakura S, Fujihara N, Saito T et al. National surveillance of species distribution in blood isolates of Candida species in Japan and their susceptibility to six antifungal agents including voriconazole and micafungin. J. Antimicrob. Chemother.53, 283–289 (2004).
  • Wiederhold NP, Lewis RE. The echinocandin antifungals: an overview of the pharmacology, spectrum and clinical efficacy. Expert Opin. Investig. Drugs12, 1313–1333 (2003).
  • Ostrosky-Zeichner L, Rex JH, Pappas PG et al. Antifungal susceptibility survey of 2000 bloodstream Candida isolates in the United States. Antimicrob. Agents Chemother.47, 3149–3154 (2003).
  • Manavathu EK, Ganesan LT, Cutright PH et al. In vitro antifungal activity of voriconazole in two-drug combination with micafungin, caspofungin and amphotericin B. Proceedings of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA, Abstract J-125 (2001).
  • Steinbach WJ, Stevens DA, Denning DW. Combination and sequential antifungal therapy for invasive aspergillosis: review of published in vitro and in vivo interactions and 6281 clinical cases from 1966 to 2001. Clin. Infect. Dis.37, S188–S224 (2003).
  • Tawara S, Ikeda F, Maki K et al. In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Antimicrob. Agents Chemother.44, 57–62 (2000).
  • Tomishima M, Ohki H, Yamada A et al. FK463, a novel water-soluble echinocandin lipopeptide: synthesis and antifungal activity. J. Antibiot. (Tokyo)52, 674–676 (1999).
  • Uchida C, Nishiyama Y, Yokota N et al. In vitro antifungal activity of a novel lipopeptide antifungal agent, FK463, against various fungal pathogens. J. Antibiot. (Tokyo)53, 1175–1181 (2000).
  • Choi JH, Brummer E, Stevens DA. Combined action of micafungin, a new echinocandin, and human phagocytes for antifungal activity against Aspergillus fumigatus. Microbes Infect.6, 383–389 (2004).
  • Zeng J, Kamei K, Zheng J et al. Susceptibility of Pseudoallescheria boydii and Scedosporium apiospermum to new antifungal agents. Jap. J. Med. Mycol.45, 101–104 (2004).
  • Ikeda F, Wakai Y, Matsumoto S et al. Efficacy of FK463, a new lipopeptide antifungal agents, in mouse models of disseminated candidiasis and aspergillosis. Antimicrob. Agents Chemother.44, 614–618 (2000).
  • Maesaki S, Hossan MA, Miyazaki Y et al. Efficacy of FK463, a (1,3)-β-d-glucan synthase inhibitor, in disseminated azole-resistant Candida albicans infection in mice. Antimicrob. Agents Chemother.44, 1728–1730 (2000).
  • Kohno S, Niki Y, Takematsu Y et al. The latest diagnosis and treatment on deep-seated mycoses. Expectations for micafungin, the first candin in Japan. Jpn J. Antibiot.56, 1–14 (2003).
  • Matsumoto S, Wakai Y, Nakai T et al. Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of pulmonary aspergillosis. Antimicrob. Agents Chemother.44, 619–621 (2000).
  • Groll AH, Mickiene D, Petraitis V et al. Compartmental pharmocokinetics and tissue distribution of the antifungal echinocandin lipopeptide micafungin (FK463) in rabbits. Antimicrob. Agents Chemother.45, 3322–3327 (2001).
  • Petraitis V, Petraitien R, Groll AH et al. Comparative antifungal activities and plasma pharmocokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits. Antimicrob. Agents Chemother.46, 1857–1869 (2002).
  • Ito M, Nozu R, Kuramochi T et al. Prophylactic effect of FK463, a novel antifungal lipopeptide, against Pneumocystis carinii infection in mice. Antimicrob. Agents Chemother.44, 2259–2262 (2000).
  • Borg-von Zepelin M, Zaschke K, Gross U et al. Effect of micafungin (FK463) on Candida albicans adherence to epithelial cells. Chemotherapy48, 148–153 (2002).
  • Kohno S, Masoaka T, Yamaguchi H et al. A multicenter, open-label clinical study of micafungin (FK463) in the treatment of deep-seated mycosis in Japan. Scand. J. Infect. Dis.36, 372–379 (2004).
  • Pettengell K, Mynhardt J, Kluyta R et al. Successful treatment of oesophageal candidiasis by micafungin: a novel systemic anifungal agent. Aliment. Pharmacol. Ther.20, 475–481 (2004).
  • De Wet N, Llanos-Cuentas A, Suleiman J et al. A randomized, double-blind, parallel-group, dose-response study of micafungin compared with fluconazole for the treatment of esophageal candidiasis in HIV-positive patients. Clin. Infect. Dis.39, 842–849 (2004).
  • Suleiman J, Della Negra M, Llanos-Cuentas A et al. Open label study of micafungin in the treatment of esophageal candidiasis (EC). Proceedings of the 42nd Conference on Antimicrobial Agents and Chemotherapy, CA, USA, Abstract M-892 (2002).
  • Ostrosky-Zeichner L, Kontoyiannis D, Raffali J et al. International, open-label, noncomparative, clinical trial of micafungin alone and in combination for treatment of newly diagnosed and refractory candidemia. Eur. J. Clin. Microbiol. Infect. Dis.24, 654–661 (2005).
  • Ullmann AJ, Van Burik JA, McSweeney P et al. An open phase II study of the efficacy of micafungin alone and in combination for the treatment of invasive aspergillosis (IA) in adults and children. Clin. Microbiol. Infect.9, 6 (2003).
  • Ratanatharathorn V, Flynn P, Van Buril J-A et al. Micafungin in combination with systemic antifungal agents in the treatment of refractory aspergillosis (RA) in bone marrow transpl.ant (BMT) patients. Proceedings of the 44th Annual Meeting of the American Society of Hematology. PA, USA, Abstract 2472 (2002).
  • van Burik JH, Ratanatharathorn V, Stepan DE et al. Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation. Clin. Infect. Dis.39, 1407–1416 (2004).
  • Powles R, Sirohi B, Chopra R et al. Use of FK463, a novel echinocandin analog in patients undergoing stem cell transplantation (SCT) for hematologic malignancies, a matched pair comparison of biochemical toxicity with historical controls. Bone Marrow Transpl.29, S247 (2002).
  • Powles R, Sirohi B, Chopra R et al. Assessment of maximum tolerated dose and pharmacokinetics of FK463 in neutropenic patients after haematopoietic stem cell transplantation. Blood98, 361 (2001).
  • Kontoyiannis DP, Buell D, Frisbee-Hume S et al. Initial experience with FK463 for the treatment of candidemia in cancer patients. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA, Abstract J-1629 (2001).
  • Yokote T, Akika T, Oka S et al. Successful treatment with micafungin of invasive pulmonary aspergillosis in acute myeloid leukemia, with renal failure due to amphotericin B therapy. Ann. Hematol.83, 64–66 (2004).
  • Ota S, Tanaka J, Kahata K et al. Successful micafungin (fk463) treatment of invasive pulmonary asperigillosis in a patient with acute lymphoblastic leukemia in a Phase II study. Int. J. Hematol.79, 390–393 (2004).
  • Singer MS, Seibel NL, Vezina G et al. Successful treatment of invasive aspergillosis in two patients with acute myelogenous leukemia. J. Pediatr. Hematol. Oncol.25, 252–256 (2003).
  • Raasch RH. Anidualfungin: review of a new echinocandin antifungal agent. Expert Rev. Anti Infect. Ther.2, 499–508 (2004).
  • Hector FR. Compounds active against cell walls of medically important fungi. Clin. Microbiol. Rev.6, 1–21 (1993).
  • Pfaller MA, Messer SA, Coffman S. In vitro susceptibilities of clinical yeasts isolates to a new echinocandin derivative, LY303366, and other antifungal agents. Antimicrob. Agents Chemother.41, 763–766 (1997).
  • Pfaller MA, Boyken L, Hollis RJ et al. In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp., including 315 isolates resistant to fluconazole. J. Clin. Microbiol.43, 5425–5427 (2005).
  • Arevalo MP, Carrillo-Munoz AJ, Salgado J et al. Antifungal activity of the echinocandin anidulafungin (VER002, LY-303366) against yeast pathogens: a comparative study with M27-A microdilution method. J. Antimicrob. Chemother.51, 163–166 (2003).
  • Marco F, Danes C, Almela M et al. Trend in frequency and in in vitro susceptibilities to antifungal agents, including voriconazole and anidulafungin, of Candida bloodstream isolates. Results from a six year study (1996–2001). Diag. Microbiol. Infect. Dis.46, 259–264 (2003).
  • Pfaller MA, Hollis R, Goldstein BP et al. In vitro activity of anidulafungin (ANID) and other agents against 526 esophageal candidiasis (EC) isolates. Proceedings of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, IL, USA (2003).
  • Groll AH, Mickiene D, Petraitiene R et al. Pharmacokinetic and pharmacodynamic modeling of anidulafungin (LY303366): reappraisal of its efficacy in neutropenic animal models of opportunistic mycoses using optimal plasma sampling. Antimicrob. Agents Chemother.45, 2845–2855 (2001).
  • Serrano MC, Valverde-Conde A, Chavez MM et al. In vitro activity of voriconazole, itraconazole, caspofungin, anidulafungin (VER002, LY303366) and amphotericin B against Aspergillus species. Diagn. Microbiol. Infect. Dis.45, 131–135 (2003).
  • Odabasi Z, Paetznick VL, Rodriguez JR et al. In vitro activity of anidulafungin against selected clinically important mold isolates. Antimicrob. Agents Chemother.48, 1912–1915 (2004).
  • Krause DS, Reinhardt J, Vazquez JA et al. Phase 2, randomized, dose-ranging study evaluating the safety and efficacy of anidulafungin in invasive candidiasis and candidemia. Antimicrob. Agents Chemother.2021–2024 (2004).
  • Krause DS, Simjee AE, van Rensburg C et al. A randomized, double-blind trial of anidulafungin versus fluconazole for the treatment of esophageal candidiasis. Clin. Infect. Dis.39, 770–775 (2004).
  • Pfaller MA, Diekema DJ, Boyken L et al. Effectiveness of anidulafungin in eradicating Candida species in invasive candidiasis. Antimicrob. Agents Chemother.49, 4795–4797 (2005).
  • Reboli A, Rotstein C, Pappas P et al. Anidualfungin versus fluconazole for treatment of candidemia and invasive candidiasis (C/IC). Proceedings of the 45th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington DC, USA, Abstract M-718 (2005).
  • Johnson MD, MacDougall C, Ostrosky-Zeichner L et al. Combination antifungal therapy. Antimicrob. Agents Chemother.48, 693–715 (2004).
  • Roling EE, Klepser ME, Wasson A et al. Antufungal activities of fluconazole, caspofungin (MK0991), and anidulafungin (LY 303366) alone and in combination against Candida species and Cryptococcus neoformans via time-kill methods. Diagn. Microbiol. Infect. Dis.43, 13–17 (2002).
  • Petraitis V, Petraitiene R, Sarafandi AA et al. Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin. J. Infect. Dis.187, 1834–1843 (2003).
  • Gil Lamaignere C, Muller FM. Differential effects of the combination of caspofungin and terbinafine against Candida albicans, Candida dubliniensis and Candida kefyr.Int. J. Antimicrob. Agents23, 520–523 (2004).
  • Perea S, Gonzalez G, Fothergill AW et al. In vitro interaction of caspofungin acetate with voriconazole against clinical isolates of Aspergillus species. Antimicrob. Agents Chemother.46, 3039–3041 (2002).
  • Kohno S, Maesaki S, Iwakawa J et al. Synergistic effects of combination of FK463 with amphotericin B: enhanced efficacy in murine model of invasive pulmonary aspergillosis. Program and Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario, Abstract 1686 (2000).
  • Nakajima M, Tamada S, Toshida K et al. Pathological findings in a murine pulmonary aspergillosis model: treatment with FK463, amphotericin B and a combination of FK463 and amphotericin B. Program and Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario, Abstract 1685 (2000).
  • Arikan S, Lozano-Chiu M, Paetznick V et al. In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp. Antimicrob. Agents Chemother.46, 245–247 (2002).
  • Cuenca-Estrella M, Gomez-Lopez A, Garcia-Effron G et al. Combined activity in vitro of caspofungin, amphotericin B, and azole agents against itraconazole-resistant clinical isolates of Aspergillus fumigatus. Antimicrob. Agents Chemother.49, 1232–1235 (2005).
  • Sabatelli F. In vitro and in vivo interaction of posaconazole (POS) and caspofungin (CSP) against Aspergillus. Proceedings of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA (2003).
  • Chiou CC, Mavrogiorgos N, Tillem E et al. Synergy, pharmacodynamics, and time-sequenced ultrastructural changes of the interaction between nikkomycin Z and the echinocandin FK463 against Aspergillus fumigatus. Antimicrob. Agents Chemother.45, 3310–3321 (2001).
  • Stevens DA. Drug interaction in vitro between a polyene (AmBisone; Ambi) and an echinocandin (FK463; FK) vs. Aspergillus species. Proceedings of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy. CA, USA (1999).
  • Ostrosky-Zeichner L, Matar M, Paetznick VL et al. In-vitro synergy testing of anidulafungin (AFG) and micafungin (MFG) in combination with amphotericin B (AMB) against Aspergillus spp. and Fusarium spp. Proceedings of the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy. CA, USA, Abstract M-1816 (2002).
  • O’Shaughnessy EM, Peter J, Walsh TJ. In vitro additive and synergistic effect of two echinocandins, caspofungin and micafungin with voriconazole against Aspergillus fumigatus. Proceedings of the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy. CA, USA, Abstract M-856 (2002).
  • Philip A, Odabasi Z, Rodriguez JR et al. In vitro synergy testing of anidulafungin (ANID) with itraconazole (ITR) and voriconazole (VOR) against Aspergillus spp. and Fusarium spp. Proceedings of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA (2003).
  • Warn PA, Sharp A, Morrissey G et al. In vivo activity of micafungin in a persistently neutropenic murine model of disseminated infection caused by Candida tropicalis. J. Antimicrob. Chemother.50, 1071–1074 (2002).
  • Wheat LJ. Combination therapy for aspergillosis: is it needed, and which combination? J. Infect. Dis.187, 1831–1833 (2003).
  • Luque JC, Clemons KV, Stevens DA. Efficacy of micafungin alone or in combination against systemic murine aspergillosis. Antimicrob. Agents Chemother.47, 1452–1455 (2003).
  • Warn PA, Morrissey G, Morrissey J et al. Activity of micafungin (FK463) against an itraconazole-resistant strain of Aspergillus fumigatus and a strain of Aspergillus terreus demonstrating in vivo resistance to amphotericin B. J. Antimicrob. Chemother.51, 913–919 (2003).
  • Marr K. Combination antifungal therapy: where are we now, and where are we going? Oncology18(Suppl. 7), 24–29 (2004).
  • Aliff TB, Maslak PG, Jurcic JG et al. Refractory Aspergillus pneumonia in patients with acute leukemia – successful therapy with combination caspofungin and liposomal amphotericin. Cancer97, 1025–1032 (2003).
  • Thiebaut A Sr, Antal D, Breysse MC et al. Refractory invasive fungal infections in patients with hematologic malignancies: combination of new antifungal agents (voriconazole or caspofungin) with amphotericin B. Program and Abstracts of the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy. CA, USA (2002).
  • Castagnola E, Machetti M, Cappelli B et al. Caspofungin associated with liposomal amphotericin B or voriconazole for treatment of refractory fungal pneumonia in children with acute leukaemia or undergoing allogeneic bone marrow transplantation.Clin. Microbiol. Infect.10(3), 255–257 (2004).
  • Hubel K, Chemnitz J, Brochhagen HG. Successful treatment of chronic disseminated candidiasis with caspofungin and itraconazole in a patient with progressive acute leukemia and prolonged neutropenia. Int. J. Hematol.79, 289–292 (2004).
  • Wertz KK, Pretzlaff RK. Caspofungin in a pediatric patient with persistent candidemia. Pediatr. Crit. Care Med.5, 181–183 (2004).
  • Kontoyiannis DP, Hachem R, Lewis RE et al. Efficacy and toxicity of caspofungin in combination with liposomal amphotericin B as primary or salvage treatment of invasive aspergillosis in patients with hematologic malignancies. Cancer98, 292–299 (2003).
  • Gentina T, De Botton S, Alfandari S et al. Combination antifungals for treatment of pulmonary invasive aspergillosis (IA) refractory to amphotericin B (AmB) in leukaemia patients. Program and Abstracts of the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy. CA, USA (2002).
  • Steinbach WJ, Schell WA, Miller JL et al. Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of scopulariopsis infections in immunocompromised patients. J. Infect.48, 112–116 (2004).
  • Marr KA, Boeckh M, Carter RA et al. Combination antifungal therapy for invasive aspergillosis. Clin. Infect. Dis.39, 797–802 (2004).
  • Singh N, Limaye A, Safdar N et al. Combination of voriconazole (VRC) and caspofungin (CAS) as primary therapy for invasive aspergillosis (IA) in solid organ transplant (SOT) recipients. Proceedings of the 45th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington DC, USA, Abstract M-717 (2005).
  • Cesaro S, Toffolutti T, Messina C et al. Safety and efficacy of caspofungin and liposomal amphotericin B, followed by voriconazole in young patients affected by refractory invasive mycosis. Eur. J. Haematol.73, 50–55 (2004).
  • Maertens J, Glasmacher A, Herbrecht R et al. Multicenter, noncomparative study of caspofungin (CAS) combined with other antifungals in adults with invasive Aspergillosis (IA) refractory (R) or intolerant (I) to prior therapy (Rx): final data. Proceedings of the 45th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington DC, USA, Abstract M-954 (2005).
  • Viscoli C. Combination therapy for invasive aspergillosis. Clin. Infect. Dis.39, 803–805 (2004).
  • Cesaro S, Visintin G. Combination antifungal therapy for invasive aspergillosis. Clin. Infect. Dis.40, 1073–1075 (2005).
  • Marr KA, Boeckh M, Kim HW. Reply to Cesaro and Visintin. Clin. Infect. Dis.40(7), 1075–1076 (2005).
  • Ohyama T, Kurihara Y, Ono Y et al. Arborcandins A, B, C, D, E and F, novel 1,3-beta-glucan synthase inhibitors: production and biological activity.J. Antibiot.53, 1108–1116 (2000).
  • Onishi J, Meinz M, Thompson J et al. Discovery of novel antifungal (1,3)-d-glucan synthase inhibitors. Antimicrob. Agents Chemother.44, 368–377 (2000).
  • Pelaez F, Cabello A, Platas G et al. The discovery of enfumafungin, a novel antifungal compound produced by endophytic Hormonema species – biological activity and taxonomy of the producing organisms. Syst. Appl. Microbiol.23, 333–343 (2000).

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