245
Views
58
CrossRef citations to date
0
Altmetric
Review

Developing liquid chromatography ion mobility mass spectometry techniques

, , , , , & show all
Pages 553-565 | Published online: 09 Jan 2014

References

  • Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol. Cell. Proteomics 1, 845–867 (2002).
  • Adkins JN, Varnum SM, Auberry KJ et al. Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. Mol. Cell. Proteomics 1, 947–955 (2002).
  • Tirumalai RS, Chan KC, Prieto DA, Issaq HJ, Conrads TP, Veenstra TD. Characterization of the low molecular weight human serum proteome. Mol. Cell. Proteomics 2, 1096–1103 (2003).
  • Wu SL, Choudhary G, Ramstrom M, Bergquist J, Hancock WS. Evaluation of shotgun sequencing for proteomic analysis of human plasma using HPLC coupled with either ion trap or fourier transform mass spectrometry. J. Proteome Res. 2, 383–393 (2003).
  • Shen Y, Jacobs JM, Camp DG II et al. Ultra-high-efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome. Anal. Chem. 76, 1134–1144 (2004).
  • Zhou M, Lucas DA, Chan KC et al. An investigation into the human serum “interactome”. Electrophoresis 25, 1289–1298 (2004).
  • Mehta AI, Ross S, Lowenthal MS et al. Biomarker amplification by serum carrier protein binding. Dis. Markers 19, 1–10 (2003).
  • Zhang H, Li XJ, Martin DB, Aebersold R. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Nature Biotechnol. 21, 660–666 (2003).
  • Anderson NL, Anderson NG, Haines LR, Hardie DB, Olafson RW, Pearson TW. Mass spectrometric quantitation of peptides and proteins using stable isotope standards and capture by anti-peptide antibodies (SISCAPA). J. Proteome Res. 3, 235–244 (2004).
  • Nedelkov D, Tubbs KA, Niederkofler EE, Kiernan UA, Nelson RW. High-throughput comprehensive analysis of human plasma proteins: a step toward population proteomics. Anal. Chem. 76, 1733–1737 (2004).
  • Rodriguez-Pineiro AM, Ayude D, Rodriguez-Berrocal FJ, de la Cadena MP. Concanavalin A chromatography coupled to two-dimensional gel electrophoresis improves protein expression studies of the serum proteome. J. Chromatogr. B 803, 337–343 (2004).
  • Hagglund P, Bunkenborg J, Elortza F, Jensen ON, Roepstorff P. A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation. J. Proteome Res. 3, 556–566 (2004).
  • Anderson L. Candidate-based proteomics in the search for biomarkers of cardiovascular disease. J. Physiol. 563.1, 23–60 (2005).
  • Zolg JW, Langen, H. How industry is approaching the search for new diagnostic markers and biomarkers. Mol. Cell. Proteomics 3, 345–354 (2004).
  • Cohen MJ, Karasek FW. Plasma chromatography – a new dimension for gas chromatography and mass spectrometry. J. Chromatogr. Sci. 8, 330 (1970).
  • St. Louis RH, Hill HH Jr. Ion mobility spectrometry in analytical chemistry. Crit. Rev. Anal. Chem. 21, 321–355 (1990).
  • Hilderbrand AE, Valentine SJ, Clemmer DE. Mobilities: biological systems and clusters. In: Encyclopedia of Mass Spectrometry (Theory and Ion Chemistry, Volume 1). Gross ML, Caprioli R, Armentrout P (Eds), Elsevier, Oxford, UK, 506–520 (2003).
  • Hoaglund CS, Valentine SJ, Sporleder CR, Reilly JP, Clemmer DE. Three-dimensional ion mobility/TOFMS analysis of electrosprayed biomolecules. Anal. Chem. 70, 2236–2242 (1998).
  • Valentine SJ, Kulchania M, Srebalus Barnes CA, Clemmer DE. Multidimensional separations of complex peptide mixtures: a combined high-performance liquid chromatography/ion mobility/time-of-flight mass spectrometry approach. Int. J. Mass Spectrom. 212, 97–109 (2001).
  • Srebalus Barnes CA, Hilderbrand AE, Valentine SJ, Clemmer DE. Resolving isomeric peptide mixtures: a combined HPLC/ion mobility-TOFMS analysis of a 4000-component combinatorial library. Anal. Chem. 74, 26–36 (2002).
  • Myung S, Lee YL, Moon MH et al. Development of high-sensitivity ion trap-IMS-TOF techniques: a high-throughput nano-LC/IMS/TOF separation of the drosophila fly proteome. Anal. Chem. 75, 5137–5145 (2003).
  • Moon MH, Myung S, Plasencia M, Hilderbrand AE, Clemmer DE. Nanoflow LC/ion mobility/CID/TOF for proteomics: analysis of a human urinary proteome. J. Proteome Res. 2, 589–597 (2003).
  • Collins DC, Xiang Y, Lee ML. Comprehensive ultra-high pressure capillary liquid chromatography/ion mobility spectrometry. Chromatographia 55, 123–128 (2002).
  • Matz LM, Dion HM, Hill HH. Evaluation of capillary liquid chromatography-electrospray ionization ion mobility spectrometry with mass spectrometry detection. J. Chromatogr. A 946, 59–68 (2002).
  • Hoaglund-Hyzer CS, Li J, Clemmer DE. Mobility labeling for parallel CID of ion mixtures. Anal. Chem. 72, 2737–2740 (2000).
  • Taraszka JA, Gao X, Valentine SJ et al. Proteome profiling for assessing diversity: analysis of individual heads of Drosophila melanogaster using LC-ion mobility-MS. J. Proteome Res. (In Press).
  • St. Louis RH, Hill HH. Ion mobility spectrometry in analytical-chemistry. Crit. Rev. Anal. Chem. 21, 321–355 (1990).
  • Clemmer DE, Jarrold MF. Ion mobility measurements and their applications to clusters and biomolecules. J. Mass Spectrom. 32, 577–592 (1997).
  • Hoaglund Hyzer CS, Counterman AE, Clemmer DE. Anhydrous protein ions. Chem. Rev. 99, 3037–3079 (1999).
  • Collins DC, Lee ML. Developments in ion mobility spectrometry-mass spectrometry. Anal. Bioanal. Chem. 372, 66–73 (2002).
  • Wyttenbach T, Bowers MT. Gas-phase conformations: the ion mobility/ion chromatography method. Modern Mass Spectrom. Topics Curr. Chem. 225, 207–232 (2003).
  • Mason EA, McDaniel EW. Transport Properties of Ions in Gases. Wiley, NY, USA (1988).
  • Valentine SJ, Counterman AE, Hoaglund CS, Reilly JP, Clemmer DE. Gas-phase separations of protease digests. J. Am. Soc. Mass Spectrom. 9, 1213–1216 (1998).
  • Taraszka JA, Counterman AE, Clemmer DE. Gas-phase separations of complex tryptic peptide mixtures. Fresenius J. Anal. Chem. 369, 234–245 (2001).
  • Hoaglund CS, Valentine SJ, Clemmer DE. An ion trap interface for ESI-ion mobility experiments. Anal. Chem. 69, 4156–4161 (1997).
  • Tang K, Shvartsburg AA, Lee H et al. High-sensitivity ion mobility spectrometry/mass spectrometry using electrodynamic ion funnel interfaces. Anal. Chem. 70, 3330–3339 (2005).
  • Shaffer SA, Prior DC, Anderson GA, Udseth HR, Smith RD. An ion funnel interface for improved ion focusing and sensitivity using electrospray ionization mass spectrometry. Anal. Chem. 70, 4111–4119 (1998).
  • Him T, Tolmachev AV, Harkewicz R et al. Design and implementation of a new electrodynamic ion funnel. Anal. Chem. 72, 2247–2255 (2000).
  • Valentine SJ, Koeniger SL, Clemmer DE. A split-field drift tube for separation and efficient fragmentation of biomolecular ions. Anal. Chem. 75, 6202–6208 (2003).
  • Koeniger SL, Valentine SJ, Myung S, Plasencia M, Lee YL, Clemmer DE Development of field modulation in a split-field drift tube for high-throughput multi-dimensional separations. J. Proteome Res. 4, 25–35 (2005).
  • Taraszka JA, Kurulugama R, Sowell RA et al. Mapping the proteome of Drosophila melanogaster: analysis of embryos and adult heads by LC-IMS-MS methods. J. Proteome Res. (In Press) .
  • Levitan IB, Kaczmarek LK. The Neuron: Cell and Molecular Biology, Oxford University Press, NY, USA (1991).
  • Shen Y, Jacobs JM, Camp DG II et al.Ultra-high efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome. Anal. Chem. 76, 1134–1144 (2004).
  • Lee YJ, Hoaglund-Hyzer CS, Taraszka JA, Zientara GA, Counterman AE, Clemmer DE. Collision-induced dissociation of mobility-separated ions using an orifice-skimmer cone at the back of a drift tube. Anal. Chem. 73, 3549–3555 (2001).
  • Gillig KJ, Ruotolo B, Stone EG et al. Coupling high-pressure MALDI with ion mobility/orthogonal time-of-flight mass spectrometry. Anal. Chem. 72, 3965–3971 (2000).
  • Gillig KJ, Ruotolo BT, Stone EG, Russell DH. An electrostatic focusing ion guide for ion mobility-mass spectrometry. Int. J. Mass Spectrom. 239, 43–49 (2004).
  • Revercomb HW, Mason EA. Anal. Chem. 47, 970 (1975).
  • Wittmer D, Chen YH, Luckenbill BK, Hill HH Jr. Electrospray-ionization ion mobility spectrometry. Anal. Chem. 66, 2348–2355 (1994).
  • Chen YH, Hill HH Jr, Wittmer DP. Thermal effects on electrospray ionization ion mobility spectrometry. Int. J. Mass Spectrom. Ion Processes 154, 1–13 (1996).
  • Hudgins RR, Woenckhaus J, Jarrold MF. High resolution ion mobility measurements for gas phase proteins: correlation between solution phase and gas phase conformations. Int. J. Mass Spectrom. Ion Processes 165/166, 497–507 (1997).
  • Guevremont R, Siu KWM, Wang J, Ding L. Combined ion mobility time-of-flight mass spectrometry study of electrospray-generated ions. Anal. Chem. 69, 3959–3965 (1997).
  • Counterman AE, Valentine SJ, Srebalus CA, Henderson SC, Hoaglund CS, Clemmer DE. High-order structure and dissociation of gaseous peptide aggregates that are hidden in mass spectra. J. Am. Soc. Mass Spectrom. 9, 743–759 (1998).
  • Evans CR, Jorgensen JW. Multidimensional LC-LC and LC-CE for high-resolution separations of biological molecules. Anal. Bioanal. Chem. 378, 1952–1961 (2004).
  • Shelimov KB, Jarrold MF. “Denaturation” and refolding of cytochrome c in vacuo. J. Am. Chem. Soc. 118, 10313–10314 (1996).
  • Valentine SJ, Anderson JG, Ellington AD, Clemmer DE. Disulfide-intact and -reduced lysozyme in the gas phase: conformations and pathways of folding and unfolding. J. Phys. Chem. B 101, 3891–3900 (1997).
  • Counterman AE, Clemmer DE. Large anhydrous polyalanine ions: evidence for extended helices and onset of a more compact state. J. Am. Chem. Soc. 123, 1490–1498 (2001).
  • Hudgins RR, Woenckhaus J, Jarrold MF. High resolution ion mobility measurements for gas phase proteins: correlation between solution phase and gas phase conformations. Int. J. Mass Spectrom. Ion Processes 165, 497–507 (1997).
  • Badman ER, Hoaglund-Hyzer CS, Clemmer DE. Monitoring structural changes of proteins in an ion trap over ∼10–200 ms: unfolding transitions in cytochrome c ions. Anal. Chem. 73, 6000–6007 (2001).
  • Valentine SJ, Clemmer DE. H/D exchange levels of shape-resolved cytochrome c conformers in the gas phase. J. Am. Chem. Soc. 119, 3558–3566 (1997).
  • Mao Y, Woenckhaus J, Kolafa J, Ratner MA, Jarrold MF. Thermal unfolding of unsolvated cytochrome c: experiment and molecular dynamics simulations. J. Am. Chem. Soc. 121, 2712–2721 (1999).
  • Gidden J, Wyttenbach T, Jackson AT, Serivens JH, Bowers MT. Gas-phase conformations of synthetic polymers: poly(ethylene glycol), poly(propylene glycol), and poly(tetramethylene glycol). J. Am. Chem. Soc. 122, 4692–4699 (2000).
  • Valentine SJ, Clemmer DE. Temperature-dependent H/D exchange of compact and elongated cytochrome c ions in the gas phase. J. Am. Soc. Mass Spectrom. 13, 719–723 (2002).
  • Badman ER, Hoaglund-Hyzer CS, Clemmer DE. Monitoring structural changes of proteins in an ion trap over ∼10–200 ms: unfolding transitions in cytochrome c ions. Anal. Chem. 73, 6000–6007 (2001).
  • Myung S, Badman ER, Lee YJ, Clemmer DE. Structural transitions of electrosprayed ubiquitin ions stored in an ion trap over ∼10 ms to 30 s. J. Phys. Chem. A 106, 9976–9982 (2002).
  • Ruotolo BT, Gillig KJ, Woods AS et al. Analysis of phosphorylated peptides by ion mobility-mass spectrometry. Anal. Chem. 76, 6727–6733 (2004).
  • Synder AP, Dworzanksi JP, Tripathi A, Maswadeh WM, Wick CH. Correlation of mass spectrometry identified bacterial biomarkers from a fielded pyrolysis-gas chromatography-ion mobility spectrometry biodetector with the microbiological gram stain classification scheme. Anal. Chem. 76, 6492–6499 (2004).
  • Jackson SN, Wang HYJ, Woods AS. Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS. J. Am. Soc. Mass Spectrom. 16, 133–138 (2005).
  • Dworsanski JP, Tripathi A, Snyder AP, Maswdeh WM, Wick CH. Novel biomarkers for Gram-type differentiation of bacteria by pyrolysis-gas chromatography-mass spectrometry. J. Anal. Appl. Pyrolysis 73, 29–38 (2005).
  • Ochoa ML, Harrington PB. Chemometric studies for the characterization and differentiation of microorganisms using in situ derivatization and thermal desorption ion mobility spectrometry. Anal. Chem. 77, 854–863 (2005).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.