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Drug Profile

Paricalcitol in the treatment of secondary hyperparathyroidism

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Pages 159-165 | Published online: 10 Jan 2014

References

  • Pitts TO, Piraino BH, Mitro R et al. Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate, and severe renal failure. J. Clin. Endocrinol. Metab. 67, 876–881 (1988).
  • Reichel H, Deibert B, Schmidt-Gayk H, Ritz E. Calcium metabolism in early chronic renal failure: implications for the pathogenesis of hyperparathyroidism. Nephrol. Dial. Transplant 6, 162–169 (1991).
  • Slatopolsky E, Brown A, Dusso A. Role of phosphorus in the pathogenesis of secondary hyperparathyroidism. Am. J. Kidney Dis. 37, S54–S57 (2001).
  • Silver J, Kilav R, Naveh-Many T. Mechanisms of secondary hyperparathyroidism. Am. J. Physiol. Renal Physiol. 283, F367–F376 (2002).
  • Llach F, Yudd M. Paricalcitol in dialysis patients with calcitriol-resistant secondary hyperparathyroidism. Am. J. Kidney Dis. 38, S45–S50 (2001).
  • Cozzolino M, Brancaccio D, Gallieni M, Slatopolsky E. Pathogenesis of vascular calcification in chronic kidney disease. Kidney Int. 68, 429–436 (2005).
  • Kettler M, Gross M, Ritz E. Calcification and cardiovascular problems in renal failure. Kidney Int. 67(Suppl. 94), S120–S127 (2005).
  • Brown AJ, Finch J, Slatopolsky E. Differential effects of 19-nor-1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 on intestinal calcium and phosphorus transport. J. Lab. Clin. Med. 139(5), 279–284 (2002).
  • Holliday LS, Gluck SL, Slatopolsky E, Brown AJ. 1,25-dihydroxy-19-nor-vitamin D(2), a vitamin D analog with reduced bone resorbing activity in vitro. J. Am. Soc. Nephrol. 11, 1857–1864 (2000).
  • Takahashi F, Finch JL, Denda M, Dusso AS, Brown AJ, Slatopolsky E. A new analog of 1,25-(OH)2D3, 19-nor-1,25-(OH)2D2, suppresses serum PTH and parathyroid gland growth in uremic rats without elevation of intestinal vitamin D receptor content. Am. J. Kidney Dis. 30(1), 105–112 (1997).
  • Finch JL, Brown AJ, Slatopolsky E. Differential effects of 1,25-dihydroxy-vitamin D3 and 19-nor-1,25-dihydroxy-vitamin-D2 on calcium and phosphorus resorption in bone. J. Am. Soc. Nephrol. 10, 980–985 (1999).
  • Slatopolsky E, Brown A, Dusso A. Pathogenesis of secondary hyperparathyroidism. Kidney Int. Supp. 56, S14–S19 (1999).
  • Hsu CH, Vanholder R, Patel S et al. Subfractions in uremic plasma ultrafiltrate inhibit calcitriol metabolism. Kidney Int. 40, 868–873 (1991).
  • Lu KC, Lin SH, Yu FC et al. Influence of metabolic acidosis on serum 1,25(OH)2D3 levels in chronic renal failure. Miner. Electrolyte Metab. 21, 398–402 (1995).
  • Sata KA, Gray RW, Lemann J Jr. Urinary excretion of 25-hydroxyvitamin D in health and the nephrotic syndrome. J. Lab. Clin. Med. 99, 325–330 (1982).
  • Jacob AI, Sallman A, Santiz Z et al. Defective photoproduction of cholecalciferol in normal and uremic humans. J. Nutr. 114, 1313–1319 (1984).
  • Slatopolsky E, Finch J, Denda M et al. Phosphorus restriction prevents parathyroid gland growth: high phosphorus directly stimulates PTH secretion in vitro. J. Clin. Invest. 97, 2534–2540 (1996).
  • Almaden Y, Canalejo A, Hernandez A et al. Direct effect of phosphorus on PTH secretion from whole rat parathyroid gland in vitro. J. Bone Miner. Res. 11, 970–976 (1996).
  • Denda M, Finch J, Slatopolsky E. Phosphorus accelerates the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure. Am. J. Kidney Dis. 28, 596–602 (1996).
  • Block GA, Hulbert-Shearon TE, Levin NW, Port FK. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am. J. Kidney Dis. 31, 607–617 (1998).
  • Ganesh SK, Stack AG, Levin NW et al. Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J. Am. Soc. Nephrol. 12, 2131–2138 (2001).
  • Reslerova M, Moe SM. Vascular calcification in dialysis patients: pathogenesis and consequences. Am. J. Kidney Dis. 42(3 Suppl. 1), S96–S99 (2003).
  • Mee AP, Davenport LK, Hoyland JA, Davies M, Mawer EB. Novel and sensitive detection systems for the vitamin D receptor – in situ reverse transcriptase-polymerase chain reaction and immunogold cytochemistry. J. Mol. Endocrinol. 16, 183–196 (1996).
  • Dusso AS, Brown AJ. Mechanisms of vitamin D action and its regulation. Am. J. Kidney Dis. 32(Suppl.), 13–24 (1998).
  • National Kidney Foundation. K/DOQI clinical practice guidelines for bone metabolism in chronic kidney disease. Am. J. Kidney Dis. 42(Suppl. 3), S1–S201 (2003).
  • Chapuy MC, Meunier PJ. Vitamin D insufficiency in adults and the elderly. In: Vitamin D. Feldman D, Glorieux FH, Pike JW (Eds). Academic, San Diego, CA, USA, 679–693 (1997).
  • Goodman WG. Coronary-artery calcifications in young adults with end-stage renal disease who are undergoing dialysis. N. Engl. J. Med. 342, 1478–1483 (2003).
  • Qunibi WY, Nolan CA, Ayus JC. Cardiovascular calcification in patients with end-stage renal disease: a century-old phenomenon. Kidney Int. Supp. 82, 73–80 (2002).
  • Mallik NP, Berlyne GM. Arterial calcification after vitamin-D therapy in hyperphosphatemic renal failure. Lancet 2, 1316–1320 (1968).
  • Goldsmith D, Ritz E, Covic A. Vascular calcification: a stiff challenge for the nephrologist; does preventing bone disease cause arterial disease? Kidney Int. 66, 1315–1333 (2004).
  • Sprague SM. Suppression of parathyroid hormone secretion in hemodialysis patients: comparison of paricalcitol with calcitriol. Am. J. Kidney Dis. 3(Suppl.), S51–S56 (2001).
  • Slatopolsky E, Finch J, Ritter C et al. A new analog of calcitriol, 19-nor-1,25-(OH)2D2, suppresses parathyroid hormone secretion in uremic rats in the absence of hypercalcemia. Am. J. Kidney Dis. 26, 852–860 (1995).
  • Coburn J, Maung H, Elangovan L et al. Doxercalciferol safely suppresses PTH levels in patients with secondary hyperparathyroidism associated with chronic kidney disease stages 3 and 4. Am. J. Kidney Dis. 43(5), 877–890 (2004).
  • Cato A III, Cady WW, Soltanek C, Qasawa B, Chang M, Stoll R. Effect of hemodialysis on the pharmacokinetics of 19-nor-1α25-dihydroxyvitamin D2. Am. J. Kidney Dis. 32, S55–S60 (1998).
  • Brandi L, Egfjord M, Olgaard K. Pharmacokinetics of 1,25 (OH)2D3 and 1(OH)D3 in normal and uraemic men. Nephrol. Dial. Trans. 17, 829–842 (2002).
  • Staniforth M, Cheng S, Coyne D. Once weekly intravenous paricalcitol in the treatment of secondary hyperparathyroidism in hemodialysis patients. Clin. Nephrol. 63(6), 454–460 (2005).
  • Martin KJ, Gonzalez E, Lindberg JS et al. Paricalcitol dosing according to body weight or severity of hyperparathyroidism: a double-blind, multicenter, randomized study. Am. J. Kidney Dis. 38(5 Suppl. 5), S57–S63 (2001).
  • Sprague SM, Llach F, Amdahl M, Taccetta C, Batlle D. Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism. Kidney Int. 63, 1483–1490 (2003).
  • Llach F, Keshav G, Glodblat MV et al. Suppression of parathyroid hormone secretion in hemodialysis patients by a novel vitamin D analogue: 19-nor-1,25-dihydroxyvitamin D2. Am. J. Kidney Dis. 32, S48–S54 (1998).
  • Lindberg J. A long term, multicenter study of the efficacy and safety of paricalcitol in end-stage renal disease. Clin. Nephrol. 56, 315–323 (2001).
  • Coyne DW, Grieff M, Ahya SN, Giles K, Norwood K, Slatapolsky E. Differential effects of acute administration of 19-nor-1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 on serum calcium and phosphorus in hemodialysis patients. Am. J. Kidney Dis. 40, 1283–1288 (2002).
  • Marin KJ, Gonzalez EA, Gellens M et al. 19-Nor-1-α-25-dihydroxyvitamin D2 (paricalcitol) safely and effectively reduces the levels of intact parathyroid hormone in patients on hemodialysis. J. Am. Soc. Nephrol. 9, 1427–1432 (1998).
  • Slatopolsky E, Cozzolino M, Lu Y. Efficacy of 19-Nor-1,25-(OH)2D2 in the prevention and treatment of hyperparthyroid bone disease in experimental uremia. Kidney Int. 63, 2020–2027 (2003).
  • Martin KJ, Gonzalez EA, Gellens ME, Hamm LL, Abboud H, Lindberg J. Therapy of secondary hyperparathyroidism with 19-nor-1α, 25-dihydroxyvitamin D2. Am. J. Kidney Dis. 32(2 Suppl. 2), S61–S66 (1998).
  • Martin KJ, Gonzalez EA. Vitamin D analogs for the management of secondary hyperparathyroidism. Rev. Port. Nefrol. Hipert. 19(Suppl. 1), 81–86 (2005).
  • Teng M, Wolf M, Lowrie E, Ofsthun N, Lazarus M, Thadhani R. Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. N. Eng. J. Med. 349, 446–456 (2003).
  • Dobrez DG, Mathes A, Amdahl M et al. Paricalcitol-treated patients experience improved hospitalization outcomes compared with calcitriol-treated patients in real-world clinical settings. Nephrol. Dial. Transplant 19, 1174–1181 (2004).
  • Coyne D, Acharya M, Qiu P et al. Paricalcitol capsule for the treatment of secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease. Am. J. Kidney Dis. 47, 263–276 (2005).
  • Agarwal R, Acharya M, Tian J et al. Antiproteinuric effects of oral paricalcitol in chronic kidney disease. Kidney Int. 68, 2823–2828 (2005).
  • Baker LR, Abrams L, Roe CJ et al. 1,25(OH)2D3 administration in moderate renal failure: a prospective double blind trial. Kidney Int. 35, 661–669 (1989).
  • Nordal KP, Dahl E. Low dose calcitriol versus placebo in patients with predialysis chronic renal failure. J. Clin. Endocrinol. Metab. 67, 929–936 (1988).
  • Coburn J, Maung H, Elangovan L et al. Doxercalciferol safely suppresses PTH levels in patients with secondary hyperparathyroidism associated with chronic kidney disease stages 3 and 4. Am. J. Kidney Dis. 43(5), 877–890 (2004).
  • Hamdy NA et al. Effect of alfacalcidol on natural course of renal bone disease in mild and moderate renal failure. BMJ 310(6976), 358–363 (1995).
  • Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet 351, 805–806 (1998).
  • Couttenye MM, D’Haese P, Verschoren WJ et al. Low bone turnover in patients with renal failure. Kidney Int. 56(Suppl. 73), S70–S76 (1999).
  • Coen G, Ballanti P, Bonucci E et al. Renal osteodystrophy in predialysis and hemodialysis patients: comparison of histologic patterns and diagnostic predictivity of intact PTH. Nephron 91, 103–111 (2002).
  • Nemeth EF, Heaton WH, Miller M et al. Pharmacodynamics of the type II calcimimetics compound cinacalcet HCl. J. Pharmacol. Exp. Ther. 308, 627–635 (2004).
  • Cardus A, Gallego C, Muray S et al. Differential effect of vitamin D analogues on the proliferation of vascular smooth muscle cells. Nefrologia 23(Suppl. 2), 117–121 (2003).

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