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Review

Sensitivity of anterior pituitary hormones to irradiation

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Pages 633-649 | Published online: 10 Jan 2014

References

  • Kirsch DG, Tarbell NJ. Conformal radiation therapy for childhood CNS tumors. Oncologist9, 442–450 (2004).
  • Littley MD, Shalet SM, Beardwell CG, Ahmed SR, Applegate G, Sutton ML. Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q. J. Med.70, 145–160 (1989).
  • Lam KS, Tse VK, Wang C, Yeung RT, Ho JH. Effects of cranial irradiation on hypothalamic–pituitary function – a 5-year longitudinal study in patients with nasopharyngeal carcinoma. Q. J. Med.78, 165–176 (1991).
  • Littley MD, Shalet SM, Beardwell CG, Robinson EL, Sutton ML. Radiation-induced hypopituitarism is dose-dependent. Clin. Endocrinol.31, 363–373 (1989).
  • Brennan BM, Rahim A, Mackie EM, Eden OB, Shalet SM. Growth hormone status in adults treated for acute lymphoblastic leukaemia in childhood. Clin. Endocrinol.48, 777–783 (1998).
  • Adan L, Trivin C, Sainte-Rose C, Zucker JM, Hartmann O, Brauner R. GH deficiency caused by cranial irradiation during childhood: factors and markers in young adults. J. Clin. Endocrinol. Metab.86, 5245–5251 (2001).
  • Agha A, Sherlock M, Brennan S et al. hypothalamic–pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. J. Clin. Endocrinol. Metab.90, 6355–6360 (2005).
  • Barendsen GW. Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int. J. Radiat. Oncol. Biol. Phys.8, 1981–1997 (1982).
  • Fowler JF. The linear-quadratic formula and progress in fractionated radiotherapy. Br. J. Radiol.62, 679–694 (1989).
  • Schmiegelow M, Lassen S, Poulsen HS et al. Cranial radiotherapy of childhood brain tumours: growth hormone deficiency and its relation to the biological effective dose of irradiation in a large population based study. Clin. Endocrinol.53, 191–197 (2000).
  • Bentzen SM. Quantitative clinical radiobiology. Acta Oncol.32, 259–275 (1993).
  • Bentzen SM, Overgaard M, Overgaard J. Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity. Eur. J. Cancer29A, 1373–1376 (1993).
  • Yaes RJ. LQ and time model. Radiother. Oncol.21, 143–144 (1991).
  • Yaes RJ, Patel P, Maruyama Y. On using the linear-quadratic model in daily clinical practice. Int. J. Radiat. Oncol. Biol. Phys.20, 1353–1362 (1991).
  • Thames HD, Hendry JH, Moore JV, Ang KK, Travis EL. The high steepness of dose-response curves for late-responding normal tissues. Radiother. Oncol.15, 49–53 (1989).
  • Duffner PK, Cohen ME, Voorhess ML et al. Long-term effects of cranial irradiation on endocrine function in children with brain tumors. A prospective study. Cancer56, 2189–2193 (1985).
  • Clayton PE, Shalet SM. Dose dependency of time of onset of radiation-induced growth hormone deficiency. J. Pediatr.118, 226–228 (1991).
  • Littley MD, Shalet SM, Morgenstern GR, Deakin DP. Endocrine and reproductive dysfunction following fractionated total body irradiation in adults. Q. J. Med.78, 265–274 (1991).
  • Ogilvy-Stuart AL, Clark DJ, Wallace WH et al. Endocrine deficit after fractionated total body irradiation. Arch. Dis. Child.67, 1107–1110 (1992).
  • Brauner R, Rappaport R, Prevot C et al. A prospective study of the development of growth hormone deficiency in children given cranial irradiation, and its relation to statural growth. J. Clin. Endocrinol. Metab.68, 346–351 (1989).
  • Spoudeas HA, Charmandari E, Brook CG. Hypothalamo-pituitary-adrenal axis integrity after cranial irradiation for childhood posterior fossa tumours. Med. Pediatr. Oncol.40, 224–229 (2003).
  • Livesey EA, Hindmarsh PC, Brook CG et al. Endocrine disorders following treatment of childhood brain tumours. Br. J. Cancer61, 622–625 (1990).
  • Foote KD, Friedman WA, Buatti JM, Bova FJ, Meeks SA. Linear accelerator radiosurgery in brain tumor management. Neurosurg. Clin. N. Am.10, 203–242 (1999).
  • Laws ER Jr, Vance ML. Radiosurgery for pituitary tumors and craniopharyngiomas. Neurosurg. Clin. N. Am.10, 327–336 (1999).
  • Colin P, Jovenin N, Delemer B et al. Treatment of pituitary adenomas by fractionated stereotactic radiotherapy: a prospective study of 110 patients. Int. J. Radiat. Oncol. Biol. Phys.62, 333–341 (2005).
  • Sklar CA, Constine LS. Chronic neuroendocrinological sequelae of radiation therapy. Int. J. Radiat. Oncol. Biol. Phys.31, 1113–1121 (1995).
  • Constine LS, Woolf PD, Cann D et al. hypothalamic–pituitary dysfunction after radiation for brain tumors. N. Engl. J. Med.328, 87–94 (1993).
  • Shalet SM, Clayton PE, Price DA. Growth and pituitary function in children treated for brain tumours or acute lymphoblastic leukaemia. Horm. Res.30, 53–61 (1988).
  • Sklar CA. Growth and pubertal development in survivors of childhood cancer. Pediatrician18, 53–60 (1991).
  • Chrousos GP, Poplack D, Brown T, O'Neill D, Schwade J, Bercu BB. Effects of cranial radiation on hypothalamic-adenohypophyseal function: abnormal growth hormone secretory dynamics. J. Clin. Endocrinol. Metab.54, 1135–1139 (1982).
  • Samaan NA, Bakdash MM, Caderao JB, Cangir A, Jesse RH Jr, Ballantyne AJ. Hypopituitarism after external irradiation. Evidence for both hypothalamic and pituitary origin. Ann. Intern. Med.83, 771–777 (1975).
  • Blacklay A, Grossman A, Ross RJ et al. Cranial irradiation for cerebral and nasopharyngeal tumours in children: evidence for the production of a hypothalamic defect in growth hormone release. J. Endocrinol.108, 25–29 (1986).
  • Lam KS, Wang C, Yeung RT et al. Hypothalamic hypopituitarism following cranial irradiation for nasopharyngeal carcinoma. Clin. Endocrinol.24, 643–651 (1986).
  • Darzy KH, Aimaretti G, Wieringa G, Gattamaneni HR, Ghigo E, Shalet SM. The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval. J. Clin. Endocrinol. Metab.88, 95–102 (2003).
  • Guo YP, Hendry JH, Morris ID, Davis JR, Beardwell CG. Cell proliferation and death in the irradiated pituitary gland and its modification by growth stimulants. Int. J. Radiat. Oncol. Biol. Phys.38, 175–181 (1997).
  • Vincent PC. Apoptosis and the assessment of radiation injury. Stem Cells13(Suppl. 1), 153–164 (1995).
  • Dainiak N. Mechanisms of radiation injury: impact of molecular medicine. Stem Cells15(Suppl. 2), 1–5 (1997).
  • Nishioka H, Hirano A, Haraoka J, Nakajima N. Histological changes in the pituitary gland and adenomas following radiotherapy. Neuropathology22, 19–25 (2002).
  • Nishioka H, Ito H, Haraoka J, Hirano A. Histological changes in the hypofunctional pituitary gland following conventional radiotherapy for adenoma. Histopathology38, 561–566 (2001).
  • Rodemann HP, Bamberg M. Cellular basis of radiation-induced fibrosis. Radiother. Oncol.35, 83–90 (1995).
  • Vankelecom H, Matthys P, Van Damme J, Heremans H, Billiau A, Denef C. Immunocytochemical evidence that S-100-positive cells of the mouse anterior pituitary contain interleukin-6 immunoreactivity. J. Histochem. Cytochem.41, 151–156 (1993).
  • Robinson IC, Fairhall KM, Hendry JH, Shalet SM. Differential radiosensitivity of hypothalamo-pituitary function in the young adult rat. J. Endocrinol.169, 519–526 (2001).
  • Hochberg Z, Kuten A, Hertz P, Tatcher M, Kedar A, Benderly A. The effect of single-dose radiation on cell survival and growth hormone secretion by rat anterior pituitary cells. Radiat. Res.94, 508–512 (1983).
  • Rappaport R, Brauner R. Growth and endocrine disorders secondary to cranial irradiation. Pediatr. Res.25, 561–567 (1989).
  • Toogood AA, Ryder WD, Beardwell CG, Shalet SM. The evolution of radiation-induced growth hormone deficiency in adults is determined by the baseline growth hormone status. Clin. Endocrinol.43, 97–103 (1995).
  • Iranmanesh A, Grisso B, Veldhuis JD. Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminescence assay. J. Clin. Endocrinol. Metab.78, 526–535 (1994).
  • Reutens AT, Veldhuis JD, Hoffman DM, Leung KC, Ho KK. A highly sensitive growth hormone (GH) enzyme-linked immunosorbent assay uncovers increased contribution of a tonic mode of GH secretion in adults with organic GH deficiency. J. Clin. Endocrinol. Metab.81, 1591–1597 (1996).
  • Baum HB, Biller BM, Katznelson L et al. Assessment of growth hormone (GH) secretion in men with adult-onset GH deficiency compared with that in normal men – a clinical research center study. J. Clin. Endocrinol. Metab.81, 84–92 (1996).
  • Darzy KH, Pezzoli SS, Thorner MO, Shalet SM. The dynamics of growth hormone (GH) secretion in adult cancer survivors with severe GH deficiency acquired after brain irradiation in childhood for nonpituitary brain tumors: evidence for preserved pulsatility and diurnal variation with increased secretory disorderliness. J. Clin. Endocrinol. Metab.90, 2794–2803 (2005).
  • Darzy KH, Murray RD, Gleeson HK, Pezzoli SS, Thorner MO, Shalet SM. The impact of short-term fasting on the dynamics of 24-hour GH secretion in patients with severe radiation-induced GH deficiency. J. Clin. Endocrinol. Metab.91(3), 987–994 (2005).
  • Rappaport R, Brauner R, Czernichow P et al. Effect of hypothalamic and pituitary irradiation on pubertal development in children with cranial tumors. J. Clin. Endocrinol. Metab.54, 1164–1168 (1982).
  • Toogood AA. Endocrine consequences of brain irradiation. Growth. Horm. IGF Res.14(Suppl. A), S118–S124 (2004).
  • Bath LE, Anderson RA, Critchley HO, Kelnar CJ, Wallace WH. hypothalamic–pituitary-ovarian dysfunction after prepubertal chemotherapy and cranial irradiation for acute leukaemia. Hum. Reprod.16, 1838–1844 (2001).
  • Muller J. Disturbance of pubertal development after cancer treatment. Best Pract. Res. Clin. Endocrinol. Metab.16, 91–103 (2002).
  • Leiper AD, Stanhope R, Kitching P, Chessells JM. Precocious and premature puberty associated with treatment of acute lymphoblastic leukaemia. Arch. Dis. Child.62, 1107–1112 (1987).
  • Ogilvy-Stuart AL, Clayton PE, Shalet SM. Cranial irradiation and early puberty. J. Clin. Endocrinol. Metab.78, 1282–1286 (1994).
  • Roth C, Schmidberger H, Schaper O et al. Cranial irradiation of female rats causes dose-dependent and age-dependent activation or inhibition of pubertal development. Pediatr. Res.47, 586–591 (2000).
  • Roth C, Lakomek M, Schmidberger H, Jarry H. Cranial irradiation induces premature activation of the gonadotropin-releasing-hormone. Klin. Padiatr.213, 239–243 (2001).
  • Roth C, Schmidberger H, Lakomek M, Witt O, Wuttke W, Jarry H. Reduction of gamma-aminobutyric acid-ergic neurotransmission as a putative mechanism of radiation induced activation of the gonadotropin releasing-hormone-pulse generator leading to precocious puberty in female rats. Neurosci. Lett.297, 45–48 (2001).
  • Groot-Loonen JJ, van Setten P, Otten BJ, van’t Hof MA, Lippens RJ, Stoelinga GB. Shortened and diminished pubertal growth in boys and girls treated for acute lymphoblastic leukaemia. Acta Paediatr.85, 1091–1095 (1996).
  • Hokken-Koelega AC, van Doorn JW, Hahlen K, Stijnen T, de Muinck Keizer-Schrama SM, Drop SL. Long-term effects of treatment for acute lymphoblastic leukemia with and without cranial irradiation on growth and puberty: a comparative study. Pediatr. Res.33, 577–582 (1993).
  • Didcock E, Davies HA, Didi M, Ogilvy Stuart AL, Wales JK, Shalet SM. Pubertal growth in young adult survivors of childhood leukemia. J. Clin. Oncol.13, 2503–2507 (1995).
  • Sklar C. Reproductive physiology and treatment-related loss of sex hormone production. Med. Pediatr. Oncol.33, 2–8 (1999).
  • Rose SR, Schreiber RE, Kearney NS et al. Hypothalamic dysfunction after chemotherapy. J. Pediatr. Endocrinol. Metab.17, 55–66 (2004).
  • Schmiegelow M, Feldt-Rasmussen U, Rasmussen AK, Lange M, Poulsen HS, Muller J. Assessment of the hypothalamo-pituitary-adrenal axis in patients treated with radiotherapy and chemotherapy for childhood brain tumor. J. Clin. Endocrinol. Metab.88, 3149–3154 (2003).
  • Arlt W, Hove U, Muller B et al. Frequent and frequently overlooked: treatment-induced endocrine dysfunction in adult long-term survivors of primary brain tumors. Neurology49, 498–506 (1997).
  • Agha A, Tomlinson JW, Clark PM, Holder G, Stewart PM. The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic–pituitary-adrenal axis. J. Clin. Endocrinol. Metab.91, 43–47 (2006).
  • Darzy KH, Shalet SM. Absence of adrenocorticotropin (ACTH) neurosecretory dysfunction but increased cortisol concentrations and production rates in ACTH-replete adult cancer survivors after cranial irradiation for nonpituitary brain tumors. J. Clin. Endocrinol. Metab.90, 5217–5225 (2005).
  • Moore JS, Monson JP, Kaltsas G et al. Modulation of 11b-hydroxysteroid dehydrogenase isozymes by growth hormone and insulin-like growth factor: in vivo and in vitro studies. J. Clin. Endocrinol. Metab.84, 4172–4177 (1999).
  • Ricardi U, Corrias A, Einaudi S et al. Thyroid dysfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy. Int. J. Radiat. Oncol. Biol. Phys.50, 1287–1294 (2001).
  • Jereczek-Fossa BA, Alterio D, Jassem J, Gibelli B, Tradati N, Orecchia R. Radiotherapy-induced thyroid disorders. Cancer Treat. Rev.30, 369–384 (2004).
  • Caron PJ, Nieman LK, Rose SR, Nisula BC. Deficient nocturnal surge of thyrotropin in central hypothyroidism. J. Clin. Endocrinol. Metab.62, 960–964 (1986).
  • Rose SR, Nisula BC. Circadian variation of thyrotropin in childhood. J. Clin. Endocrinol. Metab.68, 1086–1090 (1989).
  • Paulino AC. Hypothyroidism in children with medulloblastoma: a comparison of 3600 and 2340 cGy craniospinal radiotherapy. Int. J. Radiat. Oncol. Biol. Phys.53, 543–547 (2002).
  • Ogilvy-Stuart AL, Shalet SM, Gattamaneni HR. Thyroid function after treatment of brain tumors in children. J. Pediatr.119, 733–737 (1991).
  • Oberfield SE, Allen JC, Pollack J, New MI, Levine LS. Long-term endocrine sequelae after treatment of medulloblastoma: prospective study of growth and thyroid function. J. Pediatr.108, 219–223 (1986).
  • Rose SR, Lustig RH, Pitukcheewanont P et al. Diagnosis of hidden central hypothyroidism in survivors of childhood cancer. J. Clin. Endocrinol. Metab.84, 4472–4479 (1999).
  • Darzy KH, Shalet SM. Circadian and stimulated thyrotropin secretion in cranially irradiated adult cancer survivors. J. Clin. Endocrinol. Metab.90, 6490–6497 (2005).
  • Brada M, Rajan B, Traish D et al. The long-term efficacy of conservative surgery and radiotherapy in the control of pituitary adenomas. Clin. Endocrinol.38, 571–578 (1993).
  • Merchant TE, Kiehna EN, Sanford RA et al. Craniopharyngioma: the St. Jude Children's Research Hospital experience 1984–2001. Int. J. Radiat. Oncol. Biol.53, 533–542 (2002).
  • Habrand JL, Ganry O, Couanet D et al. The role of radiation therapy in the management of craniopharyngioma: a 25-year experience and review of the literature. Int. J. Radiat. Oncol. Biol. Phys.44, 255–263 (1999).
  • Pai HH, Thornton A, Katznelson L et al. Hypothalamic/pituitary function following high-dose conformal radiotherapy to the base of skull: demonstration of a dose-effect relationship using dose-volume histogram analysis. Int. J. Radiat. Oncol. Biol.49, 1079–1092 (2001).
  • Constine LS, Rubin P, Woolf PD, Doane K, Lush CM. Hyperprolactinemia and hypothyroidism following cytotoxic therapy for central nervous system malignancies. J. Clin. Oncol.5, 1841–1851 (1987).
  • Petterson T, MacFarlane IA, Foy PM, Hughes HJ, Jones B, Shaw D. hyperprolactinemia and infertility following cranial irradiation for brain tumours: successful treatment with bromocriptine. Br. J. Neurosurg.7, 571–574 (1993).
  • Mukherjee A, Murray RD, Columb B, Gleeson HK, Shalet SM. Acquired prolactin deficiency indicates severe hypopituitarism in patients with disease of the hypothalamic–pituitary axis. Clin. endocrinol.59, 743–748 (2003).
  • Ganz JC, Aanderud S, Mork SJ, Smievoll AI. Tumour volume reduction following gamma knife radiosurgery: the relationship between x-ray and histological findings. Acta Neurochir. Suppl.62, 39–42 (1994).
  • Ganz JC, Backlund EO, Thorsen FA. The effects of gamma knife surgery of pituitary adenomas on tumor growth and endocrinopathies. Stereotact. Funct. Neurosurg.61(Suppl. 1), 30–37 (1993).
  • Tan BC, Kunaratnam N. Hypopituitary dwarfism following radiotherapy for nasopharyngeal carcinoma. Clin. Radiol.17, 302–304 (1966).
  • Huang TS, Lui LT, Hsu MM, Chen FW. Effect of cranial irradiation on hypothalamus-pituitary function: follow-up study one year after radiotherapy.J. Formos. Med. Assoc.90, 652–658 (1991).
  • Huang TS, Huang SC, Hsu MM. A prospective study of hypothalamus pituitary function after cranial irradiation with or without radiosensitizing chemotherapy. J. Endocrinol. Invest.17, 615–623 (1994).
  • Sham J, Choy D, Kwong PW et al. Radiotherapy for nasopharyngeal carcinoma: shielding the pituitary may improve therapeutic ratio. Int. J. Radiat. Oncol. Biol. Phys.29, 699–704 (1994).
  • Richards GE, Wara WM, Grumbach MM, Kaplan SL, Sheline GE, Conte FA. Delayed onset of hypopituitarism: sequelae of therapeutic irradiation of central nervous system, eye, and middle ear tumors. J. Pediatr.89, 553–559 (1976).
  • Harrop JS, Davies TJ, Capra LG, Marks V. Hypothalamic–pituitary function following successful treatment of intracranial tumours. Clin. Endocrinol.5, 313–321 (1976).
  • Evans AE. Central Nervous System Involvement in Children with Acute Leukemia; a Study of 921 Patients. Cancer17, 256–258 (1964).
  • Chessells JM, Bailey C, Richards SM. Intensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALL X. Medical research council working party on childhood leukaemia. Lancet345, 143–148 (1995).
  • Blatt J, Bercu BB, Gillin JC, Mendelson WB, Poplack DG. Reduced pulsatile growth hormone secretion in children after therapy for acute lymphoblastic leukemia. J. Pediatr.104, 182–186 (1984).
  • Crowne EC, Wallace WH, Gibson S, Moore CM, White A, Shalet SM. Adrenocorticotrophin and cortisol secretion in children after low dose cranial irradiation. Clin. Endocrinol.39, 297–305 (1993).
  • Lando A, Holm K, Nysom K et al. Thyroid function in survivors of childhood acute lymphoblastic leukaemia: the significance of prophylactic cranial irradiation. Clin. Endocrinol.55, 21–25 (2001).
  • Vance ML. Hypopituitarism. N. Engl. J. Med.330, 1651–1662 (1994).
  • Tomlinson JW, Holden N, Hills RK et al. Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet357, 425–431 (2001).
  • Suit H, Urie M. Proton beams in radiation therapy. J. Natl Cancer Inst.84, 155–164 (1992).

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