107
Views
0
CrossRef citations to date
0
Altmetric
Drug Profile

Recent advances with insulin degludec for the treatment of Type 2 diabetes

&

References

  • The DCCT Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993;329:977-86
  • Riddle MC. The treat to target trial and related studies. Endocr Pract 2006;12(1):71-9
  • Strange P. Treat-to-target insulin titration algorithms when initiating long or intermediate acting insulin in type 2 diabetes. J Diabetes Sci Technol 2007;1(4):540-8
  • International Diabetes Federation. IDF treatment algorithm for people with type 2 diabetes. Available from: www.idf.org/sites/default/files/Type%202%20treatment%20algorithm.pdf
  • American Association of Clinical Endocrinology. AACE comprehensive diabetes management algorithm. 2013. Available from: www.aace.com/files/aace_algorithm.pdf
  • National Institute for Health and Care Excellence. Type 2 diabetes: the management of type 2 diabetes. 2008. Available from: http://guidance.nice.org.uk/cg66
  • Canadian Diabetes Association. Examples of insulin initiation and titration regimes in people with type 2 diabetes. 2013. Available from: http://guidelines.diabetes.ca/Browse/Appendices/Appendix3.aspx
  • Associazione Medici Diabetologi. Standard Italiani per la cura del diabete mellito tipo 2. 2011. Available from: www.aemmedi.it/files/Lineeguida_Raccomandazioni/2011/AMD_SID_SIMMG_2011.pdf
  • Philis-Tsimakis A, Brod M, Niemayer M, et al. Insulin degludec once daily in type 2 diabetes: simple or step-wise titration (BEGIN: once simple use). Adv Ther 2013;30(6):607-22
  • DeVries JH, Nattrass M, Pieber TR. Refining basal insulin therapy: what have we learned in the age of analogues? Diabetes Metab Res Rev 2007;23(6):441-54
  • Swinnen SG, Simon AC, Holleman F, et al. Insulin detemir versus insulin glargine for type 2 diabetes mellitus. Cochrane Database Syst Rev 2011;6(7):CD006383
  • Leiter LA, Yale J-F, Chiasson J-L, et al. Assessment of the impact of fear of hypoglycaemic episodes on glycaemic and hypoglycaemic management. Can J Diabetes 2005;29(3):00-0
  • Lepore M, Pampanelli S, Fanelli C, et al. Pharmacokinetics and pharmacodynamics of subcutaneous injection of long acting human insulin analog glargine, NPH insulin and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. Diabetes 2000;49(12):2142-8
  • McAuley V, Frier BM. Insulin analogues and other developments in insulin therapy for diabetes. Expert Opin Pharmacother 2003;4(7):1141-56
  • Owens DR, Bolli GB. Beyond the era of NPH insulin – long acting insulin analogs: chemistry, comparative pharmacology and clinical application. Diabetes Technol Ther 2008;10(5):333-49
  • Dailey G, Admane K, Mercier F, Owens D. Relationship of insulin dose, A1c lowering, and weight in type 2 diabetes: comparing insulin glargine and insulin detemir. 2010;12(12):1019-23
  • Riddle MC, Rosenstock J, Gerich J; Insulin Glargine 4002 Study Investigators. The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. 2003;26(11):3080-6
  • Hermansen K, Davies M, Derezinski T, et al. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. 2006;29(6):1269-74
  • Jonassen I, Havelund S, Ribel U, et al. Insulin degludec is a new generation ultra- long acting basal insulin with a unique mechanism of protraction based on multi hexamer formation. Diabetes 2010;59(1):A11
  • Jonassen I, Havelund S, Hoeg-Jensen T, et al. Design of the novel protraction mechanism of insulin degludec, an ultra-long acting basal insulin. Pharm Res 2012;29(8):2104-14
  • Kurtzahals P, Heise T, Strauss HM, et al. Multi-hexamer formation is the underlying basis for the ultra-long glucose lowering effect of insulin degluec. Diabetologia 2011;54(1):S426
  • Heise T, Nosek L, Bøttcher SG, et al. Ultra-long-acting insulin degludec has a flat and stable glucose lowering effect in type 2 diabetes. Diabetes Obes Metab 2012;14(10):944-50
  • Meneghini L, Atkin SL, Gough SC, et al. The efficacy and safety of insulin degludec given in variable once daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: a 26 week, randomised, open-label, parallel group, treat-to-target trial in individuals with type 2 diabetes. Diabetes care 2013;36(4):858-64
  • Tennagels N, Werner U. The metabolic and mitogenic properties of basal insulin analogues. Arch Physiol Biochem 2013;119(1):1-14
  • De Meyts P, Whittaker J. Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Discov 2002;1(10):769-83
  • Chisalita SI, Arngvist SJ. Insulin like growth factor 1 receptors are more abundant than insulin receptors in human micro and macrovascular endothelial cells. Am J Physiol Endocrinol Metab 2004;286(6):E896-901
  • Hansen BF, Danielsen GM, Drejer K, et al. Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting greater mitogenic potency. Biochem J 1996;315(1):271-9
  • Nishimura E, Sorensen AR, Hansen BF, et al. Insulin degludec: a new ultra-long, basal insulin designed to maintain full metabolic effect while minimizing mitogenic potential. Diabetologia 2010;53(1):S388-9
  • Zinman B, Fulcher G, Rao PV, et al. Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16 week, randomised, open label, phase 2 trial. Lancet 2011;377(9769):924-31
  • Zinman B, Philis-Tsimakis A, Cariou B, et al. Insulin degludec versus insulin glargine in insulin naïve patients with type 2 diabetes: a 1 year, randomised, treat-to-target trial (BEGIN Once Long). Diabetes Care 2012;35(12):2464-71
  • Rodbard HW, Cariou B, Zinman B, et al. Comparison of insulin degludec with insulin glargine in insulin-naive subjects with Type 2 diabetes: a 2-year randomized, treat-to-target trial. Diabet Med 2013;30(11):1298-304
  • Garber AJ, King AB, Del Prato S, et al. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN basal-bolus type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet 2012;21:379(9825):1498-507
  • Ratner RE, Gough SC, Mathieu C, et al. Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: a pre-planned meta-analysis of phase 3 trials. Diabetes Obes Metab 2013;15(2):175-84
  • Gough SC, Bhargava A, Jain R, et al. Low-volume insulin degludec 200 units/ml once daily improves glycemic control similarly to insulin glargine with a low risk of hypoglycemia in insulin-naive patients with type 2 diabetes: a 26-week, randomized, controlled, multinational, treat-to-target trial: the BEGIN LOW VOLUME trial. Diabetes Care 2013;36(9):2536-42
  • Freemantle N, Meneghini L, Christensen T, et al. Insulin degludec improves health-related quality of life (SF-36R) compared with insulin glargine in people with type 2 diabetes starting on basal insulin: a meta-analysis of phase 3a trials. Diabet Med 2013;30(2):226-32
  • Ericsson A, Pollock RF, Hunt B, Valentine WJ. Evaluation of the cost-utility of insulin degludec vs insulin glargine in Sweden. J Med Econ 2013;16(12):1442-52
  • Evans M, Wolden M, Gundgaard J, et al. Cost-effectiveness of insulin degludec compared with insulin glargine for patients with type 2 diabetes treated with basal insulin - from the UK healthcare cost perspective. Diabetes Obes Metab 2013. [Epub ahead of print]
  • Philis-Tsimakis A, Del Prato S, Satman I, et al. Effect of insulin degludec versus sitagliptin in patients with type 2 diabetes uncontrolled on oral antidiabetic agents. Diabetes Obes Metab 2013;15(8):760-6
  • Liebl A, Davidson J, Mersebach H, et al. A novel insulin combination of insulin degludec and insulin aspart achieves a more stable overnight glucose profile than insulin glargine: results from continuous glucose monitoring in a proof-of-concept trial. J Diabetes Sci Technol 2013;7(5):1328-36
  • Onishi Y, Ono Y, Rabøl R, et al. Superior glycaemic control with once daily insulin degludec/insulin aspart versus insulin glargine in Japanese adults with type 2 diabetes inadequately controlled with oral drugs: a randomised controlled phase 3 trial. Diabetes Obes Metab 2013;15(9):826-32
  • Niskanen L, Leiter LA, Franek E, et al. Comparison of a soluble co-formulation of insulin degludec/insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: a randomised trial. Eur J Endocrinol 2012;167(2):287-94
  • Heise T, Tack CJ, Cuddihy R, et al. A new generation ultra-long acting basal insulin with a bolus boost compared with insulin glargine in insulin-naïve people with type 2 diabetes: a randomised, controlled trial. Diabetes Care 2011;34(3):669-74
  • Booth HP, Prevost AT, Guilliford MC. Impact of body mass index on prevalence of multimorbidity in primary care: cohort study. Fam Pract 2013. [Epub ahead of print]
  • Teljeur C, Smith SM, Paul G, et al. Multimorbidity in a cohort of patients with type 2 diabetes. Eur J Gen Pract 2013;19(1):17-22
  • Ginter E, Simko V. Global prevalence and future of diabetes mellitus. Adv Exp Med Biol 2012;771:35-41
  • Rodbard HW, Gough S, Lane W, et al. Reduced risk of hypoglycaemia with insulin degludec vs insulin glargine in patients with type 2 diabetes requiring high doses of basal insulin: meta-analysis of 5 randomised BEGIN trial. Endocr Pract 2013;18:1-23. [Epub ahead of print]
  • Tolman KG, Fonseca V, Dalpiaz A, Tan MH. Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease. Diabetes Care 2007;30(3):734-43
  • Kupčová V, Arold G, Roepstorff C, et al. Insulin degludec: pharmacokinetic properties in subjects with hepatic impairment. Clin Drug Investig 2013;34:2-127-33
  • Department of Health. Turning the corner: improving diabetes care. 2006
  • Department of Health. Improving diabetes services: the NSF four years on. 2007
  • Kiss I, Arold G, Roepstorff C, et al. Insulin degludec: pharmacokinetics in patients with renal impairment. Clin Pharmokinet 2013. [Epub ahead of print]
  • Chelliah A, Burge MR. Hypoglycaemia in elderly patients with diabetes mellitus: causes and strategies for prevention. Drugs Aging 2004;21(8):511-30
  • Sorli C, Warren M, Over D, et al. Elderly patients with diabetes experience a lower rate of nocturnal hypoglycaemia with insulin degludec than insulin glargine: a meta-analysis of phase IIIa trials. Drugs Aging 2013;30(12):1009-18
  • US Department of Health and Human Services Food and Drug Administration Centre for Drug Evaluation and Research. Guidance for industry – evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes. 2008. Available from: www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071627.pdf
  • A trial comparing the efficacy and safety of insulin degludec/liraglutide and insulin degludec in subjects with type 2 diabetes (DUAL™ II). Available from: http://clinicaltrials.gov/ct2/show/NCT01392573
  • Holleman F. Long-acting insulin analogues. 2014. Available from: www.diapedia.org/management/8104096127/long-acting-insulinanalogues
  • Birkeland K, Home P, Wendisch U, et al. Insulin degludec in type 1 diabetes: a randomised controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine. Diabetes Care 2011;34:661-5
  • Heise T, Hermanski L, Nosek L, et al. Insulin degludec: four times lower pharmacodynamics variability than insulin glargine under steady-state conditions in type 1 diabetes. Diabetes Obes Metab 2012;14:859-64
  • Iwamoto Y, Clauson P, Nishida T, Kaku K. Insulin degludec in Japanese patients with type 1 diabetes mellitus: a randomised controlled trial. J Diabetes Invest 2013;4:4-62-8
  • Kiss I, Gerhard A, Roepstorff C, et al. Insulin degludec: pharmacokinetics in patients with renal impairment. Clin Pharmacokinet 2013;53:2-175-83
  • Koehler G, Heller S, Korsatko S, et al. Insulin degludec is not associated with a delayed or diminished response to hypoglycaemia compared with insulin glargine in type 1 diabetes: a double-blind randomised crossover study. Diabetologia 2014;57:40-9
  • Korsatko S, Deller S, Koehler G, et al. A comparison of the steady-state pharmacokinetic and pharmacodynamics profiles of 100 and 200 U/mL formulations of ultra-long-acting insulin degludec. Clin Drug Investig 2013;33(7):515-21
  • Korsatko S, Deller S, Mader JK, et al. Ultra-long pharmacokinetic properties of insulin degludec are comparable in elderly subjects and younger adults with type 1 diabetes mellitus. Drugs Aging 2014;31:47-53

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.