The role of reactive oxygen species in obesity therapeutics

References

• Cunningham SA, Kramer MR, Narayan KM. Incidence of childhood obesity in the United States. N Engl J Med 2014;370:403-11
   PubMed Web of Science ®Google Scholar
• National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143-421
   PubMed Web of Science ®Google Scholar
• Rubenstein AH. Obesity: a Modern Epidemic. Trans Am Clin Climatol Assoc 2005;116:103-13
   PubMedGoogle Scholar
• Rodriguez-Hernandez H, Simental-Mendia LE, Rodriguez-Ramirez G, Reyes-Romero MA. Obesity and inflammation: epidemiology, risk factors, and markers of inflammation. Int J Endocrinol 2013;2013:678159
   PubMed Web of Science ®Google Scholar
• Coelho M, Oliveira T, Fernandes R. Biochemistry of adipose tissue: an endocrine organ. Arch Med Sci 2013;9:191-200
   PubMed Web of Science ®Google Scholar
• Okamoto Y, Kihara S, Ouchi N, et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 2002;106:2767-70
   PubMed Web of Science ®Google Scholar
• Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses IR associated with both lipoatrophy and obesity. Nat Med 2001;7:941-6
   PubMed Web of Science ®Google Scholar
• Ye J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obesity 2009;33:54-66
   PubMed Web of Science ®Google Scholar
• Kayser B, Verges S. Hypoxia, energy balance and obesity: from pathophysiological mechanisms to new treatment strategies. Obes Rev 2013;14:579-92
   PubMed Web of Science ®Google Scholar
• Cancello R, Henegar C, Viguerie N, et al. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 2005;54:2277-86
   PubMed Web of Science ®Google Scholar
• Halberg N, Khan T, Trujillo ME, et al. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 2009;29:4467-83
   PubMed Web of Science ®Google Scholar
• Lee KY, Gesta S, Boucher J, et al. The differential role of Hif1β/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation. Cell Metab 2011;14:491-503
   PubMed Web of Science ®Google Scholar
• Lee YS, Kim JW, Osborne O, et al. Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell 2014;157:1339-52
   PubMed Web of Science ®Google Scholar
• Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of IR. Nature 2006;440:944-8
   PubMed Web of Science ®Google Scholar
• Musatov A, Robinson NC. Susceptibility of mitochondrial electron-transport complexes to oxidative damage. Focus on cytochrome c oxidase. Free Radic Res 2012;46:1313-26
   PubMed Web of Science ®Google Scholar
• Gutteridge JM. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 1995;41:1819-28
   PubMed Web of Science ®Google Scholar
• Widlansky ME, Gutterman DD. Regulation of endothelial function by mitochondrial reactive oxygen species. Antioxid Redox Signal 2011;15:1517-30
   PubMed Web of Science ®Google Scholar
• Ballinger SW, Patterson C, Knight-Lozano CA, et al. Mitochondrial integrity and function in atherogenesis. Circulation 2002;106:544-9
   PubMed Web of Science ®Google Scholar
• Singh U, Jialal I. Oxidative stress and atherosclerosis. Pathophysiology 2006;13:129-42
   PubMedGoogle Scholar
• Kowaltowski AJ, Vercesi AE. Mitochondrial damage induced by conditions of oxidative stress. Free Radic Biol Med 1999;26:463-71
   PubMed Web of Science ®Google Scholar
• Rocha M, Apostolova N, Herance JR, et al. Perspectives and potential applications of mitochondria-targeted antioxidants in cardiometabolic diseases and type 2 diabetes. Med Res Rev 2014;34:160-89
   PubMed Web of Science ®Google Scholar
• Victor VM. New insights into IR, cardiovascular diseases and oxidative stress: pathophysiological and clinical consequences. Curr Pharm Des 2013;19:5661-2
   PubMed Web of Science ®Google Scholar
• Kagan VE, Serbinova EA, Stoyanovsky DA, et al. Assay of ubiquinones and ubiquinols as antioxidants. Methods Enzymol 1994;234:343-54
   PubMed Web of Science ®Google Scholar
• Matsuda M, Shimomura I. Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Obes Res ClinPract 2013;7:e330-41
   PubMed Web of Science ®Google Scholar
• Karaouzene N, Merzouk H, Aribi M, et al. Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men. Nutr Metab Cardiovasc Dis 2011;21:792-9
   PubMed Web of Science ®Google Scholar
• Al-Aubaidy HA, Jelinek HF. Oxidative DNA damage and obesity in type 2 diabetes mellitus. Eur J Endocrinol 2011;164(6):899-904
   PubMed Web of Science ®Google Scholar
• Vincent HK, Innes KE, Vincent KR. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes Metab 2007;9(6):813-39
   PubMed Web of Science ®Google Scholar
• Tabur S, Torun AN, Sabuncu T, et al. Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation. Eur J Endocrinol 2010;162(3):535-41
   PubMed Web of Science ®Google Scholar
• Celik S, Tangi F, Kilicaslan E, et al. Increased acylation stimulating protein levels in young obese males is correlated with systemic markers of oxidative stress. Obesity (Silver Spring) 2013;21(8):1613-17
   PubMed Web of Science ®Google Scholar
• Il’yasova D, Wang F, Spasojevic I, et al. Urinary F2-isoprostanes, obesity, and weight gain in the IRAS cohort. Obesity (Silver Spring) 2012;20(9):1915-21
   PubMed Web of Science ®Google Scholar
• Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007;26:3100-12
   PubMed Web of Science ®Google Scholar
• Masuda K, Shima H, Watanabe M, Kikuchi K. MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein. J Biol Chem 2001;276:39002-11
   PubMed Web of Science ®Google Scholar
• Bloch-Damti A, Potashnik R, Gual P, et al. Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress. Diabetologia 2006;49:2463-73
   PubMed Web of Science ®Google Scholar
• Lee Y H, Giraud J, Davis R J, White MF. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem 2003;278:2896-902
   PubMed Web of Science ®Google Scholar
• Inoki K, Li Y, Zhu T, et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002;4:648-57
   PubMed Web of Science ®Google Scholar
• Wang Y, Inoue H, Ravnskjaer K, et al. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A 2010;107:3087-92
   PubMed Web of Science ®Google Scholar
• Yabe D, Brown MS, Goldstein JL. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A 2002;99:12753-8
   PubMed Web of Science ®Google Scholar
• Zhang K, Li L, Qi Y, et al. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 2012;153:631-46
   Google Scholar
• Guo S. Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J Endocrinol 2014;220:T1-T23
   PubMed Web of Science ®Google Scholar
• Lu M, Wan M, Leavens KF, et al. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med 2012;18:388-95
   PubMed Web of Science ®Google Scholar
• Evans-Anderson HJ, Alfieri CM, Yutzey KE. Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors. Circ Res 2008;102:686-94
   PubMed Web of Science ®Google Scholar
• Battiprolu PK, Hojayev B, Jiang N, et al. Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest 2012;122:1109-18
   PubMed Web of Science ®Google Scholar
• Li J, Sipple J, Maynard S, et al. Fanconi anemia links reactive oxygen species to IR and obesity. Antioxid Redox Signal 2012;17(8):1083-98
   PubMed Web of Science ®Google Scholar
• Scazzocchio B, Varì R, D’Archivio M, et al. Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases. J Lipid Res 2009;50(5):832-45
   PubMed Web of Science ®Google Scholar
• Olivares-Corichi IM, Viquez MJ, Gutierrez-Lopez L, et al. Oxidative stress present in the blood from obese patients modifies the structure and function of insulin. Horm Metab Res 2011;43(11):748-53
   PubMed Web of Science ®Google Scholar
• Hansel B, Giral P, Nobecourt E, et al. Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity. J Clin Endocrinol Metab 2004;89(10):4963-71
   PubMed Web of Science ®Google Scholar
• Tinahones FJ, Murri-Pierri M, Garrido-Sánchez L, et al. Oxidative stress in severely obese persons is greater in those with IR. Obesity (Silver Spring) 2009;17(2):240-6
   PubMed Web of Science ®Google Scholar
• Xu XJ, Gauthier MS, Hess DT, et al. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res 2012;53:792-801
   PubMed Web of Science ®Google Scholar
• Das SK, Sharma NK, Hasstedt SJ, et al. An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects. J Clin Endocrinol Metab 2011;96(8):E1308-13
   Web of Science ®Google Scholar
• Ost A, Svensson K, Ruishalme I, et al. Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol Med 2010;16(7-8):235-46
   PubMed Web of Science ®Google Scholar
• Hajjar DP, Gotto AM Jr. Biological relevance of inflammation and oxidative stress in the pathogenesis of arterial diseases. Am J Pathol 2013;82(5):1474-81
   Google Scholar
• Giordano A, Murano I, Mondini E, et al. Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis. J Lipid Res 2013;54(9):2423-36
   PubMed Web of Science ®Google Scholar
• Gage MC, Yuldasheva NY, Viswambharan H, et al. Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species. Atherosclerosis 2013;230:131-9
   PubMed Web of Science ®Google Scholar
• Du J, Fan LM, Mai A, Li JM. Crucial roles of Nox2-derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle-aged mice. Br J Pharmacol 2013;170(5):1064-77
   PubMed Web of Science ®Google Scholar
• Sukumar P, Kearney MT. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes 2013;62:2130-4
   PubMed Web of Science ®Google Scholar
• Gosmanov AR, Smiley DD, Robalino G, et al. Effects of oral and intravenous fat load on blood pressure, endothelial function, sympathetic activity, and oxidative stress in obese healthy subjects. Am J Physiol Endocrinol Metab 2010;299(6):E953-8
   Web of Science ®Google Scholar
• Greenstein AS, Khavandi K, Withers SB, et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 2009;119(12):1661-70
   PubMed Web of Science ®Google Scholar
• Miller-Kasprzak E, Bogdański P, Pupek-Musialik D, Jagodziński PP. IR and oxidative stress influence colony-forming unit-endothelial cells capacity in obese patients. Obesity (Silver Spring) 2011;19(4):736-42
   PubMed Web of Science ®Google Scholar
• Niemann B, Chen Y, Teschner M, et al. Obesity induces signs of premature cardiac aging in younger patients: the role of mitochondria. J Am Coll Cardiol 2011;57(5):577-85
   Google Scholar
• Handa P, Maliken BD, Nelson JE, et al. Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis. Hepatology 2013;60(1):133-45
   Web of Science ®Google Scholar
• Carazo A, León J, Casado J, et al. Hepatic expression of adiponectin receptors increases with non-alcoholic fatty liver disease progression in morbid obesity in correlation with glutathione peroxidase 1. Obes Surg 2011;21(4):492-500
   PubMed Web of Science ®Google Scholar
• Yokota T, Kinugawa S, Yamato M, et al. Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with metabolic syndrome. Diabetes Care 2013;36(5):1341-6
   PubMed Web of Science ®Google Scholar
• Boyle KE, Newsom SA, Janssen RC, et al. Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus. J Clin Endocrinol Metab 2013;98(10):E1601-9
   Web of Science ®Google Scholar
• Bravard A, Lefai E, Meugnier E, et al. FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Diabetes 2011;60(1):258-68
   PubMed Web of Science ®Google Scholar
• Aguer C, Pasqua M, Thrush AB, et al. Increased proton leak and SOD2 expression in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes. Biochim Biophys Acta 2013;1832(10):1624-33
   PubMed Web of Science ®Google Scholar
• Franko A, von Kleist-Retzow JC, Böse M, et al. Complete failure of insulin-transmitted signaling, but not obesity-induced IR, impairs respiratory chain function in muscle. J Mol Med (Berl) 2012;90(10):1145-60
   PubMed Web of Science ®Google Scholar
• Kleinridders A, Lauritzen HP, Ussar S, et al. Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. J Clin Invest 2013;123(11):4667-80
   PubMed Web of Science ®Google Scholar
• Cerveny KL, Tamura Y, Zhang Z, et al. Regulation of mitochondrial fusion and division. Trends Cell Biol 2007;17:563-9
   Google Scholar
• Ozcan U. Mitofusins: mighty regulators of metabolism. Cell 2013;155:17-18
   PubMed Web of Science ®Google Scholar
• Schneeberger M, Dietrich MO, Sebastian D, et al. Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell 2013;155(1):172-87
   PubMed Web of Science ®Google Scholar
• Dietrich MO, Liu ZW, Horvath TL. Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Cell 2013;155:188-99
   PubMed Web of Science ®Google Scholar
• Margaritis M, Channon KM, Antoniades C. Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering. Antioxid Redox Signal 2014;20:1198-215
   PubMed Web of Science ®Google Scholar
• Audikovszky M, Pados G, Seres I, et al. Orlistat increases serum paraoxonase activity in obese patients. Nutr Metab Cardiovasc Dis 2007;17(4):268-73
   PubMed Web of Science ®Google Scholar
• Scheffer PG, Schindhelm RK, van Verschuer VM, et al. No effect of atorvastatin and simvastatin on oxidative stress in patients at high risk for cardiovascular disease. Neth J Med 2013;71(7):359-65
   PubMed Web of Science ®Google Scholar
• Anand SS, Yusuf S, Vuksan V, et al. Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE). Lancet 2000;356:279-84
   PubMed Web of Science ®Google Scholar
• Murer SB, Aeberli I, Braegger CP, et al. Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents. J Nutr 2014;144(2):193-201
   PubMed Web of Science ®Google Scholar
• Gariballa S, Afandi B, Abuhaltem M, et al. Oxidative damage and inflammation in obese diabetic Emirati subjects supplemented with antioxidants and B-vitamins: a randomized placebo-controlled trail. Nutr Metab (Lond) 2013;10(1):21
   PubMedGoogle Scholar
• Chaves GV, Pereira SE, Saboya CJ, et al. Association between liver vitamin A reserves and severity of nonalcoholic fatty liver disease in the class III obese following bariatric surgery. Obes Surg 2014;24(2):219-24
   PubMed Web of Science ®Google Scholar
• Pacana T, Sanyal AJ. Vitamin E and nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care 2012;15(6):641-8
   PubMed Web of Science ®Google Scholar
• Zhou SS, Zhou Y. Excess vitamin intake: An unrecognized risk factor for obesity. World J Diabetes 2014;5(1):1-13
   PubMedGoogle Scholar
• Yan W, Li N, Hu X, et al. Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial. Int J Cardiol 2013;167(2):602-3
   PubMed Web of Science ®Google Scholar
• Cheng Z, Schmelz EM, Liu D, Hulver MW. Targeting mitochondrial alterations to prevent type 2 diabetes-Evidence from studies of dietary redox-active compounds. Mol Nutr Food Res 2014. [Epub ahead of print]
   Web of Science ®Google Scholar
• Suzuki K, Inoue T, Hioki R, et al. Association of abdominal obesity with decreased serum levels of carotenoids in a healthy Japanese population. Clin Nutr 2006;25:780-9
   PubMed Web of Science ®Google Scholar
• Ciccone MM, Cortese F, Gesualdo M, et al. Dietary intake of carotenoids and their antioxidant and anti-inflammatory effects in cardiovascular care. Mediators Inflamm 2013;782137
   PubMed Web of Science ®Google Scholar
• Hozawa A, Jacobs DR Jr, Steffes MW, et al. Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. J Hypertens 2009;27:237-42
   PubMed Web of Science ®Google Scholar
• Lin J, Cook NR, Albert C, et al. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst 2009;10:14-23
   Google Scholar
• Valero MA, Vidal A, Burgos R, et al. Meta-analysis on the role of lycopene in type 2 diabetes mellitus. Nutr Hosp 2011;26:1236-41
   PubMed Web of Science ®Google Scholar
• Hollman PC, Cassidy A, Comte B, et al. The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established. J Nutr 2011;141:S989-S1009
   PubMed Web of Science ®Google Scholar
• Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-42
   PubMed Web of Science ®Google Scholar
• De Groote D, van Belleghem K, Devière J, et al. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects. Ann Nutr Metab 2012;61:15-24
   PubMed Web of Science ®Google Scholar
• Brown VA, Patel KR, Viskaduraki M, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res 2010;70:9003-11
   PubMed Web of Science ®Google Scholar
• Rogers C, Davis B, Neufer PD, et al. A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids. Free Radic Biol Med 2014;67:330-41
   PubMed Web of Science ®Google Scholar
• Crujeiras AB, Parra D, Goyenechea E, Martínez JA. Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction. Eur J Clin Invest 2008;38(9):672-8
   PubMed Web of Science ®Google Scholar
• Gutierrez L, García JR, Rincon MD, et al. Effect of a hypocaloric diet in the oxidative stress in obese subjects without prescription of exercise and antioxidants. Med Clin (Barc) 2014. [ Epub ahead of print]
   Web of Science ®Google Scholar
• Krzystek-Korpacka M, Patryn E, Boehm D, et al. Advanced oxidation protein products (AOPPs) in juvenile overweight and obesity prior to and following weight reduction. Clin Biochem 2008;41(12):943-9
   PubMed Web of Science ®Google Scholar
• Stancliffe RA, Thorpe T, Zemel MB. Dairy attentuates oxidative and inflammatory stress in metabolic syndrome. Am J Clin Nutr 2011;94(2):422-30
   PubMed Web of Science ®Google Scholar
• Oh S, Tanaka K, Warabi E, Shoda J. Exercise reduces inflammation and oxidative stress in obesity-related liver diseases. Med Sci Sports Exerc 2013;45(12):2214-22
   PubMed Web of Science ®Google Scholar
• Boesing F, Moreira EA, Wilhelm-Filho D, et al. Roux-en-Y bypass gastroplasty: markers of oxidative stress 6 months after surgery. Obes Surg 2010;20(9):1236-44
   PubMed Web of Science ®Google Scholar
• Dadalt C, Fagundes RL, Moreira EA, et al. Oxidative stress markers in adults 2 years after Roux-en-Y gastric bypass. Eur J Gastroenterol Hepatol 2013;25(5):580-6
   PubMed Web of Science ®Google Scholar
• Melissas J, Malliaraki N, Papadakis JA, et al. Plasma antioxidant capacity in morbidly obese patients before and after weight loss. Obes Surg 2006;16(3):314-20
   PubMed Web of Science ®Google Scholar
• WHO: facts and figures. The challenge of obesity—quick statistics. Available from: www.euro.who.int/en/what-we-do/health-topics/noncommunicable-diseases/obesity/factsand-figures [Last accessed 12 February 2013]
   Google Scholar
• Maric-Bilkan C. Obesity and diabetic kidney disease. Med Clin North Am 2013;97:59-74
   PubMed Web of Science ®Google Scholar
• Curti ML, Jacob P, Borges MC, et al. Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach. J Obes 2011;2011:497401
   PubMedGoogle Scholar
• Pendyala S, Neff LM, Suarez-Fariñas M, Holt PR. Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis. Am J Clin Nutr 2011;93(2):234-42
   PubMed Web of Science ®Google Scholar
• Estadella D, da Penha Oller do Nascimento CM, Oyama LM, et al. Lipotoxicity: effects of dietary saturated and transfatty acids. Mediators Inflamm 2013;2013:137579
   PubMed Web of Science ®Google Scholar
• Greenlee H. Natural products for cancer prevention. Semin Oncol Nurs 2012;28(1):29-44
   PubMedGoogle Scholar
• Sesso HD, Buring JE, Christen WG, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians’ Health Study II randomized controlled trial. JAMA 2008;300(18):2123-33
   PubMed Web of Science ®Google Scholar
• Smith RA, Murphy MP. Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci 2010;1201:96-103
   PubMed Web of Science ®Google Scholar