Therapeutic potential of miRNAs in diabetes mellitus

References

• Danaei G, Finucane MM, Lu Y, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 2011;378(9785):31-40
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116(2):281-97
   PubMed Web of Science ®Google Scholar
• Wilczynska A, Bushell M. The complexity of miRNA-mediated repression. Cell Death Differ 2014. [Epub ahead of print]
   PubMedGoogle Scholar
• Doench JG,Sharp PA. Specificity of microRNA target selection in translational repression. Genes Dev 2004;18(5):504-11
   PubMed Web of Science ®Google Scholar
• Guay C, Roggli E, Nesca V, et al. Diabetes mellitus, a microRNA-related disease? Transl Res 2011;157(4):253-64
   PubMed Web of Science ®Google Scholar
• Poy MN, Eliasson L, Krutzfeldt J, et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature 2004;432(7014):226-30
   PubMed Web of Science ®Google Scholar
• Joglekar MV, Joglekar VM, Hardikar AA. Expression of islet-specific microRNAs during human pancreatic development. Gene Expr Patterns 2009;9(2):109-13
   PubMedGoogle Scholar
• Lynn FC, Skewes-Cox P, Kosaka Y, et al. MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes 2007;56(12):2938-45
   PubMed Web of Science ®Google Scholar
• Joglekar MV, Parekh VS, Mehta S, et al. MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3. Dev Biol 2007;311(2):603-12
   PubMedGoogle Scholar
• Baroukh N, Ravier MA, Loder MK, et al. MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines. J Biol Chem 2007;282(27):19575-88
   PubMed Web of Science ®Google Scholar
• Correa-Medina M, Bravo-Egana V, Rosero S, et al. MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas. Gene Expr Patterns 2009;9(4):193-9
   PubMed Web of Science ®Google Scholar
• Kloosterman WP, Lagendijk AK, Ketting RF, et al. Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biol 2007;5(8):e203
   PubMed Web of Science ®Google Scholar
• Plaisance V, Abderrahmani A, Perret-Menoud V, et al. MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. J Biol Chem 2006;281(37):26932-42
   PubMed Web of Science ®Google Scholar
• Cheng LC, Pastrana E, Tavazoie M, et al. miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci 2009;12(4):399-408
   PubMed Web of Science ®Google Scholar
• Melkman-Zehavi T, Oren R, Kredo-Russo S, et al. miRNAs control insulin content in pancreatic beta-cells via downregulation of transcriptional repressors. EMBO J 2011;30(5):835-45
   PubMed Web of Science ®Google Scholar
• Latreille M, Hausser J, Stützer I, et al. MicroRNA-7a regulates pancreatic beta cell function. J Clin Invest 2014;124(6):2722-35
   PubMed Web of Science ®Google Scholar
• Roggli E, Britan A, Gattesco S, et al. Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes 2010;59(4):978-86
   PubMed Web of Science ®Google Scholar
• Roggli E, Gattesco S, Caille D, et al. Changes in microRNA expression contribute to pancreatic beta-cell dysfunction in prediabetic NOD mice. Diabetes 2012;61(7):1742-51
   PubMed Web of Science ®Google Scholar
• Hezova R, Slaby O, Faltejskova P, et al. microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients. Cell Immunol 2010;260(2):70-4
   PubMed Web of Science ®Google Scholar
• Rees DA, Alcolado JC. Animal models of diabetes mellitus. Diabet Med 2005;22(4):359-70
   PubMed Web of Science ®Google Scholar
• Lovis P, Roggli E, Laybutt DR, et al. Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes 2008;57(10):2728-36
   PubMed Web of Science ®Google Scholar
• Nesca V, Guay C, Jacovetti C, et al. Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes. Diabetologia 2013;56(10):2203-12
   PubMed Web of Science ®Google Scholar
• Esguerra JL, Bolmeson C, Cilio CM, et al. Differential glucose-regulation of microRNAs in pancreatic islets of non-obese type 2 diabetes model Goto-Kakizaki rat. PLoS One 2011;6(4):e18613
   PubMed Web of Science ®Google Scholar
• Jacovetti C, Abderrahmani A, Parnaud G, et al. MicroRNAs contribute to compensatory beta cell expansion during pregnancy and obesity. J Clin Invest 2012;122(10):3541-51
   PubMed Web of Science ®Google Scholar
• Tattikota SG, Rathjen T, McAnulty SJ, et al. Argonaute2 mediates compensatory expansion of the pancreatic beta cell. Cell Metab 2014;19(1):122-34
   PubMed Web of Science ®Google Scholar
• Locke JM, da Silva Xavier G, Dawe HR, et al. Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion. Diabetologia 2014;57(1):122-8
   PubMed Web of Science ®Google Scholar
• Kameswaran V, Bramswig NC, McKenna LB, et al. Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets. Cell Metab 2014;19(1):135-45
   PubMed Web of Science ®Google Scholar
• Kornfeld JW, Baitzel C, Könner AC, et al. Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature 2013;494(7435):111-15
   PubMed Web of Science ®Google Scholar
• Trajkovski M, Hausser J, Soutschek J, et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 2011;474(7353):649-53
   PubMed Web of Science ®Google Scholar
• Herrera BM, Lockstone HE, Taylor JM, et al. Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes. Diabetologia 2010;53(6):1099-109
   PubMed Web of Science ®Google Scholar
• Granjon A, Gustin MP, Rieusset J, et al. The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway. Diabetes 2009;58(11):2555-64
   PubMed Web of Science ®Google Scholar
• Sayer AA, Dennison EM, Syddall HE, et al. Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? Diabetes Care 2005;28(10):2541-2
   PubMed Web of Science ®Google Scholar
• Gallagher IJ, Scheele C, Keller P, et al. Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Med 2010;2(2):9
   PubMedGoogle Scholar
• Liu N, Williams AH, Kim Y, et al. An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci USA 2007;104(52):20844-9
   PubMedGoogle Scholar
• Kato M, Putta S, Wang M, et al. TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol 2009;11(7):881-9
   PubMed Web of Science ®Google Scholar
• Long J, Wang Y, Wang W, et al. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Biol Chem 2010;285(30):23457-65
   PubMed Web of Science ®Google Scholar
• Kovacs B, Lumayag S, Cowan C, et al. MicroRNAs in early diabetic retinopathy in streptozotocin-induced diabetic rats. Invest Ophthalmol Vis Sci 2011;52(7):4402-9
   PubMed Web of Science ®Google Scholar
• Xiao J, Luo X, Lin H, et al. MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. J Biol Chem 2007;282(17):12363-7
   PubMedGoogle Scholar
• Chen JF, Callis TE, Wang DZ. microRNAs and muscle disorders. J Cell Sci 2009;122(Pt 1):13-20
   PubMedGoogle Scholar
• Khazaie Y, Nasr Esfahani MH. MicroRNA and Male Infertility: a Potential for Diagnosis. Int J Fertil Steril 2014;8(2):113-18
   PubMedGoogle Scholar
• Batkai S, Thum T. Analytical approaches in microRNA therapeutics. J Chromatogr B Analyt Technol Biomed Life Sci 2014;964:146-52
   PubMedGoogle Scholar
• Zeng L, Cui J, Wu H, et al. The emerging role of circulating microRNAs as biomarkers in autoimmune diseases. Autoimmunity 2014;1-11
   PubMedGoogle Scholar
• Farid WR, Verhoeven CJ, de Jonge J, et al. The Ins and Outs of MicroRNAs as Biomarkers in Liver Disease and Transplantation. Transpl Int 2014;27(12):1222-32
   PubMedGoogle Scholar
• Allegra A, Alonci A, Campo S, et al. Circulating microRNAs: new biomarkers in diagnosis, prognosis and treatment of cancer (review). Int J Oncol 2012;41(6):1897-912
   PubMed Web of Science ®Google Scholar
• Olivieri F, Rippo MR, Procopio AD, et al. Circulating inflamma-miRs in aging and age-related diseases. Front Genet 2013;4:121
   PubMedGoogle Scholar
• Zampetaki A, Kiechl S, Drozdov I, et al. Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circ Res 2010;107(6):810-17
   PubMed Web of Science ®Google Scholar
• Creemers EE, Tijsen AJ, Pinto YM. Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? Circ Res 2012;110(3):483-95
   PubMed Web of Science ®Google Scholar
• Boon RA, Vickers KC. Intercellular transport of microRNAs. Arterioscler Thromb Vasc Biol 2013;33(2):186-92
   PubMed Web of Science ®Google Scholar
• Vickers KC, Palmisano BT, Shoucri BM, et al. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 2011;13(4):423-33
   PubMed Web of Science ®Google Scholar
• Chen TS, et al. Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs. Nucleic Acids Res 2010;38(1):215-24
   PubMed Web of Science ®Google Scholar
• Valadi H, Ekström K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007;9(6):654-9
   PubMed Web of Science ®Google Scholar
• Hunter MP, Ismail N, Zhang X, et al. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 2008;3(11):e3694
   PubMed Web of Science ®Google Scholar
• Grasso M, Piscopo P, Confaloni A, et al. Circulating miRNAs as biomarkers for neurodegenerative disorders. Molecules 2014;19(5):6891-910
   PubMed Web of Science ®Google Scholar
• Zernecke A, Bidzhekov K, Noels H, et al. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal 2009;2(100):ra81
   PubMed Web of Science ®Google Scholar
• Wang K, Zhang S, Weber J, et al. Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res 2010;38(20):7248-59
   PubMed Web of Science ®Google Scholar
• Zen K, Zhang CY. Circulating microRNAs: a novel class of biomarkers to diagnose and monitor human cancers. Med Res Rev 2012;32(2):326-48
   PubMed Web of Science ®Google Scholar
• Bala S, Petrasek J, Mundkur S, et al. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology 2012;56(5):1946-57
   PubMed Web of Science ®Google Scholar
• Guay C, Regazzi R. Circulating microRNAs as novel biomarkers for diabetes mellitus. Nat Rev Endocrinol 2013;9(9):513-21
   PubMed Web of Science ®Google Scholar
• Chevillet JR, Lee I, Briggs HA, et al. Issues and prospects of microRNA-based biomarkers in blood and other body fluids. Molecules 2014;19(5):6080-105
   PubMedGoogle Scholar
• Morello M, Minciacchi VR, de Candia P, et al. Large oncosomes mediate intercellular transfer of functional microRNA. Cell Cycle 2013;12(22):3526-36
   PubMed Web of Science ®Google Scholar
• Stoorvogel W. Functional transfer of microRNA by exosomes. Blood 2012;119(3):646-8
   PubMed Web of Science ®Google Scholar
• Rottiers V, Naar AM. MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol 2012;13(4):239-50
   PubMed Web of Science ®Google Scholar
• Kosaka N, Iguchi H, Yoshioka Y, et al. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 2010;285(23):17442-52
   PubMed Web of Science ®Google Scholar
• Zhang L, Hou D, Chen X, et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res 2012;22(1):107-26
   PubMed Web of Science ®Google Scholar
• Wang K, Yuan Y, Cho JH, et al. Comparing the MicroRNA spectrum between serum and plasma. PLoS One 2012;7(7):e41561
   PubMed Web of Science ®Google Scholar
• Yang Z, Chen H, Si H, et al. Serum miR-23a, a potential biomarker for diagnosis of pre-diabetes and type 2 diabetes. Acta Diabetol 2014;51(5):823-31
   PubMed Web of Science ®Google Scholar
• Erener S, Mojibian M, Fox JK, et al. Circulating miR-375 as a biomarker of beta-cell death and diabetes in mice. Endocrinology 2013;154(2):603-8
   PubMedGoogle Scholar
• Zhao C, Dong J, Jiang T, et al. Early second-trimester serum miRNA profiling predicts gestational diabetes mellitus. PLoS One 2011;6(8):e23925
   PubMed Web of Science ®Google Scholar
• Collares CV, Evangelista AF, Xavier DJ, et al. Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients. BMC Res Note 2013;6:491
   PubMedGoogle Scholar
• Gwak JM, Kim HJ, Kim EJ, et al. MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer. Breast Cancer Res Treat 2014;147(1):39-49
   PubMed Web of Science ®Google Scholar
• Lee HM, Nguyen DT, Lu LF. Progress and challenge of microRNA research in immunity. Front Genet 2014;5:178
   PubMed Web of Science ®Google Scholar
• Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008;18(10):997-1006
   PubMed Web of Science ®Google Scholar
• Leidinger P, Backes C, Meder B, et al. The human miRNA repertoire of different blood compounds. BMC Genomics 2014;15:474
   PubMed Web of Science ®Google Scholar
• MacLellan SA, MacAulay C, Lam S, et al. Pre-profiling factors influencing serum microRNA levels. BMC Clin Pathol 2014;14:27
   PubMedGoogle Scholar
• Zhang T, Lv C, Li L, et al. Plasma miR-126 is a potential biomarker for early prediction of type 2 diabetes mellitus in susceptible individuals. Biomed Res Int 2013;2013:761617
   PubMed Web of Science ®Google Scholar
• McClelland A, Hagiwara S, Kantharidis P. Where are we in diabetic nephropathy: microRNAs and biomarkers? Curr Opin Nephrol Hypertens 2014;23(1):80-6
   PubMed Web of Science ®Google Scholar
• Mao Y, Mohan R, Zhang S, et al. MicroRNAs as pharmacological targets in diabetes. Pharmacol Res 2013;75:37-47
   PubMedGoogle Scholar
• Li Z, Rana TM. Therapeutic targeting of microRNAs: current status and future challenges. Nat Rev Drug Discov 2014;13(8):622-38
   PubMed Web of Science ®Google Scholar
• Bennett CF, Swayze EE. RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu Rev Pharmacol Toxicol 2010;50:259-93
   PubMed Web of Science ®Google Scholar
• Bumcrot D, Manoharan M, Koteliansky V, et al. RNAi therapeutics: a potential new class of pharmaceutical drugs. Nat Chem Biol 2006;2(12):711-19
   PubMed Web of Science ®Google Scholar
• Thomson DW, Bracken CP, Goodall GJ. Experimental strategies for microRNA target identification. Nucleic Acids Res 2011;39(16):6845-53
   PubMed Web of Science ®Google Scholar
• Broderick JA, Zamore PD. MicroRNA therapeutics. Gene Ther 2011;18(12):1104-10
   PubMed Web of Science ®Google Scholar
• Wang Z, Rao DD, Senzer N, et al. RNA interference and cancer therapy. Pharm Res 2011;28(12):2983-95
   PubMed Web of Science ®Google Scholar
• Jimenez V, Ayuso E, Mallol C, et al. In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9. Diabetologia 2011;54(5):1075-86
   PubMed Web of Science ®Google Scholar
• Kota J, Chivukula RR, O’Donnell KA, et al. Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model. Cell 2009;137(6):1005-17
   PubMed Web of Science ®Google Scholar
• Vester B, Wengel J. LNA (locked nucleic acid): high-affinity targeting of complementary RNA and Biochemistry DNA. 2004;43(42):13233-41
   Google Scholar
• Orom UA, Kauppinen S, Lund AH. LNA-modified oligonucleotides mediate specific inhibition of microRNA function. Gene 2006;372:137-41
   PubMed Web of Science ®Google Scholar
• Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with ‘antagomirs’. Nature 2005;438(7068):685-9
   PubMed Web of Science ®Google Scholar
• Obad S, dos Santos CO, Petri A, et al. Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet 2011;43(4):371-8
   PubMed Web of Science ®Google Scholar
• Wang Y, Liu J, Liu C, et al. MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic beta-cells. Diabetes 2013;62(3):887-95
   PubMed Web of Science ®Google Scholar
• Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature 2013;495(7441):384-8
   PubMed Web of Science ®Google Scholar
• Esau C, Davis S, Murray SF, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006;3(2):87-98
   PubMed Web of Science ®Google Scholar
• Jopling CL, Yi M, Lancaster AM, et al. Modulation of hepatitis C virus RNA abundance by a liver-specific Micro RNA. Science 2005;309(5740):1577-81
   PubMed Web of Science ®Google Scholar
• Jopling CL, Norman KL, Sarnow P. Positive and negative modulation of viral and cellular mRNAs by liver-specific microRNA miR-122. Cold Spring Harb Symp Quant Biol 2006;71:369-76
   PubMedGoogle Scholar
• Elmen J, Lindow M, Schütz S, et al. LNA-mediated microRNA silencing in non-human primates. Nature 2008;452(7189):896-9
   PubMed Web of Science ®Google Scholar
• Hildebrandt-Eriksen ES, Aarup V, Persson R, et al. A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys. Nucleic Acid Ther 2012;22(3):152-61
   PubMed Web of Science ®Google Scholar
• Lanford RE, Hildebrandt-Eriksen ES, Petri A, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010;327(5962):198-201
   PubMed Web of Science ®Google Scholar
• Lindow M, Kauppinen S. Discovering the first microRNA-targeted drug. J Cell Biol 2012;199(3):407-12
   PubMed Web of Science ®Google Scholar
• Janssen HL, Reesink HW, Lawitz EJ, et al. Treatment of HCV infection by targeting microRNA. N Engl J Med 2013;368(18):1685-94
   PubMed Web of Science ®Google Scholar
• Frost RJ, Olson EN. Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci USA 2011;108(52):21075-80
   PubMed Web of Science ®Google Scholar
• Kent OA, Mendell JT. A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes. Oncogene 2006;25(46):6188-96
   PubMed Web of Science ®Google Scholar
• van Rooij E, Purcell AL, Levin AA. Developing microRNA therapeutics. Circ Res 2012;110(3):496-507
   PubMed Web of Science ®Google Scholar
• Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 2007;4(9):721-6
   PubMed Web of Science ®Google Scholar
• Xie J, Ameres SL, Friedline R, et al. Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods 2012;9(4):403-9
   PubMedGoogle Scholar
• Lino Cardenas CL, Henaoui IS, Courcot E, et al. miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1. PLoS Genet 2013;9(2):e1003291
   PubMed Web of Science ®Google Scholar
• Bian S, Hong J, Li Q, et al. MicroRNA cluster miR-17-92 regulates neural stem cell expansion and transition to intermediate progenitors in the developing mouse neocortex. Cell Rep 2013;3(5):1398-406
   PubMed Web of Science ®Google Scholar
• Kato M, Arce L, Wang M, et al. A microRNA circuit mediates transforming growth factor-beta1 autoregulation in renal glomerular mesangial cells. Kidney Int 2011;80(4):358-68
   PubMed Web of Science ®Google Scholar
• Putta S, Lanting L, Sun G, et al. Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy. J Am Soc Nephrol 2012;23(3):458-69
   PubMed Web of Science ®Google Scholar
• Zhou Q, Gallagher R, Ufret-Vincenty R, et al. Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23∼27∼24 clusters. Proc Natl Acad Sci USA 2011;108(20):8287-92
   PubMed Web of Science ®Google Scholar
• Montgomery RL, Hullinger TG, Semus HM, et al. Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure. Circulation 2011;124(14):1537-47
   PubMed Web of Science ®Google Scholar
• Grueter CE, van Rooij E, Johnson BA, et al. A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell 2012;149(3):671-83
   PubMed Web of Science ®Google Scholar
• Chau BN, Xin C, Hartner J, et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med 2012;4(121):121ra18
   PubMed Web of Science ®Google Scholar