Is hyperhomocysteinemia a risk factor for osteoporosis?

References

• Gerritson T, Vaughn JG, Waisman HA. The identification of homocystine in the urine. Biochem. Biophys. Res. Commun.9, 493–496 (1962).
   Google Scholar
• Mudd SH, Finkelstein JD, Irreverre F, Laster L. Homocystinuria: an enzymatic defect. Science143, 1443–1445 (1964).
   PubMed Web of Science ®Google Scholar
• McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am. J. Pathol.56, 111–128 (1969).
   PubMed Web of Science ®Google Scholar
• McKusick VA. Heritable Disorders of Connective Tissue. CV Mosby, MO, USA 155 (1966).
   Google Scholar
• Carson NAJ, Neill DW. Metabolic abnormalities detected in a survey of mentally backward individuals in Northern Ireland. Arch. Dis. Child.37, 505–513 (1962).
   PubMed Web of Science ®Google Scholar
• Parrot F, Redonnet-Vernhet I, Lacombe D, Gin H. Osteoporosis in late-diagnosed adult homocystinuric patients. J. Inherit. Metab. Dis.23, 338–340 (2000).
   Google Scholar
• van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM et al. Homocysteine levels and the risk of osteoporotic fracture. N. Engl. J. Med.350, 2033–2041 (2004).
   PubMed Web of Science ®Google Scholar
• McLean RR, Jacques PF, Selhub J et al. Homocysteine as a predictive factor for hip fracture in older persons. N. Engl. J. Med.350, 2042–2049 (2004).
   PubMed Web of Science ®Google Scholar
• Goerss JB, Kim CH, Atkinson EJ, Eastell R, O’Fallon WM, Melton LJ 3rd. Risk of fractures in patients with pernicious anemia. J. Bone Miner. Res.7, 573–579 (1992).
   PubMed Web of Science ®Google Scholar
• Herrmann M, Kraenzlin M, Pape G, Sand-Hill M, Herrmann W. Relation between homocysteine and biochemical bone turnover markers and bone mineral density in peri- and post-menopausal women. Clin. Chem. Lab. Med.43, 1118–1123 (2005).
   PubMedGoogle Scholar
• Brown JP, Josse RG. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ167, S1–S34 (2002).
   PubMed Web of Science ®Google Scholar
• Cagnacci A, Baldassari F, Rivolta G, Arangino S, Volpe A. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women. Bone33, 956–959 (2003).
   PubMedGoogle Scholar
• Golbahar J, Hamidi A, Aminzadeh MA, Omrani GR. Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study. Bone35, 760–765 (2004).
   PubMedGoogle Scholar
• Small RE. Uses and limitations of bone mineral density measurements in the management of osteoporosis. Med. Gen. Med.7, 3 (2005).
   PubMedGoogle Scholar
• Briot K, Roux C. What is the role of DXA, QUS and bone markers in fracture prediction, treatment allocation and monitoring? Best. Pract. Res. Clin. Rheumatol.19, 951–964 (2005).
   PubMed Web of Science ®Google Scholar
• Dhonukshe-Rutten RA, Pluijm SM, de Groot LC, Lips P, Smit JH, van Staveren WA. Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J. Bone Miner. Res.20, 921–929 (2005).
   PubMedGoogle Scholar
• Bode MK, Laitinen P, Risteli J, Uusimaa P, Juvonen T. Atherosclerosis, type 1 collagen cross-linking and homocysteine. Atherosclerosis152, 531–532 (2000).
   PubMedGoogle Scholar
• Gerdhem P, Ivaska KK, Isaksson A et al. Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women. J. Bone Miner. Res.22, 127–134 (2007).
   Google Scholar
• Nilsson K, Gustafson L, Isaksson A, Hultberg B. Plasma homocysteine and markers of bone metabolism in psychogeriatric patients. Scand. J. Clin. Lab. Invest.65, 671–680 (2005).
   Google Scholar
• Abrahamsen B, Jorgensen HL, Nielsen TL et al. MTHFR c.677C>T polymorphism as an independent predictor of peak bone mass in Danish men – results from the Odense Androgen Study. Bone38, 215–219 (2006).
   PubMed Web of Science ®Google Scholar
• Perier MA, Gineyts E, Munoz F, Sornay-Rendu E, Delmas PD. Homocysteine and fracture risk in postmenopausal women: the OFELY study. Osteoporos. Int.18, 1329–1336 (2007).
   Web of Science ®Google Scholar
• Kuriyama M, Ueno K, Uno H et al. Clinical evaluation of serum prostate-specific antigen-α1-antichymotrypsin complex values in diagnosis of prostate cancer: a cooperative study. Int. J. Urol.5, 48–54 (1998).
   PubMedGoogle Scholar
• Green TJ, McMahon JA, Skeaff CM, Williams SM, Whiting SJ. Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial. Am. J. Clin. Nutr.85, 460–464 (2007).
   PubMed Web of Science ®Google Scholar
• Herrmann M, Stanger O, Paulweber B, Hufnagl C, Herrmann W. Folate supplementation does not affect biochemical markers of bone turnover. Clin. Lab.52, 131–136 (2006).
   PubMed Web of Science ®Google Scholar
• Herrmann M, Umanskaya N, Traber L et al. The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients – an one year double blind placebo controlled trial. Clin. Chem. Lab. Med.45, 1785–1792 (2007).
   PubMed Web of Science ®Google Scholar
• Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K. Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA293, 1082–1088 (2005).
   PubMed Web of Science ®Google Scholar
• Ozdem S, Samanci N, Tasatargil A et al. Experimental hyperhomocysteinemia disturbs bone metabolism in rats. Scand. J. Clin. Lab. Invest.67, 748–756 (2007).
   PubMed Web of Science ®Google Scholar
• Herrmann M, Wildemann B, Claes L et al. Experimental hyperhomocysteinemia reduces bone quality in rats. Clin. Chem.53, 1455–1461 (2007).
   Google Scholar
• Carmel R, Lau KH, Baylink DJ, Saxena S, Singer FR. Cobalamin and osteoblast-specific proteins. N. Engl. J. Med.319, 70–75 (1988).
   PubMedGoogle Scholar
• Kim GS, Kim CH, Park JY, Lee KU, Park CS. Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells. Metabolism45, 1443–1446 (1996).
   PubMed Web of Science ®Google Scholar
• Herrmann M, Widmann T, Colaianni G, Colucci S, Zallone A, Herrmann W. Increased osteoclast activity in the presence of increased homocysteine concentrations. Clin. Chem.51, 2348–2353 (2005).
   PubMed Web of Science ®Google Scholar
• Koh JM, Lee YS, Kim YS et al. Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation. J. Bone Miner. Res.21, 1003–1011 (2006).
   PubMed Web of Science ®Google Scholar
• Herrmann M, Schmidt J, Umanskaya N et al. Stimulation of osteoclast activity by low B-vitamin concentrations. Bone41, 581–592 (2007).
   Google Scholar