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Editorial

Role of testosterone in older men: recent advances and future directions

Pages 415-418 | Published online: 10 Jan 2014

References

  • Moffat SD, Zonderman AB, Metter EJ, Blackman MR, Harman SM, Resnick SM. Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J. Clin. Endocrinol. Metab.87(11), 5001–5007 (2002).
  • Muller M, Grobbee DE, den Tonkelaar I, Lamberts SWJ, van der Schouw YT. Endogenous sex hormones and metabolic syndrome in aging men. J. Clin. Endocrinol. Metab.90(5), 2618–2623 (2005).
  • Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of Type 2 diabetes. JAMA295(11), 1288–1299 (2006).
  • Baumgartner RN, Waters DL, Gallagher D, Morley JE, Garry PJ. Predictors of skeletal muscle mass in elderly men and women. Mech. Ageing Dev.107(2), 123–136 (1999).
  • Fink HA, Ewing SK, Ensrud KE et al. Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older men. J. Clin. Endocrinol. Metab.91(10), 3908–3915 (2006).
  • Khaw K-T, Dowsett M, Folkerd E et al. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men. Circulation116(23), 2694–2701 (2007).
  • Laughlin GA, Barrett-Connor E, Bergstrom J. Low serum testosterone and mortality in older men. J. Clin. Endocrinol. Metab.93(1), 68–75 (2008).
  • Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr. Rev.26(6), 833–876 (2005).
  • Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J. Clin. Endocrinol. Metab.86(2), 724–731 (2001).
  • Feldman HA, Longcope C, Derby CA et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J. Clin. Endocrinol. Metab.87(2), 589–598 (2002).
  • Araujo AB, Esche GR, Kupelian V et al. Prevalence of symptomatic androgen deficiency in men. J. Clin. Endocrinol. Metab.92(11), 4241–4247 (2007).
  • Orwoll E, Lambert LC, Marshall LM et al. Testosterone and estradiol in older men. J. Clin. Endocrinol. Metab.91(4), 1336–1344 (2006).
  • Yeap BB, Almeida OP, Hyde Z et al. In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health In Men Study. Eur. J. Endocrinol.156(5), 585–594 (2007).
  • Morley JE, Kaiser FE, Perry HM et al. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism46(4), 410–413 (1997).
  • Yeap BB, Almeida OP, Hyde Z et al. Higher serum free testosterone is associated with better cognitive function in older men, whilst total testosterone is not. The Health In Men Study. Clin. Endocrinol.68(3), 404–412 (2008).
  • Almeida OP, Yeap BB, Hankey GJ, Jamrozik K, Flicker L. Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch. Gen. Psych.65(3), 283–289 (2008).
  • Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB. Low SHBG, total testosterone, and symptomatic androgen deficiency are associated with development of metabolic syndrome in non-obese men. J. Clin. Endocrinol. Metab.91(3), 843–850 (2006).
  • Chubb SAP, Hyde Z, Almeida OP et al. Lower sex hormone binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men. The Health In Men Study. Eur. J. Endocrinol.158(6), 785–792 (2008).
  • Haffner SM, Laakso M, Miettinen H, Mykkanen L, Karhapaa P, Rainwater DL. Low levels of sex hormone-binding globulin and testosterone are associated with smaller, denser low density lipoprotein in normoglycemic men. J. Clin. Endocrinol. Metab.81(10), 3697–3701 (1996).
  • Kalme T, Seppälä M, Qiao Q et al. Sex hormone-binding globulin and insulin-like growth factor-binding protein-1 as indicators of metabolic syndrome, cardiovascular risk, and mortality in elderly men. J. Clin. Endocrinol. Metab.90(3), 1550–1556 (2005).
  • Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J. Clin. Endocrinol. Metab.84(10), 3666–3672 (1999).
  • Ly LP, Handelsman DJ. Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays. Eur. J. Endocrinol.152(3), 471–478 (2005).
  • Handelsman DJ. Update in andrology. J. Clin. Endocrinol. Metab.92(12), 4505–4511 (2007).
  • Hammes A, Andreassen TK, Spoelgen R et al. Role of endocytosis in cellular uptake of sex steroids. Cell122(5), 751–762 (2005).
  • Hryb DJ, Nakla AM, Kahn SM et al. Sex hormone-binding globulin in the human prostate is locally synthesized and may act as an autocrine/paracrine effector. J. Biol. Chem.277(29), 26618–26622 (2002).
  • Nieschlag E. Testosterone treatment comes of age: new options for hypogonadal men. Clin. Endocrinol.65(3), 275–281 (2006).
  • Institute of Medicine. Testosterone and Aging: Clinical Research Directions. Liverman CT, Blazer DG (Eds). The National Academies Press, Washington, DC, USA (2004).
  • Isidori AM, Giannetta E, Greco EA et al. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin. Endocrinol.63(3), 280–293 (2005).
  • Emmelot-Vonk MH, Verhaar HJJ, Nakhai Pour HR et al. Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men. JAMA299(1), 39–52 (2008).
  • Rhoden EL, Morgentaler A. Risks of testosterone replacement therapy and recommendations for monitoring. N. Engl. J. Med.350(5), 482–492 (2004).
  • Gao W, Dalton JT. Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs). Drug Discov. Today12(5–6), 241–248 (2007).
  • Handelsman DJ, Zajac JD. Androgen deficiency and replacement therapy in men. Med. J. Aust.180(10), 529–535 (2004).
  • Nieschlag E, Swerdloff R, Behre HM et al. Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. J. Androl.27(2), 135–137 (2006).
  • Bhasin S, Cunningham GR, Hayes FJ et al. Testosterone therapy in adult men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab.91(6), 1995–2010 (2006).
  • Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H. Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society Position Statement. J. Clin. Endocrinol. Metab.92(2), 405–413 (2007).
  • Travison TG, Araujo AB, O’Donnell AB, Kupelian V, McKinlay JB. A population-level decline in serum testosterone levels in American men. J. Clin. Endocrinol. Metab.92(1), 196–202 (2007).
  • Andersson AM, Jensen TK, Juul A, Petersen JH, Jorgensen T, Skakkebaek NE. Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys. J. Clin. Endocrinol. Metab.92(12), 4696–4705 (2007).
  • Mohr BA, Bhasin S, O’Donnell AB, McKinlay JB. The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. Eur. J. Endocrinol.155(3), 443–452 (2006).
  • Travison TG, Araujo AB, Kupelian V, O’Donnell AB, McKinlay JB. The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. J. Clin. Endocrinol. Metab.92(2), 549–555 (2007).
  • Muller M, den Tonkelaar I, Thijssen JHH, Grobbee DE, van der Schouw YT. Endogenous sex hormones in men aged 40–80 years. Eur. J. Endocrinol.149(6), 583–589 (2003).
  • Svartberg J, Midtby M, Bonaa KH, Sundsfjord J, Joakimsen RM, Jorde R. The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso study. Eur. J. Endocrinol.149(2), 145–152 (2003).
  • Svartberg J, von Muhlen D, Sundsfjord J, Jorde R. Waist circumference and testosterone levels in community dwelling men. The Tromso study. Eur. J. Epidemiol.19(7), 657–663 (2004).
  • Allen NE, Appleby PN, Davey GK, Key TJ. Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men. Cancer Causes Control13(4), 353–363 (2002).
  • Yki-Jarvinen H, Makimattila S, Utriainen T, Rutanen EM. Portal insulin concentrations rather than insulin sensitivity regulate serum sex hormone-binding globulin and insulin-like growth factor binding protein 1 in vivo.J. Clin. Endocrinol. Metab.80(11), 3227–3232 (1995).
  • Osuna JA, Gomez-Perez R, Arata-Bellabarba G, Villaroel V. Relationship between BMI, total testosterone, sex hormone-binding-globulin, leptin, insulin and insulin resistance in obese men. Arch. Androl.52(5), 355–361 (2006).

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