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Stem cell transplantation in the context of HIV – how can we cure HIV infection?

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References

  • Zolla-Pazner S, deCamp AC, Cardozo T et al. Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial. PLoS ONE 8(1), e53629 (2013).
  • Hutter G, Nowak D, Mossner M et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N. Engl. J. Med. 360(7), 692–698 (2009).
  • Allers K, Hutter G, Hofmann J et al. Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 117(10), 2791–2799 (2011).
  • Henrich TJ, Hu Z, Li JZ et al. Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J. Infect. Dis. 207(11), 1694–1702 (2013).
  • Lewin SR. A cure for HIV: where we‘ve been, and where we‘re headed. Lancet 381(9883), 2057–2058 (2013).
  • Barre-Sinoussi F. Functional HIV cure is no pipe dream, says codiscoverer of the virus. BMJ 346, f2947 (2013).
  • Bahner I, Kearns K, Coutinho S, Leonard EH, Kohn DB. Infection of human marrow stroma by human immunodeficiency virus-1 (HIV-1) is both required and sufficient for HIV-1-induced hematopoietic suppression in vitro: demonstration by gene modification of primary human stroma. Blood 90(5), 1787–1798 (1997).
  • Koka PS, Reddy ST. Cytopenias in HIV infection: mechanisms and alleviation of hematopoietic inhibition. Curr. HIV Res. 2(3), 275–282 (2004).
  • Martinot AJ, Meythaler M, Pozzi LA et al. Acute SIV infection in sooty mangabey monkeys is characterized by rapid virus clearance from lymph nodes and absence of productive infection in germinal centers. PLoS ONE 8(3), e57785 (2013).
  • Durand CM, Ghiaur G, Siliciano JD et al. HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy. J. Infect. Dis. 205(6), 1014–1018 (2012).
  • Carter CC, Onafuwa-Nuga A, McNamara LA et al. HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nat. Med. 16(4), 446–451 (2010).
  • Holt N, Wang J, Kim K et al. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat. Biotechnol. 28(8), 839–847 (2010).
  • Anderson J, Akkina R. Complete knockdown of CCR5 by lentiviral vector-expressed siRNAs and protection of transgenic macrophages against HIV-1 infection. Gene. Ther. 14(17), 1287–1297 (2007).
  • Van den Eede P, Van Wesenbeeck L, Verlinden Y et al. HIV-1 Genotyping of the Protease-Reverse Transcriptase and Integrase Genes to Detect Mutations That Confer Antiretroviral Resistance. Methods Mol. Biol.1030, 37–55 (2013).
  • Anderson J, Li MJ, Palmer B et al. Safety and efficacy of a lentiviral vector containing three anti-HIV genes--CCR5 ribozyme, tat-rev siRNA, and TAR decoy--in SCID-hu mouse-derived T cells. Mol. Ther. 15(6), 1182–1188 (2007).
  • Anderson J, Akkina R. Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5alpha (TRIM 5alpha) in CD34(+) cell-derived macrophages in vitro and in T cells in vivo in severe combined immunodeficient (SCID-hu) mice transplanted with human fetal tissue. Hum. Gene. Ther. 19(3), 217–228 (2008).
  • Walker JE, Chen RX, McGee J et al. Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector. J. Virol. 86(10), 5719–5729 (2012).
  • Kunisaki Y, Frenette PS. The secrets of the bone marrow niche: enigmatic niche brings challenge for HSC expansion. Nat. Med. 18(6), 864–865 (2012).
  • Balsalobre P, Diez-Martin JL, Re A et al. Autologous stem-cell transplantation in patients with HIV-related lymphoma. J. Clin. Oncol. 27(13), 2192–2198 (2009).
  • Diez-Martin JL, Balsalobre P, Re A et al. Comparable survival between HIV+ and HIV- non-Hodgkin and Hodgkin lymphoma patients undergoing autologous peripheral blood stem cell transplantation. Blood 113(23), 6011–6014 (2009).
  • Carbonaro DA, Jin X, Wang X et al. Gene therapy/bone marrow transplantation in ADA-deficient mice: roles of enzyme-replacement therapy and cytoreduction. Blood 120(18), 3677–3687 (2012).
  • Kohn DB, Hershfield MS, Carbonaro D et al. T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates. Nat. Med. 4(7), 775–780 (1998).
  • Candotti F, Shaw KL, Muul L et al. Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. Blood 120(18), 3635–3646 (2012).
  • Kohn DB, Bauer G, Rice CR et al. A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children. Blood 94(1), 368–371 (1999).
  • Bauer G, Selander D, Engel B et al. Gene therapy for pediatric AIDS. Ann. NY Acad. Sci. 918, 318–329 (2000).
  • DiGiusto DL, Krishnan A, Li L et al. RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma. Sci. Transl. Med. 2(36), 36ra43 (2010).
  • Rossi JJ, June CH, Kohn DB. Genetic therapies against HIV. Nat. Biotechnol. 25(12), 1444–1454 (2007).
  • Kalomoiris S, Lawson J, Chen RX, Bauer G, Nolta JA, Anderson JS. CD25 preselective anti-HIV vectors for improved HIV gene therapy. Hum. Gene Ther. Methods 23(6), 366–375 (2012).
  • Li L, Krymskaya L, Wang J et al. Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases. Mol. Ther. 21(6), 1259–1269 (2013).
  • Benedict CA, Tun RY, Rubinstein DB, Guillaume T, Cannon PM, Anderson WF. Targeting retroviral vectors to CD34-expressing cells: binding to CD34 does not catalyze virus-cell fusion. Hum. Gene Ther. 10(4), 545–557 (1999).
  • Yajima T, Kanda T, Yoshiike K, Kitamura Y. Retroviral vector targeting human cells via c-Kit-stem cell factor interaction. Hum. Gene Ther. 9(6), 779–787 (1998).
  • Podsakoff GM, Engel BC, Carbonaro DA et al. Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells. Mol. Ther. 12(1), 77–86 (2005).
  • Mitsuyasu RT, Merigan TC, Carr A et al. Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells. Nat. Med. 15(3), 285–292 (2009).
  • Li MJ, Kim J, Li S et al. Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy. Mol. Ther. 12(5), 900–909 (2005).

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