Targeting neutrophils in sepsis

References

• Vincent J-L, Sakr Y, Sprung CL, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006;34(2):344-53
   PubMed Web of Science ®Google Scholar
• Bone RC, Sibbald WJ, Sprung CL. The ACCP-SCCM consensus conference on sepsis and organ failure. Chest 1992;101(6):1481-3
   PubMed Web of Science ®Google Scholar
• Nascimento DC, Alves-Filho JC, Sonego F, et al. Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis. Crit Care Med 2010;38(8):1718-25
   PubMed Web of Science ®Google Scholar
• Yende S, Angus DC. Long-term outcomes from sepsis. Curr Infect Dis Rep 2007;9(5):382-6
   PubMedGoogle Scholar
• Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 2013;13(12):862-74
   PubMed Web of Science ®Google Scholar
• Dellinger RP, Vincent JL. The Surviving Sepsis Campaign sepsis change bundles and clinical practice. Crit Care 2005;9(6):653-4
   PubMedGoogle Scholar
• Kumar G, Kumar N, Taneja A, et al. Nationwide trends of severe sepsis in the 21st century (2000-2007). Chest 2011;140(5):1223-31
   PubMed Web of Science ®Google Scholar
• Ranieri VM, Thompson BT, Barie PS, et al. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 2012;366(22):2055-64
   PubMed Web of Science ®Google Scholar
• Seeley EJ, Matthay MA, Wolters PJ. Inflection points in sepsis biology: from local defense to systemic organ injury. Am J Physiol Lung Cell Mol Physiol 2012;303(5):L355-63
   Google Scholar
• Benjamim CF, Ferreira SH, Cunha FQ. Role of nitric oxide in the failure of neutrophil migration in sepsis. J Infect Dis 2000;182(1):214-23
   PubMedGoogle Scholar
• Benjamim CF, Silva JS, Fortes ZB, et al. Inhibition of leukocyte rolling by nitric oxide during sepsis leads to reduced migration of active microbicidal neutrophils. Infect Immun 2002;70(7):3602-10
   PubMed Web of Science ®Google Scholar
• Torres-Duenas D, Benjamim CF, Ferreira SH, Cunha FQ. Failure of neutrophil migration to infectious focus and cardiovascular changes on sepsis in rats: effects of the inhibition of nitric oxide production, removal of infectious focus, and antimicrobial treatment. Shock 2006;25(3):267-76
   PubMedGoogle Scholar
• Alves-Filho JC, Freitas A, Souto FO, et al. Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis. Proc Natl Acad Sci USA 2009;106(10):4018-23
   PubMed Web of Science ®Google Scholar
• Tavares-Murta BM, Zaparoli M, Ferreira RB, et al. Failure of neutrophil chemotactic function in septic patients. Crit Care Med 2002;30(5):1056-61
   PubMedGoogle Scholar
• Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell 2010;140(6):771-6
   PubMed Web of Science ®Google Scholar
• West AP, Koblansky AA, Ghosh S. Recognition and signaling by toll-like receptors. Annu Rev Cell Dev Biol 2006;22:409-37
   PubMed Web of Science ®Google Scholar
• O’Brien AD, Rosenstreich DL, Scher I, et al. Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J Immunol 1980;124(1):20-4
   PubMedGoogle Scholar
• Alves-Filho JC, de Freitas A, Russo M, Cunha FQ. Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis. Crit Care Med 2006;34(2):461-70
   PubMedGoogle Scholar
• Klesius PH, Chambers WH, Schultz RD. Effect of bacterial lipopolysaccharide on bovine polymorphonuclear neutrophil migration in vitro. Vet Immunol Immunopathol 1984;7(3-4):239-44
   PubMedGoogle Scholar
• Tavares-Murta BM, Machado JS, Ferreira SH, Cunha FQ. Nitric oxide mediates the inhibition of neutrophil migration induced by systemic administration of LPS. Inflammation 2001;25(4):247-53
   PubMedGoogle Scholar
• Savva A, Roger T. Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases. Front Immunol 2013;4:387
   PubMed Web of Science ®Google Scholar
• Heppner G, Weiss DW. High susceptibility of strain a mice to endotoxin and endotoxin-red blood cell mixtures. J Bacteriol 1965;90(3):696-703
   PubMedGoogle Scholar
• Trevelin SC, Alves-Filho JC, Sonego F, et al. Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome. Crit Care Med 2012;40(9):2631-7
   PubMedGoogle Scholar
• Konrad FM, Reutershan J. CXCR2 in acute lung injury. Mediators Inflamm 2012;2012:740987
   PubMedGoogle Scholar
• Cummings CJ, Martin TR, Frevert CW, et al. Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis. J Immunol 1999;162(4):2341-6
   PubMedGoogle Scholar
• Gainetdinov RR, Bohn LM, Walker JK, et al. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. Neuron 1999;24(4):1029-36
   PubMedGoogle Scholar
• Evron T, Daigle TL, Caron MG. GRK2: multiple roles beyond G protein-coupled receptor desensitization. Trends Pharmacol Sci 2012;33(3):154-64
   PubMedGoogle Scholar
• Lefkowitz RJ, Shenoy SK. Transduction of receptor signals by beta-arrestins. Science 2005;308(5721):512-17
   PubMed Web of Science ®Google Scholar
• Arraes SM, Freitas MS, da Silva SV, et al. Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation. Blood 2006;108(9):2906-13
   PubMedGoogle Scholar
• Chishti AD, Shenton BK, Kirby JA, Baudouin SV. Neutrophil chemotaxis and receptor expression in clinical septic shock. Intensive Care Med 2004;30(4):605-11
   PubMedGoogle Scholar
• Rios-Santos F, Alves-Filho JC, Souto FO, et al. Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. Am J Respir Crit Care Med 2007;175(5):490-7
   PubMedGoogle Scholar
• Alves-Filho JC, Sonego F, Souto FO, et al. Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat Med 2010;16(6):708-12
   PubMed Web of Science ®Google Scholar
• Opal SM, Laterre PF, Francois B, et al. Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA 2013;309(11):1154-62
   PubMed Web of Science ®Google Scholar
• Tse MT. Trial watch: sepsis study failure highlights need for trial design rethink. Nat Rev Drug Discov 2013;12(5):334
   PubMed Web of Science ®Google Scholar
• Deering RP, Orange JS. Development of a clinical assay to evaluate toll-like receptor function. Clin Vaccine Immunol 2006;13(1):68-76
   PubMedGoogle Scholar
• Secher T, Vasseur V, Poisson DM, et al. Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis. J Immunol 2009;182(12):7855-64
   PubMedGoogle Scholar
• Otsuka Y, Nagano K, Nagano K, et al. Inhibition of neutrophil migration by tumor necrosis factor. Ex vivo and in vivo studies in comparison with in vitro effect. J Immunol 1990;145(8):2639-43
   PubMedGoogle Scholar
• Khandaker MH, Xu L, Rahimpour R, et al. CXCR1 and CXCR2 are rapidly down-modulated by bacterial endotoxin through a unique agonist-independent, tyrosine kinase-dependent mechanism. J Immunol 1998;161(4):1930-8
   PubMedGoogle Scholar
• Cunha FQ, Assreuy J, Moss DW, et al. Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: role of TNF-alpha and IL-1-beta. Immunology 1994;81(2):211-15
   PubMedGoogle Scholar
• Paula-Neto HA, Alves-Filho JC, Souto FO, et al. Inhibition of guanylyl cyclase restores neutrophil migration and maintains bactericidal activity increasing survival in sepsis. Shock 2011;35(1):17-27
   PubMedGoogle Scholar
• Dal Secco D, Moreira AP, Freitas A, et al. Nitric oxide inhibits neutrophil migration by a mechanism dependent on ICAM-1: role of soluble guanylate cyclase. Nitric Oxide 2006;15(1):77-86
   PubMedGoogle Scholar
• Zhao Y, Brandish PE, Di Valentin M, et al. Inhibition of soluble guanylate cyclase by ODQ. Biochemistry 2000;39(35):10848-54
   PubMedGoogle Scholar
• Martin EL, Souza DG, Fagundes CT, et al. Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment. Am J Respir Crit Care Med 2010;182(6):762-73
   PubMedGoogle Scholar
• Sakai K, Suzuki H, Oda H, et al. Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: critical dimerization of inducible nitric-oxide synthase. J Biol Chem 2006;281(26):17736-42
   PubMedGoogle Scholar
• Le HT, Tran VG, Kim W, et al. IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals. J Immunol 2012;189(1):287-95
   PubMed Web of Science ®Google Scholar
• Ferreira AE, Sisti F, Sonego F, et al. PPAR-gamma/IL-10 Axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis. J Immunol 2014;192(5):2357-65
   PubMed Web of Science ®Google Scholar
• Spiller F, Orrico MI, Nascimento DC, et al. Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation. Am J Respir Crit Care Med 2010;182(3):360-8
   PubMedGoogle Scholar
• Dal-Secco D, Cunha TM, Freitas A, et al. Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: role of ATP-sensitive potassium channels. J Immunol 2008;181(6):4287-98
   PubMedGoogle Scholar
• Ferlito M, Wang Q, Fulton WB, et al. H2S increases survival during sepsis: protective effect of CHOP inhibition. J Immunol 2014;192(4):1806-14
   PubMedGoogle Scholar
• Liu X, Ma B, Malik AB, et al. Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immunol 2012;13(5):457-64
   PubMed Web of Science ®Google Scholar
• Raghuwanshi SK, Su Y, Singh V, et al. The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions. J Immunol 2012;189(6):2824-32
   PubMedGoogle Scholar
• Brown KA, Brain SD, Pearson JD, et al. Neutrophils in development of multiple organ failure in sepsis. Lancet 2006;368(9530):157-69
   PubMed Web of Science ®Google Scholar
• Reddy RC, Standiford TJ. Effects of sepsis on neutrophil chemotaxis. Curr Opin Hematol 2010;17(1):18-24
   PubMedGoogle Scholar
• Hoesel LM, Neff TA, Neff SB, et al. Harmful and protective roles of neutrophils in sepsis. Shock 2005;24(1):40-7
   PubMed Web of Science ®Google Scholar
• Johnston B, Burns AR, Suematsu M, et al. Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1. J Clin Invest 1999;103(9):1269-76
   PubMedGoogle Scholar
• Speyer CL, Gao H, Rancilio NJ, et al. Novel chemokine responsiveness and mobilization of neutrophils during sepsis. Am J Pathol 2004;165(6):2187-96
   PubMedGoogle Scholar
• Souto FO, Alves-Filho JC, Turato WM, et al. Essential role of CCR2 in neutrophil tissue infiltration and multiple organ dysfunction in sepsis. Am J Respir Crit Care Med 2011;183(2):234-42
   PubMedGoogle Scholar
• Alves JN, Pires KM, Lanzetti M, et al. Critical role for CCR2 and HMGB1 in induction of experimental endotoxic shock. Arch Biochem Biophys 2013;537(1):72-81
   PubMedGoogle Scholar
• Andersson U, Tracey KJ. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol 2011;29:139-62
   PubMed Web of Science ®Google Scholar
• Rahman M, Roller J, Zhang S, et al. Metalloproteinases regulate CD40L shedding from platelets and pulmonary recruitment of neutrophils in abdominal sepsis. Inflamm Res 2012;61(6):571-9
   PubMed Web of Science ®Google Scholar
• Renckens R, Roelofs JJ, Florquin S, et al. Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis. J Immunol 2006;176(6):3735-41
   PubMed Web of Science ®Google Scholar
• Yipp BG, Kubes P. NETosis: how vital is it? Blood 2013;122(16):2784-94
   PubMed Web of Science ®Google Scholar
• Meng W, Paunel-Gorgulu A, Flohe S, et al. Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice. Crit Care 2012;16(4):R137
   PubMedGoogle Scholar
• Martinod K, Wagner DD. Thrombosis: tangled up in NETs. Blood 2014;123(18):2768-76
   PubMed Web of Science ®Google Scholar
• McDonald B, Urrutia R, Yipp BG, et al. Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell Host Microbe 2012;12(3):324-33
   PubMed Web of Science ®Google Scholar
• Clark SR, Ma AC, Tavener SA, et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 2007;13(4):463-9
   PubMed Web of Science ®Google Scholar
• Sursal T, Stearns-Kurosawa DJ, Itagaki K, et al. Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates. Shock 2013;39(1):55-62
   PubMed Web of Science ®Google Scholar
• Wagner JG, Roth RA. Neutrophil migration during endotoxemia. J Leukoc Biol 1999;66(1):10-24
   PubMedGoogle Scholar
• Alves-Filho JC, Spiller F, Cunha FQ. Neutrophil paralysis in sepsis. Shock 2010;34(Suppl 1):15-21
   PubMedGoogle Scholar
• Gupta S, Koirala J, Khardori R, Khardori N. Infections in diabetes mellitus and hyperglycemia. Infect Dis Clin North Am 2007;21(3):617-38. vii
   PubMed Web of Science ®Google Scholar
• Spiller F, Carlos D, Souto FO, et al. alpha1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice. Diabetes 2012;61(6):1584-91
   PubMedGoogle Scholar
• Shetty N, Thomas B, Ramesh A. Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis. J Indian Soc Periodontol 2008;12(2):41-4
   PubMedGoogle Scholar
• Walrand S, Guillet C, Boirie Y, Vasson MP. In vivo evidences that insulin regulates human polymorphonuclear neutrophil functions. J Leukoc Biol 2004;76(6):1104-10
   PubMedGoogle Scholar
• van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001;345(19):1359-67
   PubMed Web of Science ®Google Scholar
• Ling Y, Li X, Gao X. Intensive versus conventional glucose control in critically ill patients: a meta-analysis of randomized controlled trials. Eur J Intern Med 2012;23(6):564-74
   PubMedGoogle Scholar
• Carlos D, Spiller F, Souto FO, et al. Histamine h2 receptor signaling in the pathogenesis of sepsis: studies in a murine diabetes model. J Immunol 2013;191(3):1373-82
   PubMedGoogle Scholar
• Carvalho M, Benjamim C, Santos F, et al. Effect of mast cells depletion on the failure of neutrophil migration during sepsis. Eur J Pharmacol 2005;525(1-3):161-9
   PubMedGoogle Scholar
• Nacionales DC, Gentile LF, Vanzant E, et al. Aged mice are unable to mount an effective myeloid response to sepsis. J Immunol 2014;192(2):612-22
   PubMed Web of Science ®Google Scholar
• Murohara T, Scalia R, Lefer AM. Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors. Circ Res 1996;78(5):780-9
   PubMedGoogle Scholar
• Spiecker M, Peng HB, Liao JK. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha. J Biol Chem 1997;272(49):30969-74
   PubMedGoogle Scholar
• Torres-Duenas D, Celes MR, Freitas A, et al. Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice. Br J Pharmacol 2007;152(3):341-52
   PubMedGoogle Scholar
• Fernandes D, Assreuy J. Nitric oxide and vascular reactivity in sepsis. Shock 2008;30(Suppl 1):10-13
   PubMedGoogle Scholar
• Freitas A, Alves-Filho JC, Victoni T, et al. IL-17 receptor signaling is required to control polymicrobial sepsis. J Immunol 2009;182(12):7846-54
   PubMedGoogle Scholar
• Fredenburgh LE, Perrella MA, Mitsialis SA. The role of heme oxygenase-1 in pulmonary disease. Am J Respir Cell Mol Biol 2007;36(2):158-65
   PubMed Web of Science ®Google Scholar
• Freitas A, Alves-Filho JC, Secco DD, et al. Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation. Br J Pharmacol 2006;149(4):345-54
   PubMedGoogle Scholar
• Freitas A, Alves-Filho JC, Trevelin SC, et al. Divergent role of heme oxygenase inhibition in the pathogenesis of sepsis. Shock 2011;35(6):550-9
   PubMedGoogle Scholar
• Czaikoski PG, Nascimento DC, Sonego F, et al. Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis. Shock 2013;39(4):389-96
   PubMedGoogle Scholar
• Larsen R, Gozzelino R, Jeney V, et al. A central role for free heme in the pathogenesis of severe sepsis. Sci Transl Med 2010;2(51):51ra71
   PubMedGoogle Scholar
• Mestriner FL, Spiller F, Laure HJ, et al. Acute-phase protein alpha-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism. Proc Natl Acad Sci USA 2007;104(49):19595-600
   PubMedGoogle Scholar
• Spiller F, Costa C, Souto FO, et al. Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice. Am J Respir Crit Care Med 2011;183(7):922-31
   PubMedGoogle Scholar
• Eisenfeld L, Krause PJ, Herson VC, et al. Enhancement of neonatal neutrophil motility (chemotaxis) with adult fresh frozen plasma. Am J Perinatol 1992;9(1):5-8
   PubMedGoogle Scholar