779
Views
15
CrossRef citations to date
0
Altmetric
SPECIAL FOCUS: 10-year anniversary issue - Review

STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?

, , &

References

  • Cai X, Chiu YH, Chen ZJ. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol Cell 2014;54(2):289-96
  • Dubensky TWJr, Kanne DB, Leong ML. Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants. Therapeutic advances in vaccines 2013;1(4):131-43
  • Zhang L, Mo J, Swanson KV, et al. NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity 2014;40(3):329-41
  • Bhat N, Fitzgerald KA. Recognition of cytosolic DNA by cGAS and other STING-dependent sensors. Eur J Immunol 2014;44(3):634-40
  • Barber GN. STING-dependent cytosolic DNA sensing pathways. Trends Immunol 2014;35(2):88-93
  • Unterholzner L. The interferon response to intracellular DNA: why so many receptors? Immunobiology 2013;218(11):1312-21
  • Xiao TS, Fitzgerald KA. The cGAS-STING pathway for DNA sensing. Mol Cell 2013;51(2):135-9
  • Paludan SR, Bowie AG. Immune sensing of DNA. Immunity 2013;38(5):870-80
  • Mangan MS, Latz E. NLRC3 puts the brakes on STING. Immunity 2014;40(3):305-6
  • Gursel I, Gursel M, Yamada H, et al. Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J Immunol 2003;171(3):1393-400
  • Konno H, Konno K, Barber GN. Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to prevent sustained innate immune signaling. Cell 2013;155(3):688-98
  • Civril F, Deimling T, de Oliveira Mann CC, et al. Structural mechanism of cytosolic DNA sensing by cGAS. Nature 2013;498(7454):332-7
  • Li XD, Wu J, Gao D, et al. Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 2013;341(6152):1390-4
  • Burdette DL, Monroe KM, Sotelo-Troha K, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 2011;478(7370):515-18
  • Sauer JD, Sotelo-Troha K, von Moltke J, et al. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun 2011;79(2):688-94
  • Burdette DL, Vance RE. STING and the innate immune response to nucleic acids in the cytosol. Nat Immunol 2013;14(1):19-26
  • Gray PM, Forrest G, Wisniewski T, et al. Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities. Cell Immunol 2012;278(1-2):113-19
  • Danilchanka O, Mekalanos JJ. Cyclic dinucleotides and the innate immune response. Cell 2013;154(5):962-70
  • Ishikawa H, Ma Z, Barber GN. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009;461(7265):788-92
  • Gall A, Treuting P, Elkon KB, et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 2012;36(1):120-31
  • Ahn J, Gutman D, Saijo S, Barber GN. STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci U S A 2012;109(47):19386-91
  • Ablasser A, Hemmerling I, Schmid-Burgk JL, et al. TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner. J Immunol 2014;192(12):5993-7
  • Nickerson KM, Christensen SR, Shupe J, et al. TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol 2010;184(4):1840-8
  • Baban B, Chandler PR, Johnson BA3rd, et al. Physiologic Control of IDO competence in splenic dendritic cells. J Immunol 2011;187(5):2329-35
  • Baban B, Chandler PR, Sharma MD, et al. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol 2009;183(4):2475-83
  • Archer KA, Durack J, Portnoy DA. STING-Dependent Type I IFN Production inhibits cell-mediated immunity to listeria monocytogenes. PLoS Pathog 2014;10(1):e1003861
  • Munn DH, Mellor AL. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol 2012;34:137-43
  • Bolhassani A, Javanzad S, Saleh T, et al. Polymeric nanoparticles: potent vectors for vaccine delivery targeting cancer and infectious diseases. Hum Vaccin Immunother 2014;10(2):321-32
  • Huang L, Li L, Lemos H, et al. Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses. J Immunol 2013;191(7):3509-13
  • Huang L, Lemos HP, Li L, et al. Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T Cells. J Immunol 2012;188(10):4913-20
  • Lemos H, Huang L, Chandler PR, et al. Activation of the sting adaptor attenuates experimental autoimmune encephalitis. J Immunol 2014;192:5571-8
  • Mellor AL, Munn DH. Physiologic control of the functional status of foxp3+ regulatory T cells. J Immunol 2011;186(8):4535-40
  • de la Fuente H, Cibrian D, Sanchez-Madrid F. Immunoregulatory molecules are master regulators of inflammation during the immune response. FEBS Lett 2012;586(18):2897-905
  • McGaha TL, Huang L, Lemos H, et al. Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. Immunol Rev 2012;249(1):135-57
  • Rodrigo-Garzon M, Berraondo P, Ochoa L, et al. Antitumoral efficacy of DNA nanoparticles in murine models of lung cancer and pulmonary metastasis. Cancer Gene Ther 2010;17(1):20-7
  • Henson PM, Bratton DL, Fadok VA. The phosphatidylserine receptor: a crucial molecular switch? Nat Rev Mol Cell Biol 2001;2(8):627-33
  • Ravishankar B, Liu H, Shinde R, et al. Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase. Proc Natl Acad Sci USA 2012;109(10):3909-14
  • Ravishankar B, Shinde R, Liu H, et al. Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance. Proc Natl Acad Sci USA 2014;111(11):4215-20
  • Schoggins JW, Macduff DA, Imanaka N, et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 2014;505:691-5
  • Banchereau J, Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006;25(3):383-92
  • Boasso A. Wounding the immune system with its own blade: HIV-induced tryptophan catabolism and pathogenesis. Curr Med Chem 2011;18(15):2247-56
  • Baccala R, Welch MJ, Gonzalez-Quintial R, et al. Type I interferon is a therapeutic target for virus-induced lethal vascular damage. Proc Natl Acad Sci US A 2014;111(24):8925-30
  • Huang L, Li L, Klonowski KD, et al. Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection. PLoS One 2013;8(6):e66546
  • Makala LH, Baban B, Lemos H, et al. Leishmania major attenuates host immunity by stimulating local indoleamine 2,3-dioxygenase expression. J Infect Dis 2011;203(5):715-25
  • Popov A, Abdullah Z, Wickenhauser C, et al. Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. J Clin Invest 2006;116(12):3160-70
  • Johnson BA3rd, Baban B, Mellor AL. Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy. Immunotherapy 2009;1(4):645-61
  • Huang L, Baban B, Johnson BA, Mellor AL. Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege. Int Rev Immunol 2010;29:133-55
  • Munn DH. Blocking IDO activity to enhance anti-tumor immunity. Front Biosci (Elite Ed) 2012;4:734-45
  • Fuertes MB, Kacha AK, Kline J, et al. Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells. J Exp Med 2011;208(10):2005-16
  • Deng L, Liang H, Xu M, et al. STING-dependent Cytosolic DNA sensing promotes radiation-induced type i interferon-dependent antitumor immunity in immunogenic tumors. Immunity 2014;41:843-52
  • Woo SR, Fuertes MB, Corrales L, et al. STING-Dependent Cytosolic DNA. sensing mediates innate immune recognition of immunogenic tumors. Immunity 2014;41:830-42
  • Cheon H, Borden EC, Stark GR. Interferons and their stimulated genes in the tumor microenvironment. Semin Oncol 2014;41(2):156-73
  • Zhu Q, Man SM, Gurung P, et al. Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation. J Immunol 2014;193(10):4779-82
  • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 2011;331(6024):1565-70
  • Couzin-Frankel J. Breakthrough of the year 2013. Cancer immunotherapy. Science 2013;342(6165):1432-3
  • Page DB, Postow MA, Callahan MK, et al. Immune modulation in cancer with antibodies. Annu Rev Med 2014;65:185-202
  • Lara PNJr, Douillard JY, Nakagawa K, et al. Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. J Clinc Oncol 2011;29(22):2965-71
  • Fruh M, Cathomas R, Siano M, et al. Carboplatin and paclitaxel plus ASA404 as first-line chemotherapy for extensive-stage small-cell lung cancer: a multicenter single arm phase II trial (SAKK 15/08). Clin Lung Cancer 2013;14(1):34-9
  • Conlon J, Burdette DL, Sharma S, et al. Mouse, but not Human STING, binds and signals in response to the vascular disrupting agent 5,6-Dimethylxanthenone-4-Acetic Acid. J Immunol 2013;190(10):5216-25
  • Gao P, Ascano M, Zillinger T, et al. Structure-function analysis of STING activation by c[G(2’,5’)pA(3’,5’)p] and targeting by antiviral DMXAA. Cell 2013;154(4):748-62
  • Yi G, Brendel VP, Shu C, et al. Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides. PLoS One 2013;8(10):e77846
  • Cavlar T, Deimling T, Ablasser A, et al. Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J 2013;32(10):1440-50
  • Downey CM, Aghaei M, Schwendener RA, Jirik FR. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2’3’-cGAMP, induces M2 macrophage repolarization. PLoS One 2014;9(6):e99988
  • Blaauboer SM, Gabrielle VD, Jin L. MPYS/STING-Mediated TNF-alpha, Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3’-5’)-Cyclic-Di-Guanosine-Monophosphate In Vivo. J Immunol 2014;192(1):492-502
  • Dittmar M, Woletz K, Kahaly GJ. Reduced DNASE1 gene expression in thyroid autoimmunity. Horm Metab Res 2013;45(4):257-60
  • Martinez-Valle F, Balada E, Ordi-Ros J, et al. DNase1 activity in systemic lupus erythematosus patients with and without nephropathy. Rheumatol Int 2010;30(12):1601-4
  • Liu Y, Jesus AA, Marrero B, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med 2014;371(6):507-18
  • Jeremiah N, Neven B, Gentili M, et al. Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations. J Clin Invest 2014;124(12):5516-20
  • Rice G, Patrick T, Parmar R, et al. Clinical and molecular phenotype of Aicardi-Goutieres syndrome. Am J Hum Genet 2007;81(4):713-25
  • Kawane K, Ohtani M, Miwa K, et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 2006;443(7114):998-1002
  • Munoz D, Escartin A, Dapena D, et al. Adverse events during the titration phase of interferon-beta in remitting-relapsing multiple sclerosis are not predicted by body mass index nor by pharmacodynamic biomarkers. BMC Neurol 2013;13:82

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.