456
Views
34
CrossRef citations to date
0
Altmetric
Perspective

Allergies and Asthma: Do Atopic Disorders Result from Inadequate Immune Homeostasis arising from Infant Gut Dysbiosis?

&
Pages 379-388 | Received 04 Oct 2015, Accepted 05 Jan 2016, Published online: 07 Feb 2016

References

  • Barker D, Barker M, Fleming T, et al. Developmental biology: support mothers to secure future public health. Nature. 2013 Dec 12;504(7479):209–211.
  • Goenka A, Kollmann TR. Development of immunity in early life. J Infect. 2015;71:SS112–SS120.
  • Dowling DJ, Levy O. Ontogeny of early life immunity. Trends Immunol. 2014 Jul;35(7):299–310.
  • Levy BD, Serhan CN. Resolution of acute inflammation in the lung. Annu Rev Physiol. 2014;76:467–492.
  • Spergel JM. From atopic dermatitis to asthma: the atopic march. Ann Allergy Asthma Immunol. 2010 Aug;105(2):99–106. quiz 07-9, 17.
  • Dharmage SC, Lowe AJ, Matheson MC, et al. Atopic dermatitis and the atopic march revisited. Allergy. 2014 Jan;69(1):17–27.
  • Ohnmacht C, Marques R, Presley L, et al. Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity. Cell Microbiol. 2011 May;13(5):653–659.
  • Vangay P, Ward T, Gerber JS, et al. Antibiotics, pediatric dysbiosis, and disease. Cell Host Microbe. 2015 May 13;17(5):553–564.
  • Backhed F, Roswall J, Peng Y, et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe. 2015 May 13;17(5):690–703.
  • Sommer F, Backhed F. The gut microbiota–masters of host development and physiology. Nat Rev Microbiol. 2013 Apr;11(4):227–238.
  • Ye Y. Identification and quantification of abundant species from pyrosequences of 16s rRNA by consensus alignment. Proceedings (IEEE Int Conf Bioinformatics Biomed). 2011 Feb 4;2010:153–157.
  • Yatsunenko T, Rey FE, Manary MJ, et al. Human gut microbiome viewed across age and geography. Nature. 2012 Jun;486(7402):222–227.
  • Jeurink PV, Van Esch BC, Rijnierse A, et al. Mechanisms underlying immune effects of dietary oligosaccharides. Am J Clin Nutr. 2013 Aug;98(2):572S–577S.
  • Penders J, Stobberingh EE, Van Den Brandt PA, et al. The role of the intestinal microbiota in the development of atopic disorders. Allergy. 2007 Nov;62(11):1223–1236.
  • Penders J, Thijs C, van den Brandt PA, et al. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut. 2007 May;56(5):661–667.
  • Sjogren YM, Jenmalm MC, Bottcher MF, et al. Altered early infant gut microbiota in children developing allergy up to 5 years of age. Clin Exp Allergy. 2009 Apr;39(4):518–526.
  • Bisgaard H, Li N, Bonnelykke K, et al. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. J Allergy Clin Immunol. 2011 Sep;128(3):646–652 e1-e5.
  • Johansson MA, Sjogren YM, Persson JO, et al. Early colonization with a group of Lactobacilli decreases the risk for allergy at five years of age despite allergic heredity. PLoS One. 2011;6(8):e23031.
  • Abrahamsson TR, Jakobsson HE, Andersson AF, et al. Low diversity of the gut microbiota in infants with atopic eczema. J Allergy Clin Immunol. 2012 Feb;129(2):434–440, 40 e1-e2.
  • Abrahamsson TR, Jakobsson HE, Andersson AF, et al. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin Exp Allergy. 2014 Jun;44(6):842–850.
  • Bjorksten B, Sepp E, Julge K, et al. Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol. 2001 Oct;108(4):516–520.
  • Kalliomaki M, Kirjavainen P, Eerola E, et al. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol. 2001 Jan;107(1):129–134.
  • Ravel J, Gajer P, Abdo Z, et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A. 2011 Mar 15;108(Suppl 1):4680–4687.
  • Power SE, O’Toole PW, Stanton C, et al. Intestinal microbiota, diet and health. Br J Nutr. 2014 Feb;111(3):387–402.
  • Benson AK, Kelly SA, Legge R, et al. Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18933–18938.
  • Olivares M, Laparra JM, Sanz Y. Host genotype, intestinal microbiota and inflammatory disorders. Br J Nutr. 2013 Jan;109(Suppl 2):S76–S80.
  • Romero R, Hassan SS, Gajer P, et al. The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome. 2014;2(1):4.
  • Tischer C, Zock JP, Valkonen M, et al. Predictors of microbial agents in dust and respiratory health in the Ecrhs. BMC Pulm Med. 2015;15:48.
  • Dunn RR, Fierer N, Henley JB, et al. Home life: factors structuring the bacterial diversity found within and between homes. PLoS One. 2013;8(5):e64133.
  • Fujimura KE, Johnson CC, Ownby DR, et al. Man’s best friend? The effect of pet ownership on house dust microbial communities. J Allergy Clin Immunol. 2010 Aug;126(2):410–412, 12 e1-e3.
  • Sordillo JE, Alwis UK, Hoffman E, et al. Home characteristics as predictors of bacterial and fungal microbial biomarkers in house dust. Environ Health Perspect. 2011 Feb;119(2):189–195.
  • Barberán A, Dunn RR, Reich BJ, et al. The ecology of microscopic life in household dust. Proc Biol Sci. 2015 Sep;282(1814):20151139.
  • Kettleson EM, Adhikari A, Vesper S, et al. Key determinants of the fungal and bacterial microbiomes in homes. Environ Res. 2015 Apr;138:130–135.
  • Candela M, Biagi E, Maccaferri S, et al. Intestinal microbiota is a plastic factor responding to environmental changes. Trends Microbiol. 2012 Aug;20(8):385–391.
  • Zoetendal EG, De Vos WM. Effect of diet on the intestinal microbiota and its activity. Curr Opin Gastroenterol. 2014 Mar;30(2):189–195.
  • Biedermann L, Zeitz J, Mwinyi J, et al. Smoking cessation induces profound changes in the composition of the intestinal microbiota in humans. PLoS One. 2013;8(3):e59260.
  • Frese SA, Mills DA. Birth of the infant gut microbiome: moms deliver twice! Cell Host Microbe. 2015 May 13;17(5):543–544.
  • Fujimura KE, Slusher NA, Cabana MD, et al. Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther. 2010 Apr;8(4):435–454.
  • Biedermann L, Rogler G. The intestinal microbiota: its role in health and disease. Eur J Pediatr. 2015 Feb;174(2):151–167.
  • Dominguez-Bello MG, Costello EK, Contreras M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11971–11975.
  • Jakobsson HE, Abrahamsson TR, Jenmalm MC, et al. Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section. Gut. 2014 Apr;63(4):559–566.
  • Penders J, Thijs C, Vink C, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006 Aug;118(2):511–521.
  • Nylund L, Satokari R, Nikkilä J, et al. Microarray analysis reveals marked intestinal microbiota aberrancy in infants having eczema compared to healthy children in at-risk for atopic disease. BMC Microbiol. 2013;13:12.
  • Molloy J, Allen K, Collier F, et al. The potential link between gut microbiota and IgE-mediated food allergy in early life. Int J Environ Res Public Health. 2013 Dec;10(12):7235–7256.
  • Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science. 2010 Dec 24;330(6012):1768–1773.
  • El Aidy S, Hooiveld G, Tremaroli V, et al. The gut microbiota and mucosal homeostasis: colonized at birth or at adulthood, does it matter? Gut Microbes. 2013 Mar-Apr;4(2):118–124.
  • Ishikawa H, Tanaka K, Maeda Y, et al. Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells. Clin Exp Immunol. 2008 Jul;153(1):127–135.
  • Ostman S, Rask C, Wold AE, et al. Impaired regulatory T cell function in germ-free mice. Eur J Immunol. 2006 Sep;36(9):2336–2346.
  • Noval Rivas M, Burton OT, Wise P, et al. A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. J Allergy Clin Immunol. 2013 Jan;131(1):201–212.
  • Yamashita H, Takahashi K, Tanaka H, et al. Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model. Allergy. 2012 Feb;67(2):201–209.
  • Braun-Fahrländer C, Riedler J, Herz U, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med. 2002 Sep;347(12):869–877.
  • Riedler J, Braun-Fahrländer C, Eder W, et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet. 2001 Oct;358(9288):1129–1133.
  • Renz-Polster H, David MR, Buist AS, et al. Caesarean section delivery and the risk of allergic disorders in childhood. Clin Exp Allergy. 2005 Nov;35(11):1466–1472.
  • Havstad S, Wegienka G, Zoratti EM, et al. Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood. J Allergy Clin Immunol. 2011 Oct;128(4):880–85.e4.
  • Kuitunen M, Kukkonen K, Juntunen-Backman K, et al. Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort. J Allergy Clin Immunol. 2009 Feb;123(2):335–341.
  • Wegienka G, Johnson CC, Havstad S, et al. Indoor pet exposure and the outcomes of total IgE and sensitization at age 18 years. J Allergy Clin Immunol. 2010 Aug;126(2):274–279, 79.e1-e5.
  • Fujimura KE, Demoor T, Rauch M, et al. House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection. Proc Natl Acad Sci U S A. 2014 Jan;111(2):805–810.
  • Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204–12209.
  • Sjogren YM, Tomicic S, Lundberg A, et al. Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses. Clin Exp Allergy. 2009 Dec;39(12):1842–1851.
  • Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009 Oct;461(7268):1282–1286.
  • Sun J, Furio L, Mecheri R, et al. Pancreatic beta-cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota. Immunity. 2015 Aug 18;43(2):304–317.
  • Furusawa Y, Obata Y, Fukuda S, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec;504(7480):446–450.
  • Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014 Feb;20(2):159–166.
  • Imamura F, Micha R, Khatibzadeh S, et al. Dietary quality among men and women in 187 countries in 1990 and 2010: a systematic assessment. Lancet Glob Health. 2015;3:e132–e142.
  • Sefik E, Geva-Zatorsky N, Oh S, et al. MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORgamma(+) regulatory T cells. Science. 2015 Aug 28;349(6251):993–997.
  • Gibson MK, Crofts TS, Dantas G. Antibiotics and the developing infant gut microbiota and resistome. Curr Opin Microbiol. 2015 Jul;27:51–56.
  • Johnson CC, Ownby DR, Alford SH, et al. Antibiotic exposure in early infancy and risk for childhood atopy. J Allergy Clin Immunol. 2005 Jun;115(6):1218–1224.
  • Ong M-S, Umetsu DT, Mandl KD. Consequences of antibiotics and infections in infancy: bugs, drugs, and wheezing. Ann Allergy Asthma Immunol. 2014 May;112(5):441–45.e1.
  • Droste JH, Wieringa MH, Weyler JJ, et al. Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease? Clin Exp Allergy. 2000 Nov;30(11):1547–1553.
  • Yoo J, Tcheurekdjian H, Lynch SV, et al. Microbial manipulation of immune function for asthma prevention: inferences from clinical trials. Proc Am Thorac Soc. 2007 Jul;4(3):277–282.
  • Baldridge MT, Nice TJ, McCune BT, et al. Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection. Science. 2015 Jan;347(6219):266–269.
  • Wallace JG, Gohir W, Sloboda DM. The impact of early life gut colonization on metabolic and obesogenic outcomes: what have animal models shown us?. J Dev Orig Health Dis. 2016;7(1):15–24.
  • Ley RE. Obesity and the human microbiome. Curr Opin Gastroenterol. 2010 Jan;26(1):5–11.
  • Lejeune JT, Rajala-Schultz PJ. Food safety: unpasteurized milk: a continued public health threat. Clin Infect Dis. 2009 Jan;48(1):93–100.
  • Perkin MR, Strachan DP. Which aspects of the farming lifestyle explain the inverse association with childhood allergy? J Allergy Clin Immunol. 2006 Jun;117(6):1374–1381.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.