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Special Report

p38 MAPK inhibitors in dermatology

Pages 403-407 | Published online: 10 Jan 2014

References

  • Segar R, Krebs EG. The MAPK signaling cascade. FASEB J.9, 726–798 (1995).
  • Robison MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr. Opin. Cell. Biol.9, 180–186 (1997).
  • Hanks SK, Hunter T. Protein kinases 6: the eukaryotic protein kinase superfamily, kinase (catalytic) domain structure and classification. FASEB J.9, 576–596 (1995).
  • Ono K, Han J. The p38 signal transduction pathway: activation and function. Cell Signal.12, 1–13 (2000).
  • Han J, Lee JD, Bibbs L, Ulevitch RJ. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science265, 808–811 (1994).
  • Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev.81, 807–869 (2001).
  • Stein B, Yang MX, Young DB et al. p38–2, a novel mitogen-activated protein kinase with distinct properties. J. Biol. Chem.272, 19509–19517 (1997).
  • Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb MJ. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J.15, 4629–4642 (1996).
  • McLaughlin MM, Kumar S, McDonnell PC et al. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. J. Biol. Chem.271, 8488–8492 (1996).
  • Pargellis C, Regan J. Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis. Curr. Opin. Investig. Drugs4, 566–571 (2003).
  • Cirillo PF, Pargellis C, Regan J. The non-diaryl heterocycle classes of p38 MAP kinase inhibitors. Curr. Top. Med. Chem.2, 1021–1035 (2002).
  • Pargellis C, Tong L, Churchill L et al. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat. Struct. Biol.9, 268–272 (2002).
  • Lee MR, Dominguez C. MAP kinase inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr. Med. Chem.12, 2979–2994 (2005).
  • Schreiber S, Feagan B, D’Haens G et al. Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn’s disease: a randomized, double-blind, placebo-controlled trial. Clin. Gastroenterol. Hepatol.4, 325–334 (2006).
  • Ravid A, Rubinstein E, Gamady A, Rotem C, Liberman UA, Koren R. Vitamin D inhibits the activation of stress-activated protein kinases by physiological and environmental stresses in keratinocytes. J. Endocrinol.173, 525–532 (2002).
  • Garmyn M, Mammone T, Pupe A, Gan D, Declercq L, Maes D. Human keratinocytes respond to osmic stress by p38 MAP kinase regulated induction of HSP70 and HSP27. J. Invest. Dermatol.117, 1290–1295 (2001).
  • Bachelor MA, Silvers AL, Bowden GT. The role of p38 in UVA-induced cyclooxygenase-2 gene expression in the human keratinocyte cell line, HaCaT. Oncogene21, 7092–7099 (2002).
  • Chen W, Bowden GT. Activation of p38 MAP kinase and ERK are required for ultraviolet-B induced c-fos gene expression in human keratinocytes. Oncogene18, 7469–7476 (1999).
  • Chen W, Tang Q, Gonzales MS, Bowden GT. Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene20, 3921–3926 (2001).
  • Zhu F, Zhang Y, Bode AM, Dong Z. Involvement of ERKs and mitogen- and stress-activated protein kinase C in UVC-induced phosphorylation of ATF2 in JB6 cells. Carcinogenesis25, 1847–1852 (2004).
  • Souza K, Maddock DA, Zhang Q et al. Arsenite activation of PI3K/AKT cell survival pathway is mediated by p38 in cultured human keratinocytes. Mol. Med.7, 767–772 (2001).
  • Efimova T, LaCelle P, Welter JF, Eckert RL. Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1 MEK3, p38/RK, AP1 signal transduction pathway. J. Biol. Chem.273, 24387–24395 (1998).
  • Jans R, Atanasova G, Jadot M, Poumay Y. Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38. J. Invest. Dermatol.123, 564–573 (2004).
  • Pfundt R, Wingens M, Bergers M, Zweers M, Frenken M, Schalkwijk J. TNF-α and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway. Arch. Dermatol. Res.292, 180–187 (2000).
  • Sayama K, Hanakawa Y, Shirakata Y et al. Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation. J. Biol. Chem.276, 999–1004 (2001).
  • Efimova T, Broome AM, Eckert RL. A regulatory role of p38 δ MAPK in keratinocyte differentiation. Evidence for p38δ-ERK 1/2 complex formation. J. Biol. Chem.278, 34277–34285 (2003).
  • Zhang L, Pelech SL, Mayrand D, Grenier D, Heino J, Uitto VJ. Bacterial heat shock protein-60 increases epithelial cell proliferation through the ERK1/2 MAP kinases. Exp. Cell Res.266, 11–20 (2001).
  • Jaakkola P, Kontusaari S, Kauppi T, Maata A, Jalkane M. Wound reepithelialization activates a growth factor-responsive enhancer in migrating keratinocytes. FASEB J.12, 959–969 (1998).
  • Henry G, Li W, Garner W, Woodley DT. Migration of human keratinocytes in plasma and serum and wound re-epithelialisation. Lancet361, 574–576 (2003).
  • Turchi L, Chasot AA, Bourget I et al. Cross-talk between RhoGTPases and stress activated kinases for matrix metalloproteinase-9 induction in response to keratinocytes injury. J. Invest. Dermatol.121, 1291–1300 (2003).
  • Johansen C, Kragballe K, Westergaard M, Henningsen J, Kristiansen K, Iversen L. The mitogen-activated kinases p38 and ERK1/2 are increased in lesional psoriatic skin. Br. J. Dermatol.152, 37–42 (2005).
  • Funding AT, Johansen C, Kragballe K et al. Mitogen- and stress-activated protein kinase 1 is activated in lesional psoriatic epidermis and regulates the expression of proinflammatory cytokines. J. Invest. Dermatol.126, 1784–1791 (2006).
  • Arthur JS, Darragh J. Signaling downstream of p38 in psoriasis. J. Invest. Dermatol.126, 1689–1691 (2006).
  • Mason JC, Lidington EA, Yarwood H, Lublin DM, Haskard DO. Induction of endothelial cell decay-accelerating factor by vascular endothelial growth factor: a mechanism for cytoprotection against complement-mediated injury during inflammatory angiogenesis. Arthritis Rheum.44, 138–150 (2001).
  • Kumar P, Miller AI, Polverini PJ. p38 MAPK mediates γ-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway. J. Biol. Chem.279, 43352–43360 (2004).
  • Arrighi JF, Rebsamen M, Rousset F, Kindler V, Hauser C. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharides, TNF-α and contact sensitizers. J. Immunol.166, 3837–3845 (2001).
  • Nakagawa S, Ohtani T, Mizutani M et al. p38 mitogen-activated protein kinase mediates dual role of ultraviolet B radiation in induction of maturation and apoptosis of monocyte-derived dendritic cells. J. Invest. Dermatol.123, 361–370 (2004).
  • Cruz MT, Duarte CB, Goncalo M, Carvalho AP, Lopes MC. Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells. Am. J. Physiol.277, C1050–C1057 (1999).
  • Boisleve F, Kerdine-Romar S, Rougier-Larzat N, Pallardy M. Nickel and DNCB induce CCR7 expression on human dendritic cells through different signaling pathways: role of TNF-α and MAPK. J. Invest. Dermatol.123, 494–502 (2004).
  • Takanami-Ohnishi Y, Amano S, Kimura S et al. Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. J. Biol. Chem.277, 37896–37903 (2002).
  • Ihn H. Pathogenesis of fibrosis: role of TGF-β and CTGF. Curr. Opin. Rheumatol.14, 681–685 (2002).
  • Ihn H. The role of TGF-β signaling in the pathogenesis of fibrosis in scleroderma. Arch. Immunol. Ther. Exp.50, 325–331 (2002).
  • Ihn H. Pathogenesis of scleroderma: the role of autocrine TGF-β signaling. Connective Tissue36, 209–216 (2004).
  • Fisher GJ, Talwar HS, Lin J et al. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo.J. Clin. Invest.101, 1432–1440 (1998).
  • Ravanti L, Heino J, Lopez-Otin C, Kahari VM. Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three dimensional collagen is mediated by p38 mitogen-activated protein kinase. J. Biol. Chem.274, 2446–2455 (1999).
  • Ravanti L, Hakkinen L, Larjava H et al. Transforming growth factor-β induce collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase. J. Biol. Chem.274, 37292–37300 (1999).
  • Ravanti L, Toriseva M, Penttinen R et al. Expression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor-β via p38 mitogen-activated protein kinase. FASEB J.15, 1098–1100 (2001).
  • Brauchle M, Gluck D, Di Padova F, Han J, Gram H. Independent role of p38 and ERK1/2 mitogen-activated protein kinases in the upregulation of matrix metalloproteinase-1. Exp. Cell Res.258, 135–144 (2000).
  • Xu J, Clark RA, Parks WC. p38 mitogen-activated protein kinase is a bi-directional regulator of human fibroblast collagenase-1 induction by three dimentional collagen lattices. Biochem. J.355, 437–447 (2001).
  • Reunanen N, Li SP, Ahonen M, Foschi M, Han J, Kahari VM. Activatation of p38 α MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization. J. Biol. Chem.277, 32360–32368 (2002).
  • Hieta N, Impola U, Lopez-Otin C, Saarialho-Kere U, Kahari VM. Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture. J. Invest. Dermatol.121, 997–1004 (2003).
  • Ihn H, Yamane K, Asano Y, Kubo M, Tamaki K. IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase-dependent pathway. J. Immunol.168, 1895–1902 (2002).
  • Ihn H, Yamane K, Tamaki K. Increased phophorylation and activation of mitogen-activated protein kinase p38 in scleroderma fibroblasts. J. Invest. Dermatol.125, 247–255 (2005).
  • Sato M, Shegogue D, Gore EA, Smith EA, McDermotte PJ, Trojanowska M. Role of p38 MAPK in transforming growth factor β stimulation of collagen production by scleroderma and healthy dermal fibroblasts. J. Invest. Dermatol.118, 704–711 (2002).
  • Daian T, Ohtusru A, Rogounovitch T et al. Insulin-like growth factor-I enhances transforming growth factor-β-induced extracellular matrix protein production through the p38/activating transcription factor-2 signaling pathway in keloid fibroblasts. J. Invest. Dermatol.120, 956–962 (2003).
  • Dobreva I, Waeber G, Mooser V, James RW, Widmann C. LDLs induce fibroblast spreading independently of the LDL receptor via activation of the p38 MAPK pathway. J. Lipid Res.44, 2382–2390 (2003).
  • Hirano S, Rees RS, Gilmont RR. MAP kinase pathways involving hsp27 regulate fibroblast-mediated wound contraction. J. Surg. Res.102, 77–84 (2002).

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