Herpes simplex keratitis: classification, pathogenesis and therapy

References

• Whitley RJ, Roizman B. Herpes simplex virus infections. Lancet357, 1513–1518 (2001).
   PubMed Web of Science ®Google Scholar
• Umene K, Sakaoke H. Evolution of herpes simplex type 1 under herpes viral evolutionary processes. Arch. Virol.144, 637–656 (1999).
   PubMedGoogle Scholar
• Remeijer L, Osterhaus A, Verjans G. Human herpes simplex virus keratitis: the pathogenesis revisited. Ocul. Immunol. Inflamm.12, 255–285 (2004).
   PubMed Web of Science ®Google Scholar
• Hill JM, Sedarati F, Javier RT, Wagner EK. Stevens JG. Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology174, 117–125 (1990).
   PubMed Web of Science ®Google Scholar
• Summers BC, Margolis TP, Leib DA. Herpes simplex virus type 1 corneal infection results in periocular disease by zosteriform spread. J. Virol..75, 5069–5075 (2001).
   PubMedGoogle Scholar
• Pepose JS, Keadle TL, Morrison LA. Ocular herpes simplex: changing epidemiology, emerging disease patterns, and the potential of vaccine prevention and therapy. Am. J. Ophthalmol.141, 547–557 (2006).
   PubMed Web of Science ®Google Scholar
• Holland EJ, Brilakis HS, Schwartz GS. Herpes simplex keratitis. In: Cornea. Krachmer JH, Mannis MJ, Holland EJ (Eds), Elsevier Mosby, PA, USA 1043–1074 (2005).
   Google Scholar
• Biswas PS, Rouse BT. Early events in HSV keratitis – setting the stage for a blinding disease. Microbes Infect.7, 799–810 (2005).
   PubMed Web of Science ®Google Scholar
• Liesegang T. Epidemiology of ocular herpes simplex. Natural history in Rochester, Minn, 1950 through 1982. Arch. Ophthalmol.107, 1160–1165 (1989).
   PubMed Web of Science ®Google Scholar
• Pepose JD. Herpes simplex virus disease: anterior segment of the eye, In: Ocular Infection and Immunity. Pepose JD, Holland GN, Wilhelmus KR (Eds), Mosby, St. Louis, MO, USA 905–932 (1996).
   Google Scholar
• Streilen JW, Dana MR, Ksander BR. Immunity causing blindness: five different paths to herpes stromal keratitis. Immunol. Today18, 443–449 (1997).
   PubMedGoogle Scholar
• Metcalf JF, Hamilton DS, Reichert RW. Herpetic keratitis in athymic (nude) mice. Infect. Immun.26, 1164–1171 (1979).
   PubMed Web of Science ®Google Scholar
• Mercadal CM, Bouley DM, DeStephano D, Rouse BT. Herpetic stromal keratitis in the reconstituted SCID mouse model. J. Virol.67, 3404–3408 (1993).
   PubMedGoogle Scholar
• Tullo AB, Coupes D, Klapper P, Cleator G, Chikara D. Analysis of glycoproteins expressed by isolates of herpes simplex virus causing different forms of keratitis in man. Curr. Eye Res.6, 33–38 (1987).
   PubMed Web of Science ®Google Scholar
• Zheng X, Silverman RH, Zhou A et al. Increased severity of HSV-1 keratitis and mortality in mice lacking the 2–5A-dependent RNAse L gene. Invest. Ophthalmol. Vis. Sci.42, 120–126 (2001).
   PubMedGoogle Scholar
• Lafferty WE. The changing epidemiology of HSV-1 and HSV-2 and implications for serological testing. Herpes9, 51–55 (2002).
   PubMedGoogle Scholar
• Cherpes TL, Meyn LA, Hillier SL. Cunninlingus and vaginal intercourse are risk factors for herpes simplex type q acquisition in women. Sexually Transm. Dis.32, 84–89 (2001).
   Google Scholar
• Armstrong GL, Schillinger J, Markowitz L et al. Incidence of herpes simplex virus type 2 infection in the United States. Am. J. Epidemiol.153, 912–920 (2005).
   Google Scholar
• Xu F, Schillinger JA, Sternberg MR et al. Seroprevalence and coinfection with herpes simplex virus type 1 and type 2 in the United States, 1988–1994. J. Infect. Dis.185, 1019–1025 (2002).
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. Elimination of rubella and congenital rubella syndrome – United States, 1969–2004. Morb. Mortal. Wkly Rep.54, 279–282 (2005).
   PubMedGoogle Scholar
• Fleming DT, McQuillan GM et al. Herpes simplex virus type 2 in the United States, 1976 to 1994. N. Engl. J. Med.337, 1105–1011 (1997).
   PubMed Web of Science ®Google Scholar
• Gbison J, Hornung C, Alexander G et al. A cross-sectional study of herpes simplex virus type 1 and 2 in college students: occurrence and determinants of infection. J. Infect. Dis.162, 306–312 (1990).
   PubMedGoogle Scholar
• Langenberg MD, Corey L, Ashley PR et al. A prospective study ofnew infections with herpes simplex virus type 1 and type 2. N. Engl. J. Med.231, 1432–1438 (1999).
   Google Scholar
• Brown ZA, Selke S, Zeh J et al. The acquitision of herpes simplex virus during pregnancy. N. Engl. J. Med.337, 509–515 (1997).
   PubMed Web of Science ®Google Scholar
• Nahmias AJ, Lee FK, Beckman-Nahmias S. Sero-epidemiological and sociological patterns of herpes simplex virus infection in the world. Scand. J. Infect. Dis.69, 19–36 (1990).
   Google Scholar
• Holland EJ, Schwartz GS. Classification of herpes simplex virus keratitis. Cornea18, 144–154 (1999).
   PubMed Web of Science ®Google Scholar
• Holbach LM, Font RL, Naumann GO. Herpes simplex stromal and endothelial keratitis. Granulomatous cell reactions at the level of Descemet’s membrane, the stroma, and Bowmans layer. Ophthalmol.97, 722–728 (1990).
   PubMedGoogle Scholar
• Kaufmann HE, Kanai A. Ellison ED. Herpetic iritis: demonstration of virus in the anterior chamber by fluorescent antibody techniques and electron microscopy. Am. J. Ophthalmol.71, 465–469 (1971).
   PubMedGoogle Scholar
• Sundmacher R, Neumann-Haefelin D. Herpes simplex virus isolierung aus dem Kammerwasser bei fokaler iritis, endotheliitis und langdauernder keratitis disciformis mit sekundarglaukom. Klin. Monatsbl Augenheilkd175, 488–501 (1979).
   PubMed Web of Science ®Google Scholar
• Olsen TW, Hardten DR, Meiusi RS, Holland EJ. Linear endotheliitis. Am. J. Ophthalmol.117, 468–174 (1999).
   Google Scholar
• Spencer WH, Hayes TL. Scanning and transmission electron microscope observations of the topographic anatomy of dendritic lesions in the rabbit cornea. Invest. Ophthalmol.9, 183–195 (1970).
   PubMedGoogle Scholar
• Liesegang TJ. Classification of Herpes simplex virus keratitis and anterior uveitis. Cornea18, 127–143 (1994).
   Google Scholar
• Sjögren H. Zur Kenntnis der Keraoconjunctivitis sicca (Keratitis filiformis bei Hypofunktion der Tränendrüsen). Acta Ophthalmol. Suppl. 2 (1933).
   Google Scholar
• Feenstra PR, Tseng SCG. Comparison of fluorescein and rose bengal staining. Ophthalmology99, 605–617 (1999).
   Google Scholar
• Kim J, Foulks GN. Evaluation of the effect of lissamine green and rose bengal on human corneal epithelial cells. Cornea18, 328–332 (1992).
   Google Scholar
• Argueso P, Tisdale A, Spurr-Michaud S, Sumiyoshi M et al. Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye. Invest. Ophthalmol. Vis. Sci.47, 113–119 (2006).
   PubMed Web of Science ®Google Scholar
• Roat MI, Romanowksi E, Araullo-Cruz T, Gordon YJ. The antiviral effects of rose bengal and fluorescein. Arch. Ophthalmol.105, 1415–1417 (1987).
   PubMed Web of Science ®Google Scholar
• Wilhelmus KR, Coster DJ, Donovan HC, Falcon MG, Jones BR. Prognosis indicators of herpetic keratitis. Analysis of a five-year observation period after corneal ulceration. Arch. Ophthalmol.99, 1578–82 (1971).
   Google Scholar
• Thygeson P. Marginal herpes simplex keratitis simulating catarrhal ulcer. Invest. Ophthalmol. Vis. Sci.10, 1006 (1981).
   Google Scholar
• Pavan-Langston D. Herpetic infections. In: The Cornea. Smolin G, Thoft RA (Eds). Little, Brown Boston, MA, USA 183–215 (1994).
   Google Scholar
• Wilhelmus KR, Coster DJ, Jones BR. Acylcovir and debridement in the treatment of ulcerative herpetic keratitis. Am. J. Ophthalmol.91, 323–327 (1981).
   PubMedGoogle Scholar
• Brik D, Dunkel E, Pavan-Langston D. Herpetic keratitis: persistence of viral particles despite topical and systemic antiviral therapy. Report of two cases and review of the literature. Arch. Ophthalmol.111, 522–527 (1993).
   PubMedGoogle Scholar
• Schwartz GS, Harrison AR, Holland EJ. Etiology of immune stromal (Interstitial) keratitis. Cornea17, 278–281 (1998).
   PubMed Web of Science ®Google Scholar
• Darougar S, Wishart MS, Viswalingam ND. Epidemiological and clinical features of primary herpes simplex virus ocular infection. Br. J. Ophthalmol.69, 2–6 (1985).
   PubMed Web of Science ®Google Scholar
• Williams HP, Falcon MG, Jones BR. Corticosteroids in the management of herpetic eye disease. Trans. Ophthalmol. Soc. UK97, 341–344 (1977).
   PubMedGoogle Scholar
• Norn MS. Dendritic (herpetic) keratitis. I. Incidence, seasonal variations, recurrent rate, visual impairment, therapy. Acta Ophthalmol. (Copenh.)48, 91–107 (1994).
   Google Scholar
• Russell RG, Nasisse MP, Larsen S, Rouse BT. Role of T-lymphocytes in the pathogenesis of herpetic stromal keratitis. Invest. Ophthalmol. Vis. Sci.25, 938–944 (1984).
   PubMed Web of Science ®Google Scholar
• Wilhelmus KR, Gee L, Hauck WW et al. Herpetic Eye Disease Study. A controlled trial of topical corticosteroids for herpes simplex stormal keratitis. Ophthalmology101, 1883–1896 (1994).
   PubMed Web of Science ®Google Scholar
• Thomas J, Gangappa S, Kanangat S, Rouse BT. On the essential involvement of neutrophils in the immunopathologic disease; herpetic stromal keratitis. J. Immunol.158, 1383–1391 (1997).
   PubMed Web of Science ®Google Scholar
• Babu JS, Thomas J, Kanangat S et al. Viral replication is required for induction of ocular immunopathology by herpes simplex virus. J. Virol.. J. Virol.70, 101–107 (1996).
   PubMed Web of Science ®Google Scholar
• Daheshia M, Kanangat S, Rouse BT. Production of key molecules by ocular neutrophils early after herpetic infection of the cornea. Exp. Eye Res.67, 619–624 (1998).
   PubMed Web of Science ®Google Scholar
• Deshpande SP, Zheng M, Lee S. Rouse BT. Mechanisms of pathogenesis in herpetic immunoinflammatory ocular lesions. Vet. Microbiol.86, 17–26 (2002).
   PubMed Web of Science ®Google Scholar
• Vannas A, Ahonen R, Makitie J. Cornea endothelium in herpetic keratouveitis. Arch. Ophthalmol.101, 913–915 (1983).
   PubMedGoogle Scholar
• Oh JO. Endothleial lesions of rabbit cornea produced by herpes simplex virus. Invest. Ophthalmol.9, 196–205 (1970).
   PubMedGoogle Scholar
• Ohashi Y, Yamamoto S, Nishida K et al. Demonstration of herpes simplex virus DNA in idiopathic corneal endotheliopathy. Am. J. Ophthalmol.112, 419–423 (1991).
   PubMed Web of Science ®Google Scholar
• Walpita P, Darougar S, Thaker U. A rapid and sensitive culture test for detecting herpes simplex virus from the eye. Br. J. Ophthalmol.69, 637–639 (1985).
   PubMed Web of Science ®Google Scholar
• Subhan S, Jose RJ, Duggirala A et al. Diagnosis of herpes simplex virus-1 keratitis: comparison of giemsa stain, immunofluorescence assay and polymerase chain reaction. Curr. Eye Res.29, 209–213 (2002).
   Google Scholar
• Athmanathan S, Bandlapally S. Rao GN. Comparison of the sensitivity of a 24-hr shell vial assay, and conventional tube culture, in the isolation of herpes simplex virus-1 from corneal scrapings. BMC Clin. Path.1, 1–5 (2002).
   Google Scholar
• Johnson FB, Luker G, Chow C. Comparison of shell vial culture and the suspension infection method for the rapid detection of herpes simplex viruses. Diag. Microbiol. Infect. Dis.16, 61–66 (1993).
   PubMedGoogle Scholar
• Kowalski RP, Gordon YJ, Romanowski EG. A comparison of enzyme immunoassay and polymerase chain reaction with the clinical examination for diagnosing ocular herpetic disease. Ophthalmology100, 530–534 (1993).
   PubMed Web of Science ®Google Scholar
• Whiley DM, Mackay IM, Syrmis MW, Witt MJ, Sloots TP. Detection and differentiation of herpes simplex virus type 1 and 2 by a duplex LightCycler PCR that incorporates an internal control PCR reaction. J. Clin. Virol.30, 32–38 (2004).
   PubMed Web of Science ®Google Scholar
• Chichili GR, Athmanathan S, Farhatullah S et al. Multiplex polymerase chain reaction for the detection of herpes simplex virus, varicella-zoster virus and cytomegalovirus in ocular specimens. Curr. Eye Res.27, 85–90 (2003).
   PubMed Web of Science ®Google Scholar
• Berra A, Dutt JE, Foster CS. Detection of herpes simplex virus type-1 an in situ polymerase chain reaction technique. Cornea15, 55–61 (1996).
   PubMedGoogle Scholar
• Kowalski RP, Karenchak LM, Shah C, Gordon JS. Elivis; A new 24-hour test for detecting herpes simplex virus from ocular samples. Arch. Ophthalmol.120, 960–962 (2002).
   PubMedGoogle Scholar
• Colimon R, Minjolle S. Andre P et al. New types of primers (stair primers) for PCR amplification of the variable V3 region of the human immunodeficiency virus. J. Virol. Methods58, 7–19 (1996).
   PubMedGoogle Scholar
• Robert PY, Traccard I, Adenis JP et al. Multiplex detection of the herpesvirus in tear fluid using the “stair primers” PCR method: prospective study of 93 patients. J. Med. Virol.66, 506–511 (2002).
   PubMedGoogle Scholar
• Cunningham ET, Short GA, Irvine AR, Duker JS, Margolis TP. Acquired immunodeficiency syndrome associated herpes simplex virus retinitis; clinical description and use of polymerase chain reaction-based assay as a diagnostic tool. Arch. Ophthalmol.114, 834–840 (1996).
   PubMedGoogle Scholar
• Abd El-Aal AM, El Sayed M, Mohammed E, Ahmed M, Fathy M. Evaluation of herpes simplex detection in corneal scraping by three molecular methods. Curr. Microbiol.52, 379–382 (2006).
   PubMedGoogle Scholar
• Kaye SB, Baker K, Bonshek R et al. Human herpes viruses in the cornea. Br. J. Ophthalmol.84, 563–571 (2000).
   PubMedGoogle Scholar
• Kipp CJ. Further observations on malarial keratitis. Trans. Am. Ophthalmol. Soc.5, 331–340 (1889).
   PubMedGoogle Scholar
• Graupner K, Müller F. Zur Behandlung der Keratitis dendritica mit para-Fluorphenylalanin. Graefes Arch. Klin. Exp. Ophthalmol.171, 103–104 (1966).
   Google Scholar
• Howard GM, Kaufman HE. Herpes Simplex keratitis. Arch. Ophthalmol.127–141 (1962).
   PubMedGoogle Scholar
• Wilhelmus KR. The treatment of herpes simplex virus epithelial keratitis. Trans. Am. Ophthal. Soc.98, 505–530 (2000).
   PubMedGoogle Scholar
• Kaufman HE, Nesburn AB, Maloney ED. IDU therapy of herpes simplex. Arch. Ophthalmol.67, 583–591 (1962).
   PubMedGoogle Scholar
• Bauer DJ. A history of the discovery and clinical application of antiviral drugs. Br. Med. Bull.41, 309–314 (1985).
   PubMed Web of Science ®Google Scholar
• Whitley R, Alford C, Hess F et al. Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs20, 267–282 (1980).
   PubMed Web of Science ®Google Scholar
• Carmine AA, Brogden RN, Heel RC et al. Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections. Drugs23, 329–353 (1982).
   PubMed Web of Science ®Google Scholar
• Wellings PC, Awdry PN, Bors FH, Jones BR, Kaufman HE. Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers. Am. J. Ophthalmol.73, 932–942 (1972).
   PubMed Web of Science ®Google Scholar
• Kaufman HE. Treatment of viral diseases of the cornea and external eye. Prog. Ret. Eye Res.19, 69–86 (2000).
   PubMed Web of Science ®Google Scholar
• Kaufman HE, Heidelberger C. Therapeutic antiviral action of 5-trifluoromethyl-2′-deoxyuridine. Science145, 585–586 (1964).
   PubMed Web of Science ®Google Scholar
• Heidelberger C, King DH. Trifluorothymidine. Pharmacol. Ther.6, 427 (1979).
   Web of Science ®Google Scholar
• Gordon YJ. The evolution of antiviral therapy for external ocular viral infection over twenty-five years. Cornea19, 673–680 (2000).
   PubMed Web of Science ®Google Scholar
• Coster DJ, Wilhelmus KR, Michaud R, Jones BR. A comparison of acyclovir and idoxuridine as treatment of for ulcerative herpetic keratitis. Br. J. Ophthalmol.64, 763–765 (1980).
   PubMedGoogle Scholar
• Pavan-Langston D, Foster CS. Trifluorothymidine and idoxuridine therapy of ocular herpes. Am. J. Ophthalmol.84, 818–825 (1977).
   PubMedGoogle Scholar
• Pavan-Langston D, Lass J, Hettinger M, Udall I. Acyclovir and vidarabine in the treatment of ulcerative herpes simplex keratitis – comparative masked clinical trial. Ophthalmology92, 829–835 (1981).
   Google Scholar
• Hoh HB, Hurley C, Claoue C et al. Randomised trial of ganciclovir and acylcovir in the treatment of herpes simplex dendritic keratitis a multicenter study.Br. J. Ophthalmol.80, 140–143 (1996).
   PubMed Web of Science ®Google Scholar
• Castela N, Vermerie N, Chast F et al. Ganciclovir ophthalmic gel in herpes simplex virus rabbit keratitis intraocular penetration and efficacy. J. Ocul. Pharmacol.10, 439–451 (1994).
   PubMedGoogle Scholar
• Tabbara KF. Treatment of herpetic keratitis. Ophthalmology112, 1640–1644 (2005).
   PubMedGoogle Scholar
• Lairson DR, Begley CE, Reynolds TF, Wilhelmus KR. Prevention of herpes simplex virus eye disease: a cost-effectiveness analysis. Arch. Ophthalmol.121, 108–112 (2003).
   PubMedGoogle Scholar
• Beutner KR. Valacyclovir: a review of its antiviral activity, pharmacokinetic properties, and clinical efficacy. Antiviral Res.28, 281–290 (1995).
   PubMed Web of Science ®Google Scholar
• Sozen E, Avunduk AM, Akyol N. Comparsion of efficacy of oral valacyclovir and topical acyclovir in the treatment of herpes simplex keratitis: a randomized clinical trial. Chemotherapy52, 29–31 (2006).
   PubMed Web of Science ®Google Scholar
• Kaufman HE, Varnell ED, Thompson HW. Trifluridine, cidofovir and penciclovir in the treatment of experimental herpetic keratitis. Arch. Ophthalmol.116, 777–780 (1998).
   PubMedGoogle Scholar
• Romanowski B, Aoki FY, Martel AY et al. Efficacy and safety of famciclovir for treating mucocutaneous herpes simplex infection in HIV-infected individuals. Collaborative Famciclovir HIV Study Group. AIDS14, 1211–1217 (2000).
   PubMed Web of Science ®Google Scholar
• Schacker T, Hu H, Koelle M et al. Famciclovir for the suppression of symptomatic and assymptomatic herpes simplex reactivation in HIV-infected persons. A double-blind, placebo-controlled trial. Ann. Intern. Med.128, 21–28 (1998).
   PubMed Web of Science ®Google Scholar
• Maudgal PC, De Clercq E. Bromovinyldeoxyuridine treatment of herpetic keratitis clinically resistant to other antiviral agents. Curr. Eye Res.10, 193–199 (1991).
   PubMed Web of Science ®Google Scholar
• Bultmann H, Brandt CR. Peptides containing membrane-transiting motifs inhibit virus entry. J. Biol. Chem.277, 36018–36023 (2002).
   PubMed Web of Science ®Google Scholar
• Bultmann H, Busse JS, Brandt CR. Modified FGF4 signal peptide inhibits entry ofherpes simplex virus type q. J. Virol..75, 2634–2645 (2001).
   PubMed Web of Science ®Google Scholar
• Akkaranwongsa R, Cullinan AE, Zinkel A et al. Corneal toxicity of cell-penetrating peptides that inhibit herpes simplex virus entry. J. Ocul. Pharmacol. Ther.22, 279–289 (2006).
   PubMedGoogle Scholar
• Robbins RM, Galin MA. A model of steroid effects in herpes simplex keratitis. Arch. Ophthalmol.93, 828–830 (1975).
   PubMedGoogle Scholar
• Dawson C, Togni B, Moore TE Jr, Coleman V. Herpes virus infection of human mesodermal tissue (cornea) detected by electron microscopy. Nature217, 460–462 (1968).
   PubMed Web of Science ®Google Scholar
• Mukherjee G, Mohan M, Angra SK. Topical corticosteroid in herpetic keratitis. East Arch. Ophthalmol.7, 34–40 (1981).
   Google Scholar
• Barron BA, Gee L, Hauck WW et al, for the Herpetic Eye Disease Study Group. A controlled trial of oral acyclovir for herpes simplex stromal keratitis. Ophthalmology101, 1871–1882 (1994).
   PubMed Web of Science ®Google Scholar
• Herpetic Eye Disease Study Group. A controlled trial of oral acyclovir for the prevention of stromal keratits or iritis in patients with herpes simplex virus epithelial keratitis. Arch. Ophthalmol.703–712 (1997).
   PubMedGoogle Scholar
• Herpetic Eye Disease Study Group. Acyclovir for the prevention of recurrent herpes simplex virus eye disease. N. Engl. J. Med.339, 300–306 (1998).
   PubMed Web of Science ®Google Scholar
• Moyes AL, Sugar A, Musch DC, Barnes RD. Antiviral therapy after penetrating keratoplasty for herpes simplex keratitis. Arch. Ophthalmol.112, 601–607 (1994).
   PubMedGoogle Scholar
• Collum LMT, Akhtar J, McGettrick P. Oral acyclovir in herpetic keratitis. Trans. Ophthalmol. Soc. UK104, 629–632 (1985).
   PubMedGoogle Scholar
• Schwab IR. Oral acyclovir in the management of Herpes simplex ocular infections. Ophthalmology95, 423–430 (1988).
   PubMed Web of Science ®Google Scholar
• Hung SO, Patterson A, Clarke DI, Rees PJ. Oral acyclovir in the management of dendritic herpetic corneal ulceration. Br. J. Ophthalmol.68, 398–400 (1984).
   PubMedGoogle Scholar
• Schwartz GS, Holland EJ. Oral acyclovir for the management of herpes simplex keratitis in children. Ophthalmology107, 2278–2282 (2000).
   PubMedGoogle Scholar
• Dhaliwal DK, Romanowksi EG, Yates KA et al. Valacyclovir inhibition of recovery of ocular herpes simplex virus type 1 after experimental reactivation by laser in situ keratomileusis. J. Cataract Refract. Surg.27, 1288–1293 (2001).
   PubMed Web of Science ®Google Scholar
• Halberstadt M, Machens M, Gahlenbek KA, Bohnke M, Garweg JG. The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin. Br. J. Ophthalmol.86, 646–652 (2002).
   PubMed Web of Science ®Google Scholar
• Larkin DFP. Corneal transplantation for herpes simplex keratitis. Br. J. Opthalmol.82, 107–108 (1998).
   PubMedGoogle Scholar
• Foster CS, Barney NP. Systemic acyclovir and penetrating Keratoplasty for herpes simplex keratitis. Doc. Ophthalmol.80, 363–369 (1992).
   PubMedGoogle Scholar
• Ficker LA, Kirkness CM, Rise NSC et al. The changing management and improved prognosis for corneal grafting in herpes simplex keratitis. Ophthalmol96, 1587–1596 (1989).
   Google Scholar
• Barney NP, Foster SF. A prospective randomized trial of oral acyclovir after penetrating keratoplasty for herpes simplex keratitis. Cornea117, 445–449 (1994).
   Google Scholar
• Lomholt JA, Baggesen K, Ehlers N. Recurrence and rejection rates following corneal transplantation for herpetic keratitis. Acta Ophthalmol. Scand.73, 29–32 (1995).
   PubMedGoogle Scholar
• Langston RHS, Pavan-Langston D, Dohlmann CH. Penetrating keratoplasty for herpetic keratitis: prognosis and therapeutic determinants. Trans. Am. Acad. Ophthalmol.79, 577–583 (1975).
   Google Scholar
• Gold D, Corey L. Acyclovir prophylaxis for herpes simplex virus infection. Antimicrob. Agents Chemother.95, 361–367 (1987).
   Google Scholar
• Mertz GJ, Jones CC, Mills J et al. Long-term acyclovir suppression of frequently recurring genital herpes simplex virus infection: a multicentered doubleblind trial. JAMA260, 201–206 (1988).
   PubMed Web of Science ®Google Scholar
• Schmidt OW, Fife KH, Corey L. Reinfection is an uncommon occurrence in patients with symptomatic recurrent genital herpes. J. Infect. Dis.149, 645–646 (1984).
   PubMedGoogle Scholar
• Herpetic Eye Disease Study Group. Oral acyclovir for herpes simplex viral eye disease. Arch. Ophthalmol.118, 1030–1036 (2000).
   PubMedGoogle Scholar
• The Australian Corneal Graft Registry. 1990 to 1992. Report Aust. NZ J Ophthalmol.21(Suppl.), 32 (1993).
   Google Scholar
• Beyer CF, Byrd TJ, Hill JM et al. Herpes simplex virus and persistent epithelial defects after penetrating keratoplasty. Am. J. Ophthalmol.109, 95–96 (1990).
   PubMedGoogle Scholar
• Mannis MJ, Plotnik RD, Schwab IR et al. Herpes simplex dendritic keratitis after keratoplasty. Am. J. Ophthalmol.11, 480–484 (1990).
   Google Scholar
• Biswas S, Suresh P, Bonshek RE et al. Graft failure in human donor corneas due to transmission of herpes simplex virus. Br. J. Ophthalmol.84, 701–705 (2000).
   PubMedGoogle Scholar
• Cockerham GC, Krafft AE, McLean IW. Herpes simplex virus in primary graft failure. Arch. Ophthalmol.115, 586–589 (1997).
   PubMedGoogle Scholar
• De Kessel RJ, Koppen C,Ieven M, Zeyen T. Primary graft failure caused by herpes simplex virus type 1. Cornea20, 187–190 (2001).
   PubMedGoogle Scholar
• Tullo AB, Marcyniuk B, Bonshek R et al. Herpes virus in donor cornea. Eye4, 766–767 (1990).
   PubMedGoogle Scholar
• Asbell PA, Centifanto-Fitzgerald YM, Chandler JW, Kaufman HE. Analysis of viral DNA in isolates from patients with recurrent herpetic keratitis. Invest. Ophthalmol. Vis. Sci.25, 951–954 (1984).
   PubMedGoogle Scholar
• Sucato G, Wald A, Wakabayashi E, Vieira J, Corey L. Evidence of latency and reactivation of both herpes simplex virus (HSV-1) and HSV-2 in the genital region. J. Infect. Dis.177, 1069–1072 (1998).
   PubMed Web of Science ®Google Scholar
• Buchman TG, Roizman B, Nahmias AJ. Demonstration of exogenous reinfection with herpes simplex virus type-2 restriction endonuclease fingerprinting of viral DNA. J. Infect. Dis.140, 295–304 (1979).
   PubMed Web of Science ®Google Scholar
• Lewis ME, Leung WC, Jeffrey VM, Warren KG. Detection of multiple strains of latent herpes simplex virus type I within individual human hosts. J. Virol.52, 300–305 (1984).
   PubMed Web of Science ®Google Scholar
• Wander AH, Centifanto YM, Kaufman HE. Strain specificity of clinical isolates of herpes simplex virus. Arch. Ophthalmol.98, 1458–1461 (1980).
   PubMedGoogle Scholar
• Centifanto-Fitzgerald YM, Yamaguchi T, Kaufman HE, Tongnon M, Roizman B. Ocular disease pattern induced by herpes simplex virus is genetically determined by a specific region of viral DNA. J. Exp. Med.155, 475–489 (1982).
   PubMed Web of Science ®Google Scholar
• Remeijer L, Maertzdorf J, Buitenwerf J, Osterhaus AD, Verjains FM. Corneal herpes simplex virus type 1 superinfection in patients with recrudescent herpetic keratitis. Invest. Ophthalmol. Vis. Sci.43, 358–363 (2002).
   PubMed Web of Science ®Google Scholar
• Nicholls SM, Shimeld C, Easty DL, Hill TJ. Recurrent herpes simplex after corneal transplantation in rats. Invest. Ophthalmol. Vis. Sci.37, 425–435 (1996).
   PubMed Web of Science ®Google Scholar
• Zheng X, Marquart ME, Loustch JM et al. HSV-1 migration in latently infected and naive rabbits after penetrating keratoplasty. Invest. Ophthalmol. Vis. Sci..40, 2490–2497 (1999).
   PubMedGoogle Scholar
• Magg DJ, Chang E, Nasisse MP, Mitchell WJ. Persistence of herpes simplex virus type I DNA in chronic conjunctival and eyelid lesions of mice. J. Virol..72, 9166–9172 (1998).
   PubMedGoogle Scholar
• Remeijer L, Maertzdorf J, Doornenbal P, Verjans GM, Osterhaus AD. Herpes simplex virus 1 transmission through corneal transplantation. Lancet357, 442 (2001).
   PubMed Web of Science ®Google Scholar
• Robert PY, Adenis JP, Denis F, Alain S, Ranger-Rogez S. Herpes simplex virus DNA in corneal transplants: prospective study of 38 recipients. J. Med. Virol.71, 69–74 (2003).
   PubMedGoogle Scholar
• O’Brien WJ, Tsao LS, Taylor JL. Tissue-specific accumulation of latency-associated transcripts in herpes virus-infected rabbits. Invest. Ophthalmol. Vis. Sci.39, 1847–1853 (1998).
   PubMedGoogle Scholar
• Cook SD, Hill JM, Lynas C. Maitland NJ. Latency-associated transcripts in corneas and ganglia of HSV-1 infected rabbits. Br. J. Ophthalmol.75, 644–648 (1991).
   PubMedGoogle Scholar
• Bearer EL. Breakefield XO, Schuback D, Reese TS, LAVail JH. Retrogade axonal transport of herpes simplex virus: evidence for a single mechanism and role for tegument. Proc. Natl. Acad. Sci. USA97, 8146–8150 (2000).
   PubMed Web of Science ®Google Scholar
• Topp KS, Meade LB, LaVail JH. Microtubule polarity in the peripheral processes of trigeminal ganglion cells: relevance for the retrograde transport of herpes simplex virus. J. Neurosci.314, 318–325 (1994).
   Google Scholar
• Posavad CM. Koelle DM, Corey L. Tipping the scales of herpes simplex reactivation; the important responses are local. Nature Med.4, 381–382 (1998).
   PubMed Web of Science ®Google Scholar
• Koelle DM, Ghiasi H. Prospects for developing an effective vaccine against ocular herpes simplex virus infection. Curr. Eye Res.30, 929–942 (2005).
   PubMed Web of Science ®Google Scholar