Advanced search
Publication Cover
Expert Review of Ophthalmology Volume 2, 2007 - Issue 1
Submit an article Journal homepage
7
Views
0
CrossRef citations to date
0
Altmetric
Key Paper Evaluation

Circulating antiretinal autoantibodies and age-related macular degeneration: what is the link?

Svetlana Cherepanoff Research Officer, Save Sight Institute, University of Sydney and Prince of Wales Medical Research Institute Barker St, Randwick, NSW 2031, Australia. [email protected]
&
Mark C Gillies Associate Professor, Save Sight Institute, University of Sydney, Department of Ophthalmology, PO Box 4337, Sydney, NSW 2001, Australia. [email protected]
Pages 27-31 | Published online: 09 Jan 2014

References

  • Joachim SC, Bruns K, Lackner KJ, Pfeiffer N, Grus FH. Analysis of IgG antibody patterns against retinal antigens and antibodies to α-crystallin, GFAP, and α-enolase in sera of patients with “wet” age-related macular degeneration. Graefes Arch. Clin. Exp. Ophthalmol. DOI: 10.1007/s00417-006-0429-9 (2006).
  • Penfold PL, Madigan MC, Gillies MC, Provis JM. Immunological and aetiological aspects of macular degeneration. Prog. Retin. Eye Res.20, 385–414 (2001).
  • Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog. Retin. Eye Res.20, 705–732 (2001).
  • Haines JL, Hauser MA, Schmidt S et al. Complement factor H variant increases the risk of age-related macular degeneration. Science308, 419–421 (2005).
  • Hageman GS, Anderson DH, Johnson LV et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc. Natl Acad. Sci. USA102, 7227–7232 (2005).
  • Klein RJ, Zeiss C, Chew EY et al. Complement factor H polymorphism in age-related macular degeneration. Science308, 385–389 (2005).
  • Okamoto H, Umeda S, Obazawa M et al. Complement factor H polymorphisms in Japanese population with age-related macular degeneration. Mol. Vis.12, 156–158 (2006).
  • Sepp T, Khan JC, Thurlby DA et al. Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers. Invest. Ophthalmol. Vis. Sci.47, 536–540 (2006).
  • Gold B, Merriam JE, Zernant J et al. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat. Genet.38, 458–462 (2006).
  • Chant SM, Heckenlively J, Meyers-Elliott RH. Autoimmunity in hereditary retinal degeneration. I. Basic studies. Br. J. Ophthalmol.69, 19–24 (1985).
  • Penfold PL, Provis JM, Furby JH, Gatenby PA, Billson FA. Autoantibodies to retinal astrocytes associated with age-related macular degeneration. Graefes Arch. Clin. Exp. Ophthalmol.228, 270–274 (1990).
  • Gurne DH, Tso MO, Edward DP, Ripps H. Antiretinal antibodies in serum of patients with age-related macular degeneration. Ophthalmology98, 602–607 (1991).
  • Chen H, Wu L, Pan S, Wu DZ. An immunologic study on age-related macular degeneration. Yen Ko Hsueh Pao (Eye Science)9, 113–120 (1993).
  • Gu X, Meer SG, Miyagi M et al. Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. J. Biol. Chem.278, 42027–42035 (2003).
  • Patel N, Ohbayashi M, Nugent AK et al. Circulating anti-retinal antibodies as immune markers in age-related macular degeneration. Immunology115, 422–430 (2005).
  • Cherepanoff S, Mitchell P, Wang JJ, Gillies MC. Retinal autoantibody profile in early age-related macular degeneration: preliminary findings from the Blue Mountains Eye Study. Clin. Exp. Ophthalmol.34, 590–595 (2006).
  • Joachim SC, Grus FH, Pfeiffer N. Analysis of autoantibody repertoires in sera of patients with glaucoma. Eur. J. Ophthalmol.13, 752–758 (2003).
  • Grus FH, Joachim SC, Hoffmann EM, Pfeiffer N. Complex autoantibody repertoires in patients with glaucoma. Mol. Vis.10, 132–137 (2004).
  • Avrameas S, Ternynck T. Natural autoantibodies: the other side of the immune system. Res. Immunol.146, 235–248 (1995).
  • Wu KH, Madigan MC, Billson FA, Penfold PL. Differential expression of GFAP in early v late AMD: a quantitative analysis. Br. J. Ophthalmol.87, 1159–1166 (2003).
  • Augusteyn RC. α-crystallin: a review of its structure and function. Clin. Exp. Optometry87, 356–366 (2004).
  • Crabb JW, Miyagi M, Gu X et al. Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc. Natl Acad. Sci. USA99, 14682–14687 (2002).
  • Aaronson RM, Graven KK, Tucci M, McDonald RJ, Farber HW. Non-neuronal enolase is an endothelial hypoxic stress protein. J. Biol. Chem.270, 27752–27757 (1995).
  • Gitlits VM, Toh BH, Sentry JW. Disease association, origin, and clinical relevance of autoantibodies to the glycolytic enzyme enolase. J. Invest. Med.49, 138–145 (2001).
  • Binder CJ, Shaw PX, Chang M-K et al. Thematic review series: the immune system and atherogenesis. The role of natural antibodies in atherogenesis. J. Lipid Res.46, 1353–1363 (2005).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.