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Expert Review of Hematology Volume 9, 2016 - Issue 1
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Review

Advances in our understanding of mechanisms of venous thrombus resolution

Johanna AltmannDivision of Cardiology, Department of Internal Medicine II, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
,
Smriti SharmaDivision of Cardiology, Department of Internal Medicine II, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
&
Irene M LangDivision of Cardiology, Department of Internal Medicine II, Vienna General Hospital, Medical University of Vienna, Vienna, AustriaCorrespondence[email protected]
Pages 69-78 | Published online: 02 Dec 2015

References

  • Papers of special note have been highlighted as:
  • * of interest
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*Summarizes the role of inflammation in thrombus resolution

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** Splenectomy delays thrombus resolution, mediated by increased levels of circulating phospholipids and disturbed angiogenesis

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** Platelet-endothelial CAM 1 mediates monocyte recruitment to resolving thrombi and is essential for thrombus resolution

* Gives an overview of the cellular and molecular mechanisms of angiogenesis

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** Endothelial cell-specific deletion of the VEGF receptor 2causes misguided thrombus resolution. Defective thrombus angiogenesis may contribute to the pathogenesis of chronic thromboembolic pulmonary hypertension

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